Localization of immunoreactive androgen in testicular tissue.

abstract：:The adrenergic control of cAMP and 3',5'-cyclic GMP (cGMP) in dispersed adult rat pinealocytes was investigated. Norepinephrine treatment increased cAMP and cGMP content 60- and 400-fold, respectively; both alpha- and beta-adrenoceptors had to be activated for these responses to occur. Beta-Adrenergic stimulation alon...

journal_title：Endocrinology

authors： Vanecek J,Sugden D,Weller J,Klein DC

更新日期：1985-06-01 00:00:00

abstract：:Neonatal exposure to high doses of estrogen results in permanent suppression of prostate growth and reduced sensitivity to androgens in adulthood. It is unclear whether alterations in prostate growth are due to a direct effect of estrogens on the gland or are the result of hypothalamic-pituitary-gonadal axis suppressi...

journal_title：Endocrinology

authors： Jarred RA,Cancilla B,Prins GS,Thayer KA,Cunha GR,Risbridger GP

更新日期：2000-09-01 00:00:00

abstract：:Type 2 deiodinase (D2), which is highly expressed in brown adipose tissue (BAT), is an enzyme that amplifies thyroid hormone signaling in individual cells. Mice with inactivation of the D2 pathway (D2KO) exhibit dramatically impaired thermogenesis in BAT, leading to hypothermia during cold exposure and a greater susce...

journal_title：Endocrinology

authors： Hall JA,Ribich S,Christoffolete MA,Simovic G,Correa-Medina M,Patti ME,Bianco AC

更新日期：2010-09-01 00:00:00

abstract：:Intraluteal infusion of the prostaglandin (PG) synthesis inhibitor, sodium meclofenamate (Mec) causes premature luteolysis in rhesus monkeys. To evaluate further the actions of PG synthesis inhibitors in primate luteal function, we examined the in vitro effects of Mec and another inhibitor, flurbiprofen (Flur), on PG,...

journal_title：Endocrinology

authors： Zelinski-Wooten MB,Sargent EL,Molskness TA,Stouffer RL

更新日期：1990-03-01 00:00:00

abstract：:Congenital hypothyroidism with thyroid dysgenesis (TD) is a frequent human condition characterized by elevated levels of TSH in response to reduced thyroid hormone levels. Congenital hypothyroidism is a genetically heterogeneous disease. In the majority of cases studied, no causative mutations have been identified and...

journal_title：Endocrinology

authors： Amendola E,De Luca P,Macchia PE,Terracciano D,Rosica A,Chiappetta G,Kimura S,Mansouri A,Affuso A,Arra C,Macchia V,Di Lauro R,De Felice M

更新日期：2005-12-01 00:00:00

abstract：:PTH stimulates bone formation and increases hematopoietic stem cells through mechanisms as yet uncertain. The purpose of this study was to identify mechanisms by which PTH links actions on cells of hematopoietic origin with osteoblast-mediated bone formation. C57B6 mice (10 d) were nonlethally irradiated and then admi...

journal_title：Endocrinology

authors： Koh AJ,Novince CM,Li X,Wang T,Taichman RS,McCauley LK

更新日期：2011-12-01 00:00:00

abstract：:Insulin is a potent regulator of Sp1 transcription factor. To examine if glucagon, which usually antagonizes insulin, regulates Sp1, we assessed the levels of Sp1 by Western blotting from H-411E cells exposed to glucagon with or without insulin. Glucagon alone (1.5 x 10(-9) to 1.5 x 10(-5) M) stimulated Sp1 accumulati...

journal_title：Endocrinology

authors： Keembiyehetty CN,Candelaria RP,Majumdar G,Raghow R,Martinez-Hernandez A,Solomon SS

更新日期：2002-04-01 00:00:00

abstract：:Thyroid hormone (T3) is required for postnatal skeletal growth. It exerts its effect by binding to nuclear receptors, TRs including TRα1 and TRβ1, which are present in most cell types. These cell types include chondrocytes and osteoblasts, the interactions of which are known to regulate endochondral bone formation. In...

journal_title：Endocrinology

authors： Desjardin C,Charles C,Benoist-Lasselin C,Riviere J,Gilles M,Chassande O,Morgenthaler C,Laloé D,Lecardonnel J,Flamant F,Legeai-Mallet L,Schibler L

更新日期：2014-08-01 00:00:00

abstract：:Vasoactive intestinal polypeptide (VIP) was measured by RIA in the hypophysial portal blood of rats after total hypophysectomy. The mean (+/- SE) VIP concentrations were 1332 +/- 171 pg/ml (range, 300-3868 pg/ml) under urethane anesthesia and 1735 +/- 707 pg/ml under pentobarbital anesthesia. The concentrations of VIP...

journal_title：Endocrinology

authors： Shimatsu A,Kato Y,Matsushita N,Katakami H,Yanaihara N,Imura H

更新日期：1981-02-01 00:00:00

abstract：:Early obesity and late onset of insulin resistance associated with hormonal imbalances occur in FSH receptor-deficient follitropin receptor knockout female mice. This study tests the hypothesis that chronic high-fat diet aggravates obesogenic changes in a depot-specific manner and explores some molecular links of horm...

journal_title：Endocrinology

authors： Zhang H,Chen X,Aravindakshan J,Sairam MR

更新日期：2007-12-01 00:00:00

abstract：:Germ cells were isolated from 30-day-old rat testes and purified by a Percoll gradient. Germ cells were cultured for 24 h to eliminate contaminant cells by utilizing the property of many nongerm cells of attaching to plastic surfaces. Germ cells were subsequently seeded on top of 7-day-old Sertoli cell monolayers. RNA...

journal_title：Endocrinology

authors： Rivarola MA,Sanchez P,Saez JM

更新日期：1985-11-01 00:00:00

abstract：:A1/A2 noradrenergic neurons in the medulla oblongata are well known to mediate stress signals in the central nervous system. Stress activates A1/A2 noradrenergic neurons, and then noradrenaline (NA) stimulates ACTH secretion through hypothalamic CRH. On the other hand, PRL-releasing peptide (PrRP) was recently isolate...

journal_title：Endocrinology

authors： Maruyama M,Matsumoto H,Fujiwara K,Noguchi J,Kitada C,Fujino M,Inoue K

更新日期：2001-05-01 00:00:00

abstract：:In cultured rat pituitary cells, increases in the cytosolic calcium concentration ([Ca2+]i) and LH release are induced by activation of GnRH receptors as well as by nonreceptor-mediated stimuli. Treatment of pituitary cells with the myosin light chain kinase (MLCK) inhibitor, wortmannin, attenuated GnRH-induced LH rel...

journal_title：Endocrinology

authors： Rao K,Paik WY,Zheng L,Jobin RM,Tomić M,Jiang H,Nakanishi S,Stojilkovic SS

更新日期：1997-04-01 00:00:00

abstract：:Sertoli cell intracellular protein 1 (SCc1) and 2 (SCc2) are polypeptides found in rat Sertoli cell cultures incubated with either FSH or (Bu)2cAMP. They were first identified in [35S]methionine-labeled Sertoli cell lysates using two-dimensional gel electrophoresis. Here we extend these observations by showing that SC...

journal_title：Endocrinology

authors： Gregory CW,DePhilip RM

更新日期：1992-11-01 00:00:00

abstract：:The pineal hormone melatonin regulates reproductive function in seasonally breeding mammals. Recent studies using 125I-labeled 2-iodomelatonin (I-MEL) reveal that the distribution of putative melatonin receptors is species-specific; only the hypophysial pars tuberalis (PT) is a consistent site of I-MEL binding in all ...

journal_title：Endocrinology

authors： Weaver DR,Reppert SM

更新日期：1990-11-01 00:00:00

abstract：:The low-density lipoprotein receptor (Ldlr) is a key molecule involved with lipid clearance. The Ldlr(-/-) mouse has been used extensively as a model for studying atherosclerosis. This study sought to characterize the energy balance phenotype of Ldlr(-/-) mice with respect to weight gain, body composition, energy expe...

journal_title：Endocrinology

authors： Ngai YF,Quong WL,Glier MB,Glavas MM,Babich SL,Innis SM,Kieffer TJ,Gibson WT

更新日期：2010-11-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is more severe in male than female mice eating a soy-based diet. We sought to determine whether the detrimental effects are mediated by the phytoestrogens present in soy, the mechanism by which phytoestrogens act, and to test whether estrogen modulates the sexually dimorphic phenotype...

journal_title：Endocrinology

authors： Haines CD,Harvey PA,Luczak ED,Barthel KK,Konhilas JP,Watson PA,Stauffer BL,Leinwand LA

更新日期：2012-09-01 00:00:00

abstract：:Puberty is associated with an increase in the plasma concentration of sex steroids, GH, and insulin-like growth factor-I (IGF-I). Gonadal steroid hormones are important for the normal pubertal growth spurt and skeletal growth. The mechanism by which gonadal steroids induce skeletal growth is still not fully understood...

journal_title：Endocrinology

authors： Maor G,Segev Y,Phillip M

更新日期：1999-04-01 00:00:00

abstract：:We recently described a novel GnRH receptor signaling pathway mediated by the prostaglandins (PGs) F(2alpha) and PGI(2), which acts through an autocrine/paracrine modality to limit autoregulation of the GnRH receptor and inhibit LH but not FSH release. Here we further explore the cross talk between GnRH and the PG rec...

journal_title：Endocrinology

authors： Naidich M,Shterntal B,Furman R,Pawson AJ,Jabbour HN,Morgan K,Millar RP,Jia J,Tomic M,Stojilkovic S,Stern N,Naor Z

更新日期：2010-06-01 00:00:00

abstract：:L-Asparaginase (ASNase), a drug widely used in the treatment of acute lymphoblastic leukemia, has been reported to decrease serum T4-binding globulin (TBG) levels, while results of serum albumin determinations were conflicting. This effect in vivo has been attributed to depressed liver protein synthesis, but this hypo...

journal_title：Endocrinology

authors： Bartalena L,Martino E,Antonelli A,Pacchiarotti A,Robbins J,Pinchera A

更新日期：1986-09-01 00:00:00

abstract：:The concentration of testosterone (T) and 5alpha-dihydrotestosterone (DHT) in plasma, seminal fluid, and epididymis of male Wistar rats have been determined by radioimmunoassay. The DHT/T ratio rose from 0.1 in blood to 1 in testicular fluid and 4 in epididymal fluid. This ratio is 2 in tissues of "caput" epididymis a...

journal_title：Endocrinology

authors： Pujol A,Bayard F,Louvet JP,Boulard C

更新日期：1976-01-01 00:00:00

abstract：:COP9 signalosome subunit 5 (CSN5) plays a key role in carcinogenesis of multiple cancers and contributes to the stabilization of target proteins through deubiquitylation. However, the underlying role of CSN5 in thyroid carcinoma has not been reported. In this research, our data showed that CSN5 was overexpressed in th...

journal_title：Endocrinology

authors： Xie P,Wang H,Fang J,Du D,Tian Z,Zhen J,Liu Y,Ding Y,Fu B,Liu F,Huang D,Yu J

更新日期：2021-03-01 00:00:00

abstract：:Gonadal differentiation is dependent upon a cascade of molecular and morphological events. Steroidogenic factor 1 (SF-1) and DAX-1 have been implicated in this process. A SF-1 binding site has been reported to be present on the DAX-1 gene. We therefore used immunocytochemistry to determine whether these two transcript...

journal_title：Endocrinology

authors： Majdic G,Saunders PT

更新日期：1996-08-01 00:00:00

abstract：:An assay was developed to detect tritium-labeled ovine FSH beta-subunit [( 3H]oFSH beta) secreted from primary ovine pituitary cultures. This procedure used affinity-enriched antibodies raised against reduced and carbamylmethylated oFSH beta (RCM-oFSH beta) in a two-cycle immunoextraction procedure. A discrete species...

journal_title：Endocrinology

authors： Whitfield GK,Miller WL

更新日期：1984-07-01 00:00:00

abstract：:Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a posttranscriptional regulator of genes that are essential for spermatid elongation and completion of spermatogenesis. It also prevents Leydig cells (LCs) from gonadotropin overstimulation of androgen production. In transgenic (Tg) mice carrying deletions...

journal_title：Endocrinology

authors： Kavarthapu R,Tsai-Morris CH,Fukushima M,Pickel J,Dufau ML

更新日期：2013-06-01 00:00:00

abstract：:The multifunctional cytokine tumor necrosis factor-alpha (TNF alpha) stimulates osteoclastic resorption. It is not known which steps in osteoclast formation are affected by TNF alpha. We have investigated the effects of recombinant human TNF alpha (rhTNF alpha) on osteoclast development and osteoclastic resorption in ...

journal_title：Endocrinology

authors： van der Pluijm G,Most W,van der Wee-Pals L,de Groot H,Papapoulos S,Löwik C

更新日期：1991-09-01 00:00:00

abstract：:The concentrations and contents of vasoactive intestinal peptide (VIP) and cholecystokinin (CCK) in the brain and of these peptides along with secretin and glucagon-like immunoreactivity (GLI) in the gut were compared in a group of 16 5-day fasted adult Sprague-Dawley rats with the corresponding peptides in a group of...

journal_title：Endocrinology

authors： Zheng B,Eng J,Yalow RS

更新日期：1987-02-01 00:00:00

abstract：:The expression and functions of receptors for the beta-chemokine, regulated upon activation, normal T cell expressed, and secreted (RANTES)/CCL5, were investigated in osteoblasts. Both primary osteoblasts and the MC3T3-E1 osteoblast cell line express the RANTES receptors, CCR1, 3, 4, and 5 (by RT-PCR), which encode fu...

journal_title：Endocrinology

authors： Yano S,Mentaverri R,Kanuparthi D,Bandyopadhyay S,Rivera A,Brown EM,Chattopadhyay N

更新日期：2005-05-01 00:00:00

abstract：:A serum-free, hormone- and factor-supplemented, defined medium was developed which maintains functional activity of primary cultures of adult islet cells and continuous islet cell lines. Medium supplements examined included proteose peptone (PP), transferrin (TrFe), insulin-like growth factor-I (IGF-I), an insulinotro...

journal_title：Endocrinology

authors： Clark SA,Chick WL

更新日期：1990-04-01 00:00:00

abstract：:Ghrelin, an endogenous ligand for the GH secretagogue receptor, induces GH secretion, food intake, and positive energy balance. Although ghrelin exhibits a variety of hormonal actions, the mechanisms regulating ghrelin expression and secretion remain unclear. To understand regulation of human ghrelin gene expression, ...

journal_title：Endocrinology

authors： Kanamoto N,Akamizu T,Tagami T,Hataya Y,Moriyama K,Takaya K,Hosoda H,Kojima M,Kangawa K,Nakao K

更新日期：2004-09-01 00:00:00