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Effect of insulin-like growth factor I in murine muscular dystrophy.

Abstract：

:In muscular dystrophy there is an imbalance between muscle protein synthesis and protein degradation, resulting in net muscle catabolism and progressive muscle weakness and wasting. Both insulin and insulin-like growth factor I (IGF-I) are known to have an anabolic effect on skeletal muscle, which is believed to be enhanced in the presence of elevated concentrations of amino acids. We examined the effects of 4-week administration of recombinant human IGF-I (rhIGF-I), both alone and supplemented with a high protein diet (HPD), on muscle metabolism, morphology, and function in the 129 ReJ dystrophic mouse. rhIGF-I significantly reduced muscle protein degradation (P < 0.001), increased muscle protein content (P < 0.05), decreased fiber area variability (P < 0.01), and increased hind limb utilization (P < 0.01). Supplementation of rhIGF-I therapy with a HPD resulted in a significant increase in muscle protein synthesis (P < 0.05) in addition to a further increase in the above parameters. We conclude that rhIGF-I causes an improvement in muscle metabolism, morphology, and function in dystrophic mice, and this effect is further enhanced by the presence of a HPD.

journal_name

Endocrinology

journal_title

Endocrinology

authors

Zdanowicz MM,Moyse J,Wingertzahn MA,O'Connor M,Teichberg S,Slonim AE

doi

10.1210/endo.136.11.7588220

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

4880-6

issue

11

eissn

0013-7227

issn

1945-7170

journal_volume

136

pub_type

杂志文章

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