The juvenile-peripubertal transition period in the female rat: establishment of a diurnal pattern of pulsatile luteinizing hormone secretion.

abstract：:We investigated the effects of thyroid status on nitric oxide synthase (NOS) gene expression in the rat hypothalamic paraventricular (PVN) and supraoptic nuclei (SON). Propylthiouracil (PTU)-induced hypothyroidism in male rats produced a highly significant reduction in NOS gene transcripts in the PVN and SON, as asses...

journal_title：Endocrinology

authors： Ueta Y,Levy A,Chowdrey HS,Lightman SL

更新日期：1995-10-01 00:00:00

abstract：:The direct actions of kit-ligand/stem cell factor (KL) in developing ovarian follicles were investigated. Previous studies have shown that granulosa cells express KL that can support oocyte development. The current study demonstrates that KL can also act directly on theca cells to promote cellular growth and different...

journal_title：Endocrinology

authors： Parrott JA,Skinner MK

更新日期：1997-09-01 00:00:00

abstract：:Primary cultures of enzymatically dispersed rat anterior pituitary cells were used to examine the effect of pure 31 kilodalton bovine inhibin on GnRH-induced up-regulation of GnRH binding sites. After 2 days in culture, the cells were exposed to stimuli with or without test substances for 10 h, followed by evaluation ...

journal_title：Endocrinology

authors： Wang QF,Farnworth PG,Findlay JK,Burger HG

更新日期：1989-01-01 00:00:00

abstract：:Oscillations in intracellular calcium levels have been described in GnRH-1 neurons in both prenatal and adult cells. However, differences have been reported in the mechanisms underlying these [Ca(2+)](i) oscillations, dependent on the model used. The goal of this study was to address whether these changes depend on th...

journal_title：Endocrinology

authors： Constantin S,Klenke U,Wray S

更新日期：2010-08-01 00:00:00

abstract：:Glucocorticoids regulate hippocampal function in part by modulating gene expression through the glucocorticoid receptor (GR). GR binding is highly cell type specific, directed to accessible chromatin regions established during tissue differentiation. Distinct classes of GR binding sites are dependent on the activity o...

journal_title：Endocrinology

authors： Pooley JR,Flynn BP,Grøntved L,Baek S,Guertin MJ,Kershaw YM,Birnie MT,Pellatt A,Rivers CA,Schiltz RL,Hager GL,Lightman SL,Conway-Campbell BL

更新日期：2017-05-01 00:00:00

abstract：:Mediators of lymphocyte infiltration in inflammatory thyroid disease have yet to be identified. Here we examine the ability of IL-1beta to enhance the production of chemoattractants by human thyrocytes. Primary cultures, when treated with the cytokine, release T lymphocyte chemotactic activity. The effect of IL-1beta ...

journal_title：Endocrinology

authors： Gianoukakis AG,Martino LJ,Horst N,Cruikshank WW,Smith TJ

更新日期：2003-07-01 00:00:00

abstract：:The intraislet insulin hypothesis has been proposed to explain absent glucagon responses to hypoglycemia. Recently we directly confirmed this hypothesis by restoring glucagon secretion via provision of a pancreatic artery insulin infusion, which was switched off at the time of hypoglycemia in Wistar rats made diabetic...

journal_title：Endocrinology

authors： Zhou H,Zhang T,Oseid E,Harmon J,Tonooka N,Robertson RP

更新日期：2007-06-01 00:00:00

abstract：:NG108-15 cells, which have a rounding-up morphology when cultured in serum-supplemented medium, extend neurites when stimulated for 3 d with angiotensin II (Ang II). The aim of the present study was to investigate whether growth factor receptors are necessary for mediating the effects of Ang II. A 3-d treatment with A...

journal_title：Endocrinology

authors： Plouffe B,Guimond MO,Beaudry H,Gallo-Payet N

更新日期：2006-10-01 00:00:00

abstract：:The lipolysis, ketosis and hypertriglyceridemia of fasted rats in late pregnancy may be related to decreased insulin secretion geared to decreased glucose availability. In odd-carbon fatty acid enriched (OCE) rats, the odd-carbon fatty acids (OCFA) mobilized during fasting provide terminal three-carbon residues which ...

journal_title：Endocrinology

authors： Kim S,Pi-Sunyer FX

更新日期：1977-02-01 00:00:00

abstract：:The insulin-like growth factor I (IGF-I) receptor is a transmembrane tyrosine kinase that mediates the growth-promoting effects of IGF-I and IGF-II. Changes in IGF-I receptor messenger RNA levels are reflected in cell surface receptor number, and modulation of IGF-I receptor levels affects tumorigenicity in numerous c...

journal_title：Endocrinology

authors： Tajinda K,Carroll J,Roberts CT Jr

更新日期：1999-10-01 00:00:00

abstract：:The rat PTH molecule contains five sequence differences from either the bovine or the human hormone within the biologically active 1-34 region. A synthetic rat 1-34 peptide was tested for activity by in vitro activation of canine and rat renal adenylate cyclase and binding to canine renal membrane receptors. The mean ...

journal_title：Endocrinology

authors： Keutmann HT,Griscom AW,Nussbaum SR,Reiner BF,Goud AN,Potts JT Jr,Rosenblatt M

更新日期：1985-09-01 00:00:00

abstract：:The membrane fraction from the ovaries of pseudopregnant rats exhibits specific, high affinity binding of high density lipoproteins (HDL). Previous studies have indicated that HDL binding in this tissue is up-regulated by hCG and may be involved in supplying cholesterol as substrate for steroid hormone production. To ...

journal_title：Endocrinology

authors： Ferreri K,Menon KM

更新日期：1990-04-01 00:00:00

abstract：:Transcription activator-like effector nucleases (TALENs) are a powerful approach for targeted genome editing and have been proved to be effective in several organisms. In this study, we reported that TALENs can induce somatic mutations in Nile tilapia, an important species for worldwide aquaculture, with reliably high...

journal_title：Endocrinology

authors： Li MH,Yang HH,Li MR,Sun YL,Jiang XL,Xie QP,Wang TR,Shi HJ,Sun LN,Zhou LY,Wang DS

更新日期：2013-12-01 00:00:00

abstract：:It is believed that a combination of environmental factors with mutagens induces carcinomas derived from thyroid follicular cells. In this study we tried to ascertain whether a single short-term exposure to external radiation is sufficient to induce thyroid carcinomas in rats under long-term high or low dietary iodine...

journal_title：Endocrinology

authors： Boltze C,Brabant G,Dralle H,Gerlach R,Roessner A,Hoang-Vu C

更新日期：2002-07-01 00:00:00

abstract：:An increasing body of evidence has linked AMP-activated protein kinase (AMPK) and malonyl coenzyme A (CoA) to the regulation of energy balance. Thus, factors that activate AMPK and decrease the concentration of malonyl CoA in peripheral tissues, such as exercise, decrease triglyceride accumulation in the adipocyte and...

journal_title：Endocrinology

authors： Ruderman NB,Saha AK,Kraegen EW

更新日期：2003-12-01 00:00:00

abstract：:The purpose of this study was to examine how the physical characteristics of light influence the short photoperiod-induced atrophy of the reproductive system. In the first experiment, groups of Syrian hamsters were exposed to a 14-h light, 10-h dark (14:10) photoperiod, a 11:13 photoperiod or a 11:13 photoperiod exten...

journal_title：Endocrinology

authors： Brainard GC,Vaughan MK,Reiter RJ

更新日期：1986-08-01 00:00:00

abstract：:Light and electron microscopic triple immunostaining was performed on coronal vibratome sections prepared from the hypothalamus of ovariectomized (OVX) and OVX plus estrogen-treated African green monkeys (Cercopithecus aethiops). Immunoreactivity for progesterone receptors (PRs) and neuropeptide-Y (NPY) was visualized...

journal_title：Endocrinology

authors： Horvath TL,Shanabrough M,Naftolin F,Leranth C

更新日期：1993-07-01 00:00:00

abstract：:Molecular mechanisms underlying unloading-induced reduction of bone formation have not yet been fully understood. In vitro, Runx2 has been suggested to be involved in mechanical signaling in osteoblasts. However, the roles of Runx2 in vivo during the bone response to mechanical stimuli have not yet been known. The pur...

journal_title：Endocrinology

authors： Salingcarnboriboon R,Tsuji K,Komori T,Nakashima K,Ezura Y,Noda M

更新日期：2006-05-01 00:00:00

abstract：:Glucose homeostasis depends on the coordinated secretion of glucagon, insulin, and Glucagon-like peptide (GLP)-1 by pancreas and intestine. Obesity, which is associated with an increased risk of developing insulin resistance and type 2 diabetes, affects the function of these organs. Here, we investigate the functional...

journal_title：Endocrinology

authors： Dusaulcy R,Handgraaf S,Skarupelova S,Visentin F,Vesin C,Heddad-Masson M,Reimann F,Gribble F,Philippe J,Gosmain Y

更新日期：2016-10-01 00:00:00

abstract：:Several studies have shown that insulin-like growth factor-binding proteins (IGF-BPs) modify IGF activity. To investigate their role in regulating growth, the number and size of IGF-BPs in porcine serum and the role of nutritional and endocrine factors in controlling their relative abundance were determined. IGF-BPs w...

journal_title：Endocrinology

authors： McCusker RH,Campion DR,Jones WK,Clemmons DR

更新日期：1989-07-01 00:00:00

abstract：:As ovariectomy induces obesity in rats, we have investigated the influence of ovariectomy and hormone replacement on the proliferation and differentiation capacities of rat cultured preadipocytes removed from different fat depots (femoral sc, parametrial, and perirenal). Ovariectomy induced increased proliferation and...

journal_title：Endocrinology

authors： Lacasa D,Garcia E,Agli B,Giudicelli Y

更新日期：1997-07-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) has a biphasic clinical phenotype with failure to thrive in the neonatal period followed by hyperphagia and severe obesity commencing in childhood among other endocrinological and neurobehavioral abnormalities. The syndrome results from loss of function of several clustered, paternally expr...

journal_title：Endocrinology

authors： Stefan M,Ji H,Simmons RA,Cummings DE,Ahima RS,Friedman MI,Nicholls RD

更新日期：2005-10-01 00:00:00

abstract：:In the present study we have examined the effects of FSH, forskolin, and (Bu)2cAMP on messenger RNA (mRNA) levels for all known subunits of cAMP-dependent protein kinase in rat Sertoli cells, using newly developed complementary DNA (cDNA) probes. mRNAs for the three regulatory subunits [RI alpha, RII51, (RII beta), an...

journal_title：Endocrinology

authors： Oyen O,Sandberg M,Eskild W,Levy FO,Knutsen G,Beebe S,Hansson V,Jahnsen T

更新日期：1988-06-01 00:00:00

abstract：:Lactating rats exhibit stable individual differences in pup licking/grooming (LG) over the first week postpartum. Such naturally occurring variations in maternal behavior are associated with differences in estrogen-inducible oxytocin receptors in the medial preoptic area (MPOA) of the hypothalamus. We compared levels ...

journal_title：Endocrinology

authors： Champagne FA,Weaver IC,Diorio J,Sharma S,Meaney MJ

更新日期：2003-11-01 00:00:00

abstract：:To investigate the respective role in PRL secretion of gamma-aminobutyric acid (GABA), either derived from the central nervous system or circulating in plasma, experiments were performed using ethanolamine-O-sulfate (EOS), a specific inhibitor of GABA catabolism. Intracerebroventricular injection of EOS (2 mg/kg) indu...

journal_title：Endocrinology

authors： Apud JA,Racagni G,Iuliano E,Cocchi D,Casanueva F,Müller EE

更新日期：1981-04-01 00:00:00

abstract：:Antisera against proopiomelanocortin (POMC)-derived peptides have previously been employed to demonstrate immunostainable materials in the male reproductive tract and in the corpus luteum of rat ovary. The present study was designed to determine how the distribution of such stainable materials varies in mouse ovary as...

journal_title：Endocrinology

authors： Shaha C,Margioris A,Liotta AS,Krieger DT,Bardin CW

更新日期：1984-07-01 00:00:00

abstract：:The physiology and regulation of steroid synthesis in the brain have emerged as important for understanding brain function. Neurosteroids, those steroids synthesized de novo in nervous tissue, have been associated with numerous central nervous system functions, including myelination, mental retardation, and epilepsy. ...

journal_title：Endocrinology

authors： Micevych P,Sinchak K

更新日期：2008-06-01 00:00:00

abstract：:Estrogens have pronounced effects on thermoregulation, as illustrated by the occurrence of hot flushes secondary to estrogen withdrawal in menopausal women. Because neurokinin B (NKB) gene expression is markedly increased in the infundibular (arcuate) nucleus of postmenopausal women, and is modulated by estrogen withd...

journal_title：Endocrinology

authors： Dacks PA,Krajewski SJ,Rance NE

更新日期：2011-12-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] and 24,25-(OH)2D3 differentially affect the specific activity of alkaline phosphatase (ALPase) and phospholipase-A2 (PLA2) of plasma membranes and extracellular matrix vesicles produced by costochondral reserve zone and growth zone cartilage chondrocytes in culture. In the prese...

journal_title：Endocrinology

authors： Schwartz Z,Schlader DL,Swain LD,Boyan BD

更新日期：1988-12-01 00:00:00

abstract：:The present work extends our previous report that the intracerebroventricular (i.c.v.) injection of interleukin-1beta(IL-1beta, 80 ng) significantly blunted the testosterone response to 1 U/kg human CG (hCG), an effect that we attributed to the stimulation of inhibitory pathways connecting the hypothalamus to the test...

journal_title：Endocrinology

authors： Ogilvie K,Rivier C

更新日期：1998-07-01 00:00:00