Multiple elements and protein factors coordinate the basal and cyclic adenosine 3',5'-monophosphate-induced transcription of the lutropin receptor gene in rat granulosa cells.

abstract：:Signals derived from other pituitary cells can have a dramatic effect on PRL gene expression and secretion by mammotropes. However, the intracellular mechanisms by which these effects are manifested on the target cell remain unexplored. Inasmuch as calcium is a key modulator of both gene expression and hormone export ...

journal_title：Endocrinology

authors： Abraham EJ,Villalobos C,Frawley LS

更新日期：1998-06-01 00:00:00

abstract：:TGF-beta is a multifunctional factor involved in regulating a variety of cellular activities. In mammals, TGF-beta is known to regulate reproduction, including ovarian functions. The role of TGF-beta in lower vertebrates, such as fish, is poorly understood. To examine the role of TGF-beta in fish reproduction, cDNAs e...

journal_title：Endocrinology

authors： Kohli G,Hu S,Clelland E,Di Muccio T,Rothenstein J,Peng C

更新日期：2003-05-01 00:00:00

abstract：:Hyp mice, the murine homolog of human X-linked hypophosphatemia (XLH), are characterized in part by elevated renal loss of phosphate (Pi) and hypophosphatemia. The lesion responsible for this syndrome is believed to be defective Na+ gradient-dependent phosphate transport across renal brush border membranes (BBM). It h...

journal_title：Endocrinology

authors： Kiebzak GM,Dousa TP

更新日期：1985-08-01 00:00:00

abstract：:Islet β-cell dysfunction that leads to impaired insulin secretion is a principal source of pathology of diabetes. In type 2 diabetes, this breakdown in β-cell health is associated with compromised islet-enriched transcription factor (TF) activity that disrupts gene expression programs essential for cell function and i...

journal_title：Endocrinology

authors： Davidson RK,Kanojia S,Spaeth JM

更新日期：2021-02-01 00:00:00

abstract：:Several neuropeptides with the C-terminal RFamide sequence have been identified in the hypothalamus of a variety of vertebrates. Among the RFamide peptide groups, however, only LPXRFamide peptides, including gonadotropin-inhibitory hormone, have been characterized in the avian brain. In the present study, we sought fo...

journal_title：Endocrinology

authors： Ukena K,Tachibana T,Iwakoshi-Ukena E,Saito Y,Minakata H,Kawaguchi R,Osugi T,Tobari Y,Leprince J,Vaudry H,Tsutsui K

更新日期：2010-05-01 00:00:00

abstract：:Thyroid hormone accelerates energy expenditure (EE) and is critical for cold-induced thermogenesis. To define the metabolic role played by thyroid hormone in the dissipation of calories from diet, hypothyroid mice were studied for 60 d in a comprehensive lab animal monitoring system. Hypothyroidism decreased caloric i...

journal_title：Endocrinology

authors： Ueta CB,Olivares EL,Bianco AC

更新日期：2011-09-01 00:00:00

abstract：:Parathyroid tissue from patients with hyperparathyroidism (HPT) exhibited reduced immunohistochemical reactivity with monoclonal antiparathyroid antibodies, previously shown to stain intensely the surface of normal human parathyroid cells and to interfere with a receptor mechanism of these cells which is involved in t...

journal_title：Endocrinology

authors： Juhlin C,Klareskog L,Nygren P,Ljunghall S,Gylfe E,Rastad J,Akerström G

更新日期：1988-06-01 00:00:00

abstract：:Thyroid cell growth and function are regulated by hormones and growth factors binding to cell surface receptors that are coupled via G proteins, Gs and Gq, to the adenylyl cyclase and phospholipase C signal transduction systems, respectively. Activating mutations of the TSH receptor and G alpha s have been documented ...

journal_title：Endocrinology

authors： Zeiger MA,Saji M,Gusev Y,Westra WH,Takiyama Y,Dooley WC,Kohn LD,Levine MA

更新日期：1997-08-01 00:00:00

abstract：:Mediators of lymphocyte infiltration in inflammatory thyroid disease have yet to be identified. Here we examine the ability of IL-1beta to enhance the production of chemoattractants by human thyrocytes. Primary cultures, when treated with the cytokine, release T lymphocyte chemotactic activity. The effect of IL-1beta ...

journal_title：Endocrinology

authors： Gianoukakis AG,Martino LJ,Horst N,Cruikshank WW,Smith TJ

更新日期：2003-07-01 00:00:00

abstract：:Electrical stimulation of the preoptic area resulted in a significant increase in the secretion rate of immunoreactive somatostatin (IRS) and its concentration in the hypophysial portal blood of urethane-anesthetized rats. In contrast, stimulation of the ventromedial nucleus did not cause any changes in portal immunor...

journal_title：Endocrinology

authors： Chihara K,Arimura A,Kubli-Garfias C,Schally AV

更新日期：1979-12-01 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP)ergic nerves innervate both the neurohypophysis and the hypothalamus. To test the hypothesis that VIP is a releasing factor for neurohypophyseal hormones, rats were given intracerebroventricular (icv) infusions of VIP in doses varying from 0.3 pmol/kg.min to 3 nmol/kg.min for 5 m...

journal_title：Endocrinology

authors： Bardrum B,Ottesen B,Fahrenkrug J,Fuchs AR

更新日期：1988-11-01 00:00:00

abstract：:The lipid phosphatase, phosphatase and tensin homolog (PTEN), is a key element in controlling cell growth and survival and has a well established role as tumor suppressor protein in many neoplasia. Several data indicate that silencing of PTEN gene expression may be relevant in follicular thyroid cell transformation. T...

journal_title：Endocrinology

authors： Tell G,Pines A,Arturi F,Cesaratto L,Adamson E,Puppin C,Presta I,Russo D,Filetti S,Damante G

更新日期：2004-10-01 00:00:00

abstract：:Ghrelin is produced by the gastrointestinal tract, and its systemic concentrations are mainly regulated by nutritional factors. Our aim was to investigate: 1) endogenous portal and systemic acylated and unacylated ghrelin levels (AG and UAG, respectively); 2) whether an iv glucose tolerance test (IVGTT) modifies AG an...

journal_title：Endocrinology

authors： Gauna C,Uitterlinden P,Kramer P,Kiewiet RM,Janssen JA,Delhanty PJ,van Aken MO,Ghigo E,Hofland LJ,Themmen AP,van der Lely AJ

更新日期：2007-11-01 00:00:00

abstract：:We studied the effects of vitamin D deficiency and its correction by vitamin D or calcium-lactose supplementation on vitamin D receptor (VDR) expression in skin keratinocytes, kidney, and duodenum of adult rats. VDR messenger RNA (mRNA) was assayed by Northern blot, and VDR protein was determined immunocytochemically....

journal_title：Endocrinology

authors： Zineb R,Zhor B,Odile W,Marthe RR

更新日期：1998-04-01 00:00:00

abstract：:The occurrence of the thyroid hormone-binding plasma protein transthyretin in the bloodstream was investigated for four American marsupial species. Serum samples were analyzed by incubation with radioactive T4, followed by electrophoresis, then autoradiography, and Western blotting. Transthyretin was found in serum fr...

journal_title：Endocrinology

authors： Richardson SJ,Wettenhall RE,Schreiber G

更新日期：1996-08-01 00:00:00

abstract：:The major changes in pancreatic islet function during pregnancy and after exposure to lactogens are an increase in beta-cell proliferation and enhanced insulin secretion. In this study we examined INS-1 cells as a potential model for further inquiry into PRL signaling in beta-cells. Proliferation of beta-cells, insuli...

journal_title：Endocrinology

authors： Stout LE,Svensson AM,Sorenson RL

更新日期：1997-04-01 00:00:00

abstract：:L-700,653 is a potent nonpeptidyl GH secretagogue consisting of a benzolactam structure: (4'-[[3(R)-[[3-[(2(S),3-dihydroxypropyl) amino]3-methyl-1-oxobutyl]amino]2,3,4,5-tetrahydro-2-oxo-1H-1-benzaze pin- 1-yl]methyl][1,1'-biphenyl]2-carboxamide hydrochloride). When administered sc by a Medi-Jector device at 0, 0.003,...

journal_title：Endocrinology

authors： Chang CH,Rickes EL,Marsilio F,McGuire L,Cosgrove S,Taylor J,Chen H,Feighner S,Clark JN,De Vita R

更新日期：1995-03-01 00:00:00

abstract：:Thyroid hormones (TH) are actively taken up into target cells via TH-transmembrane transporters (THTT). Their activity and expression patterns define a layer of endocrine regulation that is poorly understood. Therefore, THTT are potential targets for interfering agents (endocrine disruptors) as well as for pharmacolog...

journal_title：Endocrinology

authors： Jayarama-Naidu R,Johannes J,Meyer F,Wirth EK,Schomburg L,Köhrle J,Renko K

更新日期：2015-07-01 00:00:00

abstract：:Human IGF binding protein-3 (hIGFBP-3) overexpression in mice causes hyperglycemia, but its effect on β-cell function is unknown. We compared wild-type mice with mice overexpressing hIGFBP-3 [phoshoglycerate kinase (PGK)BP3] and mutant (Gly⁵⁶/Gly⁸⁰/Gly⁸¹)hIGFBP-3 devoid of IGF binding affinity (PGKmBP3). Intraperitone...

journal_title：Endocrinology

authors： Nguyen KH,Yao XH,Moulik S,Mishra S,Nyomba BL

更新日期：2011-06-01 00:00:00

abstract：:In humans and zebrafish, 2 glucocorticoid (GC) receptor (GR) splice variants exist: the canonical GR α-isoform (GRα), and the GRβ. In the present study, we have used the zebrafish model system in order to reveal genes affected by each of these 2 receptor isoforms. By injecting zebrafish embryos with different splice-b...

journal_title：Endocrinology

authors： Chatzopoulou A,Roy U,Meijer AH,Alia A,Spaink HP,Schaaf MJ

更新日期：2015-05-01 00:00:00

abstract：:MCF-7 cells migrate through vitronectin-coated filters in response to insulin-like growth factor I (IGF-I); migration is inhibited by the matrix metalloproteinase (MMP) inhibitor BB-94, but not by the serine proteinase inhibitor aprotinin. MMP-9 was identified in the conditioned medium of MCF-7 cells; in addition, flu...

journal_title：Endocrinology

authors： Mira E,Mañes S,Lacalle RA,Márquez G,Martínez-A C

更新日期：1999-04-01 00:00:00

abstract：:This review describes formation of the islet basement membrane and the function of extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for islet transplantation are discussed. The insulin-producing β-cell is key for maintaining glucose homeostasis. The islet microenvironment greatl...

journal_title：Endocrinology

authors： Townsend SE,Gannon M

更新日期：2019-08-01 00:00:00

abstract：:Twelve weeks of high-fat diet feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons. In the current study, we investigated whether diet-induced weight loss could restore NPY/AgRP neuronal responsiveness to ghrelin and whether ghrelin mediates rebound weight gain after ...

journal_title：Endocrinology

authors： Briggs DI,Lockie SH,Wu Q,Lemus MB,Stark R,Andrews ZB

更新日期：2013-02-01 00:00:00

abstract：:Leydig cells from mature rat testes contain high levels of 11 beta-hydroxysteroid dehydrogenase (11HSD), an enzyme that oxidatively inactivates glucocorticoids. We have proposed that the 11HSD of Leydig cells protects the testis from the effects of high levels of glucocorticoids, as may occur in stress and Cushing's d...

journal_title：Endocrinology

authors： Monder C,Miroff Y,Marandici A,Hardy MP

更新日期：1994-03-01 00:00:00

abstract：:Differentiation of endometrial stromal cells into decidual cells is a prerequisite for successful embryo implantation. Our previous studies in the mouse have shown that bone morphogenetic protein 2 (BMP2), a morphogen belonging to the TGFβ superfamily, is essential for this differentiation process. BMP2 is markedly in...

journal_title：Endocrinology

authors： Li Q,Kannan A,Das A,Demayo FJ,Hornsby PJ,Young SL,Taylor RN,Bagchi MK,Bagchi IC

更新日期：2013-01-01 00:00:00

abstract：:Elucidation of the role of Ca2+ in the secretion of insulin and glucagon is complicated by the presence of different types of cells in the pancreatic islets. Visualization of calcium in sections of guinea pig pancreas with the histochemical reagent glyoxal bis-2-hydroxyanil revealed the most intense staining in the en...

journal_title：Endocrinology

authors： Berggren PO,Ostenson CG,Petersson B,Hellman B

更新日期：1979-12-01 00:00:00

abstract：:In seasonally breeding species, an animal's photoperiodic history (the daylength or photoperiod previously experienced) influences the reproductive response to new photoperiods. However, this has only been examined over a relatively narrow range of photoperiods. We assessed whether Djungarian hamsters (Phodopus sungor...

journal_title：Endocrinology

authors： Rivkees SA,Hall DA,Weaver DR,Reppert SM

更新日期：1988-06-01 00:00:00

abstract：:Selective inhibitors of sodium glucose cotransporter-2 (SGLT2) are widely used for the treatment of type 2 diabetes and act primarily to lower blood glucose by preventing glucose reabsorption in the kidney. However, it is controversial whether these agents also act on the pancreatic islet, specifically the α cell, to ...

journal_title：Endocrinology

authors： Dai C,Walker JT,Shostak A,Bouchi Y,Poffenberger G,Hart NJ,Jacobson DA,Calcutt MW,Bottino R,Greiner DL,Shultz LD,McGuinness OP,Dean ED,Powers AC

更新日期：2020-08-01 00:00:00

abstract：:Pulmonary surfactant is a developmentally and hormonally regulated lipoprotein synthesized exclusively in alveolar type II cells. Surfactant protein-A (SP-A) gene transcription in human fetal lung in culture is stimulated by glucocorticoids and cAMP; cAMP also enhances the rate of type II cell differentiation. The CCA...

journal_title：Endocrinology

authors： Breed DR,Margraf LR,Alcorn JL,Mendelson CR

更新日期：1997-12-01 00:00:00

abstract：:Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity, which can amplify...

journal_title：Endocrinology

authors： Doig CL,Fletcher RS,Morgan SA,McCabe EL,Larner DP,Tomlinson JW,Stewart PM,Philp A,Lavery GG

更新日期：2017-06-01 00:00:00