Abstract:
:Polyadenylated RNA, extracted from rat hypothalami, cross-hybridized with a RNA probe complementary in sequence to rat PTH (rPTH) messenger RNA (mRNA). Amplification of complementary DNA (cDNA) by the polymerase chain reaction also demonstrated the presence of rPTH mRNA in the rat hypothalamus and parathyroid gland. rPTH mRNA was localized by in situ hybridization in the paraventricular and supraoptic nuclei of the rat hypothalamus. These results demonstrate the expression of the PTH gene in the central nervous system of the rat in areas which suggest roles for PTH in neuroendocrine function.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Fraser RA,Kronenberg HM,Pang PK,Harvey Sdoi
10.1210/endo-127-5-2517subject
Has Abstractpub_date
1990-11-01 00:00:00pages
2517-22issue
5eissn
0013-7227issn
1945-7170journal_volume
127pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Recent in vitro and in vivo evidence shows that secretion of parathyroid hormone (PTH) and calcitonin (CT) is stimulated by beta-adrenergic agonists and inhibited by beta-adrenergic antagonists. To assess the possible roles of adrenal medullary or adrenergic nerve terminal catecholamines in calcium homeostasis, we hav...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-107-4-977
更新日期:1980-10-01 00:00:00
abstract::This study was aimed at testing the hypothesis that different forms of fibronectin (FN), produced as a consequence of the alternative splicing of the precursor messenger RNA, play specific roles during development of the ovarian follicle. In particular, we were interested in determining the effect of the ED-I (also te...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.6.6708
更新日期:1999-06-01 00:00:00
abstract::Notch signaling directs cell fate during embryogenesis by influencing cell proliferation, differentiation, and apoptosis. Notch genes are expressed in the adult mouse ovary, and roles for Notch in regulating folliculogenesis are beginning to emerge from mouse genetic models. We investigated how Notch signaling might i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0213
更新日期:2009-02-01 00:00:00
abstract::Insulin-like growth factor-binding protein-3 (IGFBP-3), the major IGFBP in the adult circulation, is produced by a wide range of cell and tissue types. IGFBP-3 appears to be regulated by transcriptional and/or posttranslational mechanisms in a species-, cell-, and development-specific manner. In vitro and in vivo stud...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.2.7530650
更新日期:1995-02-01 00:00:00
abstract::Estradiol-17beta (E2) is suspected to exert a role in the regulation of testicular activity. Using a nonmammalian vertebrate model (the frog, Rana esculenta), we have investigated whether c-fos activity is detectable in the testis during the annual sexual cycle and whether E2 exerts a regulatory role on spermatogenesi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.7.6790
更新日期:1999-07-01 00:00:00
abstract::In the thyroid follicles and blood of goats with congenital hypothyroidism and goiter, abnormal iodoproteins (e.g. iodoalbumin) are found. To study the mechanism involved in the passage of these proteins between the follicles and the blood, the morphology of tight junctions in goiters and normal thyroids of goats was ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-1-114
更新日期:1985-07-01 00:00:00
abstract::Ghrelin has emerged as putative regulator of an array of endocrine and nonendocrine functions, including cell proliferation. Recently, we provided evidence for the expression of ghrelin in mature, but not in undifferentiated, Leydig cells of rat and human testis. Yet testicular actions of ghrelin, other than modulatio...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0732
更新日期:2004-11-01 00:00:00
abstract::The ontogenic changes in the somatotroph's responsiveness to TRH were examined in enzymatically dissociated rat pituitary cells in primary monolayer culture. Exposure to TRH (10(-8) M) caused a significant increase in GH release in cultured pituitary cells from rats ranging in age from -1 day (20 days of gestational a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-5-2368
更新日期:1986-11-01 00:00:00
abstract::Split hand/foot malformation (SHFM) is syndromic ectrodactyly often associated with mental retardation and/or craniofacial defects. Several clinical reports previously described urogenital dysplasia such as micropenis, hypospadias, and small testis in SHFM patients. Genetic lesions in the Dlx5 and Dlx6 (Dlx5/6) locus ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1265
更新日期:2008-05-01 00:00:00
abstract::Selective inhibitors of sodium glucose cotransporter-2 (SGLT2) are widely used for the treatment of type 2 diabetes and act primarily to lower blood glucose by preventing glucose reabsorption in the kidney. However, it is controversial whether these agents also act on the pancreatic islet, specifically the α cell, to ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endocr/bqaa080
更新日期:2020-08-01 00:00:00
abstract::Quantitative thyroid cell transplantation was used to evaluate the reestablishment of thyroid function in surgically thyroidectomized rats. Donor thyroid glands were enzymatically dispersed, and the cells were quantified, serially diluted, and inoculated into the sc fat pads of syngeneic recipient rats 1 day after sur...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-6-2673
更新日期:1990-12-01 00:00:00
abstract::Pharmacological amounts of 25(s),26-dihydroxyvitamin D3 were administered to normal, vitamin D-replete rats in order to assess its pharmacological activity. Treatment with 25(s),26-dihydroxyvitamin D3 (20 micrograms/day for 1 week) caused a marked and significant fall in the circulating concentration of 1,25-dihydroxy...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-121-5-1671
更新日期:1987-11-01 00:00:00
abstract::The effect of constant infusions of bovine TSH in different concentrations on the pattern of T4 and T3 secretion was examined in perfused canine thyroids isolated in situ. Each of the thyroid lobes was isolated and perfused in each animal. It was thus possible to examine the effect of two different concentrations of T...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-100-3-656
更新日期:1977-03-01 00:00:00
abstract::The present studies investigated whether insulin inhibits the stimulatory effect of dexamethasone (DEX) on angiotensinogen (ANG) gene expression and induction of hypertrophy in rat immortalized renal proximal tubular cells (IRPTCs) in a high-glucose milieu. Rat IRPTCs were cultured in monolayer. ANG and ANG mRNA expre...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220408
更新日期:2002-12-01 00:00:00
abstract::To date, the role of pancreatic hormones in pancreatic islet growth and differentiation is poorly understood. To address this issue, we examined mice with a disruption in the gene encoding prohormone convertase 2 (PC2). These mice are unable to process proglucagon, prosomatostatin, and other neuroendocrine precursors ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0088
更新日期:2003-09-01 00:00:00
abstract::Perifused anterior hemipituitaries from one male and 4 female monkeys released GH and PRL in a pulsatile pattern, with mean +/- SE interpulse intervals of 8.2 +/- 0.4 and 8.5 +/- 0.3 min, as determined by a cycle detection computer algorithm. Mean hormone concentrations in the perifusate fractions collected at 2-min i...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-116-1-1
更新日期:1985-01-01 00:00:00
abstract::GnRH peptides in the hypothalami of marsupials (tammar wallaby, short-nosed bandicoot, and eastern quoll) and a monotreme (echidna) were investigated by reverse phase HPLC and RIA with region-specific antisera. In the wallaby hypothalamic extract, a single form of GnRH was present, which eluted in the same position as...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-125-5-2244
更新日期:1989-11-01 00:00:00
abstract::GnRH neurons are regulated by hypothalamic kisspeptin neurons. Recently, galanin was identified in a subpopulation of kisspeptin neurons. Although the literature thoroughly describes kisspeptin activation of GnRH neurons, little is known about the effects of galanin on GnRH neurons. This study investigated whether gal...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1064
更新日期:2016-08-01 00:00:00
abstract::The melanocortin-3 receptor (MC3R) and MC4R are known to play critical roles in energy homeostasis. However, the physiological functions of the MC3R remain poorly understood. Earlier reports indicated that the ventral tegmental area (VTA) is one of the highest sites of MC3R expression, and we sought to determine the f...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-2049
更新日期:2014-05-01 00:00:00
abstract::LH supplementation in assisted reproductive technology cycles improves the ongoing pregnancy rate in women with poor ovarian response (POR). However, our knowledge of the precise role of LH during the follicular phase of the menstrual cycle is incomplete. To explore the role of LH in the maturation of small antral fol...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00123
更新日期:2018-06-01 00:00:00
abstract::Altered leptin action has been implicated in the pathophysiology of heart failure in obesity, a hallmark of which is extracellular matrix remodeling. Here, we characterize the direct influence of leptin on matrix metalloproteinase (MMP) activity in primary adult rat cardiac fibroblasts and focus on elucidating the mol...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-1166
更新日期:2011-05-01 00:00:00
abstract::The utility of the established ACTH secreting mouse pituitary tumor cell line AtT20 for investigating early glucocorticoid inhibition was examined. Three different strains of the cell line D1, D16v, and D16:16, respectively, were analyzed. In initial studies CRF and phorbol esters were used as secretagogues to examine...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.131.6.1332850
更新日期:1992-12-01 00:00:00
abstract::Insulin receptor substrate-1 (IRS-1), the primary substrate for the insulin receptor tyrosine kinase in most cells and tissues, is a key component of the insulin signaling network. Numerous studies have documented the trafficking of IRS-1 from the cell membrane to intracellular, extranuclear compartments. During the c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220321
更新日期:2002-11-01 00:00:00
abstract::In order to delineate the ages of onset and decline in sensitivity to growth hormone (GH) in rats, the ability of ovine GH in vitro to stimulate amino acid uptake and protein synthesis was studied in diaphragm muscle. GH (25 mug/ml) produced a significant, but small (12-17%), stimulation of alpha-aminoisobutyric acid ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-98-5-1273
更新日期:1976-05-01 00:00:00
abstract::The distribution pattern of messenger RNAs (mRNAs) for insulin-like growth factor I (IGF-I), IGF-II, and the type 1 IGF receptor and the detection of IGF-binding sites in sections of ovine ovary were demonstrated using in situ hybridization and autoradiography. Ovaries were collected from 30 ewes at time points throug...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.12.7588270
更新日期:1995-12-01 00:00:00
abstract::To test the hypothesis that angiotensin (Ang) II induces profibrotic gene expression through endogenous aldosterone, we measured the effect of 4 h infusion (600 ng/kg x min) of Ang II on tissue mRNA expression of plasminogen activator inhibitor 1 (PAI-1), preproendothelin-1 (ppET-1), TGF-beta, and osteopontin in wild-...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1296
更新日期:2009-05-01 00:00:00
abstract::Dopamine D2 receptor agonists are commonly used in the control of PRL-secreting adenomas, and the sensitivity of dopamine agonists during long term therapy is exquisite. However, the molecular mechanisms responsible for the maintenance of this cellular sensitivity to dopamine agonists remain poorly understood. In the ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.10.5433
更新日期:1997-10-01 00:00:00
abstract::The Elovl3 gene belongs to the Elovl gene family, which encodes for enzymes involved in the elongation of very long chain fatty acids. The recognized role for the enzyme is to control the elongation of saturated and monounsaturated fatty acids up to 24 carbons in length. Elovl3 was originally identified as a highly ex...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1402
更新日期:2008-06-01 00:00:00
abstract::Recent studies have demonstrated that passive immunization of neonatal rats to GRF inhibited their somatic growth through the suppression of GH secretion. In this study, we investigated the changes in pituitary GRF receptor (GRFR) expression in GRF antibody (GRF-ab) treated rats. Neonatal rats were treated from day 1 ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.6.8641220
更新日期:1996-06-01 00:00:00
abstract::After reproductive senescence or gonadectomy, changes occur in neural gene expression, ultimately altering brain function. The endocrine mechanisms underlying these changes in gene expression beyond immediate hormone loss are poorly understood. To investigate this, we measured changes in gene expression the dorsal str...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2131
更新日期:2013-05-01 00:00:00