Improvement of insulin sensitivity after peroxisome proliferator-activated receptor-alpha agonist treatment is accompanied by paradoxical increase of circulating resistin levels.


:We studied the effect of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) activation on serum concentrations and tissue expression of resistin, adiponectin, and adiponectin receptor-1 and -2 (AdipoR1 and AdipoR2) mRNA in normal mice and mice with insulin resistance induced by lipogenic, simple-carbohydrate diet (LD). Sixteen weeks of LD feeding induced obesity with liver steatosis and increased insulin levels but did not significantly affect circulating adiponectin or resistin. Treatment with PPAR-alpha agonist fenofibrate decreased body weight and fat pad weight and ameliorated liver steatosis in LD-fed mice with concomitant reduction in blood glucose, free fatty acid, triglyceride, serum insulin levels, and homeostasis model assessment index values. Euglycemic-hyperinsulinemic clamp demonstrated the development of whole-body and liver insulin resistance in LD-fed mice, which were both normalized by fenofibrate. Fenofibrate treatment markedly increased circulating resistin levels on both diets and adiponectin levels in chow-fed mice only. Fat adiponectin mRNA expression was not affected by fenofibrate treatment. Resistin mRNA expression increased in subcutaneous but not gonadal fat after fenofibrate treatment. In addition to fat, a significant amount of adiponectin mRNA was also expressed in the muscle. This expression markedly increased after fenofibrate treatment in chow- but not in LD-fed mice. Adipose tissue expression of AdipoR1 mRNA was significantly reduced in LD-fed mice and increased after fenofibrate treatment. In conclusion, PPAR-alpha activation ameliorated the development of insulin resistance in LD-fed mice despite a major increase in serum resistin levels. This effect could be partially explained by increased AdipoR1 expression in adipose tissue after fenofibrate treatment.






Haluzik MM,Lacinova Z,Dolinkova M,Haluzikova D,Housa D,Horinek A,Vernerova Z,Kumstyrova T,Haluzik M




Has Abstract


2006-09-01 00:00:00














  • Anatabine ameliorates experimental autoimmune thyroiditis.

    abstract::Tobacco smoking favorably influences the course of Hashimoto thyroiditis, possibly through the antiinflammatory proprieties of nicotine. In this study we tested anatabine, another tobacco alkaloid, in a model of experimental autoimmune thyroiditis. Experimental autoimmune thyroiditis was induced by different doses of ...


    pub_type: 杂志文章


    authors: Caturegli P,De Remigis A,Ferlito M,Landek-Salgado MA,Iwama S,Tzou SC,Ladenson PW

    更新日期:2012-09-01 00:00:00

  • Hepatic messenger ribonucleic acid activity profile of rats subjected to alterations in thyroidal and adrenocortical states: evidence for significant interaction.

    abstract::We have previously established the value of 2-dimensional electrophoretic mRNA activity profiles for investigating the hepatic genomic response to several metabolic perturbations, such as thyroid hormone or GH treatment, diabetes, high carbohydrate diet, starvation, and uremia. We now report the effects of adrenalecto...


    pub_type: 杂志文章


    authors: Beyer HS,Carr FE,Mariash CN,Oppenheimer JH

    更新日期:1985-06-01 00:00:00

  • Heat shock proteins bind calcitonin.

    abstract::We have demonstrated two heat shock proteins (HSP's) in the human placenta that specifically bind calcitonin. Binding specificity was shown by ligand-affinity chromatography and by competitive binding studies. The HSP's were identified by Western analysis and by amino acid sequence. Our observations are consistent wit...


    pub_type: 杂志文章


    authors: Dana RC,Welch WJ,Deftos LJ

    更新日期:1990-01-01 00:00:00

  • Voltage-independent calcium channels mediate slow oscillations of cytosolic calcium that are glucose dependent in pancreatic beta-cells.

    abstract::Pancreatic beta-cells and HIT-T15 cells exhibit oscillations of cytosolic calcium ([Ca2+]i) that are dependent on glucose metabolism and appear to trigger pulsatile insulin secretion. Significantly, differences in the pattern of this [Ca2+]i oscillatory activity may have important implications for our understanding of...


    pub_type: 杂志文章


    authors: Leech CA,Holz GG 4th,Habener JF

    更新日期:1994-07-01 00:00:00

  • Accelerated exocytosis and H2O2 generation in isolated thyroid follicles enhance protein iodination.

    abstract::Open pig thyroid follicles in which the apical surface of the follicle cells is in direct contact with the incubation medium were used to study the effect of stimulated exocytosis and stimulated H2O2 generation on the iodination of protein in the incubation medium. In previous studies on this system of follicles we ha...


    pub_type: 杂志文章


    authors: Björkman U,Ekholm R

    更新日期:1988-02-01 00:00:00

  • Expression of ovary-specific acidic protein in steroidogenic tissues: a possible role in steroidogenesis.

    abstract::Ovary-specific acidic protein (OSAP) is a novel molecule discovered from a genomic project designed to identify ovary-selective genes in mice. Whereas public databases suggest extraovarian expression of OSAP, its tissue distribution has not yet been well documented. Thus, the expression profile of mouse and human OSAP...


    pub_type: 杂志文章


    authors: Matsumoto T,Minegishi K,Ishimoto H,Tanaka M,Hennebold JD,Teranishi T,Hattori Y,Furuya M,Higuchi T,Asai S,Kim SH,Miyakoshi K,Yoshimura Y

    更新日期:2009-07-01 00:00:00

  • Adrenalectomy-induced alterations of calmodulin-dependent hippocampal adenylate cyclase activity: role of guanine nucleotide-binding proteins.

    abstract::Ca2+/calmodulin-dependent processes are altered by manipulations of the hypothalamic-pituitary-adrenal axis. In particular, adrenalectomy (ADX) attenuates hippocampal, but not cortical, calmodulin-dependent adenylate cyclase activity measured during the active (waking) phase of rats. The involvement of calmodulin- and...


    pub_type: 杂志文章


    authors: Gannon MN,Akompong T,Billingsley ML,McEwen BS

    更新日期:1994-02-01 00:00:00

  • Spermatogonial Type 3 Deiodinase Regulates Thyroid Hormone Target Genes in Developing Testicular Somatic Cells.

    abstract::Premature overexposure to thyroid hormone causes profound effects on testis growth, spermatogenesis, and male fertility. We used genetic mouse models of type 3 deiodinase (DIO3) deficiency to determine the genetic programs affected by premature thyroid hormone action and to define the role of DIO3 in regulating thyroi...


    pub_type: 杂志文章


    authors: Martinez ME,Lary CW,Karaczyn AA,Griswold MD,Hernandez A

    更新日期:2019-12-01 00:00:00

  • Multi- and Transgenerational Consequences of Bisphenol A on Sexually Dimorphic Cell Populations in Mouse Brain.

    abstract::Bisphenol A (BPA) is an endocrine-disrupting compound used to manufacture plastics; it is present in linings of food cans, bottles, thermal receipts, and many other everyday items and is detectable in human urine and blood. Exposure to BPA during development can disrupt sexual differentiation of some brain regions. Mo...


    pub_type: 杂志文章


    authors: Goldsby JA,Wolstenholme JT,Rissman EF

    更新日期:2017-01-01 00:00:00

  • Minireview: SLCO and ABC transporters: a role for steroid transport in prostate cancer progression.

    abstract::Androgens play a critical role in the development and progression of prostate cancer (PCa), and androgen deprivation therapy via surgical or medical castration is front-line therapy for patients with advanced PCa. However, intratumoral testosterone levels are elevated in metastases from patients with castration-resist...


    pub_type: 杂志文章,评审


    authors: Cho E,Montgomery RB,Mostaghel EA

    更新日期:2014-11-01 00:00:00

  • Diurnal variation in hepatic expression of the rat S14 gene is synchronized by the photoperiod.

    abstract::We have analyzed the factors responsible for the circadian variation in rat hepatic mRNA-S14. Regulation of this sequence, which is found in lipogenic tissues and encodes a protein (S14) believed to be associated with fatty acid synthesis, is an excellent model of the interaction of thyroid hormone and dietary factors...


    pub_type: 杂志文章


    authors: Kinlaw WB,Fish LH,Schwartz HL,Oppenheimer JH

    更新日期:1987-04-01 00:00:00

  • Involvement of the hippocampus in central nervous system-mediated glucoregulation in rats.

    abstract::To find out whether the hippocampus is involved in central nervous system-mediated glucoregulation, we injected saline, neostigmine, dopamine, norepinephrine, bombesin, beta-endorphin, somatostatin, and prostaglandin F2 alpha into the dorsal hippocampus in anesthetized fed rats. After injection of dopamine, norepineph...


    pub_type: 杂志文章


    authors: Uemura K,Iguchi A,Yatomi A,Miura H,Honmura A,Yanase M,Sakamoto N

    更新日期:1989-05-01 00:00:00

  • Contrasted impact of maternal rat food restriction on the fetal endocrine pancreas.

    abstract::The effects of food restriction of the mother (65% restriction of ad libitum food intake) on fetal and maternal insulin secretion and islet function were studied at 21 days gestation in three different rat populations: 1) undernourished from 0-7 days gestation, 2) undernourished from 7-14 days gestation, and 3) undern...


    pub_type: 杂志文章


    authors: Alvarez C,Martín MA,Goya L,Bertin E,Portha B,Pascual-Leone AM

    更新日期:1997-06-01 00:00:00

  • Direct inhibitory effect of long term estradiol treatment on dopamine synthesis in tuberoinfundibular dopaminergic neurons: in vitro studies using hypothalamic slices.

    abstract::The mechanism of the inhibitory effect of long term treatment with estradiol on dopamine synthesis in tuberoinfundibular dopaminergic (TIDA) neurons was studied by using hypothalamic slices from ovariectomized rats. Treatment with 2 mg estradiol valerate (EV) at a 3-week interval increased the weight of the anterior p...


    pub_type: 杂志文章


    authors: Arita J,Kimura F

    更新日期:1987-08-01 00:00:00

  • Oxidative stress triggers cardiac fibrosis in the heart of diabetic rats.

    abstract::Diabetic cardiomyopathy is characterized by myocyte loss and myocardial fibrosis, leading to decreased elasticity and impaired contractile function. The study examines the downstream signaling whereby oxidative stress, induced by hyperglycemia, leads to myocardial fibrosis and impaired contractile function in the left...


    pub_type: 杂志文章


    authors: Aragno M,Mastrocola R,Alloatti G,Vercellinatto I,Bardini P,Geuna S,Catalano MG,Danni O,Boccuzzi G

    更新日期:2008-01-01 00:00:00

  • Prostate-Specific Deletion of Cdh1 Induces Murine Prostatic Inflammation and Bladder Overactivity.

    abstract::Benign prostatic hyperplasia (BPH) is an age-related debilitating prostatic disease that is frequently associated with prostatic inflammation and bothersome lower urinary tract symptoms (LUTS). Animal models have shown that formalin- and bacterial-induced prostatic inflammation can induce bladder dysfunction; however,...


    pub_type: 杂志文章


    authors: Pascal LE,Mizoguchi S,Chen W,Rigatti LH,Igarashi T,Dhir R,Tyagi P,Wu Z,Yang Z,de Groat WC,DeFranco DB,Yoshimura N,Wang Z

    更新日期:2021-01-01 00:00:00

  • Prolactin restores plasma testosterone levels and stimulates testicular growth in hamsters exposed to short day-length.

    abstract::In male hamsters, light deprivation was reported to reduce both testis weight and prolactin (PRL) levels. Therefore, we decided to examine the effects of PRL on testicular function in hamsters exposed to short day-length. Adult hamsters were exposed to 5 h of light per day to induce gonadal atrophy, and, starting two ...


    pub_type: 杂志文章


    authors: Bartke A,Croft BT,Dalterio S

    更新日期:1975-12-01 00:00:00

  • Propylthiouracil (PTU) pharmacology in the rat. I. Serum and thyroid PTU measurements by radioimmunoassay.

    abstract::We have developed a highly sensitive and specific RIA for propylthiouracil (PTU) which uses 125I-labeled PTU as the radioactive ligand. At a final antibody dilution of 1:10,000, the detection limit for PTU was 100 pg; cross-reactivity with circulating, urinary, and intrathyroid PTU metabolites was negligible. Using th...


    pub_type: 杂志文章


    authors: Halpern R,Cooper DS,Kieffer JD,Saxe V,Mover H,Maloof F,Ridgway EC

    更新日期:1983-09-01 00:00:00

  • Down-regulation of hypothalamic corticotropin-releasing hormone messenger ribonucleic acid (mRNA) precedes early-life experience-induced changes in hippocampal glucocorticoid receptor mRNA.

    abstract::Early-life experiences, including maternal interaction, profoundly influence hormonal stress responses during adulthood. In rats, daily handling during a critical neonatal period leads to a significant and permanent modulation of key molecules that govern hormonal secretion in response to stress. Thus, hippocampal glu...


    pub_type: 杂志文章


    authors: Avishai-Eliner S,Eghbal-Ahmadi M,Tabachnik E,Brunson KL,Baram TZ

    更新日期:2001-01-01 00:00:00

  • Lipopolysaccharide induces a significant increase in expression of iron regulatory hormone hepcidin in the cortex and substantia nigra in rat brain.

    abstract::Hepcidin plays an essential role in maintaining normal iron homeostasis outside the brain. This recently discovered iron regulation hormone is predominantly expressed in the liver, and regulated by iron and hypoxia. As an antimicrobial peptide, this hormone is also elevated during infections and inflammation. In this ...


    pub_type: 杂志文章


    authors: Wang Q,Du F,Qian ZM,Ge XH,Zhu L,Yung WH,Yang L,Ke Y

    更新日期:2008-08-01 00:00:00

  • Voltage-dependent calcium current in human decidual cells and its relation to prolactin secretion.

    abstract::Human decidual cells synthesize and release decidual PRL (dPRL) immunologically and biochemically identical to human pituitary PRL. However, stimulators and inhibitors of PRL secretion such as TRH, bromocriptine or dopamine have no effect on dPRL release. The evidence for the involvement of Ca2+ in dPRL release is bas...


    pub_type: 杂志文章


    authors: Sartor P,Couderc B,Corcuff JB,Odessa MF,Mayer G,Dufy B

    更新日期:1992-06-01 00:00:00

  • TGF-β effects on prostate cancer cell migration and invasion are mediated by PGE2 through activation of PI3K/AKT/mTOR pathway.

    abstract::TGF-β plays an important role in the progression of prostate cancer. It exhibits both tumor suppressor and tumor-promoting activities. Correlations between cyclooxygenase (COX)-2 overexpression and enhanced production of prostaglandin (PG)E2 have been implicated in cancer progression; however, there are no studies ind...


    pub_type: 杂志文章


    authors: Vo BT,Morton D Jr,Komaragiri S,Millena AC,Leath C,Khan SA

    更新日期:2013-05-01 00:00:00

  • Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins.

    abstract::The inhibitor of apoptosis proteins (IAPs) constitutes a family of highly conserved apoptosis suppressor proteins that were originally identified in baculoviruses. Although IAP homologs have recently been demonstrated to suppress apoptosis in mammalian cells, their expression and role in human ovarian epithelial cance...


    pub_type: 杂志文章


    authors: Li J,Feng Q,Kim JM,Schneiderman D,Liston P,Li M,Vanderhyden B,Faught W,Fung MF,Senterman M,Korneluk RG,Tsang BK

    更新日期:2001-01-01 00:00:00

  • Dietary protein restriction in artificially reared neonatal rats causes a reduction of insulin-like growth factor-I gene expression.

    abstract::To determine in neonates the effects of protein restriction on growth, serum IGF-I, and IGF-I gene expression, we adapted a technique for rearing neonatal rats (days 6-18 of life) artificially by continuous infusion of milk through a gastrostomy. The artificially reared (AR) animals were given isocaloric diets contain...


    pub_type: 杂志文章


    authors: Moats-Staats BM,Brady JL Jr,Underwood LE,D'Ercole AJ

    更新日期:1989-11-01 00:00:00

  • Effect of light irradiance and wavelength on the Syrian hamster reproductive system.

    abstract::The purpose of this study was to examine how the physical characteristics of light influence the short photoperiod-induced atrophy of the reproductive system. In the first experiment, groups of Syrian hamsters were exposed to a 14-h light, 10-h dark (14:10) photoperiod, a 11:13 photoperiod or a 11:13 photoperiod exten...


    pub_type: 杂志文章


    authors: Brainard GC,Vaughan MK,Reiter RJ

    更新日期:1986-08-01 00:00:00

  • 5 alpha-reductase, aromatase, and androgen receptor levels in the monkey brain during fetal development.

    abstract::To elucidate the metabolic fate and possible role of androgens and their derivatives during primate fetal development, aromatase (AROM), 5 alpha-reductase (5 alpha R), and androgen receptor (AR; cytosolic) levels were assessed in the brain, heart (HRT), lung (LNG), and skeletal muscle (MUS) of fetal rhesus monkeys. An...


    pub_type: 杂志文章


    authors: Sholl SA,Goy RW,Kim KL

    更新日期:1989-02-01 00:00:00

  • 17 beta-estradiol stimulates cancellous bone formation in female rats.

    abstract::Estrogen is generally considered to maintain bone mass through suppression of bone resorption. We have previously demonstrated that administration of pharmacological doses of estrogen increases bone formation in rats. Because such high doses of estrogen might induce bone formation through some mechanism other than the...


    pub_type: 杂志文章


    authors: Chow JW,Lean JM,Chambers TJ

    更新日期:1992-05-01 00:00:00

  • Microwave stabilization enhances immunocytochemical detection of estrogen receptor in frozen sections of macaque oviduct.

    abstract::We have found that microwave (MW) stabilization greatly improves detection of the estrogen receptor (ER) in frozen sections of rhesus monkey oviduct by immunocytochemistry (ICC). Fresh samples of fimbriae were MW-irradiated, frozen, and then cryosectioned. The frozen sections were also MW-treated and then fixed in a p...


    pub_type: 杂志文章


    authors: Slayden OD,Koji T,Brenner RM

    更新日期:1995-09-01 00:00:00

  • Identification and characterization of binding proteins for inhibin and activin in human serum and follicular fluids.

    abstract::Inhibins and activins are produced by a variety of tissues and may have important endocrine and paracrine roles in development, reproduction, and hematopoiesis. However, little is known regarding the physical properties or concentrations of inhibin and activin in biological fluids. Binding proteins for inhibin or acti...


    pub_type: 杂志文章


    authors: Krummen LA,Woodruff TK,DeGuzman G,Cox ET,Baly DL,Mann E,Garg S,Wong WL,Cossum P,Mather JP

    更新日期:1993-01-01 00:00:00

  • Activation of the Na+/H+ exchanger by cellular pH and extracellular Na+ in rat adipocytes; inhibition by isoproterenol.

    abstract::The activity of the Na+/H+ exchanger was studied by measuring the effects of intracellular pH (pHi) and extracellular Na+ [(Na+)o] on pHi recovery and 22Na uptake in rat adipocytes. The resting pHi was acidified from 7.30 +/- 0.02 to 6.99 +/- 0.01 with nigericin in the absence of (Na+)o. pHi recovery induced by 30 mM ...


    pub_type: 杂志文章


    authors: Arsenis G

    更新日期:1995-07-01 00:00:00