The calcium oscillator of GnRH-1 neurons is developmentally regulated.

abstract：:Both the estrogen responsiveness and -binding capacity of cultured rat uterine cells were decreased dramatically when the medium was not changed at 24-h intervals. Treatment of cells for 24 h with 1 nM 17 beta-estradiol in fresh medium led to a 3-fold increase in progesterone receptor concentration, but without fresh ...

journal_title：Endocrinology

authors： Kassis JA,Walent JH,Gorski J

更新日期：1984-08-01 00:00:00

abstract：:This study was designed to investigate the role of dopaminergic mechanisms in the control of aldosterone secretion. Six rhesus monkeys received metoclopramide (1.25 mg, iv), with 5% dextrose (vehicle) or with dopamine (4 micrograms/kg . min) infusions begun 60 min before the administration of the dopamine antagonists....

journal_title：Endocrinology

authors： Sowers JR,Berg G,Martin VS,Mayes DM

更新日期：1982-04-01 00:00:00

abstract：:Aged (16-month-old) female rats (n = 8/treatment) were injected for 12 days with GH (100 micrograms/100 g x day), PTH (8 micrograms/100 g x day), GH plus PTH, or vehicle (V) in an experiment designed to determine the effects of these hormones on intestinal mineral absorption in senescent rats. PTH and GH increased fra...

journal_title：Endocrinology

authors： Fleet JC,Bruns ME,Hock JM,Wood RJ

更新日期：1994-04-01 00:00:00

abstract：:IGF binding proteins-3 and -4, whether given in the perfused rat heart or given iv in the intact animal, cross the microvascular endothelium of the heart and distribute in subendothelial tissues. IGF binding protein-3, like IGF-I/II, localizes in cardiac muscle, with lesser concentrations in CT elements. In contrast, ...

journal_title：Endocrinology

authors： Knudtson KL,Boes M,Sandra A,Dake BL,Booth BA,Bar RS

更新日期：2001-09-01 00:00:00

abstract：:The formation of ovarian follicles and subsequent development after birth are critical processes for female reproduction, and inappropriate coordination of these processes contributes to ovarian pathologies, such as premature ovarian failure and infertility. Identification and functional investigation of the factors i...

journal_title：Endocrinology

authors： Wang N,Zhang P,Guo X,Zhou Z,Sha J

更新日期：2011-03-01 00:00:00

abstract：:Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin-mediated cell ablation to reduce Sertoli cell population size. Results...

journal_title：Endocrinology

authors： Rebourcet D,Darbey A,Monteiro A,Soffientini U,Tsai YT,Handel I,Pitetti JL,Nef S,Smith LB,O'Shaughnessy PJ

更新日期：2017-09-01 00:00:00

abstract：:The sympathetic nervous system is a physiological regulator of bone homeostasis. Autonomic nerves are indeed present in bone, bone cells express the β2-adrenergic receptors (β2AR), and pharmacological or genetic disruption of sympathetic outflow to bone induces bone gain in rodents. These recent findings implied that ...

journal_title：Endocrinology

authors： Ma Y,Nyman JS,Tao H,Moss HH,Yang X,Elefteriou F

更新日期：2011-04-01 00:00:00

abstract：:The synthesis of androgens by theca-interstitial cells is stimulated by LH and the insulin/insulin-like growth factor I (IGF-I) system. An essential element of the steroidogenesis is the uptake of plasma cholesterol and transformation to steroid hormones. In the rat, the uptake of cholesterol by the theca-interstitial...

journal_title：Endocrinology

authors： Li X,Peegel H,Menon KM

更新日期：2001-01-01 00:00:00

abstract：:We previously reported that TNF-alpha-induced apoptosis of lactotropes is estrogen dependent and predominant at proestrus. Here we observed that TNF-alpha (50 ng/ml) failed to induce apoptosis of anterior pituitary cells from ovariectomized rats cultured in the presence of progesterone (10(-6) m). However, progesteron...

journal_title：Endocrinology

authors： Candolfi M,Jaita G,Zaldivar V,Zárate S,Ferrari L,Pisera D,Castro MG,Seilicovich A

更新日期：2005-02-01 00:00:00

abstract：:The adrenal cortex contains a kallikrein-like enzyme that may lead to bradykinin (BK) formation. This study was designed to determine whether BK acts on adrenocortical cells to stimulate steroid secretion. BK, Lys-BK, a specific BK 2 (B2) receptor agonist, and desArg9-BK, a specific BK 1 (B1) receptor agonist, all sti...

journal_title：Endocrinology

authors： Rosolowsky LJ,Campbell WB

更新日期：1992-04-01 00:00:00

abstract：:Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar male and female pups we...

journal_title：Endocrinology

authors： Jaimes-Hoy L,Gutiérrez-Mariscal M,Vargas Y,Pérez-Maldonado A,Romero F,Sánchez-Jaramillo E,Charli JL,Joseph-Bravo P

更新日期：2016-08-01 00:00:00

abstract：:GH binding proteins (GHBPs) are present in the blood of several species and by complexing with circulating GH may alter its clearance and distribution. The actions of human GHBP (hGHBP) have hitherto been studied indirectly via their effects on the clearance of hGH. In the present experiments, recombinant preparations...

journal_title：Endocrinology

authors： Fairhall KM,Carmignac DF,Robinson IC

更新日期：1992-10-01 00:00:00

abstract：:To examine the role of androgen receptor (AR) in Sertoli cells (SC), we used a SC-specific AR knockout (S-AR-/y) mouse to further evaluate the chronological changes of seminiferous tubules and the molecular mechanisms of SC androgen/AR signals on spermatogenesis. Testes morphology began changing as early as postnatal ...

journal_title：Endocrinology

authors： Wang RS,Yeh S,Chen LM,Lin HY,Zhang C,Ni J,Wu CC,di Sant'Agnese PA,deMesy-Bentley KL,Tzeng CR,Chang C

更新日期：2006-12-01 00:00:00

abstract：:Inhibin was first characterized in mammals as a gonadal dimeric protein that inhibited pituitary follicle-stimulating hormone (FSH) secretion. As in mammals, the inhibin-specific α subunit (INHA/Inha/inha) has also been characterized in teleosts; however, its functions and physiological importance in fish reproduction...

journal_title：Endocrinology

authors： Lu H,Zhao C,Zhu B,Zhang Z,Ge W

更新日期：2020-12-01 00:00:00

abstract：:Kisspeptins are hypothalamic neuropeptides encoded by KISS1 and recently described as major regulators of GnRH release from hypothalamic neurons. Although 17beta-estradiol (E2)-induced up-regulation of KISS1 expression has been documented in anteroventral periventricular nucleus neurons, E2 down-regulates KISS1 expres...

journal_title：Endocrinology

authors： Huijbregts L,de Roux N

更新日期：2010-08-01 00:00:00

abstract：:We used autoradiography to test the hypothesis that a major function of thyroid hormone-binding proteins in plasma is to ensure uniform distribution of thyroid hormones among cells of a given tissue. The distribution of [125I]T4 within rat hepatic lobules was determined after its single pass perfusion through the port...

journal_title：Endocrinology

authors： Mendel CM,Weisiger RA,Jones AL,Cavalieri RR

更新日期：1987-05-01 00:00:00

abstract：:Previously, we have demonstrated an inhibitory effect of oxytocin (OXT) on progesterone (P) and androstenedione (A) release of porcine luteal cell cultures. The present study examines whether OXT modulates P, A, or estradiol (E2) release of so-called small luteal cells (SLC) or of granulosa-derived large luteal cells ...

journal_title：Endocrinology

authors： Pitzel L,Jarry H,Wuttke W

更新日期：1990-05-01 00:00:00

abstract：:Chloroquine is widely used as a lysosomal enzyme inhibitor, and while effects on DNA repair and membrane recycling have also been reported, there has been no investigation of effects on the processing of secretory products. To determine whether chloroquine had any effect on secretion and secretory organelles, we monit...

journal_title：Endocrinology

authors： Conconi MV,Walker AM

更新日期：1984-03-01 00:00:00

abstract：:To ascertain if reductions in fetal plasma cortisol cause increases in fetal plasma ACTH, we treated pregnant ewes or their fetuses with aminoglutethimide (10 mg/kg BW) and metyrapone (20 mg/kg BW) and measured the hormonal responses with RIAs. When given to fetuses (n = 9) at 0.90 +/- 0.01 gestation (term-145 days), ...

journal_title：Endocrinology

authors： Rose JC,Turner CS,Ray D,Rawashdeh N

更新日期：1988-09-01 00:00:00

abstract：:The influences of mating on serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were evaluated in 4-day cyclic proestrous rats of the Wistar strain. Blood samples were collected via guillotine from mated and unmated controls at 1900-2000 h or 2100--2200 h. Serum LH levels were determined by tw...

journal_title：Endocrinology

authors： Moss RL,Dudley CA,Schwartz NB

更新日期：1977-02-01 00:00:00

abstract：:GH promotes the conversion of cultured preadipose 3T3 cells into adipose cells. The serum of most animals also promotes this differentiation. In order to determine the extent to which GH is responsible for the adipogenic activity of serum, we used a specific antiserum able to suppress completely the adipogenic activit...

journal_title：Endocrinology

authors： Nixon T,Green H

更新日期：1984-02-01 00:00:00

abstract：:The maternal plasma concentrations of GH and PRL increase dramatically upon the initiation of lactation in the rat. In light of the fact that these two hormones have evolved from one common precursor, we sought to determine if the neuroendocrine mechanisms regulating their concomitant increase during lactation are com...

journal_title：Endocrinology

authors： Wehrenberg WB,Gaillard RC

更新日期：1989-01-01 00:00:00

abstract：:Recent research progress indicates a close link between ghrelin, a natural ligand of GH secretagogues receptor (GHS-R), and both the metabolic balance and body composition. To clarify the involvement of ghrelin and GHS-R in the process of adipogenesis, we measured the expression of GHS-R and peroxisome proliferator-ac...

journal_title：Endocrinology

authors： Choi K,Roh SG,Hong YH,Shrestha YB,Hishikawa D,Chen C,Kojima M,Kangawa K,Sasaki S

更新日期：2003-03-01 00:00:00

abstract：:The ovulatory LH surge results in follicular inflammation with an increase in cytokines and PGs. Reactive oxygen species (ROS) are also produced during inflammatory processes. To study ROS generation during the ovulatory cascade, preovulatory follicles were dissected from immature female rats primed with PMSG. Follicl...

journal_title：Endocrinology

authors： Kodaman PH,Behrman HR

更新日期：2001-02-01 00:00:00

abstract：:Prior published reports have demonstrated that glucose-oxidized low-density lipoproteins (g-OxLDL) enhance the proliferative response of vascular smooth muscle cells (SMC) to IGF-I. Our previous studies have determined that the regulation of cleavage of integrin-associated protein (IAP) by matrix-metalloprotease-2 (MM...

journal_title：Endocrinology

authors： Allen LB,Capps BE,Miller EC,Clemmons DR,Maile LA

更新日期：2009-03-01 00:00:00

abstract：:It was previously reported that PRL can stimulate FSH release in immature female rats and PRL-deficient male dwarf mice. We have examined the effects of PRL-producing ectopic pituitary grafts on plasma FSH and LH levels in adult male golden hamsters during exposure to both long (14 h of light, 10 h of darkness) and sh...

journal_title：Endocrinology

authors： Bartke A,Siler-Khodr TM,Hogan MP,Roychoudhury P

更新日期：1981-01-01 00:00:00

abstract：:PGs are important mediators of the ovulatory process and prostaglandin G/H synthase-2 (PGHS-2) is a key rate-limiting enzyme in the PG biosynthetic pathway. To determine whether PGHS-2 is regulated in equine follicles before ovulation and, if so, to characterize its time course of induction, preovulatory follicles wer...

journal_title：Endocrinology

authors： Sirois J,Doré M

更新日期：1997-10-01 00:00:00

abstract：:In an attempt to further define the optimum experimental conditions for the in vitro study of PRL endocrinology, the effect of extracellular leucine concentration on PRL secretion was assessed. Rat pituitary cells, maintained in short term monolayer culture, were washed free of serum and placed in Minimum Essential Me...

journal_title：Endocrinology

authors： Cross M,Walker AM

更新日期：1984-01-01 00:00:00

abstract：:The present study was undertaken to evaluate the efficacy of an estradiol-chemical delivery system (E2-CDS) for the brain vs. estradiol benzoate (E2-BNZ) in suppressing serum testosterone (T) and weights of the ventral prostate and seminal vesicle in male rats. Also, the role of serum T in the weight reduction of andr...

journal_title：Endocrinology

authors： Anderson WR,Rahimy MH,Brewster ME,Bodor N,Simpkins JW

更新日期：1991-08-01 00:00:00

abstract：:Administration of a single injection of estradiol (E2) causes a maximum increase in DNA synthesis in the uterine luminal epithelium approximately 24 h later. We previously reported that animals receiving a second injection of E2 15-18 h after the first show an apparent decrease in DNA synthesis measured in this cell t...

journal_title：Endocrinology

authors： Kirkland JL,Mukku VR,Hardy M,Stancel GM

更新日期：1984-03-01 00:00:00