The effect of somatostatin on the release of thyrotropin and its subunits from bovine anterior pituitary cells in vitro.

abstract：:Interaction between Sertoli cells and germ cells is likely to be critical for normal development of the testis. We have established and characterized cocultures of neonatal Sertoli cells and gonocytes and have begun to study the physical and functional relationship between these cells in vitro. Cells were isolated fro...

journal_title：Endocrinology

authors： Orth JM,Boehm R

更新日期：1990-12-01 00:00:00

abstract：:In the present work we describe homologous desensitization of gonadotropin release from pituitary cells in response to short-term exposure to GnRH. Like the release process itself, desensitization requires receptor occupancy by an agonist. In contrast, however, inhibition of LH release by chelation of extracellular ca...

journal_title：Endocrinology

authors： Smith WA,Conn PM

更新日期：1983-01-01 00:00:00

abstract：:Cachexia, defined as an involuntary weight loss ≥ 5%, is a serious and dose-limiting side effect of chemotherapy that decreases survival in cancer patients. Alterations in lipid metabolism are thought to cause the lipodystrophy commonly associated with cachexia. Ghrelin has been proposed to ameliorate the alterations ...

journal_title：Endocrinology

authors： Garcia JM,Scherer T,Chen JA,Guillory B,Nassif A,Papusha V,Smiechowska J,Asnicar M,Buettner C,Smith RG

更新日期：2013-09-01 00:00:00

abstract：:Insulin resistance and smoking are significant risk factors for cardiac and cerebral vascular diseases. Because vascular smooth muscle cells play a key role in the development and progression of atherosclerosis, we investigated the effect of nicotine on insulin-induced mitogenic signaling in aortic vascular smooth mus...

journal_title：Endocrinology

authors： Wada T,Naito M,Kenmochi H,Tsuneki H,Sasaoka T

更新日期：2007-02-01 00:00:00

abstract：:The mechanisms whereby tissue sensitivity to PRL is controlled are not well understood. Here we report that expression of mRNA and protein for members of the SOCS/CIS/JAB family of cytokine signaling inhibitors is increased by PRL administration in ovary and adrenal gland of the lactating rat deprived of circulating P...

journal_title：Endocrinology

authors： Tam SP,Lau P,Djiane J,Hilton DJ,Waters MJ

更新日期：2001-11-01 00:00:00

abstract：:Androgens are required for the development and function of the prostate. In a normal human prostate, androgens control the synthesis of proteins such as prostate-specific antigen and human glandular kallikrein. The prostate secretes these proteins as well as a number of other compounds to form the prostatic fluid. Usi...

journal_title：Endocrinology

authors： Prescott JL,Tindall DJ

更新日期：1998-04-01 00:00:00

abstract：:We previously reported that RU486 can reverse progesterone (P)-induced suppression of the estrogen receptor (ER) in the uterus of pregnant rhesus monkeys, but we did not determine whether estrogen (E) could act through its receptor in the presence of P and RU486. To pursue this question, we treated spayed rhesus monke...

journal_title：Endocrinology

authors： Slayden OD,Hirst JJ,Brenner RM

更新日期：1993-04-01 00:00:00

abstract：:Women with type 1 diabetes are subfertile. Diabetes negatively affects pregnancy by causing early miscarriage and poor prenatal outcomes. In this study we examine consequences of maternal type 1 diabetes on early embryo development, metabolic gene expression, and the pattern of insulin receptor (IR) and IGF-I receptor...

journal_title：Endocrinology

authors： Ramin N,Thieme R,Fischer S,Schindler M,Schmidt T,Fischer B,Navarrete Santos A

更新日期：2010-09-01 00:00:00

abstract：:As4.1 cells are derived from a renin-expressing kidney tumor induced by tissue-specific oncogene-mediated tumorigenesis in transgenic mice. These cells express high levels of renin messenger RNA (mRNA) and synthesize prorenin and renin; they were therefore used as a model to further investigate the molecular biology o...

journal_title：Endocrinology

authors： Thompson HA,Burson JM,Lang JA,Gross KW,Sigmund CD

更新日期：1995-07-01 00:00:00

abstract：UNLABELLED:Triple A syndrome is a rare, autosomal recessive cause of adrenal failure. Additional features include alacrima, achalasia of the esophageal cardia, and progressive neurodegenerative disease. The AAAS gene product is the nuclear pore complex protein alacrima-achalasia-adrenal insufficiency neurological disor...

journal_title：Endocrinology

authors： Prasad R,Metherell LA,Clark AJ,Storr HL

更新日期：2013-09-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) is synthesized and secreted by thyroid parafollicular (PF) cells. As all PF granules contain 5-HT, it is released whenever PF cells secrete. Because 5-HT stimulates follicular (F) cells and can modulate their response to TSH, 5-HT has been proposed to be a paracrine PF to F cell transmitter....

journal_title：Endocrinology

authors： Tamir H,Hsiung SC,Liu KP,Blakely RD,Russo AF,Clark MS,Nunez EA,Gershon MD

更新日期：1996-10-01 00:00:00

abstract：:Anorexia is a debilitating manifestation of many malignancies. The etiology of cancer anorexia is poorly understood, and effective treatment options are limited. To investigate the role of central melanocortin receptor signaling in the pathogenesis of cancer anorexia, we assessed the effects on food intake of the mela...

journal_title：Endocrinology

authors： Wisse BE,Frayo RS,Schwartz MW,Cummings DE

更新日期：2001-08-01 00:00:00

abstract：:The influence of hormones on the synthesis of phospholipids of lung lamellar bodies was studied using lung tissue explants from 16- to 22-week gestational age human abortuses. Lung explants were incubated in a defined medium containing either no hormonal additions or insulin (2.5 micrograms/ml), cortisol (0.2 microgra...

journal_title：Endocrinology

authors： Snyder JM,Longmuir KJ,Johnston JM,Mendelson CR

更新日期：1983-03-01 00:00:00

abstract：:It has been suggested that ewes carrying the Booroola gene (Fec(B)) consistently ovulate more follicles because they recruit more primordial follicles and/or have a lower rate of atresia. If the former is correct, the pool of follicles would be depleted sooner in Fec(B) animals. We have studied follicular dynamics and...

journal_title：Endocrinology

authors： Gonzalez-Bulnes A,Souza CJ,Campbell BK,Baird DT

更新日期：2004-06-01 00:00:00

abstract：:GH is considered to play a role in the pathogenesis of diabetic retinopathy, causing neovascularization in the retina. The present study was conducted to assess the possibility that GH may play a role in ocular development by determining whether GH is expressed in the eye of the chicken during development. In the 17-d...

journal_title：Endocrinology

authors： Takeuchi S,Haneda M,Teshigawara K,Takahashi S

更新日期：2001-12-01 00:00:00

abstract：:The effects of insulin treatment and dietary glucose on the responsiveness of adipose tissue to insulin and GH after hypophysectomy were studied. Male rats, 130-150 g, were hypophysectomized. Glucose metabolism was measured by determining the production of CO2 from [14C]glucose and the incorporation of glucose into li...

journal_title：Endocrinology

authors： Gause I,Isaksson O,Lindahl A,Edén S

更新日期：1985-03-01 00:00:00

abstract：:Little is known about the mechanism for the prolonged residence time of 25-hydroxyvitamin D (25OHD) in blood. Several lines of evidence led us to propose that skeletal muscle could function as the site of an extravascular pool of 25OHD. In vitro studies investigated the capacity of differentiated C2 murine muscle cell...

journal_title：Endocrinology

authors： Abboud M,Puglisi DA,Davies BN,Rybchyn M,Whitehead NP,Brock KE,Cole L,Gordon-Thomson C,Fraser DR,Mason RS

更新日期：2013-09-01 00:00:00

abstract：:Activin A is a gonadal protein originally isolated from follicular fluid and is recognized as a local regulator of granulosa cell differentiation. Whether activin A promotes folliculogenesis, however, still remains unclarified. The present study was designed to elucidate the effect of activin A on follicular growth in...

journal_title：Endocrinology

authors： Yokota H,Yamada K,Liu X,Kobayashi J,Abe Y,Mizunuma H,Ibuki Y

更新日期：1997-11-01 00:00:00

abstract：:The glycoprotein FSH, a product of pituitary gonadotrope cells, regulates ovarian follicle development in females and spermatogenesis in males. FSH is a heterodimer of the common α gonadotropin subunit and the hormone-specific FSHβ subunit (a product of the Fshb gene). Using a conditional knockout approach (Cre-lox), ...

journal_title：Endocrinology

authors： Li Y,Schang G,Wang Y,Zhou X,Levasseur A,Boyer A,Deng CX,Treier M,Boehm U,Boerboom D,Bernard DJ

更新日期：2018-07-01 00:00:00

abstract：:Down regulation of insulin receptor number by insulin at physiological concentrating (10(-9) M) has been demonstrated in primary cultures of adult rat liver parenchymal cells in monolayer. However, because insulin is rapidly degraded in this culture system, special efforts are necessary to maintain the concentration o...

journal_title：Endocrinology

authors： Blackard WG,Guzelian PS,Small ME

更新日期：1978-08-01 00:00:00

abstract：:We previously found that the sustained rise in active sodium transport by the toad urinary bladder after exposure to insulin is associated with the synthesis of a membrane protein with a molecular weight of 25,000. Studying the effects of insulin on the incorporation of uridine into RNA of epithelial cells of the blad...

journal_title：Endocrinology

authors： Cobb MH,Yang CP,Scott WN

更新日期：1981-12-01 00:00:00

abstract：:The somatic Sertoli cells of the testis are major targets for FSH and are important for the regulation of spermatogenesis. The binding of FSH to Sertoli cells activates the cAMP-dependent protein kinase A signaling pathway, resulting in phosphorylation of the cAMP response element-binding protein (CREB), which is requ...

journal_title：Endocrinology

authors： Walker WH,Fucci L,Habener JF

更新日期：1995-08-01 00:00:00

abstract：:Tuberoinfundibular peptide of 39 residues (TIP39) and the PTH-2 receptor (PTH2R) constitute a peptide-receptor neuromodulator system. Based on the abundance of TIP39 fibers and axonal terminals as well as PTH2R-containing neurons and their processes in the hypothalamic para- and periventricular and arcuate nuclei TIP3...

journal_title：Endocrinology

authors： Cservenák M,Bodnár I,Usdin TB,Palkovits M,Nagy GM,Dobolyi A

更新日期：2010-12-01 00:00:00

abstract：:Basal serum gonadotropin levels were monitored weekly in female hamsters from birth to 10 weeks of age. Hamsters raised on three different photoperiods presented uniform pre- and postpubertal patterns of serum LH and FSH, suggesting that gonadotropin release in the young hamster occurs independently of ambient photope...

journal_title：Endocrinology

authors： Smith SG 3rd,Matt KS,Prestowitz WF,Stetson MH

更新日期：1982-04-01 00:00:00

abstract：:Transfer of corticosterone from serum to milk was studied in lactating rats after ether and pentobarbital anesthesia. Two minutes after the onset of anesthesia stress, total serum and milk corticosterone concentrations were not significantly different. By 30 min, corticosterone concentrations in serum increased to a p...

journal_title：Endocrinology

authors： Yeh KY

更新日期：1984-10-01 00:00:00

abstract：:We investigated the contribution of corticotropin-releasing factor (CRF) receptors types 1 and 2 (CRF(1) and CRF(2)) in mediating the ACTH response to shock, alcohol injection, or endotoxemia in the rat. Peptidic (Astressin B and Astressin(2)-B) and nonpeptidic (NBI 30775) CRF antagonists were injected iv before the s...

journal_title：Endocrinology

authors： Rivier CL,Grigoriadis DE,Rivier JE

更新日期：2003-06-01 00:00:00

abstract：:Insulin is a potent regulator of Sp1 transcription factor. To examine if glucagon, which usually antagonizes insulin, regulates Sp1, we assessed the levels of Sp1 by Western blotting from H-411E cells exposed to glucagon with or without insulin. Glucagon alone (1.5 x 10(-9) to 1.5 x 10(-5) M) stimulated Sp1 accumulati...

journal_title：Endocrinology

authors： Keembiyehetty CN,Candelaria RP,Majumdar G,Raghow R,Martinez-Hernandez A,Solomon SS

更新日期：2002-04-01 00:00:00

abstract：:Light and electron microscopic triple immunostaining was performed on coronal vibratome sections prepared from the hypothalamus of ovariectomized (OVX) and OVX plus estrogen-treated African green monkeys (Cercopithecus aethiops). Immunoreactivity for progesterone receptors (PRs) and neuropeptide-Y (NPY) was visualized...

journal_title：Endocrinology

authors： Horvath TL,Shanabrough M,Naftolin F,Leranth C

更新日期：1993-07-01 00:00:00

abstract：:The amount of corticosterone bound to proteins in the adenohypophysis and dorsal hippocampus was studied concurrently with the plasma ACTH concentration in 4-week adrenalectomized male rats under steady-state conditions achieved by infusing the steroid at a constant rate for 45 min. Corticosterone binding was measured...

journal_title：Endocrinology

authors： Rotsztejn WH,Normand M,Lalonde J,Fortier C

更新日期：1975-07-01 00:00:00

abstract：:Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased t...

journal_title：Endocrinology

authors： Makanji Y,Walton KL,Chan KL,Gregorevic P,Robertson DM,Harrison CA

更新日期：2011-10-01 00:00:00