κ-Opioid Receptor Is Colocalized in GnRH and KNDy Cells in the Female Ovine and Rat Brain.

abstract：:Basal or hypothalamic extract-induced ACTH or TSH secretory capacity as well as intracellular ACTH content were assessed in cultured rat adenohypophyseal cells after various pretreatments of the donor animals. Medium and intracellular ACTH or TSH were measured by radioimmunoassay. Ten-day to 2-month adrenalectomy enha...

journal_title：Endocrinology

authors： Yasuda N,Takebe K,Greer MA

更新日期：1976-03-01 00:00:00

abstract：:Recent studies have revealed that C-type natriuretic peptide (CNP) is a potent stimulator of endochondral bone growth. Nevertheless, the effect of CNP on bone turnover has not yet been well studied. To elucidate this issue, we investigated the bone phenotype of a mouse model with elevated plasma CNP concentrations (SA...

journal_title：Endocrinology

authors： Kondo E,Yasoda A,Fujii T,Nakao K,Yamashita Y,Ueda-Sakane Y,Kanamoto N,Miura M,Arai H,Mukoyama M,Inagaki N,Nakao K

更新日期：2015-07-01 00:00:00

abstract：:We characterized four antipeptide polyclonal antibodies (abs) able to specifically recognize each thyroid hormone receptor (TR) isoform. The abs immunoprecipitated both the in vitro synthesized receptor and the receptor expressed in E. coli and their specificity was confirmed by competition studies and immunohistochem...

journal_title：Endocrinology

authors： Falcone M,Miyamoto T,Fierro-Renoy F,Macchia E,DeGroot LJ

更新日期：1992-11-01 00:00:00

abstract：:Epigenetic aberrations, including DNA methylation, histone modifications, and micro-RNA dysregulation, are now well established in the development and progression of ovarian cancer, and their gradual accumulation is associated with advancing disease stage and grade. Epigenetic aberrations are relatively stable, associ...

journal_title：Endocrinology

authors： Balch C,Fang F,Matei DE,Huang TH,Nephew KP

更新日期：2009-09-01 00:00:00

abstract：:Exposure to estrogen during the developmental period causes reproductive dysfunction in mammals, because the developing brain is highly sensitive to estrogens. In the present study, we report that long-term exposure to supraphysiological doses of estrogen during the neonatal critical period causes irreversible suppres...

journal_title：Endocrinology

authors： Minabe S,Ieda N,Watanabe Y,Inoue N,Uenoyama Y,Maeda KI,Tsukamura H

更新日期：2017-09-01 00:00:00

abstract：:Recent evidence has linked mitochondrial dysfunction and DNA damage, increased oxidative stress in skeletal muscle, and insulin resistance (IR). The purpose of this study was to determine the role of the DNA repair enzyme, human 8-oxoguanine DNA glycosylase/apurinic/apyrimidinic lyase (hOGG1), on palmitate-induced mit...

journal_title：Endocrinology

authors： Yuzefovych LV,Schuler AM,Chen J,Alvarez DF,Eide L,Ledoux SP,Wilson GL,Rachek LI

更新日期：2013-08-01 00:00:00

abstract：:α7-Nicotinic acetylcholine receptor (α7nAChR) agonists confer protection against a wide variety of cytotoxic insults and suppress oxidative stress and apoptosis in various cell systems, including hepatocytes. We recently demonstrated that nicotine, when combined with a high-fat diet (HFD), triggers oxidative stress, a...

journal_title：Endocrinology

authors： Hasan MK,Friedman TC,Sims C,Lee DL,Espinoza-Derout J,Ume A,Chalfant V,Lee ML,Sinha-Hikim I,Lutfy K,Liu Y,Mahata SK,Sinha-Hikim AP

更新日期：2018-02-01 00:00:00

abstract：:Neurotensin (NT) and Neuromedin N (NN) are two biologically active peptides present in one copy each in the C-terminal region of a 169-residue precursor. Four basic Lys-Arg doublets occur within the precursor and represent putative processing sites. We investigated the effects of dexamethasone on the biosynthesis and ...

journal_title：Endocrinology

authors： de Nadai F,Rovere C,Bidard JN,Laur J,Martinez J,Cuber JC,Kitabgi P

更新日期：1993-04-01 00:00:00

abstract：:Tumor progression largely depends on blood supply and neovessel formation, and angiogenesis is emerging as a promising target for cancer therapy. Vascular endothelial growth factor (VEGF), a major proangiogenic molecule, stimulates angiogenesis via promoting endothelial proliferation, survival and migration. VEGF has ...

journal_title：Endocrinology

authors： Ye C,Feng C,Wang S,Wang KZ,Huang N,Liu X,Lin Y,Li M

更新日期：2004-02-01 00:00:00

abstract：:Maternal nutrition can affect the susceptibility of the offspring to metabolic disease later in life, suggesting that this period is a window of opportunity for intervention to reduce the risk of metabolic disease. Resveratrol, a natural polyphenol, has a wide range of beneficial properties including anti-obesogenic, ...

journal_title：Endocrinology

authors： Ros P,Díaz F,Freire-Regatillo A,Argente-Arizón P,Barrios V,Argente J,Chowen JA

更新日期：2020-08-01 00:00:00

abstract：:The evolution of the IGF binding protein (IGFBP) gene family has been difficult to resolve. Both chromosomal and serial duplications have been suggested as mechanisms for the expansion of this gene family. We have identified and annotated IGFBP sequences from a wide selection of vertebrate species as well as Branchios...

journal_title：Endocrinology

authors： Daza DO,Sundström G,Bergqvist CA,Duan C,Larhammar D

更新日期：2011-06-01 00:00:00

abstract：:Kisspeptin is the product of the Kiss1 gene that regulates GnRH secretion. In sheep, Kiss1 mRNA-expressing cells are found in the preoptic area (POA) and arcuate nucleus (ARC), and expression is up-regulated in the caudal ARC during the periovulatory period. We hypothesized that kisspeptin neurons in the ARC are activ...

journal_title：Endocrinology

authors： Smith JT,Li Q,Pereira A,Clarke IJ

更新日期：2009-12-01 00:00:00

abstract：:Cholesterol pellets inserted directly into mammary glands of 4- and 10-week-old mice resulted in lactogens, such as human growth hormone and prolactin, and epidermal growth factor. The effects of cholesterol the binding of lactogens and epidermal growth factor to the livers of these same animals was unaffected. Pellet...

journal_title：Endocrinology

authors： Vonderhaar BK

更新日期：1993-07-01 00:00:00

abstract：:To elucidate the temporal profile of adaptive changes of the islets of Langerhans to the increased insulin demands of pregnancy, we have studied islet cell proliferation and insulin secretion during gestation in the rat. 5-Bromo-2'-deoxyuridine incorporation into dividing islet cells was significantly (P less than 0.0...

journal_title：Endocrinology

authors： Parsons JA,Brelje TC,Sorenson RL

更新日期：1992-03-01 00:00:00

abstract：:To evaluate the possible existence of masked gonadotropin receptors in the corpus luteum, we characterized the effects of alcohols and neuraminidase on [125I]iodohuman LH binding to in vitro preparations of luteal tissue from the rhesus monkey and pseudopregnant rat. The presence of 1-8% (vol/vol) ethanol enhanced spe...

journal_title：Endocrinology

authors： Danforth DR,Stouffer RL

更新日期：1985-08-01 00:00:00

abstract：:Prolonged stimulation of cells by beta-adrenergic receptor agonists may lead to diminished responsiveness of the cells to subsequent activation by catecholamines. This phenomenon has been termed desensitization; the mechanism(s) for desensitization may involve an apparent loss in the number of beta-adrenergic receptor...

journal_title：Endocrinology

authors： Tsujimoto G,Manger WM,Hoffman BB

更新日期：1984-04-01 00:00:00

abstract：:The present studies were conducted to further evaluate inositol phosphate formation and metabolism in prostaglandin F2 alpha (PGF2 alpha)-stimulated bovine luteal cells. Corpora lutea were dispersed with collagenase, and luteal cells were prelabeled for 3 h with [3H]inositol. Inositol phosphates produced in response t...

journal_title：Endocrinology

authors： Duncan RA,Davis JS

更新日期：1991-03-01 00:00:00

abstract：:To study the interaction of TSH receptor (TSHR) autoantibodies with receptor protein; it is necessary first to express the receptor in the proper conformation including the formation of correct disulfide bridges. However, the reducing environment of the Escherichia coli (E. coli) cytoplasm prevents the generation of p...

journal_title：Endocrinology

authors： Bobovnikova Y,Graves PN,Vlase H,Davies TF

更新日期：1997-02-01 00:00:00

abstract：:Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones whose physiological roles are particularly important during development. The activity of the GH/IGF-1 axis is controlled by complex neuroendocrine systems including two hypothalamic neuropeptides, GH-releasing hormone (GHRH) and ...

journal_title：Endocrinology

authors： Lecomte MJ,Bertolus C,Ramanantsoa N,Saurini F,Callebert J,Sénamaud-Beaufort C,Ringot M,Bourgeois T,Matrot B,Collet C,Nardelli J,Mallet J,Vodjdani G,Gallego J,Launay JM,Berrard S

更新日期：2018-04-01 00:00:00

abstract：:The present study investigated whether activation of the hexosamine biosynthesis pathway might mediate at least in part the high glucose effect on angiotensinogen (ANG) gene expression and immortalized renal proximal tubular cell (IRPTC) hypertrophy. IRPTC were cultured in monolayer. ANG, renin, and beta-actin mRNA ex...

journal_title：Endocrinology

authors： Hsieh TJ,Fustier P,Zhang SL,Filep JG,Tang SS,Ingelfinger JR,Fantus IG,Hamet P,Chan JS

更新日期：2003-10-01 00:00:00

abstract：:Circadian clocks have been described in each tissue of the hypothalamo-pituitary-ovarian axis. Although a role for the clock in the timing of ovulation is indicated, the impact of diseases that disrupt fertility on clock function or the clocks' role in the etiology of these pathologies has yet to be fully appreciated....

journal_title：Endocrinology

authors： Sellix MT,Murphy ZC,Menaker M

更新日期：2013-04-01 00:00:00

abstract：:The mineralocorticoid receptor (MR) is a member of the steroid-thyroid hormone receptor superfamily of ligand-dependent transcription factors with diverse functions including the biological actions of aldosterone. Identification of the various transcriptional coregulators of MR is essential for understanding the compl...

journal_title：Endocrinology

authors： Kuppusamy M,Gomez-Sanchez EP,Beloate LN,Plonczynski M,Naray-Fejes-Toth A,Fejes-Toth G,Gomez-Sanchez CE

更新日期：2017-07-01 00:00:00

abstract：:We have reported that calcitonin (CT) treatment induced downregulation of the CT receptor (CTR) in mouse osteoclast-like cells (OCLs). Here, we studied the features of homologous down-regulation of the CTR in mature mouse OCLs. Treatment with salmon CT (sCT) and human CT (hCT) reduced [125I]sCT specific binding. The d...

journal_title：Endocrinology

authors： Wada S,Udagawa N,Nagata N,Martin TJ,Findlay DM

更新日期：1996-01-01 00:00:00

abstract：:In this study, we investigated the hypothalamic regulatory role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the control of LH and PRL secretion. Overiectomized ewes were surgically prepared with bilateral guide tubes directed at the preoptic area (POA) or medial basal hypothalamus (MBH). After rec...

journal_title：Endocrinology

authors： Anderson ST,Sawangjaroen K,Curlewis JD

更新日期：1996-08-01 00:00:00

abstract：:Thyroid hormones regulate bone homeostasis, and exogenously induced hyperthyroidism and hypothyroidism in mice was recently found to be associated with an altered expression of the Wnt inhibitor Dickkopf-1 (Dkk1), a determinant of bone mass. Here, we assessed the role of Dkk1 in thyroid hormone-induced changes in bone...

journal_title：Endocrinology

authors： Tsourdi E,Colditz J,Lademann F,Rijntjes E,Köhrle J,Niehrs C,Hofbauer LC,Rauner M

更新日期：2019-03-01 00:00:00

abstract：:GH deficiency is known to be clinically associated with a high incidence of nonalcoholic fatty liver disease, and this can be reversed by GH administration. Here we investigated the mechanistic basis for this phenomenon using engineered male mice lacking different signaling elements of the GH receptor, hepatic stat5a/...

journal_title：Endocrinology

authors： Barclay JL,Nelson CN,Ishikawa M,Murray LA,Kerr LM,McPhee TR,Powell EE,Waters MJ

更新日期：2011-01-01 00:00:00

abstract：:The N-terminal fragment of PRL (16K PRL) is an antiangiogenic factor that, in vitro, inhibits several components of angiogenesis including basic fibroblast growth factor (bFGF)-induced cell division, migration, and organization of capillary endothelial cells. An essential step in the regulation of angiogenesis is the ...

journal_title：Endocrinology

authors： Lee H,Struman I,Clapp C,Martial J,Weiner RI

更新日期：1998-09-01 00:00:00

abstract：:Prokineticin-1 (PK1) is a recently described protein with a wide range of functions, including tissue-specific angiogenesis, modulation of inflammatory responses, and regulation of hemopoiesis. The aim of this study was to investigate the localization and expression of PK1 and PK receptor-1 (PKR1), their signaling pat...

journal_title：Endocrinology

authors： Denison FC,Battersby S,King AE,Szuber M,Jabbour HN

更新日期：2008-07-01 00:00:00

abstract：:The present studies were designed to evaluate the binding characteristics of arginine vasopressin (AVP), using rat anterior pituitary dispersed cells, in correlation with the biological activity of the peptide. Synthetic AVP released ACTH from dispersed anterior pituitary cells in a concentration-dependent fashion, wi...

journal_title：Endocrinology

authors： Spinedi E,Negro-Vilar A

更新日期：1984-06-01 00:00:00

abstract：:High-density lipoprotein mediates a normal physiological process called reverse cholesterol transport. This process enables the transfer of cholesterol from peripheral tissues to the liver for further metabolism and eventual secretion in the form of bile. The scavenger receptor of the B class (SR-BI), human homolog of...

journal_title：Endocrinology

authors： Cao WM,Murao K,Imachi H,Yu X,Dobashi H,Yoshida K,Muraoka T,Kotsuna N,Nagao S,Wong NC,Ishida T

更新日期：2004-12-01 00:00:00