Abstract:
:This study was designed to investigate the role of dopaminergic mechanisms in the control of aldosterone secretion. Six rhesus monkeys received metoclopramide (1.25 mg, iv), with 5% dextrose (vehicle) or with dopamine (4 micrograms/kg . min) infusions begun 60 min before the administration of the dopamine antagonists. Metoclopramide, in the presence of vehicle, increased plasma aldosterone concentrations from 4.5 +/- 0.5 ng/dl to a maximum of 26 +/- 4.1 ng/dl and PRL concentrations from 8.1 +/- 1.3 ng/ml to a maximum of 118.4 +/- 7.6 ng/ml. Dopamine infusion inhibited the aldosterone and PRL responses to metoclopramide. The administration of metoclopramide resulted in a rise in plasma 18-hydroxycorticosterone from 10.4 +/- 1.5 ng/dl to a maximum concentration of 41 +/- 4.2 ng/dl. The aldosterone and 18-hydroxycorticosterone responses displayed a parallel time course, with significant responses of both occurring 5 min after metoclopramide administration. Plasma concentrations of electrolytes, PRA, plasma cortisol, 11-deoxycorticosterone, corticosterone, and 18-hydroxy-11-deoxycorticosterone were not altered by metoclopramide. The results of this investigation demonstrate that aldosterone and PRL responses to metoclopramide are mediated by their antagonist activities at dopamine receptors. Rather than simply affecting secretion, dopaminergic mechanisms appear to modulate the late pathway of adrenal glomerulosa biosynthesis of aldosterone. A parallel time course of stimulation of 18-hydroxycorticosterone and aldosterone secretion, with no change in other aldosterone precursors, strongly suggests that dopamine modulates the activity of the glomerulosa 18-hydroxylase enzyme.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Sowers JR,Berg G,Martin VS,Mayes DMdoi
10.1210/endo-110-4-1173subject
Has Abstractpub_date
1982-04-01 00:00:00pages
1173-7issue
4eissn
0013-7227issn
1945-7170journal_volume
110pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Orally delivered salt stimulates renal salt excretion more effectively than does iv delivered salt. Although the mechanisms that underlie this "postprandial natriuresis" are poorly understood, the peptide uroguanylin (UGn) is thought to be a key mediator. However, the lack of selective assays for UGn gene products has...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1725
更新日期:2008-09-01 00:00:00
abstract::The somatic Sertoli cells of the testis are major targets for FSH and are important for the regulation of spermatogenesis. The binding of FSH to Sertoli cells activates the cAMP-dependent protein kinase A signaling pathway, resulting in phosphorylation of the cAMP response element-binding protein (CREB), which is requ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.8.7628390
更新日期:1995-08-01 00:00:00
abstract::The aim of this study was to investigate the direct effect of leptin on GH gene expression and secretion and the role of nitric oxide as a possible mediator in pig anterior pituitary cells. Pituitary cells from adult sows were treated for 4 or 24 h with rhleptin (from 0.1 nM to 1 microM) alone or in association with G...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.2.8653
更新日期:2002-02-01 00:00:00
abstract::Adrenomedullin (AM), a potent and novel vasodilator 52-residue peptide originally isolated from pheochromocytoma, is processed from a precursor molecule (preproAM) in which another unique 20-residue sequence, termed proadrenomedullin N-terminal 20 peptide (PAMP), exists. Using [125I Tyr0] rat PAMP as a radioligand, we...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.7.8770930
更新日期:1996-07-01 00:00:00
abstract::To investigate the physiological role of GRF and somatostatin (SRIF) in GH secretion in adult male rats, we prepared in vitro models using the perifusion system of cultured rat anterior pituitary cells exposed to various combinations of human GRF-(1-44)NH2 (hGRF) and SRIF. We studied the following three models on GRF ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-123-4-1928
更新日期:1988-10-01 00:00:00
abstract::The LHX3 transcription factor is required for pituitary and nervous system development in mammals. Mutations in the human gene are associated with hormone-deficiency diseases. The gene generates two mRNAs, hLHX3a and hLHX3b, which encode three proteins with different properties. Here, the cis elements and trans-acting...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0970
更新日期:2006-01-01 00:00:00
abstract::The effect of bovine corneal extracellular matrix (ECM) on gonadotropin-primed rat granulosa cells in vitro was studied by examining the following parameters: 1) rate of cell attachment to culture dishes; 2) modulation of cell morphology; 3) specific binding of [125I]human(h)CG to LH/hCG receptors; 4) cAMP response to...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-5-1878
更新日期:1986-05-01 00:00:00
abstract::A central feature of glucocorticoid (GC)-induced osteoporosis is decreased bone formation, secondary to decreased numbers of functional osteoblasts. We find that ERK activity is essential for serum-induced osteoblast proliferation in vitro because inhibition of MAPK/ERK kinase activity by U0126 completely abolished bo...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220769
更新日期:2003-02-01 00:00:00
abstract::Thyroid cell growth and function are regulated by hormones and growth factors binding to cell surface receptors that are coupled via G proteins, Gs and Gq, to the adenylyl cyclase and phospholipase C signal transduction systems, respectively. Activating mutations of the TSH receptor and G alpha s have been documented ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.8.5347
更新日期:1997-08-01 00:00:00
abstract::The expression of the lutropin receptor (LHR) in granulosa cells is a complex phenomenon under the hormonal control of FSH and estradiol. Using primary cultures of granulosa cells from immature female rats pretreated with diethylstilbestrol (a compound with estrogen-like activity), the role of FSH in LHR induction was...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.5.6722
更新日期:1999-05-01 00:00:00
abstract::Fundamental complications of insulin resistance and type 2 diabetes include the development of nonalcoholic fatty liver disease and an atherogenic fasting dyslipidemic profile, primarily due to increases in hepatic very-low-density lipoprotein (VLDL) production. Recently, central glucagon-like peptide-2 receptor (GLP2...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00416
更新日期:2018-09-01 00:00:00
abstract::Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that is thought to play a major role in the regulation of growth and differentiation of thyroid cells. However, little is known of its detailed mechanisms of action in thyrocytes. We have therefore studied the molecular mechanisms of TGF-beta1 ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.1.7918
更新日期:2001-01-01 00:00:00
abstract::PTHrP is produced in vessels and acts as a local modulator of tone. We recently reported that PTHrP(1-34) is able to induce vasorelaxation in rat uterine arteries, but in pregnancy, this response is blunted and becomes strictly endothelium dependent. The present study aimed to get insights into the mechanisms involved...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0568
更新日期:2008-02-01 00:00:00
abstract::Glucocorticoids are potent inhibitors of prostaglandin (PG) release in vitro, but they fail to influence basal PG production in vivo. To test one possible explanation for this apparent discrepancy in the present study we investigated the effect of dexamethasone (DEX) on basal and antidiuretic hormone-stimulated renal ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-6-2856
更新日期:1986-12-01 00:00:00
abstract::PRL receptor (PRL-R) expression has been analyzed in human hematopoietic tissues using flow cytofluorometric analysis with a series of biotinylated monoclonal antibodies (mAbs) directed against the extracellular domain of the rat liver PRL-R. In the thymus, more than 75% of cells were labeled by the anti-PRL-R mAb. Re...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.5.8156910
更新日期:1994-05-01 00:00:00
abstract::We have found notable sex difference in peptidylarginine deiminase (EC 3.5.3.15) in rat pituitaries. Pituitaries collected from 3-week to 6-month-old male rats, and those from 3-week-old females showed negligible enzyme activities. The enzyme activity of female pituitaries increased markedly by 2 months, and even furt...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-6-2666
更新日期:1989-06-01 00:00:00
abstract::Male Sprague-Dawley rats were injected ip with 1 microgram pertussis toxin (PTX)/100 g BW. The rats were killed 24, 48, and 72 h after injection, and their pancreases were removed. At each time point, insulin secretion by isolated islets was measured under basal and glucose-stimulated conditions and in the absence and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.5.7720630
更新日期:1995-05-01 00:00:00
abstract::Notch signaling directs cell fate during embryogenesis by influencing cell proliferation, differentiation, and apoptosis. Notch genes are expressed in the adult mouse ovary, and roles for Notch in regulating folliculogenesis are beginning to emerge from mouse genetic models. We investigated how Notch signaling might i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0213
更新日期:2009-02-01 00:00:00
abstract::The time sequence of the metabolism of [4-14C] pregnenolone to testosterone in homogenates of human and rat testis was studied with special emphasis on the chain of events in the early 15 min of incubation. The incubations were performed at 32 C in the presence of NAD and a NADPH-generating system. The various interme...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-120-5-1909
更新日期:1987-05-01 00:00:00
abstract::Brief exposure of male rats to estrogens during the neonatal period interrupts normal prostate development, alters epithelial cell differentiation, and predisposes this gland to hyperplasia and severe dysplasia analogous to prostatic intraepithelial neoplasia (PIN) with aging. Previous work demonstrated that the reduc...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0035
更新日期:2003-11-01 00:00:00
abstract::Kisspeptin-neurokinin B-dynorphin (KNDy) cells of the hypothalamus are a key component in the neuroendocrine regulation of GnRH secretion. Evidence in sheep and other species suggests that dynorphin released by KNDy cells inhibits pulsatile GnRH secretion by acting upon κ-opioid receptors (KOR). However, the precise a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2015-1763
更新日期:2016-06-01 00:00:00
abstract::Parathyroid tissue from patients with hyperparathyroidism (HPT) exhibited reduced immunohistochemical reactivity with monoclonal antiparathyroid antibodies, previously shown to stain intensely the surface of normal human parathyroid cells and to interfere with a receptor mechanism of these cells which is involved in t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-122-6-2999
更新日期:1988-06-01 00:00:00
abstract::Angiogenic factors, including vascular endothelial growth factor (VEGF), are expressed during follicular development. Our objective was to investigate the role of VEGF in the early follicular phase to test whether early cyclic follicle development and selection are angiogenesis-dependent processes. After documentation...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.7.8896
更新日期:2002-07-01 00:00:00
abstract::A protein [steroidogenesis-inducing protein (SIP)] has been isolated from human ovarian follicular fluid and shown previously to stimulate steroidogenesis in Leydig cells, adrenal cells, and early luteal cells. Since proteins and peptides known to regulate steroidogenesis, such as gonadotropins and growth factors, als...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.2.1733710
更新日期:1992-02-01 00:00:00
abstract::Ewes were treated systemically during the periovulatory period with the antihistamines diphenhydramine (H1-receptor antagonist) and(or) cimetidine (H2-receptor antagonist). None of the treatments prevented ovulation. However, the combination of drugs inhibited subsequent function of the corpus luteum (CL) as assessed ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-6-2417
更新日期:1986-12-01 00:00:00
abstract::The mammalian suprachiasmatic nucleus is the site of the circadian rhythm generator. The degrees of expression there of several neuropeptides, including vasopressin and vasoactive intestinal polypeptide, follow a diurnal rhythm. The vasopressin V1a receptor, whose activation results in phosphoinositol hydrolysis and m...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.2.8344200
更新日期:1993-08-01 00:00:00
abstract::Mammary glands from second generation vitamin D-deficient mice and rats were examined for their ability to make the major milk proteins, casein and alpha-lactalbumin, both in vivo and in vitro. The glands from the rachitic animals were morphologically indistinguishable from those of age-matched controls. When placed i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-121-3-865
更新日期:1987-09-01 00:00:00
abstract::An assay was developed to detect tritium-labeled ovine FSH beta-subunit [( 3H]oFSH beta) secreted from primary ovine pituitary cultures. This procedure used affinity-enriched antibodies raised against reduced and carbamylmethylated oFSH beta (RCM-oFSH beta) in a two-cycle immunoextraction procedure. A discrete species...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-115-1-154
更新日期:1984-07-01 00:00:00
abstract::TSH is the most important biomarker in the interpretation of thyroid function in man. Its levels are determined by circulating thyroid hormone (TH) levels that feed back centrally to regulate the expression of the subunits that comprise TSH from the pituitary. The nuclear corepressor 1 (NCoR1), is a critical coregulat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1504
更新日期:2012-10-01 00:00:00
abstract::To examine diurnal differences in the proportions of receptors that were occupied and activated by basal and stress levels of corticosterone, we measured available type I (mineralocorticoid) and type II (glucocorticoid) adrenal steroid receptor levels in brain, pituitary, and immune tissues of unstressed and acutely s...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.5.8404640
更新日期:1993-11-01 00:00:00