Mechanism of action of l-CDB-4022, a potential nonhormonal male contraceptive, in the seminiferous epithelium of the rat testis.

abstract：:Estrogen unresponsiveness among primate species can result from overexpression of a heterogeneous nuclear ribonucleoprotein (hnRNP) that competes with estrogen receptor (ER) for binding to the estrogen-response element (ERE). This hnRNP has been coined the "ERE-binding protein" (ERE-BP). The ERE-BP is a member of the ...

journal_title：Endocrinology

authors： Chen H,Stuart W,Hu B,Nguyen L,Huang G,Clemens TL,Adams JS

更新日期：2005-10-01 00:00:00

abstract：:Changes in serum and pituitary LH and FSH concentrations have been measured in the newborn male rat before, during, and up to 24 h after birth. A sudden and transient increase of serum and pituitary gonadotropins is observed at birth, which is followed by a rapid increase of absolute and relative testicular weights be...

journal_title：Endocrinology

authors： Corbier P,Kerdelhue B,Picon R,Roffi J

更新日期：1978-12-01 00:00:00

abstract：:Five studies are reported which were designed to define the effects of an estrogen and a progestogen, alone and in combination, on tissue concentrations (heart, kidney, and liver) of two trace metals (zinc, copper) and four bulk cations (sodium, potassium, calcium, magnesium). Male rats received Premarin (0.08 mg) and...

journal_title：Endocrinology

authors： Yunice AA,Lindeman RD

更新日期：1975-11-01 00:00:00

abstract：:In the present study we have used a high affinity photoaffinity label (PAL) agonist (pGlu-His-Trp-Ser-125I-iodoTyr-D-Lys(para-N3-Benzoyl)-Leu-Arg-P roNHEt) and a PAL antagonist (NAcD2Nal-D4ClPhe-D3Pal-Ser-125I-iodo-NMeTyr-D-L ys(para-N3-Benzoyl)Leu-Lys(Isp) - Pro-D-Ala-NH2) to covalently label the GnRH receptor. Rat p...

journal_title：Endocrinology

authors： Janovick JA,Haviv F,Fitzpatrick TD,Conn PM

更新日期：1993-08-01 00:00:00

abstract：:Carboxypeptidase H (CP-H, EC 3.4.17.10) removes C-terminal basic amino acids from insulin and many other peptide hormone intermediates in endocrine and neural tissues. CP-H was studied in two rat insulinoma-derived clonal beta-cell lines that were chosen in part because their profile of hormone production is restricte...

journal_title：Endocrinology

authors： Fiedorek FT Jr,Parkinson D

更新日期：1992-09-01 00:00:00

abstract：:Women with polycystic ovary syndrome (PCOS) and hyperandrogenism have altered hormone levels and suffer from ovarian dysfunction leading to subfertility. We have attempted to generate a model of hyperandrogenism by feeding mice chow supplemented with dehydroepiandrosterone (DHEA), an androgen precursor that is often e...

journal_title：Endocrinology

authors： Jimenez PT,Frolova AI,Chi MM,Grindler NM,Willcockson AR,Reynolds KA,Zhao Q,Moley KH

更新日期：2013-12-01 00:00:00

abstract：:TRH is a potent stimulator of pituitary TSH release, but its function in the physiological regulation of thyroid activity is still controversial. The purpose of the present study was to investigate TRH and catecholamine secretion into hypophysial portal blood of hypothyroid and hyperthyroid rats, and in rats bearing p...

journal_title：Endocrinology

authors： Rondeel JM,de Greef WJ,van der Schoot P,Karels B,Klootwijk W,Visser TJ

更新日期：1988-07-01 00:00:00

abstract：:The amount of corticosterone bound to proteins in the adenohypophysis and dorsal hippocampus was studied concurrently with the plasma ACTH concentration in 4-week adrenalectomized male rats under steady-state conditions achieved by infusing the steroid at a constant rate for 45 min. Corticosterone binding was measured...

journal_title：Endocrinology

authors： Rotsztejn WH,Normand M,Lalonde J,Fortier C

更新日期：1975-07-01 00:00:00

abstract：:Methylamine and monensin are two agents known to interfere with the recycling of membrane receptors. In the present investigation, we studied their effects on the binding, intracellular distribution, and action of insulin in isolated pancreatic acini prepared from diabetic mice. These drugs had several similar effects...

journal_title：Endocrinology

authors： Potau N,Bailey AC,Roach E,Williams JA,Goldfine ID

更新日期：1984-07-01 00:00:00

abstract：:It has been suggested that ewes carrying the Booroola gene (Fec(B)) consistently ovulate more follicles because they recruit more primordial follicles and/or have a lower rate of atresia. If the former is correct, the pool of follicles would be depleted sooner in Fec(B) animals. We have studied follicular dynamics and...

journal_title：Endocrinology

authors： Gonzalez-Bulnes A,Souza CJ,Campbell BK,Baird DT

更新日期：2004-06-01 00:00:00

abstract：:The effect of amino acid substitutions introduced to the third alpha-helix in bovine GH (bGH) was investigated. A GH analog (bGH-M8), in which three amino acids were substituted to form an idealized amphiphilic alpha-helix, possessed the same specific binding affinity as wild-type bGH to cell membranes prepared from 3...

journal_title：Endocrinology

authors： Okada S,Chen WY,Wiehl P,Kelder B,Goodman HM,Guller S,Sonenberg M,Kopchick JJ

更新日期：1992-04-01 00:00:00

abstract：:The mechanisms underlying the glucose dependence of arginine vasopressin (AVP)-stimulated insulin secretion were examined in a hamster insulin-secreting cell line (HIT cells). At 1.67 mM glucose, 100 nM AVP stimulated biphasic changes in free cytosolic Ca2+ ([Ca2+]i) and insulin secretion. The initial spike of [Ca2+]i...

journal_title：Endocrinology

authors： Lu M,Soltoff SP,Yaney GC,Boyd AE 3rd

更新日期：1993-05-01 00:00:00

abstract：:We evaluated the capacity of estradiol (E(2)) to regulate PTHrP production, cell growth, tumor growth, and metastasis to the skeleton in breast cancer. In estrogen receptor (ER)-negative human breast cancer cells, MDA-MB-231, and cells transfected with full-length cDNA encoding ER (S-30), E(2) caused a marked decrease...

journal_title：Endocrinology

authors： Rabbani SA,Khalili P,Arakelian A,Pizzi H,Chen G,Goltzman D

更新日期：2005-07-01 00:00:00

abstract：:The issue of how progesterone affects mammary gland growth is controversial, and the mechanism governing the effects of the hormone remains mostly unknown. We have previously shown that G protein-coupled receptor 30 (GPR30) is a progestin target gene whose expression correlates with progestin-induced growth inhibition...

journal_title：Endocrinology

authors： Ahola TM,Manninen T,Alkio N,Ylikomi T

更新日期：2002-09-01 00:00:00

abstract：:The activin/follistatin system is implicated in growth and differentiation of various cell types. Follistatin (FS), through binding and neutralizing activin, plays a major role in the regulation of activin bioavailability. We previously reported that ovarian PA1 cells constitutively secrete FS and show a decreased pro...

journal_title：Endocrinology

authors： Delbaere A,Sidis Y,Schneyer AL

更新日期：1999-06-01 00:00:00

abstract：:Pancreatic beta-cells and HIT-T15 cells exhibit oscillations of cytosolic calcium ([Ca2+]i) that are dependent on glucose metabolism and appear to trigger pulsatile insulin secretion. Significantly, differences in the pattern of this [Ca2+]i oscillatory activity may have important implications for our understanding of...

journal_title：Endocrinology

authors： Leech CA,Holz GG 4th,Habener JF

更新日期：1994-07-01 00:00:00

abstract：:A novel class of targeted chemotherapeutic agents based on cytotoxic compounds linked to LHRH analogs was tested in a long term superfusion system in order to determine their effects on different types of rat pituitary cells. The compounds investigated included two cytotoxic LHRH agonists, T-98 ([D-Lys6]LHRH coupled t...

journal_title：Endocrinology

authors： Rékási Z,Szöke B,Nagy A,Groot K,Rékási ES,Schally AV

更新日期：1993-05-01 00:00:00

abstract：:In the present study, we investigated the role of the multidrug resistance (mdr) P-glycoprotein (Pgp) at the blood-brain barrier in the control of access of cortisol and corticosterone to the mouse and human brain. [(3)H]Cortisol poorly penetrated the brain of adrenalectomized wild-type mice, but the uptake was 3.5-fo...

journal_title：Endocrinology

authors： Karssen AM,Meijer OC,van der Sandt IC,Lucassen PJ,de Lange EC,de Boer AG,de Kloet ER

更新日期：2001-06-01 00:00:00

abstract：:Relaxin was localized in cells of corpora lutea of pregnant rats at the ultrastructural level using a highly specific antirat relaxin serum and the unlabeled peroxidase-antiperoxidase technique. Electron-dense, membrane-bound granules (maximum diameter, 270 nm), which are present in luteal cells during the last third ...

journal_title：Endocrinology

authors： Anderson MB,Sherwood OD

更新日期：1984-04-01 00:00:00

abstract：:Japanese quail, a species with a precocial pattern of development, were used as a model for studying the ontogeny of thyroid responses to TSH. Thiourea was administered to embryos early in incubation, and the effects were assessed by measuring thyroid 32P uptake, serum thyroid hormones, thyroid weights, and body weigh...

journal_title：Endocrinology

authors： McNabb FM,Stanton FW,Weirich RT,Hughes TE

更新日期：1984-04-01 00:00:00

abstract：:In the ovarian follicle, oocyte-secreted factors induce cumulus-specific genes and repress mural granulosa cell specific genes to establish these functionally distinct cell lineages. The mechanism establishing this precise morphogenic pattern of oocyte signaling within the follicle is unknown. The present study invest...

journal_title：Endocrinology

authors： Watson LN,Mottershead DG,Dunning KR,Robker RL,Gilchrist RB,Russell DL

更新日期：2012-09-01 00:00:00

abstract：:Molecular size heterogeneities of PRL and GH in mice of the high mammary tumor C3H/St strain and low mammary tumor C57BL/St strain were compared under different physiological states. At least three size variants, the big (void volume), the intermediate (dimeric), and the little (monomeric) forms, of both hormones were...

journal_title：Endocrinology

authors： Sinha YN

更新日期：1980-12-01 00:00:00

abstract：:Insulin-like growth factor (IGF) action in the brain is modulated by IGF-binding proteins (IGFBPs) whose abundance can be altered by other locally expressed growth factors. However, the mechanisms involved are unclear. We here employed the neuroblastoma cell line SK-N-MC as a model to define the mechanisms involved in...

journal_title：Endocrinology

authors： Russo VC,Rekaris G,Baker NL,Bach LA,Werther GA

更新日期：1999-07-01 00:00:00

abstract：:Angiotensin II (Ang II) is one of numerous hormones recently shown to be synthesized and secreted by adipose cells. Although the function of Ang II in adipose tissue is unknown, several studies indirectly suggest that it may be involved in control of adiposity. Little is known, however, about direct actions of Ang II ...

journal_title：Endocrinology

authors： Jones BH,Standridge MK,Moustaid N

更新日期：1997-04-01 00:00:00

abstract：:Embryonic poly(A)-binding protein (EPAB) is the predominant poly(A)-binding protein in Xenopus, mouse, and human oocytes and early embryos before zygotic genome activation. EPAB is required for translational activation of maternally stored mRNAs in the oocyte and Epab(-/-) female mice are infertile due to impaired ooc...

journal_title：Endocrinology

authors： Yang CR,Lowther KM,Lalioti MD,Seli E

更新日期：2016-01-01 00:00:00

abstract：:Studies were performed to determine whether the postovulatory secretion of FSH in the rabbit is an LHRH-mediated event. Does were mated and then injected at 12 and 18 h postcoitum with pentobarbital (30 mg/kg BW), an agent known to block endogenous LHRH release. The injection of this barbiturate had no measurable effe...

journal_title：Endocrinology

authors： Mills TM,Copland JA,Coy DH,Schally AV

更新日期：1983-09-01 00:00:00

abstract：:The mechanism of the hypophosphatemic effect of thyrocalcitonin (TCT) is uncertain and may involve removal of inorganic phosphate (P1) from the plasma by heretofore unidentified organs. Rats, 192 g. thyroparathyroidectomized 16-24 h earlier, received 100 MRC mU TCT or vehicle (V) SC and 100 muCi 32PO4 iv. One h later ...

journal_title：Endocrinology

authors： Meyer RA Jr,Meyer MH

更新日期：1975-04-01 00:00:00

abstract：:Cytochrome P450 enzymes catalyze the degradation of drugs and xenobiotics, but also catalyze a wide variety of biosynthetic processes, including most steps in steroidogenesis. The catalytic rate of a P450 enzyme is determined in large part by the rate of electron transfer from its redox partners. Type I P450 enzymes, ...

journal_title：Endocrinology

authors： Miller WL

更新日期：2005-06-01 00:00:00

abstract：:This study examined the requirement for 17 beta-estradiol (E) and relaxin (R) during the preparturient period (approximately the last 30 h of gestation) for normal parturition and pup survival in the rat. On the evening of day 21 of pregnancy, primiparous Sprague-Dawley rats were bilaterally ovariectomized or sham ope...

journal_title：Endocrinology

authors： Cheah SH,Sherwood OD

更新日期：1988-05-01 00:00:00

abstract：:To determine the effect of aromatase inhibitors on peripheral aromatization, male rhesus monkeys were infused with [7-3H]androstenedione and [4-14C]estrone before and during treatment with 4-hdyroxy-androstene-3,17-dione (50 mg/kg each; four monkeys) or 4-acetoxy-androstene-3,17-dione (700 mg each; two monkeys). In al...

journal_title：Endocrinology

authors： Brodie AM,Longcope C

更新日期：1980-01-01 00:00:00