Distinct, tissue-specific regulation of vitamin D receptor in the intestine, kidney, and skin by dietary calcium and vitamin D.

abstract：:Hypoxia plays a vital role in the progression of endometriosis. Additionally, integrin-mediated aberrant adhesion is also essential for establishment of endometriotic lesions. In this study, we sought to determine the function of hypoxia in integrin-mediated adhesion of endometrial stromal cells (ESCs) in endometriosi...

journal_title：Endocrinology

authors： Lin X,Dai Y,Xu W,Shi L,Jin X,Li C,Zhou F,Pan Y,Zhang Y,Lin X,Zhang S

更新日期：2018-04-01 00:00:00

abstract：:Chronic exposure to stressors impairs the function of multiple organ systems and has been implicated in increased disease risk. In the rodent, the chronic variable stress (CVS) paradigm has successfully modeled several stress-related illnesses. Despite striking disparities between men and women in the prevalence and e...

journal_title：Endocrinology

authors： Borrow AP,Bales NJ,Stover SA,Handa RJ

更新日期：2018-07-01 00:00:00

abstract：:Nitric oxide (NO) has emerged as an intracellular and intercellular messenger in a number of biological systems. In the present study, we demonstrated that NO was produced by cultured rat Leydig cells, and that inducible nitric oxide synthase (iNOS) messenger RNA (mRNA) was expressed in Leydig cells. NO was measured a...

journal_title：Endocrinology

authors： Tatsumi N,Fujisawa M,Kanzaki M,Okuda Y,Okada H,Arakawa S,Kamidono S

更新日期：1997-03-01 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor-β superfamily and plays a critical role in regulating ovarian follicle function. Currently, the role of BMP2 during cumulus expansion remains to be determined. The aim of this study was to investigate the effect of BMP2 on the regulation of ...

journal_title：Endocrinology

authors： Bai L,Chang HM,Cheng JC,Chu G,Leung PCK,Yang G

更新日期：2017-10-01 00:00:00

abstract：:We studied the effects of 17 beta-estradiol (E2) and PTH on alkaline phosphatase activity in SaOS-2 cells that had been passaged and grown continually in the presence (SaOS + Dex) or absence (SaOS - Dex) of 10(-8) M dexamethasone (Dex). We showed that the more differentiated SaOS + Dex cells had higher alkaline phosph...

journal_title：Endocrinology

authors： Rao LG,Wylie JN,Sutherland MS,Murray TM

更新日期：1994-02-01 00:00:00

abstract：:LA-PTH is a long-acting parathyroid hormone (PTH) peptide analogue in preclinical development for hypoparathyroidism (HP). Like native PTH, LA-PTH contains a methionine at position 8 (Met8) that is predicted to be critical for function. We assessed the impact of Met oxidation on the functional properties of LA-PTH and...

journal_title：Endocrinology

authors： Daley EJ,Khatri A,Dean T,Vilardaga JP,Zaidi SA,Katritch V,Gardella TJ

更新日期：2021-02-01 00:00:00

abstract：:The effect of delta 9-tetrahydrocannabinol (THC) on suckling-induced oxytocin release was investigated by recording intramammary pressure changes in suckled rats treated iv with THC (0.5 mg/kg BW) or vehicle. Latency to the first posttreatment milk ejection and posttreatment milk ejection intervals and pressure wave a...

journal_title：Endocrinology

authors： Tyrey L,Murphy LL

更新日期：1988-07-01 00:00:00

abstract：:Prolonged exposure to elevated FFA levels has been shown to induce peripheral insulin resistance and to alter the beta-cell secretory response to glucose. To investigate the effects of FFAs on preproinsulin gene expression, we measured insulin release, cell content, and messenger RNA (mRNA) levels in rat islets after ...

journal_title：Endocrinology

authors： Ritz-Laser B,Meda P,Constant I,Klages N,Charollais A,Morales A,Magnan C,Ktorza A,Philippe J

更新日期：1999-09-01 00:00:00

abstract：:Maternal obesity during pregnancy increases the risk of obesity in the offspring. Several observations have pointed to a causative role for the proinflammatory cytokine IL-6, but whether it is present in the fetal circulation and how it acts on the developing fetus are unclear. We first observed that postnatal day 0 o...

journal_title：Endocrinology

authors： Sanders TR,Kim DW,Glendining KA,Jasoni CL

更新日期：2014-07-01 00:00:00

abstract：:Thyroid hormone accelerates energy expenditure (EE) and is critical for cold-induced thermogenesis. To define the metabolic role played by thyroid hormone in the dissipation of calories from diet, hypothyroid mice were studied for 60 d in a comprehensive lab animal monitoring system. Hypothyroidism decreased caloric i...

journal_title：Endocrinology

authors： Ueta CB,Olivares EL,Bianco AC

更新日期：2011-09-01 00:00:00

abstract：:Retinoids induce cellular differentiation and inhibit cellular proliferation. Proliferation of human breast carcinoma cells in vitro is markedly inhibited by these compounds. On the other hand, insulin-like growth factors (IGFs) and their receptors seem to be involved in the growth of certain breast carcinoma cells by...

journal_title：Endocrinology

authors： Fontana JA,Burrows-Mezu A,Clemmons DR,LeRoith D

更新日期：1991-02-01 00:00:00

abstract：:TGF-β plays an important role in the progression of prostate cancer. It exhibits both tumor suppressor and tumor-promoting activities. Correlations between cyclooxygenase (COX)-2 overexpression and enhanced production of prostaglandin (PG)E2 have been implicated in cancer progression; however, there are no studies ind...

journal_title：Endocrinology

authors： Vo BT,Morton D Jr,Komaragiri S,Millena AC,Leath C,Khan SA

更新日期：2013-05-01 00:00:00

abstract：:To investigate the participation of cyclic nucleotides in LHRH-mediated gonadotropin release, cells from the anterior pituitaries of 15-day-old female rats were fractionated on an albumin gradient by sedimentation at unit gravity. gonadotrophs and somatotrophs were detected in the fractions by histology and RIA of hor...

journal_title：Endocrinology

authors： Snyder G,Naor Z,Fawcett CP,McCann SM

更新日期：1980-11-01 00:00:00

abstract：:Proinflammatory cytokines have been shown to influence the expression and function of the glucocorticoid receptor (GR). Specifically, several studies have found that cytokines induce a decrease in GR function, as evidenced by reduced sensitivity to glucocorticoid effects on functional end points. To investigate the po...

journal_title：Endocrinology

authors： Pariante CM,Pearce BD,Pisell TL,Sanchez CI,Po C,Su C,Miller AH

更新日期：1999-09-01 00:00:00

abstract：:Uterine estrogen receptor (ER) and ER mRNA were measured in cycling and ovariectomized (OVX) estrogen-treated mice to probe the physiological regulation of the intracellular distribution and biosynthesis of ER. On proestrus, when plasma estradiol (E2) levels are highest, the cell nuclear ER concentration was 2.4-fold ...

journal_title：Endocrinology

authors： Bergman MD,Schachter BS,Karelus K,Combatsiaris EP,Garcia T,Nelson JF

更新日期：1992-04-01 00:00:00

abstract：:The effects of short term (1-month) and life-long 60% ad libitum food restriction on the adrenocortical response to restraint stress were compared in young and aged Fischer 344 rats. In rats restricted for 1 month (study 1), the adrenocortical response differed as a function of age. In 8-month-old animals, the initial...

journal_title：Endocrinology

authors： Stewart J,Meaney MJ,Aitken D,Jensen L,Kalant N

更新日期：1988-10-01 00:00:00

abstract：:The relationship between serum levels of rat GH (rGH), rat PRL (rPRL), corticosterone, estrogen, and testosterone and the liver-binding sites specific to [125I]iodo-human GH (hGH), -human PRL (hPRL), and -rPRL were investigated in normal rats, in rats bearing the GH- and PRL-secreting tumor (GH3), and in rats 14 days ...

journal_title：Endocrinology

authors： Furuhashi N,Fang VS

更新日期：1978-12-01 00:00:00

abstract：:Desensitization and internalization of G protein-coupled receptors can be mediated by phosphorylation within the C-terminal tail, facilitating beta-arrestin binding and targeting the receptor for internalization. Type II GnRH receptors (GnRH-Rs) show such regulation, but type I GnRH-Rs lack C-tails and are not rapidly...

journal_title：Endocrinology

authors： Caunt CJ,Hislop JN,Kelly E,Matharu AL,Green LD,Sedgley KR,Finch AR,McArdle CA

更新日期：2004-08-01 00:00:00

abstract：:Reduced and S-carbamidomethylated human GH (RCAM-hGH) was digested with human plasmin, yielding a mixture of products. These were partially separated by chromatography on DEAE-cellulose, yielding three major fractions: Da and Db, which were equipotent with native hGH in the weight gain test; and Dc, which was about ha...

journal_title：Endocrinology

authors： Mills JB,Kostyo JL,Moseley MH,Reagan CR,Wilhelmi AE

更新日期：1978-05-01 00:00:00

abstract：:Estrogen increases the alpha 1-adrenergic contractile sensitivity of the rabbit uterus. Since estrogen treatment increases prostaglandin (PG) production by the perfused rabbit uterus, and PGs contribute to the alpha 1-adrenergic contractile response, we postulated that estrogen's effects on PG production or response m...

journal_title：Endocrinology

authors： Hurd WW,Riemer RK,Goldfien A,Roberts JM

更新日期：1991-09-01 00:00:00

abstract：:To elucidate the temporal profile of adaptive changes of the islets of Langerhans to the increased insulin demands of pregnancy, we have studied islet cell proliferation and insulin secretion during gestation in the rat. 5-Bromo-2'-deoxyuridine incorporation into dividing islet cells was significantly (P less than 0.0...

journal_title：Endocrinology

authors： Parsons JA,Brelje TC,Sorenson RL

更新日期：1992-03-01 00:00:00

abstract：:Chronically elevated circulating glucocorticoid levels are although to enhance vulnerability to psychopathology. Here we hypothesized that such sustained glucocorticoid levels, disturbing corticosterone pulsatility, attenuate glucocorticoid receptor signaling and target gene responsiveness to an acute challenge in the...

journal_title：Endocrinology

authors： Sarabdjitsingh RA,Isenia S,Polman A,Mijalkovic J,Lachize S,Datson N,de Kloet ER,Meijer OC

更新日期：2010-03-01 00:00:00

abstract：:Endothelin (ET) and GnRH act through specific receptors to promote Ca2+ mobilization and influx pathways in pituitary gonadotrophs. In the present study cytoplasmic calcium ([Ca2+]i) and secretory responses to these two agonists are compared. In single gonadotrophs, low concentrations of both agonists cause oscillator...

journal_title：Endocrinology

authors： Stojilković SS,Iida T,Cesnjaj M,Catt KJ

更新日期：1992-12-01 00:00:00

abstract：:Primary cultures of enzymatically dispersed rat anterior pituitary cells were used to examine the effect of pure 31 kilodalton bovine inhibin on GnRH-induced up-regulation of GnRH binding sites. After 2 days in culture, the cells were exposed to stimuli with or without test substances for 10 h, followed by evaluation ...

journal_title：Endocrinology

authors： Wang QF,Farnworth PG,Findlay JK,Burger HG

更新日期：1989-01-01 00:00:00

abstract：:A heat-stable protein which inhibits cAMP dependent protein kinase was prepared from the bovine thyroid 100,000 X g supernatant. This protein inhibited the cAMP-dependent protein kinase both from bovine thyroid cytosol and bovine thyroid plasma membranes. The inhibitory effect was noncompetitive with histone as substr...

journal_title：Endocrinology

authors： Hashizume K,DeGroot LJ

更新日期：1979-07-01 00:00:00

abstract：:7B2 is a novel neuroendocrine polypeptide which belongs to an entirely new superfamily of proteins. In extension of previous reports on 7B2, these studies concern its expression in endocrine pancreatic tissue. They have been performed using specific antibodies prepared against two distinct synthetic fragments of 7B2 c...

journal_title：Endocrinology

authors： Benjannet S,Marcinkiewicz M,Falgueyret JP,Johnson DE,Seidah NG,Chrétien M

更新日期：1988-08-01 00:00:00

abstract：:GnRH regulates the secretion of LH and FSH, which stimulate the secretion of testicular hormones. Acting in a reciprocal fashion, these hormones, including testosterone and inhibin, exert a negative feedback effect on GnRH and gonadotropin secretion. Endogenous opioid peptides (EOPs) have been implicated to play a rol...

journal_title：Endocrinology

authors： Chowen-Breed J,Fraser HM,Vician L,Damassa DA,Clifton DK,Steiner RA

更新日期：1989-04-01 00:00:00

abstract：:It was shown previously that epidermal growth factor (EGF) plays a role in the testosterone-dependent fetal Wolffian duct differentiation. In this communication, the role of EGF was further investigated by determining whether EGF receptor plays a role in mediating the effect of EGF during Wolffian duct (male duct) dif...

journal_title：Endocrinology

authors： Gupta C,Jaumotte J

更新日期：1993-10-01 00:00:00

abstract：:Pancreatic glucokinase (GK) is considered an important element of the glucose-sensing unit in pancreatic beta-cells. It is possible that the brain uses similar glucose-sensing units, and we employed GK immunohistochemistry and confocal microscopy to examine the anatomical distribution of GK-like immunoreactivities in ...

journal_title：Endocrinology

authors： Maekawa F,Toyoda Y,Torii N,Miwa I,Thompson RC,Foster DL,Tsukahara S,Tsukamura H,Maeda K

更新日期：2000-01-01 00:00:00

abstract：:During in vitro maturation of porcine cumulus cell-oocyte complexes and in vitro luteinization of porcine granulosa cells, FSH induces the expression of the protease TNFα-converting enzyme/A disintegrin and metalloproteinase domain 17 (TACE/ADAM17) and the epidermal growth factor (EGF)-like factors, which activate the...

journal_title：Endocrinology

authors： Yamashita Y,Okamoto M,Ikeda M,Okamoto A,Sakai M,Gunji Y,Nishimura R,Hishinuma M,Shimada M

更新日期：2014-03-01 00:00:00