Dexamethasone does not inhibit antidiuretic hormone-stimulated prostaglandin production in vivo.

abstract：:Although acute leptin administration in the hypothalamus decreases food intake and increases peripheral energy metabolism, the peripheral actions of central chronic leptin administration are less understood. In this study, we investigated what effects chronic (7 d) intracerebroventricular (ICV) administration of lepti...

journal_title：Endocrinology

authors： Keung W,Palaniyappan A,Lopaschuk GD

更新日期：2011-11-01 00:00:00

abstract：:[131I]Thyroglobulin [( 131I]Tg), prepared by either enzymatic iodination of human goiter Tg in vitro or isolation from the thyroids of rats previously injected with 131I, was digested with a solubilized enzyme mixture prepared from purified hog thyroid lysosomes. The digestion was performed at 37 C for 24 h under nitr...

journal_title：Endocrinology

authors： Tokuyama T,Yoshinari M,Rawitch AB,Taurog A

更新日期：1987-08-01 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta) and adrenomedullin (AM) are multifunctional regulatory peptides that are secreted by a variety of normal and malignant cells. The TGFbetas are expressed in developing organs and adults, and their tissue distribution pattern has possible significance for signaling roles in many...

journal_title：Endocrinology

authors： Montuenga LM,Mariano JM,Prentice MA,Cuttitta F,Jakowlew SB

更新日期：1998-09-01 00:00:00

abstract：:We report here the effects of antibodies to estrogen receptor (ER) on the binding of tritiated 5 alpha-androstane-3 beta-17 beta-diol and antiestrogens to receptor in calf uterine cytosol. The antibodies, prepared from a rabbit immunized with purified estradiol-receptor complex from calf uterine nuclei, were found to ...

journal_title：Endocrinology

authors： Garcia M,Greene G,Rochefort H,Jensen EV

更新日期：1982-04-01 00:00:00

abstract：:Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females. However, the role of ESR2 in reproductive function remai...

journal_title：Endocrinology

authors： Rumi MAK,Singh P,Roby KF,Zhao X,Iqbal K,Ratri A,Lei T,Cui W,Borosha S,Dhakal P,Kubota K,Chakraborty D,Vivian JL,Wolfe MW,Soares MJ

更新日期：2017-07-01 00:00:00

abstract：:The circadian rhythm of glucocorticoids affects diverse physiological systems, including stress responses and the coordination of rhythmic functions in peripheral and central tissues. Circadian clocks are considered to be important coordinators of glucocorticoid release and loss of the core clock component Brain and m...

journal_title：Endocrinology

authors： Dumbell R,Leliavski A,Matveeva O,Blaum C,Tsang AH,Oster H

更新日期：2016-11-01 00:00:00

abstract：:Hypothalamic neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons act to sense and coordinate the brain's responses to metabolic cues. One neuronal network that is very sensitive to metabolic status is that controlling fertility. In this study, we investigated the impact of neuropeptides released by NPY and POM...

journal_title：Endocrinology

authors： Roa J,Herbison AE

更新日期：2012-11-01 00:00:00

abstract：:Previous studies established a positive relationship between oocyte competence and follistatin mRNA abundance. Herein, we used the bovine model to test the hypothesis that follistatin plays a functional role in regulation of early embryogenesis. Treatment of early embryos with follistatin during in vitro culture (befo...

journal_title：Endocrinology

authors： Lee KB,Bettegowda A,Wee G,Ireland JJ,Smith GW

更新日期：2009-05-01 00:00:00

abstract：:Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes. Elevated cytokines impair beta-cell function and survival. A recent clinical trial shows that blocking IL-1beta signaling by IL-1 receptor antagonist (IL-1Ra) improves beta-cell secretory function in patients with type 2 diabetes. In the ...

journal_title：Endocrinology

authors： Sauter NS,Schulthess FT,Galasso R,Castellani LW,Maedler K

更新日期：2008-05-01 00:00:00

abstract：:PTH is an important peptide hormone regulator of calcium homeostasis and osteoblast function. However, its mechanism of action in osteoblasts is poorly understood. Our previous study demonstrated that PTH activates mouse osteocalcin (Ocn) gene 2 promoter through the osteoblast-specific element 1 site, a recently ident...

journal_title：Endocrinology

authors： Yu S,Franceschi RT,Luo M,Zhang X,Jiang D,Lai Y,Jiang Y,Zhang J,Xiao G

更新日期：2008-04-01 00:00:00

abstract：:The plasma osteocalcin (OC) concentration correlates with histological parameters of bone formation and has been used as an index of osteoblast activity. Although the rate of OC synthesis is likely to be a major determinant of the plasma OC level, the contribution of other processes, for example, OC plasma clearance, ...

journal_title：Endocrinology

authors： Fortune CL,Farrugia W,Tresham J,Scoggins BA,Wark JD

更新日期：1989-06-01 00:00:00

abstract：:Aldo-keto-reductase 1B7/mouse vas deferens protein (AKR1B7/MVDP) is expressed in rodent steroidogenic glands and in the mouse vas deferens. In steroidogenic organs, AKR1B7/MVDP scavenges isocaproaldehyde produced from the cholesterol side-chain cleavage reaction. Akr1b7/mvdp is responsive to ACTH in adrenals and to an...

journal_title：Endocrinology

authors： Martinez A,Val P,Sahut-Barnola I,Aigueperse C,Veyssière G,Lefrançois-Martinez AM

更新日期：2003-05-01 00:00:00

abstract：:In a previous paper, we demonstrated that an inhibitory action of excess iodide on thyrotropin-induced thyroid hormone secretion occurs at a site subsequent to the generation of cyclic AMP. In the present study, however, we have found that thyroidal cyclic AMP formation induced by thyrotropin in vitro was markedly inh...

journal_title：Endocrinology

authors： Hashizume K,Akasu F,Takazawa K,Endo W,Onaya T

更新日期：1976-12-01 00:00:00

abstract：:Prostacyclin (PGI2) (1-5 micrograms in 3 microliters 0.05 M Tris/HCl buffer, pH 7.5) and its stable metabolite, 6-oxo-PGF1 alpha, were microinjected into the third ventricle of ovariectomized rats, and plasma FSH, GH, PRL, and TSH levels were measured by RIA. Control animals received 3 microliters buffer. Injection of...

journal_title：Endocrinology

authors： Ottlecz A,Samson WK,McCann SM

更新日期：1984-02-01 00:00:00

abstract：:Apolipoprotein A-IV (apo A-IV) is a satiety factor involved in the control of food intake and body weight. Our previous studies demonstrated that apo A-IV is present in areas of the hypothalamus where leptin acts to influence energy homeostasis. In the present studies, we found that leptin-deficient obese (ob/ob) mice...

journal_title：Endocrinology

authors： Shen L,Tso P,Woods SC,Sakai RR,Davidson WS,Liu M

更新日期：2007-06-01 00:00:00

abstract：:Steroid receptors, including estrogen receptor (ER) and progesterone receptors (PR), form associations with heat shock proteins (Hsps). Dissociation of Hsps activates PR, whereas retention of Hsp90 in vitro stimulates ER. Progesterone and estrogen, interacting with their receptors, regulate myometrial contractility th...

journal_title：Endocrinology

authors： Wu WX,Derks JB,Zhang Q,Nathanielsz PW

更新日期：1996-12-01 00:00:00

abstract：:The present studies were conducted to further evaluate inositol phosphate formation and metabolism in prostaglandin F2 alpha (PGF2 alpha)-stimulated bovine luteal cells. Corpora lutea were dispersed with collagenase, and luteal cells were prelabeled for 3 h with [3H]inositol. Inositol phosphates produced in response t...

journal_title：Endocrinology

authors： Duncan RA,Davis JS

更新日期：1991-03-01 00:00:00

abstract：:During preimplantation development in the mouse, it is crucial that glucose metabolism not be compromised. Any decrease in glucose uptake at this stage in development can compromise the developing embryo. We have cloned another member of the glucose transporter family, GLUT9, which is expressed embryonically. Three di...

journal_title：Endocrinology

authors： Carayannopoulos MO,Schlein A,Wyman A,Chi M,Keembiyehetty C,Moley KH

更新日期：2004-03-01 00:00:00

abstract：:Posttranslational processing of proadrenomedullin generates two biologically active peptides, adrenomedullin (AM) and proadrenomedullin N-terminal 20 peptide (PAMP). Sequence comparison of homologous proadrenomedullin genes in vertebrate evolution shows a high degree of stability in the reading frame for AM, whereas P...

journal_title：Endocrinology

authors： Martínez A,Bengoechea JA,Cuttitta F

更新日期：2006-07-01 00:00:00

abstract：:A variety of transcription factors including Wilms tumor gene (Wt-1), steroidogenic factor 1 (Sf-1), dosage-sensitive sex reversal, adrenal hypoplasia congenita on the X-chromosome, Gene 1 (Dax-1), and pre-B-cell transcription factor 1 (Pbx1) have been defined as necessary for regular adrenocortical development. Howev...

journal_title：Endocrinology

authors： Lichtenauer UD,Duchniewicz M,Kolanczyk M,Hoeflich A,Hahner S,Else T,Bicknell AB,Zemojtel T,Stallings NR,Schulte DM,Kamps MP,Hammer GD,Scheele JS,Beuschlein F

更新日期：2007-02-01 00:00:00

abstract：:The existence of cytoplasmic estrogen receptors (ERs) has been reported in the guinea pig brain using immunocytochemical techniques. While cytoplasmic ERs have been reported recently in other species, such as opossum, musk shrew, and ferrets, an exclusively cell nuclear pattern of ER immunoreactivity has been reported...

journal_title：Endocrinology

authors： Blaustein JD

更新日期：1992-09-01 00:00:00

abstract：:Bone remodeling is a complex process of coordinated resorption and formation of bone, which is regulated by systemic hormones and by local factors. We have previously shown that the peptide hormone adrenomedullin is mitogenic to osteoblastic cells in vitro and that it promotes bone growth in vivo. The aim of the prese...

journal_title：Endocrinology

authors： Naot D,Callon KE,Grey A,Cooper GJ,Reid IR,Cornish J

更新日期：2001-05-01 00:00:00

abstract：:Regularly menstruating female rhesus monkeys were implanted sc with Silastic tubing packed with estrone. The implants were replaced every 6-8 months to maintain the serum estrone and estradiol concentrations constantly elevated 1.5-2.5-fold, i.e. in the midfollicular phase range, for 4 yr. Increasing the estrone and e...

journal_title：Endocrinology

authors： Billiar RB,Richardson DW,Little B

更新日期：1989-05-01 00:00:00

abstract：:The existence of renin in a number of extrarenal tissues has been well documented, but the physiological role of extrarenal renin remains unknown. To study the physiological role of adrenal renin, we developed a serum-free culture system for adrenal capsular/zona glomrulosa explants. Explants showed good viability in ...

journal_title：Endocrinology

authors： Shier DN,Kusano E,Stoner GD,Franco-Saenz R,Mulrow PJ

更新日期：1989-07-01 00:00:00

abstract：:GH is believed to play a role in promoting insulin resistance in patients with diabetes and with GH excess. The means by which GH produces insulin resistance may be through direct suppression of glucose metabolism in target cells (insulin-independent) or by interfering with the ability of insulin to stimulate glucose ...

journal_title：Endocrinology

authors： Foster CM,Hale PM,Jing HW,Schwartz J

更新日期：1988-08-01 00:00:00

abstract：:The marked up-regulation of oxytocin (OT) receptors in rabbit amnion at term was reproduced in cultured amnion cells by raising intracellular cAMP levels. (Bu)2AMP, forskolin, or cholera toxin caused 2- to 8-fold increases in specific binding of iodinated OT antagonist. The rise in OT receptors involves activation of ...

journal_title：Endocrinology

authors： Hinko A,Soloff MS

更新日期：1993-01-01 00:00:00

abstract：:The effect of an activator of protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA), on the 5'-deiodinase (5'D) activity was studied in rat astroglial cells cultured in chemically defined medium. TPA promoted a large increase in the type II 5'D activity, which was maximal 5-10 h after addition of TPA and then d...

journal_title：Endocrinology

authors： Courtin F,Chantoux F,Gavaret JM,Toru-Delbauffe D,Jacquemin C,Pierre M

更新日期：1989-09-01 00:00:00

abstract：:A rat medullary thyroid carcinoma, which was previously shown to produce high levels of immunoreactive cholecystokinin (CCK), was used to establish a stable cell line. Transplantable tumors were subjected to four series of alternate in vitro and in vivo passages. Cells were prepared from the fourth series of tumors un...

journal_title：Endocrinology

authors： Haun RS,Beinfeld MC,Roos BA,Dixon JE

更新日期：1989-08-01 00:00:00

abstract：:The role of calcium in the angiotensin II- or potassium-mediated increase in aldosterone production was analyzed in isolated glomerulosa cells prepared from bovine adrenal glands. The response to potassium was highly dependent on the extracellular calcium concentration, and a maximal response was observed at 0.5 mM ca...

journal_title：Endocrinology

authors： Foster R,Lobo MV,Rasmussen H,Marusic ET

更新日期：1981-12-01 00:00:00

abstract：:The SMRT coregulator functions as a dual coactivator and corepressor for estrogen receptor-α (ERα) in a gene-specific manner, and in several studies its elevated expression correlates with poor outcome for breast cancer patients. A specific role of SMRT in breast cancer progression has not been elucidated, but SMRT kn...

journal_title：Endocrinology

authors： Blackmore JK,Karmakar S,Gu G,Chaubal V,Wang L,Li W,Smith CL

更新日期：2014-09-01 00:00:00