Dysregulation of corticosterone secretion in streptozotocin-diabetic rats: modulatory role of the adrenocortical nitrergic system.

abstract：:The mechanisms by which oxytocin (OT) stimulates extracellular signal-regulated kinase 1/2 (ERK1/2) are only partially understood. OT receptor (OTR) signals predominantly through Galpha(q), but ERK1/2 phosphorylation (ERK1/2-P) in PHM1 myometrial cells was not eliminated by inhibition of downstream effectors such as p...

journal_title：Endocrinology

authors： Zhong M,Yang M,Sanborn BM

更新日期：2003-07-01 00:00:00

abstract：:The amount of corticosterone bound to proteins in the adenohypophysis and dorsal hippocampus was studied concurrently with the plasma ACTH concentration in 4-week adrenalectomized male rats under steady-state conditions achieved by infusing the steroid at a constant rate for 45 min. Corticosterone binding was measured...

journal_title：Endocrinology

authors： Rotsztejn WH,Normand M,Lalonde J,Fortier C

更新日期：1975-07-01 00:00:00

abstract：:The insulin-, glucagon- and somatostatin-producing cells (beta, alpha, and delta, respectively) in the pancreatic islets derive from a common precursor stem cell and differentiate sequentially during embryonic development. The homeodomain protein islet duodenum HOX (IDX)-1 [insulin promoter factor (IPF)-1/somatostatin...

journal_title：Endocrinology

authors： Lu M,Miller C,Habener JF

更新日期：1996-07-01 00:00:00

abstract：:In humans, there is a significant decrease in serum T(3) and increase in rT(3) at different time points after myocardial infarction, whereas serum TSH and T(4) remain unaltered. We report here a time course study of pituitary-thyroid function and thyroid hormone metabolism in rats subjected to myocardial infarction by...

journal_title：Endocrinology

authors： Olivares EL,Marassi MP,Fortunato RS,da Silva AC,Costa-e-Sousa RH,Araújo IG,Mattos EC,Masuda MO,Mulcahey MA,Huang SA,Bianco AC,Carvalho DP

更新日期：2007-10-01 00:00:00

abstract：:To investigate the mechanism of insulin insensitivity during fasting and hyperresponsiveness to insulin after refeeding, insulin binding, 2-deoxyglucose uptake and glucose oxidation were measured in adipocytes from three groups of rats: control, 48 h fasted, and 48 h refed after 48 h fasting. In 48 h fasted rats, fat ...

journal_title：Endocrinology

authors： Kasuga M,Akanuma Y,Iwamoto Y,Kosaka K

更新日期：1977-05-01 00:00:00

abstract：:We have found that microwave (MW) stabilization greatly improves detection of the estrogen receptor (ER) in frozen sections of rhesus monkey oviduct by immunocytochemistry (ICC). Fresh samples of fimbriae were MW-irradiated, frozen, and then cryosectioned. The frozen sections were also MW-treated and then fixed in a p...

journal_title：Endocrinology

authors： Slayden OD,Koji T,Brenner RM

更新日期：1995-09-01 00:00:00

abstract：:In this study we tested the hypothesis that receptor-mediated transport of urocortin across the blood-brain barrier (BBB) undergoes developmental changes. Urocortin is a peptide produced by both selective brain regions and peripheral organs, and it is involved in feeding, memory, mood, cardiovascular functions, and im...

journal_title：Endocrinology

authors： Hsuchou H,Kastin AJ,Wu X,Tu H,Pan W

更新日期：2010-03-01 00:00:00

abstract：:During in vitro maturation of porcine cumulus cell-oocyte complexes and in vitro luteinization of porcine granulosa cells, FSH induces the expression of the protease TNFα-converting enzyme/A disintegrin and metalloproteinase domain 17 (TACE/ADAM17) and the epidermal growth factor (EGF)-like factors, which activate the...

journal_title：Endocrinology

authors： Yamashita Y,Okamoto M,Ikeda M,Okamoto A,Sakai M,Gunji Y,Nishimura R,Hishinuma M,Shimada M

更新日期：2014-03-01 00:00:00

abstract：:Six pony mares were ovariectomized (OVX) on day 16 of diestrus during June and July, 1972, to study short term changes in plasma luteinizing hormone (LH) concentrations. Plasma LH was higher (P less than .05) 3 days after OVX (1.76 ng/ml) than the day after OVX (1.01 ng/ml), and a gradual increase occurred over the fi...

journal_title：Endocrinology

authors： Garcia MC,Ginther OJ

更新日期：1976-04-01 00:00:00

abstract：:Somatostatin (SRIF) inhibits vasoactive intestinal peptide (VIP)-stimulated cAMP accumulation in the GH4C1 strain of rat pituitary tumor cells, and this effect is responsible for SRIF inhibition of VIP-stimulated hormone release. In this study we examined the interaction between the SRIF receptor and adenylate cyclase...

journal_title：Endocrinology

authors： Koch BD,Schonbrunn A

更新日期：1984-05-01 00:00:00

abstract：:Progesterone (P4) is essential for female fertility. The objective of this study was to evaluate the functional requirement of the nonclassical P4 receptor (PGR), PGR membrane component 1, in regulating female fertility. To achieve this goal, the Pgrmc1 gene was floxed by insertion of loxP sites on each side of exon 2...

journal_title：Endocrinology

authors： McCallum ML,Pru CA,Niikura Y,Yee SP,Lydon JP,Peluso JJ,Pru JK

更新日期：2016-09-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN) and arcuate nucleus (ARC) have reciprocal connections; catabolic metabolic information activates the ARC and inhibits SCN neuronal activity. Little is known about the influence of the SCN on the ARC. Here, we investigated whether the SCN modulated the sensitivity of the ARC to catabol...

journal_title：Endocrinology

authors： Herrera-Moro Chao D,León-Mercado L,Foppen E,Guzmán-Ruiz M,Basualdo MC,Escobar C,Buijs RM

更新日期：2016-09-01 00:00:00

abstract：:The relationship between progesterone and prostaglandin (PG) secretion in the pseudopregnant rabbit corpus luteum was investigated using isolated in vitro perfused ovaries. Progesterone and PG secretion were measured on days 1, 11, and 18 of hCG-induced pseudopregnancy. The mean progesterone secretion increased signif...

journal_title：Endocrinology

authors： Dharmarajan AM,Sueoka K,Miyazaki T,Atlas SJ,Ghodgaonkar RB,Dubin NH,Zirkin BR,Wallach EE

更新日期：1989-03-01 00:00:00

abstract：:The effects of somatostatin (SRIF) on the production and release of TSH and its subunits have been investigated in bovine anterior pituitary monolayer cultures. SRIF caused a dose-dependent inhibition of TSH and subunit release by TRH, with a half-maximal effective dose of 3 X 10(-8) M. This effect was time dependent ...

journal_title：Endocrinology

authors： Ridgway EC,Klibanski A,Martorana MA,Milbury P,Kieffer JD,Chin WW

更新日期：1983-06-01 00:00:00

abstract：:The health impacts of endocrine-disrupting chemicals (EDCs) remain debated, and their tissue and molecular targets are poorly understood. In this study, we leveraged systems biology approaches to assess the target tissues, molecular pathways, and gene regulatory networks associated with prenatal exposure to the model ...

journal_title：Endocrinology

authors： Shu L,Meng Q,Diamante G,Tsai B,Chen YW,Mikhail A,Luk H,Ritz B,Allard P,Yang X

更新日期：2019-02-01 00:00:00

abstract：:Studies in rodents demonstrate that the mitogen, IGF-I, stimulates intestinal peptide YY (PYY) expression. To investigate whether the stimulatory influence of IGF-I is exerted at the level of gene transcription, rat PYY 5'-upstream sequences (-2800/+37 bp, -770/+37 bp, -127/+37 bp) fused to the firefly luciferase (luc...

journal_title：Endocrinology

authors： Wang G,Leiter AB,Englander EW,Greeley GH Jr

更新日期：2004-02-01 00:00:00

abstract：:A neutral protease with angiotensin I-forming activity which could readily be separated from acid proteases and plasma and renal renin was obtained from extracts of dog brain. This enzyme has an apparent mol wt of 40,000 by Sephadex chromatography. On chromatofocusing, it displays isoelectric points of 7.92, 7.73, and...

journal_title：Endocrinology

authors： Husain A,Smeby RR,Wilk D,Dzau VJ,Bumpus FM

更新日期：1984-06-01 00:00:00

abstract：:Differences in the catalytic activity of the placental and gonadal isozymes of porcine aromatase cytochrome P450 (P450arom) were examined in cell lines exhibiting stable expression of recombinant enzyme. Cell lines were selected that expressed high, but similar, immunodetectable levels of each isozyme based on Western...

journal_title：Endocrinology

authors： Corbin CJ,Trant JM,Walters KW,Conley AJ

更新日期：1999-11-01 00:00:00

abstract：:Low basal GH secretion and reduced GH responsiveness to different GH secretagogues, including GHRF, have been reported in aged animals and humans. Parallel to the in vivo findings, an impaired GH responsiveness to GHRF is evident in somatotropes from old rats of either sex. We report here that in anterior pituitaries ...

journal_title：Endocrinology

authors： Parenti M,Dall'ara A,Rusconi L,Cocchi D,Müller EE

更新日期：1987-11-01 00:00:00

abstract：:We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs) together with hyperglycemia are synergistic in causing islet beta-cell damage because high glucose inhibits fat oxidation and consequently lipid detoxification. The effects of 1-2 d culture of both rat INS 832/13 cells and hu...

journal_title：Endocrinology

authors： El-Assaad W,Buteau J,Peyot ML,Nolan C,Roduit R,Hardy S,Joly E,Dbaibo G,Rosenberg L,Prentki M

更新日期：2003-09-01 00:00:00

abstract：:Orexins/hypocretins heavily innervate the posterior division of the paraventricular nucleus of the thalamus (pPVT), which expresses both orexin receptor types. The pPVT is important for adaptations to repeated stress, particularly the ability to facilitate to novel stress after repeated stress exposure. Here, we exami...

journal_title：Endocrinology

authors： Heydendael W,Sharma K,Iyer V,Luz S,Piel D,Beck S,Bhatnagar S

更新日期：2011-12-01 00:00:00

abstract：:The intraislet insulin hypothesis has been proposed to explain absent glucagon responses to hypoglycemia. Recently we directly confirmed this hypothesis by restoring glucagon secretion via provision of a pancreatic artery insulin infusion, which was switched off at the time of hypoglycemia in Wistar rats made diabetic...

journal_title：Endocrinology

authors： Zhou H,Zhang T,Oseid E,Harmon J,Tonooka N,Robertson RP

更新日期：2007-06-01 00:00:00

abstract：:Serum LH and FSH were measured at 60, 30, and 0 min before, at 5, 15, and 30 min during, and at 10, 45, and 90 min after bilateral electrical stimulation (ES) of various hypothalamic regions in 12 unanesthetized ovariectomized rhesus monkeys. ES of the arcuate-ventromedial nuclei (medial basal hypothalamus; MBH) induc...

journal_title：Endocrinology

authors： Spies HG,Norman RL,Quadri SK,Clifton DK

更新日期：1977-02-01 00:00:00

abstract：:With a recently developed microdissection technique, four circumventricular organs were removed from the rat brain, and their contents of LHRH and TRH were measured. The subfornical organ, the organon vasculosum lamia terminalis, the subcommissural organ, the area postrema all contained significant quantities of both ...

journal_title：Endocrinology

authors： Kizer JS,Palkovits M,Brownstein MJ

更新日期：1976-02-01 00:00:00

abstract：:We compared the somatomedin (SM) activity of perfusates of livers from normal and hypophysectomized (hypox) rats with and without the addition of growth hormone (GH) to the perfusions. Livers were perfused for a total of 3 hours, with a change of Waymouth's medium MB 752/l every 30 min, in a continously recirculating ...

journal_title：Endocrinology

authors： Phillips LS,Herington AC,Karl IE,Daughaday WH

更新日期：1976-03-01 00:00:00

abstract：:Studies were carried out to determine the actions of PRL on adrenocortical function in hypophysectomized female rats in the presence and absence of ACTH. PRL administration alone decreased 5 alpha-reductase activity but did not significantly affect the rates of corticosterone secretion or peripheral plasma corticoster...

journal_title：Endocrinology

authors： Colby HD

更新日期：1979-05-01 00:00:00

abstract：:The development of androgen responsiveness in the submandibular gland of normal and androgen-resistant (Tfm) mice of different ages was studied after varying hormonal treatments. Total esteroproteolytic (tamase) activity of submandibular gland homogenates was used as a marker for androgen action. Newborn mice of all f...

journal_title：Endocrinology

authors： Dunn JF,Wilson JD

更新日期：1975-06-01 00:00:00

abstract：:A complementary DNA, uterine-ovarian-specific gene 44 (UO-44), has been isolated from tamoxifen-induced rat uterine complementary DNA library using differential display techniques. UO-44 transcripts are found to be abundant in the uterus and ovary. UO-44 gene expression in the uterus is strictly regulated by estrogens...

journal_title：Endocrinology

authors： Huynh H,Ng CY,Lim KB,Ong CK,Ong CS,Tran E,Tuyen Nguyen TT,Chan TW

更新日期：2001-07-01 00:00:00

abstract：:Lefty/Ebaf polypeptides, novel members of the TGF-beta superfamily, are involved in endometrial differentiation and embryo implantation. Recently, we showed that, during undisturbed estrous cycle, lefty is present in mouse uterine horn primarily in a precursor form. Here, we show that decidual differentiation of endom...

journal_title：Endocrinology

authors： Tang M,Mikhailik A,Pauli I,Giudice LC,Fazelabas AT,Tulac S,Carson DD,Kaufman DG,Barbier C,Creemers JW,Tabibzadeh S

更新日期：2005-12-01 00:00:00

abstract：:Corticostatin-I (CSI) is the most potent of the corticostatic peptides isolated from rabbit lungs and neutrophils. CSI was localized in cells by immunohistochemistry using highly specific polyclonal antisera raised against the synthetic peptide. Western blot showed a single 4-kilodalton band, indicating that the antib...

journal_title：Endocrinology

authors： Hu J,Jothy S,Solomon S

更新日期：1993-06-01 00:00:00