Isolation and characterization of fragments of reduced and S-carbamidomethylated human growth hormone produced by plasmin digestion. I. Chemistry.

abstract：:The importance of thyroid hormone (TH) in wound healing is not well understood. To gain insight, we evaluated the impact of TH deficiency on wound-healing genes in cultured keratinocytes. By RT-PCR, keratin 6a (K6a) and 16 (K16) gene expression in TH replete cells was 3.8- (P < 0.005) and 1.9-fold (P < 0.05) greater, ...

journal_title：Endocrinology

authors： Safer JD,Crawford TM,Holick MF

更新日期：2004-05-01 00:00:00

abstract：:Although estrogens and estrogen receptors (ERs) are known to function in the male brain and reproductive tract, few studies have evaluated their involvement in the male hematopoietic and immune systems. This study was undertaken to determine the role of ERalpha in hematopoietic progenitor and B lymphocyte maturation. ...

journal_title：Endocrinology

authors： Thurmond TS,Murante FG,Staples JE,Silverstone AE,Korach KS,Gasiewicz TA

更新日期：2000-07-01 00:00:00

abstract：:Atrial natriuretic factor (ANF) was studied for its effect on renin release by rat renal cortical slices. ANF (rat) alone (10(-9)-10(-6) M) had no effect on basal renin release, but significantly (P less than 0.001) potentiated angiotensin II (AII) inhibition of renin secretion in doses as low as 10(-9) M. ANF also po...

journal_title：Endocrinology

authors： Antonipillai I,Vogelsang J,Horton R

更新日期：1986-07-01 00:00:00

abstract：:Male Sprague-Dawley rats were infused continuously for 13 days with vehicle or 75 pmol (31.2 ng)/day 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] by means of Alzet osmotic minipumps implanted s.c. Animals infused with 1,25-(OH)2D3 exhibited mild hypercalcemia (11.2 vs. 10.2 mg/dl in controls), a 136% increase in the serum ...

journal_title：Endocrinology

authors： Wronski TJ,Halloran BP,Bikle DD,Globus RK,Morey-Holton ER

更新日期：1986-12-01 00:00:00

abstract：:We analyzed the mechanism by which a Graves' disease-associated C/T polymorphism in the Kozak sequence of CD40 affects CD40 expression. CD40 expression levels on B cells in individuals with CT and TT genotypes were decreased by 13.3 and 39.4%, respectively, compared with the levels in CC genotypes (P = 0.012). Similar...

journal_title：Endocrinology

authors： Jacobson EM,Concepcion E,Oashi T,Tomer Y

更新日期：2005-06-01 00:00:00

abstract：:A myometrial explant culture system was developed to investigate the effect of progesterone and the antiprogestagen RU486 on prostacyclin (PGI2) and thromboxane A2 (TXA2) synthesis by the rat myometrium. After culture, eicosanoid synthesis was stimulated with arachidonic acid (AA) and the calcium ionophore A23187 (A23...

journal_title：Endocrinology

authors： Jeremy JY,Dandona P

更新日期：1986-08-01 00:00:00

abstract：:Regularly menstruating female rhesus monkeys were implanted sc with Silastic tubing packed with estrone. The implants were replaced every 6-8 months to maintain the serum estrone and estradiol concentrations constantly elevated 1.5-2.5-fold, i.e. in the midfollicular phase range, for 4 yr. Increasing the estrone and e...

journal_title：Endocrinology

authors： Billiar RB,Richardson DW,Little B

更新日期：1989-05-01 00:00:00

abstract：:A variety of chronic stress paradigms have been shown to increase basal activity in the hypothalamic-pituitary-adrenocortical axis, resulting in hypercorticoidism. Despite this, chronically stressed rats typically exhibit facilitated ACTH responses to acute novel stress, suggesting that the activity of some central ne...

journal_title：Endocrinology

authors： Scribner KA,Akana SF,Walker CD,Dallman MF

更新日期：1993-12-01 00:00:00

abstract：:We studied the structural and functional characteristics of insulin receptors from rat brain and liver from late gestation through adulthood as well as from cultured neuronal and glial cells from neonatal rats. Specific insulin binding was present on membrane preparations from brain and liver at all stages of developm...

journal_title：Endocrinology

authors： Lowe WL Jr,Boyd FT,Clarke DW,Raizada MK,Hart C,LeRoith D

更新日期：1986-07-01 00:00:00

abstract：:We have examined the effects of a new synthetic inhibitor of mammalian tissue collagenase, CI-1 (N-[3-N-(benzyloxycarbonyl)amino-1-(R)carboxypropyl]L-leucyl-O-methyl-L- tyrosine N-methylamide; G. D. Searle SC 40827), and a general metalloproteinase inhibitor, 1,10-phenanthroline, on ovulation, as judged by the observa...

journal_title：Endocrinology

authors： Brännström M,Woessner JF Jr,Koos RD,Sear CH,LeMaire WJ

更新日期：1988-05-01 00:00:00

abstract：:There are many precedents for the production from a single precursor of multiple peptides, with independent receptors and different bioactivities. Gastrin-releasing peptide (GRP) is initially synthesized as amino acids 1-27 of a 125-residue precursor, proGRP, and is subsequently cleaved and amidated to form GRP18-27. ...

journal_title：Endocrinology

authors： Patel O,Dumesny C,Shulkes A,Baldwin GS

更新日期：2007-03-01 00:00:00

abstract：:Circulating insulin-like growth factor (IGF) bioactivity is reduced in animals and patients with diabetes mellitus. We sought to determine whether the availability and levels of specific IGF binding proteins (BPs) are altered in animals with experimental diabetes, and might contribute to changes in circulating IGF bio...

journal_title：Endocrinology

authors： Unterman TG,Patel K,Mahathre VK,Rajamohan G,Oehler DT,Becker RE

更新日期：1990-05-01 00:00:00

abstract：:Tumoral insulin-producing cells of the RINm5F line display a poor secretory response to D-glucose. Relative to basal insulin output, which corresponds to a fractional release of stored hormone close to 25%/90 min, the glucose-induced increment in insulin release does not exceed 28 +/- 7%. The low efficiency of D-gluco...

journal_title：Endocrinology

authors： Valverde I,Barreto M,Malaisse WJ

更新日期：1988-04-01 00:00:00

abstract：:Constitutive nitric oxide synthase (cNOS) was immunolocalized to study its role in osmotic regulation. Immunoreactivity was observed in all major hypothalamic osmoregulatory structures, the organum vasculosum laminae terminalis, subfornical organ, median preoptic nucleus, and supraoptic and paraventricular nuclei. The...

journal_title：Endocrinology

authors： Wang H,Morris JF

更新日期：1996-05-01 00:00:00

abstract：:The most significant increase in metabolic syndrome over the previous decade occurred in women of reproductive age, which is alarming given that metabolic syndrome is associated with reproductive problems including subfertility and early pregnancy loss. Individuals with metabolic syndrome often consume excess fructose...

journal_title：Endocrinology

authors： Saben JL,Asghar Z,Rhee JS,Drury A,Scheaffer S,Moley KH

更新日期：2016-02-01 00:00:00

abstract：:Up-regulation of maternal islet function is essential to accommodate the increased demand for insulin during pregnancy. Previously, we suggested that lactogenic activity regulates islet function during pregnancy. However, this hypothesis was based on the effect of homologous PRLs on islets, since the homologous placen...

journal_title：Endocrinology

authors： Brelje TC,Scharp DW,Lacy PE,Ogren L,Talamantes F,Robertson M,Friesen HG,Sorenson RL

更新日期：1993-02-01 00:00:00

abstract：:Recent evidence suggests that growth hormone-releasing peptides (GHRPs) mimic an unidentified native GH-releasing hormone (GHRH)-amplifying hormone. GHRH has been shown to stimulate food intake acting on the central nervous system. The present studies were conducted to test the hypothesis that GHRPs may also potentiat...

journal_title：Endocrinology

authors： Okada K,Ishii S,Minami S,Sugihara H,Shibasaki T,Wakabayashi I

更新日期：1996-11-01 00:00:00

abstract：:Hepatic synthesis of alpha 2u-globulin and its mRNA in the male rat is dependent on androgen, glucocorticoid, T4, insulin, and GH. Some of these hormones may act directly on the liver, while others may influence alpha 2u-globulin synthesis through indirect physiological changes. In the present study the specific role ...

journal_title：Endocrinology

authors： Murty CV,Rao KV,Roy AK

更新日期：1987-11-01 00:00:00

abstract：:In mammals, skeletal muscle mass is negatively regulated by a muscle-derived growth/differentiating factor named myostatin (MSTN) that belongs to the transforming growth factor-beta superfamily. Although putative MSTN homologs have been identified from several vertebrates, nonmammalian orthologs remained poorly define...

journal_title：Endocrinology

authors： Rodgers BD,Weber GM,Sullivan CV,Levine MA

更新日期：2001-04-01 00:00:00

abstract：:Stimulators of bone resorption, such as PTH, 1,25-dihydroxycholecalciferol [1,25-(OH)2D3], or prostaglandin E2 (PGE2), do not cause calcium release from cultured calvaria of the genetically determined osteopetrotic microphthalmic (mi/ mi) mouse, due to a defect in the function of osteoclasts. To investigate the capaci...

journal_title：Endocrinology

authors： Jilka RL,Cohn DV

更新日期：1983-03-01 00:00:00

abstract：:The effects of endothelin-1 (ET) on several tissues are mediated by prostaglandins. In this study, we investigated the actions of ET on bone and determined whether they are mediated through prostaglandin-dependent pathways. Bone resorption, collagen, and non-collagen protein synthesis and inositol phosphate (IP) produ...

journal_title：Endocrinology

authors： Tatrai A,Foster S,Lakatos P,Shankar G,Stern PH

更新日期：1992-08-01 00:00:00

abstract：:Pancreatic glucokinase (GK) is considered an important element of the glucose-sensing unit in pancreatic beta-cells. It is possible that the brain uses similar glucose-sensing units, and we employed GK immunohistochemistry and confocal microscopy to examine the anatomical distribution of GK-like immunoreactivities in ...

journal_title：Endocrinology

authors： Maekawa F,Toyoda Y,Torii N,Miwa I,Thompson RC,Foster DL,Tsukahara S,Tsukamura H,Maeda K

更新日期：2000-01-01 00:00:00

abstract：:Previous studies from this laboratory have demonstrated the presence of two populations of rat Leydig cells (I and II), which differ in their capacity for hCG- or cAMP-stimulated testosterone production. In the present study, we examined the metabolism of 25-hydroxycholesterol in primary cultures of both populations o...

journal_title：Endocrinology

authors： Georgiou M,Payne AH

更新日期：1985-09-01 00:00:00

abstract：:In osteoblasts, retinoic acid (RA) modulates the synthesis of various proteins, including collagen. However, little is known about the effects of RA on the regulation of interstitial collagenase synthesis and collagen degradation. After treatment of primary osteoblast-enriched (Ob) cells from fetal rat calvariae with ...

journal_title：Endocrinology

authors： Varghese S,Rydziel S,Jeffrey JJ,Canalis E

更新日期：1994-06-01 00:00:00

abstract：:Benzodiazepines (BZs) have been shown to modulate voltage-sensitive Ca2+ channels in a number of neuronal and nonneuronal cell types and to competitively antagonize TRH binding to receptors on cells of the nervous system and anterior pituitary gland. Because interaction of TRH with its receptor is known to cause enhan...

journal_title：Endocrinology

authors： Gershengorn MC,Thaw CN,Geras-Raaka E

更新日期：1988-07-01 00:00:00

abstract：:Ghrelin was recently identified as an endogenous ligand of the GH secretagogue receptor. The novel peptide hormone is produced by gastric A-like cells, and circulating levels rise before feeding, suggestive of ghrelin as an endogenous hunger factor. ghrelin stimulates food intake and promotes adiposity after periphera...

journal_title：Endocrinology

authors： Tang-Christensen M,Vrang N,Ortmann S,Bidlingmaier M,Horvath TL,Tschöp M

更新日期：2004-10-01 00:00:00

abstract：:Loss of circulating 17β-estradiol (E2) that occurs during menopause can have detrimental effects on cognitive function. The efficacy of hormone replacement therapy declines as women become farther removed from the menopausal transition, yet the molecular mechanisms underlying this age-related switch in E2 efficacy are...

journal_title：Endocrinology

authors： Shults CL,Pinceti E,Rao YS,Pak TR

更新日期：2015-11-01 00:00:00

abstract：:The influence of the catecholamine hormones and some of their metabolites on the enzymatic degradation of met-enkephalin by rat brain homogenates has been evaluated. The enzyme activity was determined by the release of [125I]-tyrosine from radioiodinated met-enkephalin following Porapak Q column chromatography. Each o...

journal_title：Endocrinology

authors： Caffrey JL,Hodges DH

更新日期：1982-01-01 00:00:00

abstract：:A method has been developed for the purification of rat placental lactogen employing a specific radioreceptor assay (RRA). The method involves precipitation with ammonium sulfate, gel filtration on Sephadex G-100, ion-exchange chromatography on DEAE-cellulose and CM-Sephadex, and preparative isoelectric focusing. The ...

journal_title：Endocrinology

authors： Roberston MC,Friesen HG

更新日期：1975-09-01 00:00:00

abstract：:Spinal cord hemisection between T2 and T3 inhibits compensatory adrenal growth when the contralateral but not the ipsilateral adrenal is removed (p less than 0.01). Pretreatment of left adrenals with 1 or 2% lidocaine, but not with saline, before removal inhibits compensatory right adrenal growth that is normally obse...

journal_title：Endocrinology

authors： Engeland WC,Dallman MF

更新日期：1976-12-01 00:00:00