Abstract:
:Although leptin is a hormone mainly produced by the adipose tissue, it is also produced by the gastric mucosa and the mammary epithelium and is present in maternal milk. The effects of milk leptin on the neonate are not known. The purpose of the investigation was to evaluate the short-term effects of the administration of a single oral dose of leptin on 4-d-old rats as well as the effects of chronic supplementation during the lactation period with a daily oral dose of leptin (equivalent to 5 times the amount of leptin ingested normally from maternal milk during the suckling period) on body weight, the gastric leptin system, gastric food content, and thermogenic capacity. Our results show that the administration of a single oral dose of 4 ng of leptin to 4-d-old rats produces a short-term increase in leptin levels in the stomach and serum and a decrease in the weight of the gastric contents. Pups treated with a daily oral dose of leptin during the whole lactation period showed, at the end of the suckling period, compared with controls, lower gastric contents, lower leptin production by the stomach and the sc adipose tissue, and lower thermogenic capacity in brown adipose tissue. We conclude that oral leptin is absorbed by the immature gastric epithelium of the neonate, and this leptin exerts clear biological effects, down-regulating endogenous leptin production and playing a potential role in the short-term control on food intake during the lactation period.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Sánchez J,Oliver P,Miralles O,Ceresi E,Picó C,Palou Adoi
10.1210/en.2005-0112subject
Has Abstractpub_date
2005-06-01 00:00:00pages
2575-82issue
6eissn
0013-7227issn
1945-7170pii
en.2005-0112journal_volume
146pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Although the effectiveness of nuclear hormone-receptor complexes is known to depend on coregulator partner proteins, relatively little is known about the roles of coregulators in uterine development and early stages of pregnancy and implantation. Because conventional genetic deletion of the coregulator, repressor of e...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1044
更新日期:2012-08-01 00:00:00
abstract::We have previously described FSH receptor-mediated influx of 45Ca++ in cultured Sertoli cells from immature rats and receptor-enriched proteoliposomes via activation of voltage-sensitive and voltage-independent calcium channels. We have further shown that this effect of FSH does not require cholera toxin- or pertussis...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-128-6-2745
更新日期:1991-06-01 00:00:00
abstract::Hereditary vitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by mutations in the vitamin D receptor (VDR). We studied a young Saudi Arabian girl who exhibited the typical clinical features of HVDRR, but without alopecia. Analysis of her VDR gene revealed a homozygous T to C mutation in exon ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0080
更新日期:2004-11-01 00:00:00
abstract::Arginine vasopressin (AVP) stimulates the secretion of ACTH from pituitary corticotropes. We investigated the action of AVP in single corticotropes of male rats. Corticotropes were identified with the reverse hemolytic plaque assay using antibodies against ACTH. Using the whole-cell recording technique in conjunction ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.5.5999
更新日期:1998-05-01 00:00:00
abstract::Although cells of the osteoblast lineage express functional ERs, direct effects of estrogen on bone formation remain obscure. In the present study, we have investigated estrogen effects on osteoblastic and adipocytic differentiation from a mouse bone marrow stromal cell line, ST-2, which had been manipulated to overex...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.143.6.8854
更新日期:2002-06-01 00:00:00
abstract::Neuropeptide Y (NPY), a peptide synthesized in the hypothalamic arcuate nucleus, is implicated in the physiologic control of food intake and body weight. Because both genetic (e.g. in obese ob/ob mice) and acquired leptin deficiency (e.g. fasting in normal mice) increase hypothalamic NPY accumulation, and as leptin ad...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.5.6000
更新日期:1998-05-01 00:00:00
abstract::Studies were carried out to determine the actions of PRL on adrenocortical function in hypophysectomized female rats in the presence and absence of ACTH. PRL administration alone decreased 5 alpha-reductase activity but did not significantly affect the rates of corticosterone secretion or peripheral plasma corticoster...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-104-5-1299
更新日期:1979-05-01 00:00:00
abstract::We have studied the relationship between the levels of the alpha and beta subunit of TSH and alpha and TSH-beta mRNA content in pituitaries from euthyroid, short-term, and long-term hypothyroid mice and in various mouse TSH-secreting tumors. TSH, alpha, and TSH-beta were determined by specific radioimmunoassay. alpha ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-115-2-830
更新日期:1984-08-01 00:00:00
abstract::Circadian clocks have been described in each tissue of the hypothalamo-pituitary-ovarian axis. Although a role for the clock in the timing of ovulation is indicated, the impact of diseases that disrupt fertility on clock function or the clocks' role in the etiology of these pathologies has yet to be fully appreciated....
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-2066
更新日期:2013-04-01 00:00:00
abstract::The presence of multiple monomeric forms has been described for estrogen receptor (ER) in different target tissues. Using [3H]tamoxifen aziridine ([3H]TA) to covalently label ER and sodium dodecyl sulfate-polyacrylamide gel electrophoresis to analyze labeled products, ER forms were investigated in pituitary cytosol an...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.131.3.1505480
更新日期:1992-09-01 00:00:00
abstract::We have studied potential mechanisms by which zinc deficiency (ZD) may result in growth impairment in young animals. Dietary-induced ZD in young rats resulted in diminished skeletal growth as measured by tibial epiphyseal width. Treatment with bovine GH (bGH) did not increase skeletal growth suggesting GH resistance r...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-114-5-1860
更新日期:1984-05-01 00:00:00
abstract::Insulinopenic diabetes mellitus in the rat is associated with reduced circulating levels of insulin-like growth factor-I (IGF-I), resulting primarily from decreased IGF-I synthesis in liver and extrahepatic sites. Plasma GH levels in these animals are also suppressed, with loss of episodic secretion and decreased pitu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-128-2-923
更新日期:1991-02-01 00:00:00
abstract::The mouse mammary gland and uterus expressed the gene for the secretory protein lactotransferrin under various physiological conditions. Lactotransferrin, however, was induced by estrogen in a time- and dose-dependent fashion in the uterus of the immature mouse, but was not affected by estrogen in the mammary gland. D...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-2-992
更新日期:1989-02-01 00:00:00
abstract::Atrial natriuretic factor (ANF) was studied for its effect on renin release by rat renal cortical slices. ANF (rat) alone (10(-9)-10(-6) M) had no effect on basal renin release, but significantly (P less than 0.001) potentiated angiotensin II (AII) inhibition of renin secretion in doses as low as 10(-9) M. ANF also po...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-1-318
更新日期:1986-07-01 00:00:00
abstract::Mast cells are involved in atopic disorders, often exacerbated by stress, and are located perivascularly close to sympathetic and sensory nerve endings. Mast cells are activated by electrical nerve stimulation and millimolar concentrations of neuropeptides, such as substance P (SP). Moreover, acute psychological stres...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.1.5660
更新日期:1998-01-01 00:00:00
abstract::In the mouse, there is a large family of paralogous genes closely related to PRL. The objective of this report was to investigate the organization of the mouse PRL gene family locus. PRL family genes reside on chromosome 13 of the mouse genome. The PRL gene family members were localized to a series of overlapping bact...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220724
更新日期:2003-01-01 00:00:00
abstract::On the basis of our previous observations indicating that a principle [possibly transforming growth factor-beta1 (TGFbeta1)] secreted by type 1 astrocytes may increase the release of LHRH in the GT1 cell line, it was deemed of interest to analyze whether TGFbeta1 might influence LHRH gene expression in addition to LHR...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.12.8940390
更新日期:1996-12-01 00:00:00
abstract::A major issue of in the treatment of diabetes is the risk of hypoglycemia. Hypoglycemia is detected both centrally and peripherally in the porto-hepatic area. The portal locus for hypoglycemic detection was originally described using the "local irrigation of the liver" approach in a canine model. Further work using po...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1794
更新日期:2014-04-01 00:00:00
abstract::We evaluated the capacity of estradiol (E(2)) to regulate PTHrP production, cell growth, tumor growth, and metastasis to the skeleton in breast cancer. In estrogen receptor (ER)-negative human breast cancer cells, MDA-MB-231, and cells transfected with full-length cDNA encoding ER (S-30), E(2) caused a marked decrease...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0062
更新日期:2005-07-01 00:00:00
abstract::The hormonal control of the adipose conversion of 3T3 L1 cells was studied in a chemically defined medium and compared to that under serum-containing conditions. Addition of insulin to a chemically defined medium (Dulbecco's Modified Eagle's Medium-Ham's F-12, 1:1) resulted in a dose-dependent increase in glycero-3-ph...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-2-865
更新日期:1990-08-01 00:00:00
abstract::Naturally occurring and synthetic plant flavonoids, such as EMD 21388, are potent inhibitors of thyroid hormone 5'-deiodinase (5'-D) in vitro, but not when given in vivo, since they are tightly bound by serum transthyretin (TTR). EMD 21388 also inhibits the binding of T4 to human, dog, and rat serum TTR in vitro and w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-126-6-2890
更新日期:1990-06-01 00:00:00
abstract::Topiramate (TPM) treatment has been shown to reduce adiposity in humans and rodents. The reduction in adiposity is related to decreased food intake and increased energy expenditure. However, the molecular mechanisms through which TPM induces weight loss are contradictory and remain to be clarified. Whether TPM treatme...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1272
更新日期:2012-09-01 00:00:00
abstract::A primary culture system has been established for rainbow trout corpuscles of Stannius (CS). A RIA has also been developed to monitor and characterize the teleocalcin secreted by these cultures. The primary cultured CS cells actively synthesized and secreted teleocalcin for up to 39 days when maintained in amphibian a...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-123-2-913
更新日期:1988-08-01 00:00:00
abstract::Regulation of the lactogen specific binding sites of rat liver was studied in several different high lactogen states. The specific binding of [125I]iodo-hGH was determined as a measure of these sites. Hypophysectomy of pregnant rats produced a much smaller decrease in hepatic binding of [125I]iodo-hGH than was seen in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-99-5-1168
更新日期:1976-11-01 00:00:00
abstract::In mammals, the brain-specific protein munc18-1 regulates synaptic vesicle exocytosis at the synaptic junction, in a step before vesicle fusion. We hypothesize that the rate of biosynthesis of munc18-1 messenger RNA (mRNA) and the amount of munc18-1 present in neurons and neuroendocrine cells are related to the physio...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.5.8131
更新日期:2001-05-01 00:00:00
abstract::Ghrelin is a growth hormone-releasing peptide recently discovered in the stomach of rat and human as an endogenous ligand for growth hormone-secretagogue receptor. In the present study, a full-length cDNA for mouse ghrelin has been cloned from the stomach using the oligo-capping and rapid amplification methods, and th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.8.8433
更新日期:2001-08-01 00:00:00
abstract::Primary kidney cell cultures from normal rhesus monkeys were used to study the regulation of 24,25-dihydroxyvitamin D3 production. Kidney cells were grown to confluency in the modified National Cancer Institute Medium NCTC 135 with 2% fetal calf serum and then maintained in a serum-free medium (2% bovine serum albumin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-101-4-1184
更新日期:1977-10-01 00:00:00
abstract::In the bovine ovary, thecal cells are the only cell type capable of expressing the CYP17 gene in response to LH. With the onset of ovulation and luteinization in the cow, there is complete loss of P450c17alpha expression. To characterize the molecular mechanisms involved in tissue-specific regulation of the CYP17 gene...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.5.5112
更新日期:1997-05-01 00:00:00
abstract::During the third week of postnatal life, dramatic ontogenic changes occur in the morphology and enzymology of the small intestine of the infant rat, enabling the animal to make the transition from milk to solid food. To investigate the roles of T4 and GH in regulation of these changes, infant rats were hypophysectomiz...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-3-1417
更新日期:1991-09-01 00:00:00
abstract::We have investigated the possibility that IGF-1 may play a role in the regulation of antler development. Plasma IGF-1 concentrations were measured throughout the first period of development of the pedicle and first antler of red deer (Cervus elaphus) to determine whether a relationship existed between growth of antler...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-116-2-846
更新日期:1985-02-01 00:00:00