Dissociation of Molecular and Endocrine Circadian Rhythms in Male Mice Lacking Bmal1 in the Adrenal Cortex.

abstract：:Increased matrix extracellular phosphoglycoprotein (MEPE) expression occurs in several phosphate and bone-mineral metabolic disorders. To resolve whether MEPE plays a role, we created a murine model overexpressing MEPE protein (MEPE tgn) in bone. MEPE tgn mice displayed a growth and mineralization defect with altered ...

journal_title：Endocrinology

authors： David V,Martin A,Hedge AM,Rowe PS

更新日期：2009-09-01 00:00:00

abstract：:Adrenomedullin (AM), a potent and novel vasodilator 52-residue peptide originally isolated from pheochromocytoma, is processed from a precursor molecule (preproAM) in which another unique 20-residue sequence, termed proadrenomedullin N-terminal 20 peptide (PAMP), exists. Using [125I Tyr0] rat PAMP as a radioligand, we...

journal_title：Endocrinology

authors： Iwasaki H,Hirata Y,Iwashina M,Sato K,Marumo F

更新日期：1996-07-01 00:00:00

abstract：:It has previously only been possible to assess osteoclastic bone resorption in intact bone, where other cell types may modify or mediate osteoclastic responses to environmental agents. We have recently developed techniques which enable us to measure bone resorption by osteoclasts extracted from bone and have used thes...

journal_title：Endocrinology

authors： Chambers TJ,McSheehy PM,Thomson BM,Fuller K

更新日期：1985-01-01 00:00:00

abstract：:The PTH activates both adenylate cyclase and a mechanism that increases membrane-associated protein kinase-C (PKC) activity. To define the hormone's PKC activation domain we have used a panel of PTH fragments and ROS 17/2 rat osteosarcoma cells as the target cells. PTH equally and maximally increased PKC activity in R...

journal_title：Endocrinology

authors： Jouishomme H,Whitfield JF,Chakravarthy B,Durkin JP,Gagnon L,Isaacs RJ,MacLean S,Neugebauer W,Willick G,Rixon RH

更新日期：1992-01-01 00:00:00

abstract：:3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) ...

journal_title：Endocrinology

authors： Hackenmueller SA,Marchini M,Saba A,Zucchi R,Scanlan TS

更新日期：2012-11-01 00:00:00

abstract：:We studied the effect of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) activation on serum concentrations and tissue expression of resistin, adiponectin, and adiponectin receptor-1 and -2 (AdipoR1 and AdipoR2) mRNA in normal mice and mice with insulin resistance induced by lipogenic, simple-carbohydrat...

journal_title：Endocrinology

authors： Haluzik MM,Lacinova Z,Dolinkova M,Haluzikova D,Housa D,Horinek A,Vernerova Z,Kumstyrova T,Haluzik M

更新日期：2006-09-01 00:00:00

abstract：:Morphoregulator genes like members of the Hox gene family regulate uterine development and are associated with endocrine-related processes such as endometrial proliferation and differentiation in the adult uterus. Exposure to neonatal endocrine disruptors could affect signaling events governed by Hox genes, altering t...

journal_title：Endocrinology

authors： Varayoud J,Ramos JG,Bosquiazzo VL,Muñoz-de-Toro M,Luque EH

更新日期：2008-11-01 00:00:00

abstract：:The somatic Sertoli cells of the testis are major targets for FSH and are important for the regulation of spermatogenesis. The binding of FSH to Sertoli cells activates the cAMP-dependent protein kinase A signaling pathway, resulting in phosphorylation of the cAMP response element-binding protein (CREB), which is requ...

journal_title：Endocrinology

authors： Walker WH,Fucci L,Habener JF

更新日期：1995-08-01 00:00:00

abstract：:Translocator protein (TSPO) is a mitochondrial outer membrane protein of unknown function with high physiological expression in steroidogenic cells. Using TSPO gene-deleted mice, we recently demonstrated that TSPO function is not essential for steroidogenesis. The first link between TSPO and steroidogenesis was establ...

journal_title：Endocrinology

authors： Tu LN,Zhao AH,Stocco DM,Selvaraj V

更新日期：2015-03-01 00:00:00

abstract：:The two phases of the ovulatory menstrual cycle of the primate are characterized by divergent activities of the GnRH pulse generator. During the luteal phase, LH pulse frequency is significantly reduced below that observed during the follicular phase. In this report we investigate whether the decrease in pulse frequen...

journal_title：Endocrinology

authors： Lam NY,Ferin M

更新日期：1987-05-01 00:00:00

abstract：:We have studied the two estrogen receptor (ER) subtypes, ER alpha and ER beta, and chimeric constructs with ER alpha and ER beta to examine the bioactivities of these receptors and their responses to estrogen and antiestrogen ligands. Transcriptional activity of ER beta is highly dependent on cell/promoter context and...

journal_title：Endocrinology

authors： McInerney EM,Weis KE,Sun J,Mosselman S,Katzenellenbogen BS

更新日期：1998-11-01 00:00:00

abstract：:The effects of K+ depletion and ouabain (0.1, 0.5, and 1 mM) on glucagon and insulin release from the in vitro perfused rat pancreas were studied in the absence or presence of arginine (10 mM). In the absence of arginine, K+ depletion resulted in an inhibition of glucagon release, both at a low (2.8 mM) and a higher (...

journal_title：Endocrinology

authors： Leclercq-Meyer V,Marchand J,Malaisse WJ

更新日期：1983-07-01 00:00:00

abstract：:TSH receptor (TSHR) DNA vaccination induces high TSHR antibody levels in BALB/c mice housed in a conventional facility. However, under pathogen-free conditions, we observed a Th1 cellular response to TSHR antigen characterized by interferon-gamma (IFN gamma) production. In the present study we investigated the effect ...

journal_title：Endocrinology

authors： Pichurin P,Pichurina O,Chazenbalk GD,Paras C,Chen CR,Rapoport B,McLachlan SM

更新日期：2002-04-01 00:00:00

abstract：:In mammals, the brain-specific protein munc18-1 regulates synaptic vesicle exocytosis at the synaptic junction, in a step before vesicle fusion. We hypothesize that the rate of biosynthesis of munc18-1 messenger RNA (mRNA) and the amount of munc18-1 present in neurons and neuroendocrine cells are related to the physio...

journal_title：Endocrinology

authors： Kolk SM,Berghs CA,Vaudry H,Verhage M,Roubos EW

更新日期：2001-05-01 00:00:00

abstract：:This study was conducted to determine the feasibility of using replication-defective adenovirus vectors to express receptors for LH. Two vectors were constructed, one that directs the expression of wild-type human LH receptor (LHr; AdRSVLHrwt) and another that directs the expression of the constitutively activated D57...

journal_title：Endocrinology

authors： Bebia Z,Somers JP,Liu G,Ihrig L,Shenker A,Zeleznik AJ

更新日期：2001-06-01 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP)ergic nerves innervate both the neurohypophysis and the hypothalamus. To test the hypothesis that VIP is a releasing factor for neurohypophyseal hormones, rats were given intracerebroventricular (icv) infusions of VIP in doses varying from 0.3 pmol/kg.min to 3 nmol/kg.min for 5 m...

journal_title：Endocrinology

authors： Bardrum B,Ottesen B,Fahrenkrug J,Fuchs AR

更新日期：1988-11-01 00:00:00

abstract：:The trace element vanadium (V) exerts insulin-like effects in vitro. The present study examined its effects on glucose homeostasis in rats made diabetic by streptozotocin. Na3VO4 (0.2 or 0.5 mg/ml) was administered ad libitum in drinking water. Fed plasma glucose levels (approximately 26 mmol/liter) fell by 30% and 56...

journal_title：Endocrinology

authors： Brichard SM,Okitolonda W,Henquin JC

更新日期：1988-10-01 00:00:00

abstract：:Prenatal dexamethasone exposure (PDE) induces multiorgan developmental toxicities in offspring. Here we verified the transgenerational inheritance effect of ovarian developmental toxicity by PDE and explored its intrauterine programming mechanism. Pregnant rats subcutaneously received 0.2 mg/kg/d dexamethasone from ge...

journal_title：Endocrinology

authors： Lv F,Wan Y,Chen Y,Pei L,Luo D,Fan G,Luo M,Xu D,Wang H

更新日期：2018-03-01 00:00:00

abstract：:Primary cultures of enzymatically dispersed rat anterior pituitary cells were used to examine the effect of pure 31 kilodalton bovine inhibin on GnRH-induced up-regulation of GnRH binding sites. After 2 days in culture, the cells were exposed to stimuli with or without test substances for 10 h, followed by evaluation ...

journal_title：Endocrinology

authors： Wang QF,Farnworth PG,Findlay JK,Burger HG

更新日期：1989-01-01 00:00:00

abstract：:The objective of this study was to assess estrogen-dependent cellular mechanisms that could contribute to the acid pH of the vaginal lumen. Cultures of normal human cervical-vaginal epithelial (hECE) cells and endocervical cells were grown on filters, and acidification of the extracellular solutions on the luminal (L-...

journal_title：Endocrinology

authors： Gorodeski GI,Hopfer U,Liu CC,Margles E

更新日期：2005-02-01 00:00:00

abstract：:A variety of chronic stress paradigms have been shown to increase basal activity in the hypothalamic-pituitary-adrenocortical axis, resulting in hypercorticoidism. Despite this, chronically stressed rats typically exhibit facilitated ACTH responses to acute novel stress, suggesting that the activity of some central ne...

journal_title：Endocrinology

authors： Scribner KA,Akana SF,Walker CD,Dallman MF

更新日期：1993-12-01 00:00:00

abstract：:The dissociation kinetics of uterine estradiol receptor (UER) from young, middle-aged, and old mice have been studied in vitro and correlated with interactions of the steroid receptor with nuclear suspensions in a cell-free system. Furthermore, we have determined in these various age groups of mice the concentration o...

journal_title：Endocrinology

authors： Belisle S,Bellabarba D,Lehoux JG,Robel P,Baulieu EE

更新日期：1986-02-01 00:00:00

abstract：:Metastatic pheochromocytoma continues to be an incurable disease, and treatment with conventional cytotoxic chemotherapy offers limited efficacy. In the present study, we evaluated a novel topoisomerase I inhibitor, LMP-400, as a potential treatment for this devastating disease. We found a high expression of topoisome...

journal_title：Endocrinology

authors： Schovanek J,Bullova P,Tayem Y,Giubellino A,Wesley R,Lendvai N,Nölting S,Kopacek J,Frysak Z,Pommier Y,Kummar S,Pacak K

更新日期：2015-11-01 00:00:00

abstract：:The testis contains many peptides originally described as originating in the central nervous system. The physiological function of these factors in the testis is generally unknown. We previously reported that the rat testis contains both a peptide with GH-releasing hormone-like immunoactivity (tGHRH-LI) and a mRNA spe...

journal_title：Endocrinology

authors： Pescovitz OH,Berry SA,Laudon M,Ben-Jonathan N,Martin-Myers A,Hsu SM,Lambros TJ,Felix AM

更新日期：1990-11-01 00:00:00

abstract：:It is well established that sexually dimorphic neural regions are organized by steroid hormones during development. In many species, neonatal males are exposed to more testosterone than their female littermates, and ultimately it is the estradiol, produced by aromatization of testosterone, that affects sexual differen...

journal_title：Endocrinology

authors： Bodo C,Rissman EF

更新日期：2008-08-01 00:00:00

abstract：:Recent studies have revealed that C-type natriuretic peptide (CNP) is a potent stimulator of endochondral bone growth. Nevertheless, the effect of CNP on bone turnover has not yet been well studied. To elucidate this issue, we investigated the bone phenotype of a mouse model with elevated plasma CNP concentrations (SA...

journal_title：Endocrinology

authors： Kondo E,Yasoda A,Fujii T,Nakao K,Yamashita Y,Ueda-Sakane Y,Kanamoto N,Miura M,Arai H,Mukoyama M,Inagaki N,Nakao K

更新日期：2015-07-01 00:00:00

abstract：:Rats were made unilaterally cryptorchid by cutting the gubernaculum testis at birth. At 100 days age, the rats were injected with 600 IU/kg hCG. A biphasic testosterone response was seen in the scrotal (Scr) testis in response to hCG, with maxima at 1 h and 3 days after injection. The acute peak of testosterone was of...

journal_title：Endocrinology

authors： Huhtaniemi I,Bergh A,Nikula H,Damber JE

更新日期：1984-08-01 00:00:00

abstract：:Estrogen deficiency causes bone loss by increasing the number of bone-resorbing osteoclasts. Selective p38α MAPK inhibitors prevent bone-wasting effects of estrogen withdrawal but implicated mechanisms remain to be identified. Here, we show that inactivation of the p38α-encoding gene in osteoblast lineage cells with t...

journal_title：Endocrinology

authors： Thouverey C,Caverzasio J

更新日期：2015-12-01 00:00:00

abstract：:Previous studies have demonstrated that uterine progesterone (P) receptor is under dual hormonal control; estradiol (E2) induces the synthesis of cytosolic P receptor, and P induces the loss of its own receptor and antagonizes E2-induced P receptor replenishment. The objective of this study was to examine the contribu...

journal_title：Endocrinology

authors： Okulicz WC

更新日期：1986-06-01 00:00:00

abstract：:We investigated, in five cell strains per experiment, whether several cytokines known or believed to have effects on bone resorption were produced by nearly homogeneous strains of cultured normal human osteoblast-like (hOB) cells that display virtually the complete phenotype of the mature osteoblast. In unstimulated h...

journal_title：Endocrinology

authors： Chaudhary LR,Spelsberg TC,Riggs BL

更新日期：1992-05-01 00:00:00