Minireview: epigenetic changes in ovarian cancer.

abstract：:The synthesis of androgens by theca-interstitial cells is stimulated by LH and the insulin/insulin-like growth factor I (IGF-I) system. An essential element of the steroidogenesis is the uptake of plasma cholesterol and transformation to steroid hormones. In the rat, the uptake of cholesterol by the theca-interstitial...

journal_title：Endocrinology

authors： Li X,Peegel H,Menon KM

更新日期：2001-01-01 00:00:00

abstract：:Our previous work suggests that persistent protein malnutrition in immature domestic fowl (Gallus gallus domesticus) alters ACTH-adrenocortical cell interaction, possibly including ACTH receptors. To investigate this possibility, we measured some ACTH receptor parameters in isolated adrenocortical cells from normal an...

journal_title：Endocrinology

authors： Carsia RV,Weber H

更新日期：1988-02-01 00:00:00

abstract：:This study tested the hypothesis that in the female sheep, a short day (SD) breeder, puberty can occur normally in the absence of ambient short days. More specifically, the photoperiod cue timing the transition into adulthood is exposure to and then termination of a long day melatonin rhythm. Control lambs born in the...

journal_title：Endocrinology

authors： Foster DL,Ebling FJ,Claypool LE,Woodfill CJ

更新日期：1988-09-01 00:00:00

abstract：:Estrogen formation is catalyzed by the aromatase cytochrome P450 (P450AROM) enzyme. Aromatase activity has been detected in several regions in the rat brain. In the present study, we used peptide-generated polyclonal antibodies raised against a 20-amino acid synthetic fragment of the rat P450AROM protein (as deduced f...

journal_title：Endocrinology

authors： Sanghera MK,Simpson ER,McPhaul MJ,Kozlowski G,Conley AJ,Lephart ED

更新日期：1991-12-01 00:00:00

abstract：:It has been shown that acute administration of interleukin-1 (IL-1) to rats elicits a transitory increase in plasma ACTH and corticosterone (B) levels. To investigate the effects of chronic administration of IL-1 on plasma ACTH and B levels, in the present study rats were equipped with Alzet osmotic minipumps loaded w...

journal_title：Endocrinology

authors： Sweep CG,van der Meer MJ,Hermus AR,Smals AG,van der Meer JW,Pesman GJ,Willemsen SJ,Benraad TJ,Kloppenborg PW

更新日期：1992-03-01 00:00:00

abstract：:A new perfusion system of isolated rat femora was established, and the effect of PTH or calcitonin (CT) on cAMP release from the adult bone was examined. Stimulation of cAMP release from the isolated perfused bone peaked rapidly between 5 and 10 min after human PTH (hPTH)-(1-34) or eel CT injection, respectively, and ...

journal_title：Endocrinology

authors： Sugimoto T,Fukase M,Tsutsumi M,Imai Y,Hishikawa R,Yoshimoto Y,Fujita T

更新日期：1985-11-01 00:00:00

abstract：:Rats start decreasing their food intake as early as 70 min after the first ingestion of a food deficient in threonine. A decrease of the limiting essential amino acid (EAA) in the plasma was proposed to be the first anorectic signal. Because many hormones regulate feeding behavior, we studied the effect of a meal (46 ...

journal_title：Endocrinology

authors： Feurté S,Nicolaïdis S,Gerozissis K

更新日期：2000-10-01 00:00:00

abstract：:Gonadal differentiation is dependent upon a cascade of molecular and morphological events. Steroidogenic factor 1 (SF-1) and DAX-1 have been implicated in this process. A SF-1 binding site has been reported to be present on the DAX-1 gene. We therefore used immunocytochemistry to determine whether these two transcript...

journal_title：Endocrinology

authors： Majdic G,Saunders PT

更新日期：1996-08-01 00:00:00

abstract：:Primary cultures of enzymatically dispersed rat anterior pituitary cells were used to examine the effect of pure 31 kilodalton bovine inhibin on GnRH-induced up-regulation of GnRH binding sites. After 2 days in culture, the cells were exposed to stimuli with or without test substances for 10 h, followed by evaluation ...

journal_title：Endocrinology

authors： Wang QF,Farnworth PG,Findlay JK,Burger HG

更新日期：1989-01-01 00:00:00

abstract：:The neuropeptide kisspeptin (Kiss1) is integral to the advent of puberty and the generation of cyclical LH surges. Although many complex actions of Kiss1 are known, the mechanisms governing the processing/regulation of this peptide have not been unveiled. The metallo enzyme, endopeptidase 24.15 (thimet oligopeptidase)...

journal_title：Endocrinology

authors： Woitowich NC,Philibert KD,Leitermann RJ,Wungjiranirun M,Urban JH,Glucksman MJ

更新日期：2016-02-01 00:00:00

abstract：:Diastolic dysfunction is a prognosticator for future cardiovascular events that demonstrates a strong correlation with obesity. Pharmacological inhibition of dipeptidylpeptidase-4 (DPP-4) to increase the bioavailability of glucagon-like peptide-1 is an emerging therapy for control of glycemia in type 2 diabetes patien...

journal_title：Endocrinology

authors： Aroor AR,Sowers JR,Bender SB,Nistala R,Garro M,Mugerfeld I,Hayden MR,Johnson MS,Salam M,Whaley-Connell A,Demarco VG

更新日期：2013-07-01 00:00:00

abstract：:Oxytocin (OT) is released by the posterior pituitary during male orgasm and is supposed to participate in the ejaculatory process. We now report evidence demonstrating the presence of an OT receptor gene (real-time RT-PCR and Northern blot) and protein (immunohistochemistry, Western blot, and binding studies) expressi...

journal_title：Endocrinology

authors： Vignozzi L,Filippi S,Luconi M,Morelli A,Mancina R,Marini M,Vannelli GB,Granchi S,Orlando C,Gelmini S,Ledda F,Forti G,Maggi M

更新日期：2004-04-01 00:00:00

abstract：:PTH stimulates bone formation and increases hematopoietic stem cells through mechanisms as yet uncertain. The purpose of this study was to identify mechanisms by which PTH links actions on cells of hematopoietic origin with osteoblast-mediated bone formation. C57B6 mice (10 d) were nonlethally irradiated and then admi...

journal_title：Endocrinology

authors： Koh AJ,Novince CM,Li X,Wang T,Taichman RS,McCauley LK

更新日期：2011-12-01 00:00:00

abstract：:The study of the biochemical mechanisms regulating the differentiation of the ovarian androgen-producing cells has been difficult because of the lack of a method for isolating the theca-interstitial cells (TIC) from the granulosa and other cell types. We report here a simple, rapid and reproducible method for obtainin...

journal_title：Endocrinology

authors： Magoffin DA,Erickson GF

更新日期：1988-05-01 00:00:00

abstract：:Dexamethasone-induced changes in insulin and epidermal growth factor (EGF) receptor number, autophosphorylation, and kinase activity were studied in intact rat hepatocytes. Hepatocytes were freshly isolated from Sprague-Dawley rats treated with dexamethasone (1 mg/kg) for 4 days and from untreated littermates. Dexamet...

journal_title：Endocrinology

authors： Karasik A,Kahn CR

更新日期：1988-11-01 00:00:00

abstract：:Nuclear proteins extracted from purified nuclei with 0.4M KCl at pH 7.4 OR 8.5 are able to bind L-triiodothyronine (T3) giving rise to nuclear thyroid hormone binding protein-T3 (NTBP-T3) complexes. Binding is maximum in 3 h at 20 C. It is thermolabile even at 36 C, inhibited by p-hydroxymercuribenzoate and markedly e...

journal_title：Endocrinology

authors： Torresani J,DeGroot LJ

更新日期：1975-05-01 00:00:00

abstract：:Transglutaminase (TGase) activity, determined by incorporation of [1,4-14C]putrescine into casein, was demonstrated in a light membrane fraction derived from bovine calf testicular homogenates. In common with other TGases thus far identified, testicular TGase is calcium dependent. A concentration-dependent relationshi...

journal_title：Endocrinology

authors： Grasso P,Dattatreyamurty B,Dias JA,Reichert LE Jr

更新日期：1987-08-01 00:00:00

abstract：:Insulin stimulation of glucose transport involves the translocation of vesicles containing the glucose transporter Glut 4 to the plasma membrane. Since low mol wt GTP-binding proteins (LMW-GTP-binding proteins) have been implicated in the regulation of vesicular trafficking, we have analyzed these proteins in adipocyt...

journal_title：Endocrinology

authors： Cormont M,Tanti JF,Grémeaux T,Van Obberghen E,Le Marchand-Brustel Y

更新日期：1991-12-01 00:00:00

abstract：:An estrogen-binding macromolecule was identified in cytosolic fractions prepared from fetal rat lung tissue. This component sedimented at 4.5S on sucrose gradients and was heat labile and proteinaceous in nature. This estrogen-binding protein bound 17 beta-estradiol (Ka = 10(8) M-1) and estrone but had little or no af...

journal_title：Endocrinology

authors： Mendelson CR,Brown PK,MacDonald PC,Johnston JM

更新日期：1981-07-01 00:00:00

abstract：:This paper describes experiments on cultured granulosa cells isolated from ovaries of immature rats designed to locate the site of action of androgens on FSH-induced aromatase activity. Treatment of cells during a 36-h induction period with (Bu)2cAMP, 8- BrcAMP , FSH, prostaglandin E2, or cholera toxin resulted in ind...

journal_title：Endocrinology

authors： Daniel SA,Armstrong DT

更新日期：1984-06-01 00:00:00

abstract：:To study conversion of 3,5,3'-triiodothyroinine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (T2) in vitro, T3 or rT3 was incubated at pH 7.35 with homogenates of several rat tissues (liver, kidney, muscle, heart, ling, spleen, intestines, and brain) for 15 min at 37 C. The T2 generated during incub...

journal_title：Endocrinology

authors： Chopra IJ,Wu SY,Nakamura Y,Solomon DH

更新日期：1978-04-01 00:00:00

abstract：:The administration of testosterone via Silastic capsules has been shown previously to maintain advanced spermatid number quantitatively in intact rats in which LH but not FSH was suppressed, but not in hypophysectomized rats, indicating that pituitary factors in addition to LH are required for the quantitative mainten...

journal_title：Endocrinology

authors： Awoniyi CA,Zirkin BR,Chandrashekar V,Schlaff WD

更新日期：1992-06-01 00:00:00

abstract：:Ghrelin was recently identified as an endogenous ligand of the GH secretagogue receptor. The novel peptide hormone is produced by gastric A-like cells, and circulating levels rise before feeding, suggestive of ghrelin as an endogenous hunger factor. ghrelin stimulates food intake and promotes adiposity after periphera...

journal_title：Endocrinology

authors： Tang-Christensen M,Vrang N,Ortmann S,Bidlingmaier M,Horvath TL,Tschöp M

更新日期：2004-10-01 00:00:00

abstract：:Both the estrogen responsiveness and -binding capacity of cultured rat uterine cells were decreased dramatically when the medium was not changed at 24-h intervals. Treatment of cells for 24 h with 1 nM 17 beta-estradiol in fresh medium led to a 3-fold increase in progesterone receptor concentration, but without fresh ...

journal_title：Endocrinology

authors： Kassis JA,Walent JH,Gorski J

更新日期：1984-08-01 00:00:00

abstract：:This work examines the cellular pathophysiology associated with the weakened bone matrix found in a murine model of osteogenesis imperfecta murine (oim). Histomorphometric analysis of oim/oim bone showed significantly diminished bone mass, and the osteoblast and osteoclast histomorphometric parameters were increased i...

journal_title：Endocrinology

authors： Kalajzic I,Terzic J,Rumboldt Z,Mack K,Naprta A,Ledgard F,Gronowicz G,Clark SH,Rowe DW

更新日期：2002-05-01 00:00:00

abstract：:In adult male rhesus monkeys, 1 day of fasting leads to a profound suppression of LH secretion that is rapidly reversed with refeeding. To test the hypothesis that changes in insulin secretion during fasting and refeeding mediate the changes in LH secretion, blood samples for LH measurement were obtained between 0900-...

journal_title：Endocrinology

authors： Williams NI,Lancas MJ,Cameron JL

更新日期：1996-06-01 00:00:00

abstract：:The maternal skeleton resorbs during lactation to provide calcium to milk and the lost mineral content is restored after weaning. The changes are particularly marked in Ctcgrp null mice, which lose 50% of spine mineral content during lactation but restore it fully. The known calciotropic hormones are not required for ...

journal_title：Endocrinology

authors： Collins JN,Kirby BJ,Woodrow JP,Gagel RF,Rosen CJ,Sims NA,Kovacs CS

更新日期：2013-04-01 00:00:00

abstract：:Testicular cytosol from Sprague-Dawley rats was shown to possess an estradiol binding component which exhibited the properties of a receptor. Specific binding of estradiol by the receptor was shown, at 4C in vitro, to reach equilibrium by 6 h. That level of binding was maintained at a plateau for 18 h. Estradiol bindi...

journal_title：Endocrinology

authors： Abney TO

更新日期：1976-08-01 00:00:00

abstract：:T47D human breast cancer cells and BEN human lung cancer cells were preincubated with the tumor-promoting phorbol ester phorbol 12-myristate 13-acetate (PMA). In both cell lines there was a decrease in the binding of 125I-labeled salmon calcitonin ([125I]sCT) which was dependent on the dose and time of exposure to PMA...

journal_title：Endocrinology

authors： Findlay DM,Michelangeli VP,Robinson PJ

更新日期：1989-11-01 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1), in the form of either GLP-1-(7-36)amide or GLP-1-(7-37), has been shown to potently stimulate insulin release in a glucose-dependent manner and is suggested to be a physiological incretin. To explore the mechanisms by which GLP-1-(7-36)amide stimulates insulin release, we investigated ...

journal_title：Endocrinology

authors： Yada T,Itoh K,Nakata M

更新日期：1993-10-01 00:00:00