Methylamine and monensin do not block insulin internalization but do influence the intracellular distribution and action of insulin in pancreatic acini from diabetic mice.

abstract：:Tumor necrosis factor-alpha (TNF) and interleukin-1 beta (IL-1) are secreted by activated monocytes and other immune cells. Since IL-1 has been shown to elevate rat plasma ACTH and both of these cytokines induce similar acute-phase responses, the present studies of TNF were undertaken to characterize the ACTH response...

journal_title：Endocrinology

authors： Sharp BM,Matta SG,Peterson PK,Newton R,Chao C,Mcallen K

更新日期：1989-06-01 00:00:00

abstract：:It has been shown that acute administration of interleukin-1 (IL-1) to rats elicits a transitory increase in plasma ACTH and corticosterone (B) levels. To investigate the effects of chronic administration of IL-1 on plasma ACTH and B levels, in the present study rats were equipped with Alzet osmotic minipumps loaded w...

journal_title：Endocrinology

authors： Sweep CG,van der Meer MJ,Hermus AR,Smals AG,van der Meer JW,Pesman GJ,Willemsen SJ,Benraad TJ,Kloppenborg PW

更新日期：1992-03-01 00:00:00

abstract：:In a previous study we found that PTH stimulated bone resorption and release of insulin-like growth factor-I (IGF-I) and IGF-II from cultured neonatal mouse calvaria. Since IGF-I and IGF-II stimulate osteoblast proliferation and collagen synthesis, these results suggested that increased release of IGFs during resorpti...

journal_title：Endocrinology

authors： Linkhart TA,Keffer MJ

更新日期：1991-03-01 00:00:00

abstract：:The metabolic consequences of visceral obesity have been associated with amplification of glucocorticoid action by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in adipose tissue. This study aimed to assess in a rat model of diet-induced obesity the effects of pharmacological 11beta-HSD1 inhibition on the m...

journal_title：Endocrinology

authors： Berthiaume M,Laplante M,Festuccia W,Gélinas Y,Poulin S,Lalonde J,Joanisse DR,Thieringer R,Deshaies Y

更新日期：2007-05-01 00:00:00

abstract：:These experiments queried the potential for developmental change in the positive and negative feedback sensitivities of LH secretion to estradiol. Serum LH levels were compared in juvenile, peripubertal, and adult female mice after ovariectomy and challenge with a variety of 4-day steroid treatments. Since male stimul...

journal_title：Endocrinology

authors： Bronson FH

更新日期：1981-02-01 00:00:00

abstract：:The effects of hypophysectomy and GH on blood pressure and renin secretion were studied. Within 2 weeks after removal of the pituitary gland of rats, mean arterial blood pressure declined 30%, and heart rate fell 50%. No significant effect of hypophysectomy on blood volume or hematocrit was noted. Within 2 h after the...

journal_title：Endocrinology

authors： Honeyman TW,Goodman HM,Fray JC

更新日期：1983-05-01 00:00:00

abstract：:Previous studies from our laboratory have demonstrated that epidermal growth factor (EGF), induces intracellular alkalinization in chicken granulosa cells by activating a sodium-dependent and amiloride-sensitive Na+/H+ antiporter. In the present investigation we have examined the possible involvement of protein kinase...

journal_title：Endocrinology

authors： Li M,Morley P,Tsang BK

更新日期：1991-12-01 00:00:00

abstract：:Potassium deficiency produced by feeding mice a low potassium diet caused a marked decrease in plasma and testicular testosterone concentrations and a concomitant fall in the weight of seminal vesicles and in renal ornithine decarboxylase activity. All of these parameters were rapidly restored when potassium supply wa...

journal_title：Endocrinology

authors： Sánchez-Capelo A,Castells MT,Cremades A,Peñafiel R

更新日期：1996-09-01 00:00:00

abstract：:Insulin receptors were measured in cultured Zajdela rat hepatoma cells (ZHC cells), a stable cell line which presents differentiated hepatic functions. The number of sites was 50,000/cell at 2 C, and the dissociation constant for high affinity binding was 1.6 x 10(-10) M. Down-regulation of receptors occurred rapidly ...

journal_title：Endocrinology

authors： Capeau J,Flaig-Staedel C,Beck JP,Picard J

更新日期：1982-09-01 00:00:00

abstract：:The antigenic epitopes of human GH (hGH) have been investigated using monoclonal antibodies (Mabs) to hGH. A panel of 12 Mabs was incorporated into two-site binding assays in order to investigate the antigenic surface of hGH. Nine reaction patterns were observed. The Mabs were further characterized in terms of their c...

journal_title：Endocrinology

authors： Strasburger CJ,Kostyo J,Vogel T,Barnard GJ,Kohen F

更新日期：1989-03-01 00:00:00

abstract：:Type 1 transforming growth factor-beta (TGF beta 1) was found to be a potent inducer of the secretion of a 49,000 mol wt protein by normal rat kidney (NRK) cells. This protein was related to type 1 plasminogen activator inhibitor (PAI-1) on the basis of molecular mass, activity in the presence of sodium dodecyl sulfat...

journal_title：Endocrinology

authors： Newman MJ,Lane EA,Iannotti AM,Nugent MA,Pepinsky RB,Keski-Oja J

更新日期：1990-06-01 00:00:00

abstract：:Bovine placental lactogen (bPL) was found to be as potent as human GH (hGH) in its ability to bind to soluble full-size recombinant hGH-binding protein (hGHBP) and to membrane-embedded hGH receptor in intact IM-9 human lymphocytes. bPL was also capable of forming a 1:2 complex with hGHBP, although the structure of thi...

journal_title：Endocrinology

authors： Vashdi-Elberg D,Staten NR,Sakal E,Krivi GG,Gertler A

更新日期：1995-03-01 00:00:00

abstract：:Hypoxia and biological responses to hypoxia are commonly encountered in both normal and pathologic cellular processes. Here we report that extracellular superoxide dismutase (EC-SOD) plays a major role in regulating the magnitude of hypoxia-induced erythropoietin (Epo) gene expression, thus implicating superoxide as a...

journal_title：Endocrinology

authors： Zelko IN,Folz RJ

更新日期：2005-01-01 00:00:00

abstract：:Mature male rat liver cytosol contains a moderate affinity and capacity estrogen-binding protein in at least a 200-fold higher level than mature female or immature male rat liver cytosol. Binding of estradiol to this protein is very rapid, is stabilized by EDTA, and is inhibited by divalent cations. This is the major ...

journal_title：Endocrinology

authors： Dickson RB,Aten RF,Eisenfeld AJ

更新日期：1978-11-01 00:00:00

abstract：:Childhood obesity increases the risk of adult obesity and diabetes, suggesting that early overnutrition permanently programs altered energy and glucose homeostasis. In the present studies, we used a mouse model to investigate whether early overnutrition increases susceptibility to obesity and insulin resistance in res...

journal_title：Endocrinology

authors： Glavas MM,Kirigiti MA,Xiao XQ,Enriori PJ,Fisher SK,Evans AE,Grayson BE,Cowley MA,Smith MS,Grove KL

更新日期：2010-04-01 00:00:00

abstract：:Neurotensin (NT) and Neuromedin N (NN) are two biologically active peptides present in one copy each in the C-terminal region of a 169-residue precursor. Four basic Lys-Arg doublets occur within the precursor and represent putative processing sites. We investigated the effects of dexamethasone on the biosynthesis and ...

journal_title：Endocrinology

authors： de Nadai F,Rovere C,Bidard JN,Laur J,Martinez J,Cuber JC,Kitabgi P

更新日期：1993-04-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF alpha) is a growth regulatory polypeptide factor that is expressed by several prostatic tumor cell lines. In this investigation, we examined whether TGF alpha is expressed during morphogenesis of the rat prostate gland. We first examined whether the prostate gland expressed TGF al...

journal_title：Endocrinology

authors： Taylor TB,Ramsdell JS

更新日期：1993-09-01 00:00:00

abstract：:Prolactin (PRL) is an immunomodulatory hormone which promotes T-cell activation and proliferation. However, the intracellular mechanisms of this action in normal lymphocytes are unknown. Because the PRL receptor (PRLR) activates several signals also activated by the T-cell antigen receptor (TCR)/CD3 complex, we evalua...

journal_title：Endocrinology

authors： Montgomery DW,Krumenacker JS,Buckley AR

更新日期：1998-02-01 00:00:00

abstract：:Kisspeptin (encoded by the Kiss1 gene) is an important regulator of reproduction. In rodents, Kiss1 is expressed in two hypothalamic regions, the arcuate nucleus and anteroventral periventricular/ periventricular continuum, where it is regulated by sex steroids. However, the distribution, regulation, and functional si...

journal_title：Endocrinology

authors： Kim J,Semaan SJ,Clifton DK,Steiner RA,Dhamija S,Kauffman AS

更新日期：2011-05-01 00:00:00

abstract：:Localized expression of cytochromes P450 17 alpha-hydroxylase (P450c17) and aromatase (P450arom) was investigated in embryonic cell layers of elongating porcine blastocysts by immunocytochemistry. Blastocysts were flushed from the uterus on day 12 of pregnancy, fixed in paraformaldehyde, embedded in paraffin, sectione...

journal_title：Endocrinology

authors： Conley AJ,Christenson LK,Ford SP,Christenson RK

更新日期：1994-12-01 00:00:00

abstract：:Removal of fetuses at day 14 of gestation (Ftx14) in the pregnant rat leads to a marked suppression of serum levels of rat placental lactogen (rPL-II). One might attribute this to compromised placental growth in the absence of a fetus. However, if ovariectomy and fetectomy (Ftx14 Ovx14) are carried out at the same tim...

journal_title：Endocrinology

authors： Robertson MC,Owens RE,McCoshen JA,Friesen HG

更新日期：1984-01-01 00:00:00

abstract：:17α-Ethinyl estradiol (EE), a synthetic analog of natural estrogen 17β-estradiol (E2), is extensively used in hormonal contraceptives and estrogen replacement therapy, and it has also been found in sewage effluents. Given that E2 is a well-known immunomodulator, surprisingly there has been only limited information on ...

journal_title：Endocrinology

authors： Dai R,Edwards MR,Heid B,Ahmed SA

更新日期：2019-01-01 00:00:00

abstract：:Calcitonin (CT) and related peptides, such as CT gene-related peptide and salmon CT (sCT)-like peptide, are present in the rat nervous system and the pituitary gland, and sCT markedly inhibits basal and TRH-stimulated PRL release from anterior pituitary (AP) cells. Because TRH-induced PRL release is known to involve i...

journal_title：Endocrinology

authors： Shah GV,Kennedy D,Dockter ME,Crowley WR

更新日期：1990-08-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25-(OH)2D3] and 24,25-(OH)2D3 differentially affect the specific activity of alkaline phosphatase (ALPase) and phospholipase-A2 (PLA2) of plasma membranes and extracellular matrix vesicles produced by costochondral reserve zone and growth zone cartilage chondrocytes in culture. In the prese...

journal_title：Endocrinology

authors： Schwartz Z,Schlader DL,Swain LD,Boyan BD

更新日期：1988-12-01 00:00:00

abstract：:The effect of an activator of protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA), on the 5'-deiodinase (5'D) activity was studied in rat astroglial cells cultured in chemically defined medium. TPA promoted a large increase in the type II 5'D activity, which was maximal 5-10 h after addition of TPA and then d...

journal_title：Endocrinology

authors： Courtin F,Chantoux F,Gavaret JM,Toru-Delbauffe D,Jacquemin C,Pierre M

更新日期：1989-09-01 00:00:00

abstract：:We have recently demonstrated that GnRH-stimulated gonadotropin secretion is augmented by coadministration with neuropeptide-Y (NPY) in anterior pituitaries removed in the afternoon from proestrous, but not metestrous, rats. To test the hypothesis that these effects of NPY are due to an interaction with progesterone (...

journal_title：Endocrinology

authors： Knox KL,Bauer-Dantoin AC,Levine JE,Schwartz NB

更新日期：1995-01-01 00:00:00

abstract：:Regulation of the lactogen specific binding sites of rat liver was studied in several different high lactogen states. The specific binding of [125I]iodo-hGH was determined as a measure of these sites. Hypophysectomy of pregnant rats produced a much smaller decrease in hepatic binding of [125I]iodo-hGH than was seen in...

journal_title：Endocrinology

authors： Posner BI

更新日期：1976-11-01 00:00:00

abstract：:Male Sprague-Dawley rats were infused continuously for 13 days with vehicle or 75 pmol (31.2 ng)/day 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] by means of Alzet osmotic minipumps implanted s.c. Animals infused with 1,25-(OH)2D3 exhibited mild hypercalcemia (11.2 vs. 10.2 mg/dl in controls), a 136% increase in the serum ...

journal_title：Endocrinology

authors： Wronski TJ,Halloran BP,Bikle DD,Globus RK,Morey-Holton ER

更新日期：1986-12-01 00:00:00

abstract：:Actions of protein products resulting from alternative splicing of the Igf1 gene have received increasing attention in recent years. However, the significance and functional relevance of these observations remain poorly defined. To address functions of IGF-I splice variants, we examined the impact of loss of IGF-IEa a...

journal_title：Endocrinology

authors： Matheny RW Jr,Nindl BC

更新日期：2011-05-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), the principal IGF in adult rat serum, occurs complexed to specific binding proteins. After fractionation of serum on Sephadex G-200 at neutral pH, 62% of the immunoreactive IGF-I is recovered in the 150K region, 38% in the 40K region, and none is present as free 7.5K IGF-I. Adult ...

journal_title：Endocrinology

authors： Yang YW,Wang JF,Orlowski CC,Nissley SP,Rechler MM

更新日期：1989-09-01 00:00:00