Iodothyronine 5'-deiodinase activity in cultured rat myocardial cells: characteristics and effects of triiodothyronine and angiotensin II.

abstract：:Oxytocin plays a pivotal role in rat parturition, acting within the brain to facilitate its own release in the supraoptic nucleus (SON) and paraventricular nucleus, and to stimulate maternal behavior. We investigated oxytocin receptor (OTR) expression and activation perinatally. Using a (35)S-labeled riboprobe complem...

journal_title：Endocrinology

authors： Meddle SL,Bishop VR,Gkoumassi E,van Leeuwen FW,Douglas AJ

更新日期：2007-10-01 00:00:00

abstract：:Both somatostatin (SRIF) and urotensin II, a dodecapeptide from the teleost caudal neurosecretory system, inhibit PRL release from the organ-cultured rostral pars distalis of the tilapia, Sarotherodon mossambicus, in a dose-related manner. The inhibitory action of SRIF on PRL release was completely prevented by the pr...

journal_title：Endocrinology

authors： Grau EG,Nishioka RS,Bern HA

更新日期：1982-03-01 00:00:00

abstract：:One of the hypotheses attempting to explain the etiology of the human disease X-linked hypophosphatemia (XLH) posits renal hypersensitivity to parathyroid hormone (PTH). These studies were designed to test this hypothesis in vivo, using the hemizygous hypophosphatemic (Hyp/Y) mouse as an animal model for XLH. Vehicle ...

journal_title：Endocrinology

authors： Kiebzak GM,Meyer RA Jr

更新日期：1982-03-01 00:00:00

abstract：:The peroxisome proliferator-activated receptor-gamma (PPARgamma) transcription factor plays a pivotal role in adipocyte differentiation and metabolic regulation. The transcriptional activity of PPARgamma is positively modulated by ligand binding and negatively regulated by phosphorylation mediated by the MEK/ERK signa...

journal_title：Endocrinology

authors： Camp HS,Tafuri SR,Leff T

更新日期：1999-01-01 00:00:00

abstract：:The brain has traditionally been considered to be a target site of peripheral steroid hormones. By contrast, new findings over the past decade have shown that the brain itself also has the capability of forming steroids de novo, the so-called neurosteroids. De novo neurosteroidogenesis in the brain from cholesterol is...

journal_title：Endocrinology

authors： Tsutsui K

更新日期：2008-06-01 00:00:00

abstract：:Benign prostatic hyperplasia (BPH) is an age-related debilitating prostatic disease that is frequently associated with prostatic inflammation and bothersome lower urinary tract symptoms (LUTS). Animal models have shown that formalin- and bacterial-induced prostatic inflammation can induce bladder dysfunction; however,...

journal_title：Endocrinology

authors： Pascal LE,Mizoguchi S,Chen W,Rigatti LH,Igarashi T,Dhir R,Tyagi P,Wu Z,Yang Z,de Groat WC,DeFranco DB,Yoshimura N,Wang Z

更新日期：2021-01-01 00:00:00

abstract：:Sodium butyrate (NaB), a dietary micronutrient, is a potent growth inhibitor that initiates cell differentiation in many cell types, including prostate cancer cells. The molecular mechanisms by which these effects occur remain largely unknown. In this study, we investigated the effects of NaB on the expression of IGF ...

journal_title：Endocrinology

authors： Tsubaki J,Hwa V,Twigg SM,Rosenfeld RG

更新日期：2002-05-01 00:00:00

abstract：:Angiotensin II binds to the angiotensin II receptors type 1 (AT1 receptors) in adrenocortical cells and triggers an intracellular signaling cascade leading to changes in the gene expression pattern. Here, we show that stimulation with angiotensin II induces the expression of biologically active early growth response (...

journal_title：Endocrinology

authors： Thiel G,Rössler OG

更新日期：2011-11-01 00:00:00

abstract：:Studies on hormone-receptor interactions generally assume that the formation of a hormone-receptor complex is a reversible process. This assumption has been examined directly in three experiments using liver membrane receptor preparations from pregnant rats and ovine PRL (oPRL). In Exp 1, Receptors were preincubated w...

journal_title：Endocrinology

authors： van der Gugten AA,Waters MJ,Murthy GS,Friesen HG

更新日期：1980-01-01 00:00:00

abstract：:Modulation of activin and other TGF beta superfamily signaling is the primary mechanism of action for both follistatin (FS) and FS-like 3 (FSTL-3). However, most studies of these ligands use activin A due to its wide availability. We have now tested the ability of FS288 and FSTL-3 to bind and neutralize activin B rela...

journal_title：Endocrinology

authors： Schneyer A,Schoen A,Quigg A,Sidis Y

更新日期：2003-05-01 00:00:00

abstract：:Primary ovarian insufficiency (POI) resulting from ovarian autoimmunity is a poorly understood clinical condition lacking in effective treatments. Understanding the targets of the autoimmune response and induction of ovarian-specific tolerance would allow development of focused therapies to preserve fertility in an at...

journal_title：Endocrinology

authors： Otsuka N,Tong ZB,Vanevski K,Tu W,Cheng MH,Nelson LM

更新日期：2011-06-01 00:00:00

abstract：:Pulmonary alveolar type 2 cells act as a reservoir of stem cells which can be induced to proliferate during periods of lung growth and repair after lung injury. Despite the importance of this process, the mechanisms that regulate type 2 cell proliferation have not been well characterized. We show in this study that in...

journal_title：Endocrinology

authors： Mouhieddine OB,Cazals V,Maitre B,Le Bouc Y,Chadelat K,Clement A

更新日期：1994-07-01 00:00:00

abstract：:Apoptosis is a physiological process by which multicellular organisms eliminate unwanted cells. Death factors such as Fas ligand induce apoptosis by triggering a series of intracellular protein-protein interactions mediated by defined motifs found in the signaling molecules. One of these motifs is the death effector d...

journal_title：Endocrinology

authors： Leo CP,Hsu SY,McGee EA,Salanova M,Hsueh AJ

更新日期：1998-12-01 00:00:00

abstract：:Angiotensin II and extracellular potassium stimulate aldosterone production in adrenal glomerulosa cells by mobilizing the calcium messenger system. This response requires calcium influx across the plasma membrane, followed by calcium uptake into the mitochondria. It has been proposed that calcium is transported to th...

journal_title：Endocrinology

authors： Lalevée N,Resin V,Arnaudeau S,Demaurex N,Rossier MF

更新日期：2003-10-01 00:00:00

abstract：:Marked development of the mammary parenchyma (ducts, lobules, and alveoli) occurs during the last third of the 115-day gestation period in the gilt. These changes in the mammary gland are temporally correlated with elevated blood levels of relaxin, estrogen, and progesterone. We recently demonstrated that relaxin play...

journal_title：Endocrinology

authors： Winn RJ,Baker MD,Merle CA,Sherwood OD

更新日期：1994-09-01 00:00:00

abstract：:Myocardial fibrosis is a key pathological change in a variety of heart diseases contributing to the development of heart failure, arrhythmias, and sudden death. Recent studies have shown that relaxin prevents and reverses cardiac fibrosis. Endogenous expression of relaxin was elevated in the setting of heart disease; ...

journal_title：Endocrinology

authors： Gu HP,Lin S,Xu M,Yu HY,Du XJ,Zhang YY,Yuan G,Gao W

更新日期：2012-08-01 00:00:00

abstract：:Vascularly perfused duodenal loops from normal vitamin D-replete chicks were used to obtain insight with regards to the possible mechanism(s) by which 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3] rapidly stimulates intestinal Ca2+ transport (transcaltachia). The phorbol ester, 12-o-tetradecanoyl phorbol-13 acetate (TPA) (1...

journal_title：Endocrinology

authors： de Boland AR,Norman A

更新日期：1990-07-01 00:00:00

abstract：:Relaxin is a naturally occurring regulator of collagen turnover. In this study, we determined the role of endogenous relaxin in the pathogenesis of primary tubulointerstitial fibrosis after unilateral ureteric obstruction (UUO). Four- to 6-wk-old relaxin (RLX) gene-knockout (RLX(-/-)) and age-matched wild-type (RLX(+/...

journal_title：Endocrinology

authors： Hewitson TD,Mookerjee I,Masterson R,Zhao C,Tregear GW,Becker GJ,Samuel CS

更新日期：2007-02-01 00:00:00

abstract：:Atrial Natriuretic Factor (ANF) has been demonstrated within the central nervous system (CNS), where it has been implicated in the regulation of blood pressure, fluid and electrolyte balance. To explore the effect of acute plasma vol expansion on the activation of CNS ANF, changes in ANF levels of CSF drawn from the c...

journal_title：Endocrinology

authors： Cameron VA,Espiner EA

更新日期：1990-11-01 00:00:00

abstract：:Even though functional CRH receptors have been identified in several brain regions by ligand binding, the identity of brain areas expressing the CRH receptor gene has not been described. The recent cloning of the rat CRH receptor gene has permitted us to conduct an in situ hybridization histochemistry study to localiz...

journal_title：Endocrinology

authors： Wong ML,Licinio J,Pasternak KI,Gold PW

更新日期：1994-11-01 00:00:00

abstract：:The presence of estrogen receptors (ERs) in nonneural cells in brain, including glia, ependyma, and endothelia, has not previously been documented with electron microscopy. This study employed immunocytochemistry to investigate whether ER immunoreactivity (ER-ir) is present in glial, ependymal, or endothelial cells in...

journal_title：Endocrinology

authors： Langub MC Jr,Watson RE Jr

更新日期：1992-01-01 00:00:00

abstract：:The effects of L-arginine and its derivatives NG-methyl-L-arginine (Meth-arg) and NG-nitro-L-arginine (Nit-arg) on the insulin release and glucose oxidation of isolated rat islets were investigated to evaluate possible influences of nitric oxide. Also, the insulin release and flow distribution within the perfused rat ...

journal_title：Endocrinology

authors： Jansson L,Sandler S

更新日期：1991-06-01 00:00:00

abstract：:Small amounts of TRH are present in the thyroid, and TRH has been shown in several studies to have a moderate direct inhibitory effect on TSH-stimulated thyroid hormone secretion. In a recent publication, however, data were presented to demonstrate that very low doses of TRH given in short pulses induce immediate incr...

journal_title：Endocrinology

authors： Iversen E,Laurberg P

更新日期：1988-02-01 00:00:00

abstract：:GnRH neurons active in the preovulatory LH surge have been identified in several species using the early intermediate gene product, Fos, but the GnRH neurons active during episodic LH secretion remain unknown. In this study, we have used Fos and Fos-related antigens (FRA) to determine whether a subset of GnRH neurons ...

journal_title：Endocrinology

authors： Boukhliq R,Goodman RL,Berriman SJ,Adrian B,Lehman MN

更新日期：1999-12-01 00:00:00

abstract：:Maternal immune tolerance is required for extravillous trophoblasts (EVTs) to invade the decidua without rejection. Endoplasmic reticulum aminopeptidase-1 (ERAP1) generates human leukocyte antigen (HLA) class I-adapted antigenic peptides, but its function in trophoblasts lacking classical HLA class I molecules remains...

journal_title：Endocrinology

authors： Shido F,Ito T,Nomura S,Yamamoto E,Sumigama S,Ino K,Itakura A,Hattori A,Tsujimoto M,Mizutani S,Kikkawa F

更新日期：2006-04-01 00:00:00

abstract：:PTH-related protein (PTHrP) has been shown to be a major factor responsible for hypercalcemia of malignancy. PTHrP acts via the PTH/PTHrP receptor, and therefore, PTH antagonists might be expected to reverse the hypercalcemia in malignancy. In the present studies, the PTH antagonists [Tyr34]bovine (b) PTH-(7-34)NH2, [...

journal_title：Endocrinology

authors： Kukreja SC,D'Anza JJ,Wimbiscus SA,Fisher JE,McKee RL,Caulfield MP,Rosenblatt M

更新日期：1994-05-01 00:00:00

abstract：:Osteocalcin (OC), a bone specific protein expressed during differentiation and mineralization of the bone extracellular matrix, is down-regulated upon treatment with transforming growth factor (TGF)-beta 1. To address the potential role of OC gene expression in relation to TGF-beta 1 regulation of bone formation and r...

journal_title：Endocrinology

authors： Banerjee C,Stein JL,Van Wijnen AJ,Frenkel B,Lian JB,Stein GS

更新日期：1996-05-01 00:00:00

abstract：:The corpora lutea of pregnancy in the rat are highly dependent on the action of PRL and PRL-like hormones to hypertrophy and to produce progesterone needed for the maintenance of gestation. Two forms of the PRL receptor (PRL-R), designated as long (PRL-RL) and short (PRL-RS), have been described in rat tissues. To det...

journal_title：Endocrinology

authors： Telleria CM,Parmer TG,Zhong L,Clarke DL,Albarracin CT,Duan WR,Linzer DI,Gibori G

更新日期：1997-11-01 00:00:00

abstract：:Canine renal cortical PTH receptors were solubilized after occupancy of membrane-associated receptors with the agonist ligand [125I]bovine (b) PTH-(1-34). Stabilization of binding during solubilization required the use of high concentrations of BSA (optimally 5%) and appropriate detergents (0.5% 3-[(3-cholamidopropyl)...

journal_title：Endocrinology

authors： Nissenson RA,Mann E,Winer J,Teitelbaum AP,Arnaud CD

更新日期：1986-03-01 00:00:00

abstract：:In the present study, we report that ACTH induces a transient chloride current. The lack of correlation between ACTH-induced cAMP production and amplitude of the Cl- current, as well as the absence of stimulation by forskolin or 8Br-cAMP indicated that the ACTH-induced current was not cAMP-dependent. We explored the p...

journal_title：Endocrinology

authors： Chorvátová A,Gendron L,Bilodeau L,Gallo-Payet N,Payet MD

更新日期：2000-02-01 00:00:00