Role played by brainstem neurons in regulating testosterone secretion via a direct neural pathway between the hypothalamus and the testes.

abstract：:This study examined the requirement for 17 beta-estradiol (E) and relaxin (R) during the preparturient period (approximately the last 30 h of gestation) for normal parturition and pup survival in the rat. On the evening of day 21 of pregnancy, primiparous Sprague-Dawley rats were bilaterally ovariectomized or sham ope...

journal_title：Endocrinology

authors： Cheah SH,Sherwood OD

更新日期：1988-05-01 00:00:00

abstract：:Diastolic dysfunction is a prognosticator for future cardiovascular events that demonstrates a strong correlation with obesity. Pharmacological inhibition of dipeptidylpeptidase-4 (DPP-4) to increase the bioavailability of glucagon-like peptide-1 is an emerging therapy for control of glycemia in type 2 diabetes patien...

journal_title：Endocrinology

authors： Aroor AR,Sowers JR,Bender SB,Nistala R,Garro M,Mugerfeld I,Hayden MR,Johnson MS,Salam M,Whaley-Connell A,Demarco VG

更新日期：2013-07-01 00:00:00

abstract：:Six pony mares were ovariectomized (OVX) on day 16 of diestrus during June and July, 1972, to study short term changes in plasma luteinizing hormone (LH) concentrations. Plasma LH was higher (P less than .05) 3 days after OVX (1.76 ng/ml) than the day after OVX (1.01 ng/ml), and a gradual increase occurred over the fi...

journal_title：Endocrinology

authors： Garcia MC,Ginther OJ

更新日期：1976-04-01 00:00:00

abstract：:Studies were performed to determine whether the postovulatory secretion of FSH in the rabbit is an LHRH-mediated event. Does were mated and then injected at 12 and 18 h postcoitum with pentobarbital (30 mg/kg BW), an agent known to block endogenous LHRH release. The injection of this barbiturate had no measurable effe...

journal_title：Endocrinology

authors： Mills TM,Copland JA,Coy DH,Schally AV

更新日期：1983-09-01 00:00:00

abstract：:We have reported that calcitonin (CT) treatment induced downregulation of the CT receptor (CTR) in mouse osteoclast-like cells (OCLs). Here, we studied the features of homologous down-regulation of the CTR in mature mouse OCLs. Treatment with salmon CT (sCT) and human CT (hCT) reduced [125I]sCT specific binding. The d...

journal_title：Endocrinology

authors： Wada S,Udagawa N,Nagata N,Martin TJ,Findlay DM

更新日期：1996-01-01 00:00:00

abstract：:The amount and sources of T3 associated with high affinity, low capacity cellular nuclear receptors in brown adipose tissue (BAT) have been estimated by in vivo pulse-labeling techniques. Maximal binding capacity was measured by in vivo saturation analysis. Nuclear receptor occupancy at endogenous levels of T3 and T4 ...

journal_title：Endocrinology

authors： Bianco AC,Silva JE

更新日期：1987-01-01 00:00:00

abstract：:Previously, we reported that testicular macrophages constitutively release tumor necrosis factor (TNF) in vitro and are unresponsive to bacterial endotoxins [lipopolysaccharides (LPS)]. These properties are not typical of other tissue macrophages. The goals of the present study were, therefore, to establish 1) if test...

journal_title：Endocrinology

authors： Moore C,Hutson JC

更新日期：1994-01-01 00:00:00

abstract：:Alterations in the maternal endocrine, nutritional, and metabolic environment disrupt the developmental trajectory of the fetus, leading to adult diseases. Female offspring of rats, subhuman primates, and sheep treated prenatally with testosterone (T) develop reproductive/metabolic defects during adult life similar to...

journal_title：Endocrinology

authors： Manikkam M,Crespi EJ,Doop DD,Herkimer C,Lee JS,Yu S,Brown MB,Foster DL,Padmanabhan V

更新日期：2004-02-01 00:00:00

abstract：:Human myometrium contains hCG/LH receptors. There are fewer of these receptors during labor compared to no labor at preterm or term deliveries. Exogenous hCG can directly inhibit oxytocin-stimulated human myometrial contractions. These findings suggest that hCG may directly maintain myometrial quiescence during pregna...

journal_title：Endocrinology

authors： Ambrus G,Rao CV

更新日期：1994-12-01 00:00:00

abstract：:Nowadays, we are bombarded with information on a large number of endocrine-disrupting chemicals. We hear and read about endocrine-disrupting chemicals on blogs, the web, news stories, television specials, advertisements, and of course scientific articles. Reports claim these ubiquitous compounds are responsible for in...

journal_title：Endocrinology

authors： Rissman EF

更新日期：2016-08-01 00:00:00

abstract：:Progesterone (P4) inhibits apoptosis of rat granulosa cells and spontaneously immortalized granulosa cells (SIGCs), which were derived from rat granulosa cells. Defining the mechanism through which P4 mediates its action has been difficult because these cells do not express the classic nuclear P4 receptor. Previous st...

journal_title：Endocrinology

authors： Peluso JJ,Pappalardo A,Fernandez G,Wu CA

更新日期：2004-06-01 00:00:00

abstract：:GH is an important regulator of body growth and composition as well as numerous other metabolic processes. In particular, liver plays a key role in the GH/IGF-I axis, because the majority of circulating "endocrine" IGF-I results from GH-stimulated liver IGF-I production. To develop a better understanding of the role o...

journal_title：Endocrinology

authors： List EO,Berryman DE,Funk K,Jara A,Kelder B,Wang F,Stout MB,Zhi X,Sun L,White TA,LeBrasseur NK,Pirtskhalava T,Tchkonia T,Jensen EA,Zhang W,Masternak MM,Kirkland JL,Miller RA,Bartke A,Kopchick JJ

更新日期：2014-05-01 00:00:00

abstract：:Administration of the preferential mu-opioid receptor agonist, morphine, and selective K-opioid receptor agonists elicits activation of the hypothalamus-pituitary-adrenocortical axis, although the site or the molecular mechanisms for these effects have not been determined. The expression ofFos, the protein product of ...

journal_title：Endocrinology

authors： Laorden ML,Castells MT,Martínez MD,Martínez PJ,Milanés MV

更新日期：2000-04-01 00:00:00

abstract：:An increased activity of the hypothalamo-pituitary-adrenal axis resulting in exaggerated glucocorticoid secretion has been repeatedly described in patients with diabetes mellitus and in animal models of this disease. However, it has been pointed out that experimental diabetes is accompanied by a decreased glucocortico...

journal_title：Endocrinology

authors： Repetto EM,Sanchez R,Cipelli J,Astort F,Calejman CM,Piroli GG,Arias P,Cymeryng CB

更新日期：2010-01-01 00:00:00

abstract：:Implantation of an embryo induces rapid proliferation and differentiation of uterine stromal cells, forming a new structure, the decidua. One salient feature of decidua formation is a marked increase in maternal angiogenesis. Vascular endothelial growth factor (VEGF)-dependent pathways are active in the ovary, uterus,...

journal_title：Endocrinology

authors： Douglas NC,Tang H,Gomez R,Pytowski B,Hicklin DJ,Sauer CM,Kitajewski J,Sauer MV,Zimmermann RC

更新日期：2009-08-01 00:00:00

abstract：:Estradiol is known to inhibit antigen presentation in the vagina. We report here that TGFbeta mediates the action of estradiol on vaginal antigen presenting cells (APC). When vaginal APC from ovariectomized rats were incubated with increasing concentrations of TGFbeta1 and TGFbeta2 in the presence of ovalbumin-specifi...

journal_title：Endocrinology

authors： Wira CR,Roche MA,Rossoll RM

更新日期：2002-08-01 00:00:00

abstract：:Angiotensin II is one of the main physiological regulators of aldosterone biosynthesis in the zona glomerulosa of the adrenal cortex. The hormone stimulates intracellular cholesterol mobilization to the mitochondrion for steroid biosynthesis. Here we have examined whether angiotensin II also modulates exogenous lipopr...

journal_title：Endocrinology

authors： Cherradi N,Bideau M,Arnaudeau S,Demaurex N,James RW,Azhar S,Capponi AM

更新日期：2001-10-01 00:00:00

abstract：:The incidence of obesity, with its impact on the development of comorbidities, including diabetes and cardiovascular disease, represents one of the greatest global health threats of the 21st century. This is particularly damning considering the vast progress that has been made in understanding the factors and molecula...

journal_title：Endocrinology

authors： Perez-Tilve D

更新日期：2017-05-01 00:00:00

abstract：:We previously described significant differences in maximal testosterone production by Leydig cells from the following strains of inbred mice: C57BL/10J, C57BL/6J, DBA/2J, and C3H/HeJ. To evaluate whether these differences in maximal testosterone production related to the activities of the steroidogenic enzymes of the ...

journal_title：Endocrinology

authors： Stalvey JR,Payne AH

更新日期：1984-10-01 00:00:00

abstract：:To determine whether 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] regulates PTH secretion, we have tested its effects in both short term incubations (30-120 min) and long term primary cell cultures (24-96 h) of bovine parathyroid cells. In short term incubations, 10(-11)-10(-7) M 1,25-(OH)2D3 had no consistent effect on PT...

journal_title：Endocrinology

authors： Cantley LK,Russell J,Lettieri D,Sherwood LM

更新日期：1985-11-01 00:00:00

abstract：:Pancreastatin, a novel 49-amino acid peptide isolated from porcine pancreas, shows over 70% sequence homology to the central part of bovine and human chromogranin-A. Using an N-terminal and C-terminal synthetic peptide, we developed two sensitive and specific RIAs for the detection of pancreastatin-like immunoreactivi...

journal_title：Endocrinology

authors： Schmidt WE,Siegel EG,Lamberts R,Gallwitz B,Creutzfeldt W

更新日期：1988-09-01 00:00:00

abstract：:The insulin receptor substrates (IRSs) are key proteins in signal transduction from the insulin receptor. Recently, we discovered a fourth member of this family, designated IRS-4, cloned its complementary DNA from the human embryonic kidney 293 cell line, and characterized its signaling properties in this cell line. A...

journal_title：Endocrinology

authors： Fantin VR,Lavan BE,Wang Q,Jenkins NA,Gilbert DJ,Copeland NG,Keller SR,Lienhard GE

更新日期：1999-03-01 00:00:00

abstract：:Hypoglycemia associated with diabetes management is a potential risk for cardiovascular diseases. However, the effect of hypoglycemic episodes including a surge of sympathetic activity on the progression of neointima formation after vascular injury remains largely unknown. In this study, insulin was injected intraperi...

journal_title：Endocrinology

authors： Yasunari E,Mita T,Osonoi Y,Azuma K,Goto H,Ohmura C,Kanazawa A,Kawamori R,Fujitani Y,Watada H

更新日期：2014-06-01 00:00:00

abstract：:Hypothalamic peninsulae, posteriorly continuous with the brain stem, were produced in ovariectomized rhesus monkeys by aspiration of the cerebral hemispheres and all brain structures anterior and dorsal to the optic chiasm. These preparations were sustained for 52 to 60 h postoperatively by maintaining blood gases and...

journal_title：Endocrinology

authors： Hess DL,Wilkins RH,Moossy J,Chang JL,Plant TM,McCormack JT,Nakai Y,Knobil E

更新日期：1977-10-01 00:00:00

abstract：:Immunohistochemical localization of androgen in the testes of both rat and squirrel monkey has been performed using an antiserum specific to testosterone and certain related androgens. The bound antibodies were visualized by coupling with antigammaglobulin labeled either with fluorescein isothiocyanate or with a horse...

journal_title：Endocrinology

authors： Bubenik GA,Brown GM,Grota LJ

更新日期：1975-01-01 00:00:00

abstract：:The xenoestrogen bisphenol A (BPA) has been shown to mimic estrogen both in vivo and in vitro. BPA stimulates PRL secretion and the expression of a PRL regulating factor from the posterior pituitary in the estrogen-sensitive Fischer 344 rat (F344), but not in Sprague-Dawley (SD) rats. The goal of the present studies w...

journal_title：Endocrinology

authors： Steinmetz R,Mitchner NA,Grant A,Allen DL,Bigsby RM,Ben-Jonathan N

更新日期：1998-06-01 00:00:00

abstract：:We have established immortalized human granulosa cells by triple transfection of primary cells obtained from in vitro fertilization patients with SV40 DNA, Ha-ras oncogene, and a temperature sensitive (ts) mutant of the tumor suppressor gene p53 (p53val135). Forty-one clones were isolated, and their steroidogenic resp...

journal_title：Endocrinology

authors： Hosokawa K,Dantes A,Schere-Levy C,Barash A,Yoshida Y,Kotsuji F,Vlodavsky I,Amsterdam A

更新日期：1998-11-01 00:00:00

abstract：:There is increasing evidence that protein kinase C (PKC) isoforms modulate insulin-signaling pathways in both positive and negative ways. Recent reports have indicated that the novel PKCdelta mediates some of insulin's actions in muscle and liver cells. Many studies use the specific inhibitor rottlerin to demonstrate ...

journal_title：Endocrinology

authors： Kayali AG,Austin DA,Webster NJ

更新日期：2002-10-01 00:00:00

abstract：:The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues and organs, including the pituitary. However, there is no information...

journal_title：Endocrinology

authors： Rodríguez-Pacheco F,Vázquez-Martínez R,Martínez-Fuentes AJ,Pulido MR,Gahete MD,Vaudry H,Gracia-Navarro F,Diéguez C,Castaño JP,Malagón MM

更新日期：2009-10-01 00:00:00

abstract：:Prior published reports have demonstrated that glucose-oxidized low-density lipoproteins (g-OxLDL) enhance the proliferative response of vascular smooth muscle cells (SMC) to IGF-I. Our previous studies have determined that the regulation of cleavage of integrin-associated protein (IAP) by matrix-metalloprotease-2 (MM...

journal_title：Endocrinology

authors： Allen LB,Capps BE,Miller EC,Clemmons DR,Maile LA

更新日期：2009-03-01 00:00:00