The nitric oxide synthase II inhibitor NG-nitro-L-arginine stimulates pancreatic islet insulin release in vitro, but not in the perfused pancreas.

abstract：:The Djungarian hamster displays photoperiodic variations in gonadal size synchronized to the seasons by the nightly secretion of the pineal hormone melatonin. In short photoperiod (SP), the gonads regress in size, and circulating sex steroids levels decline. Thus, the brain is subject to seasonal variations of both me...

journal_title：Endocrinology

authors： Bolborea M,Laran-Chich MP,Rasri K,Hildebrandt H,Govitrapong P,Simonneaux V,Pévet P,Steinlechner S,Klosen P

更新日期：2011-10-01 00:00:00

abstract：:In the present study we used characterized perifusion model for the development of homologous desensitization to GnRH in the pituitary gonadotrope. This system relies on immobilized primary pituitary cultures that are perifused with various pulse patterns and concentrations of GnRH; these patterns and concentrations a...

journal_title：Endocrinology

authors： Janovick JA,Conn PM

更新日期：1996-05-01 00:00:00

abstract：:We examined the gene expression of V-1, a novel soluble protein with the cdc10/SWI6 motif, in pseudopregnant rat ovaries. Northern blot analysis on days 1, 5, and 11 of pseudopregnancy revealed an approximately 2-fold increase in the V-1 messenger RNA (mRNA) expression level on day 5 to that on day 1, and no significa...

journal_title：Endocrinology

authors： Song SY,Asakai R,Kenmotsu N,Taoka M,Isobe T,Yamakuni T

更新日期：1996-04-01 00:00:00

abstract：:It has been reported that the endocannabinoid anandamide (AEA) exerts an adverse effect on human sperm motility, which has been ascribed to inhibition of mitochondrial activity. This seems to be at variance with evidence suggesting a major role of glycolysis in supplying ATP for sperm motility; furthermore, the role o...

journal_title：Endocrinology

authors： Barbonetti A,Vassallo MR,Fortunato D,Francavilla S,Maccarrone M,Francavilla F

更新日期：2010-12-01 00:00:00

abstract：:The observation that angiotensin III is present in the circulation of the rat in amounts similar to those of angiotensin II has led to the notion that it may, in part, be formed by the action of converting enzyme on des-Asp-angiotensin I without the prior formation of angiotensin II. This possibility was studied in co...

journal_title：Endocrinology

authors： Garcia Del Rio C,Smellie WS,Morton JJ

更新日期：1981-02-01 00:00:00

abstract：:The in vitro effect of dopamine, haloperidol and pimozide on 32Pi incorporation into phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine by anterior pituitary glands was studied. Dopamine decreased the incorporation of 32Pi into phosphatidylinositol in a dose-related manner without affecting phospha...

journal_title：Endocrinology

authors： Canonico PL,Valdenegro CA,Macleod RM

更新日期：1982-07-01 00:00:00

abstract：:The influence of administration of ovine prolactin in vivo on intestinal fluid and ion transport in vitro was investigated using intact and hypophysectomized male rats. Prolactin administration significantly stimulated fluid, sodium,potassium, calcium, magnesium and chloride transport across everted jejunal sacs. The ...

journal_title：Endocrinology

authors： Mainoya JR

更新日期：1975-05-01 00:00:00

abstract：:The steroid sex hormone progesterone (P) induces the expression of a variety of genes through a signal transduction pathway mediated by the P receptor, a DNA-binding regulator of transcription. To identify genes and gene networks that are P dependent in the rhesus endometrium, we used a powerful technique employing su...

journal_title：Endocrinology

authors： Ace CI,Balsamo M,Le LT,Okulicz WC

更新日期：1994-03-01 00:00:00

abstract：:Insulin resistance and smoking are significant risk factors for cardiac and cerebral vascular diseases. Because vascular smooth muscle cells play a key role in the development and progression of atherosclerosis, we investigated the effect of nicotine on insulin-induced mitogenic signaling in aortic vascular smooth mus...

journal_title：Endocrinology

authors： Wada T,Naito M,Kenmochi H,Tsuneki H,Sasaoka T

更新日期：2007-02-01 00:00:00

abstract：:The secretory pattern of GH secretion is markedly sexually dimorphic in the adult rat. The patterning of GH secretion is determined by the coordinated activity of somatostatin (SS)- and GH-releasing hormone (GHRH)-containing neurosecretory cells located in the hypothalamus. In this study we examined whether there is s...

journal_title：Endocrinology

authors： Argente J,Chowen JA,Zeitler P,Clifton DK,Steiner RA

更新日期：1991-05-01 00:00:00

abstract：:Bilateral destruction of the hypothalamic paraventricular nuclei (PVN) produced a profound depression of plasma TSH and the median eminence TRH concentration in hypothyroid rats. Anterior pituitary type II iodothyronine 5'-deiodinase (5'-D) activity was consistently lower but not significantly different in sham- and P...

journal_title：Endocrinology

authors： Murakami M,Tanaka K,Greer MA,Mori M

更新日期：1988-09-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) is a pleiotropic cytokine known to control the proliferation and survival of stem cells including primordial germ cells and gonocytes. This led us to study the origin and regulation of testicular LIF. The LIF transcript was detected in the rat testis by RT-PCR from 13.5 days postcoitum...

journal_title：Endocrinology

authors： Piquet-Pellorce C,Dorval-Coiffec I,Pham MD,Jégou B

更新日期：2000-03-01 00:00:00

abstract：:Studies were performed to characterize the identity of the factors present in calf serum that stimulate endothelin (ET) production by vascular endothelial cells in culture. Two putative candidates responsible for the ET-releasing activity present in serum are members of the transforming growth factor-beta (TGF beta) s...

journal_title：Endocrinology

authors： Brown MR,Vaughan J,Jimenez LL,Vale W,Baird A

更新日期：1991-11-01 00:00:00

abstract：:In the course of previous studies using continuous monitoring of the electrophysiological correlates of GnRH pulse generator activity, characterized by episodic increases in hypothalamic multiunit electrical activity (MUA volley), it was noticed that the nocturnal slowing of pulse generator frequency was an acute phen...

journal_title：Endocrinology

authors： O'Byrne KT,Thalabard JC,Chiappini SE,Chen MD,Hotchkiss J,Knobil E

更新日期：1993-10-01 00:00:00

abstract：:Primary astroglial cells produce insulin-like growth factor (IGF)-binding proteins (IGFBPs), which modulate the biological activity of IGFs on the developing astroglia. Alterations in the synthesis of astroglial IGFBPs by hormones and growth factors may, therefore, influence the paracrine regulatory actions of IGFs. T...

journal_title：Endocrinology

authors： Bradshaw SL,Han VK

更新日期：1993-10-01 00:00:00

abstract：:To determine the effect of aromatase inhibitors on peripheral aromatization, male rhesus monkeys were infused with [7-3H]androstenedione and [4-14C]estrone before and during treatment with 4-hdyroxy-androstene-3,17-dione (50 mg/kg each; four monkeys) or 4-acetoxy-androstene-3,17-dione (700 mg each; two monkeys). In al...

journal_title：Endocrinology

authors： Brodie AM,Longcope C

更新日期：1980-01-01 00:00:00

abstract：:As part of an ongoing investigation of the role of metabolic activation of estrogens in the genesis of cancers such as estrogen-induced renal tumors in hamsters, we have 1) determined steroid-17 beta-oxidoreductase activity of microsomes and cytosol prepared from hamster kidney and liver; 2) compared the rates of 2-, ...

journal_title：Endocrinology

authors： Zhu BT,Bui QD,Weisz J,Liehr JG

更新日期：1994-11-01 00:00:00

abstract：:[125I]-[D-Ser(TBU)6]LHRH-EA binds to a single class of high affinity sites in rat anterior pituitary cells in culture at an apparent dissociation constant of 0.25 nM at 0-4C. The order of potency of a representative group of LHRH agonists and antagonists to displace the labeled ligand is similar to their LH-releasing ...

journal_title：Endocrinology

authors： Giguere V,Lefebvre FA,Labrie F

更新日期：1981-01-01 00:00:00

abstract：:Although it is evident that androgens increase muscle mass and strength, little is known about the critical molecular targets of androgens in skeletal muscle. In rodents, the skeletal alpha-actin gene is a tissue-specific gene expressed only in the levator ani and other skeletal muscles but not in the prostate or prep...

journal_title：Endocrinology

authors： Hong MH,Sun H,Jin CH,Chapman M,Hu J,Chang W,Burnett K,Rosen J,Negro-Vilar A,Miner JN

更新日期：2008-03-01 00:00:00

abstract：:T4 dynamically regulates the levels of type II iodothyronine 5'-deiodinase in the brain. Using an astrocyte cell culture model, we have shown that thyroxine increases inactivation of this enzyme through a mechanism using the actin cytoskeleton. In the absence of T4, the filamentous actin (F-actin) stress fibers are ab...

journal_title：Endocrinology

authors： Farwell AP,Leonard JL

更新日期：1992-08-01 00:00:00

abstract：:Activators of peroxisome proliferator activated receptor (PPAR) regulate fatty acid metabolism and can induce adipocyte differentiation. We show here that the gamma subtype of PPAR is expressed at high levels in adipose tissue in contrast to a variety of other tissues, where little gene expression was noted. In additi...

journal_title：Endocrinology

authors： Chawla A,Schwarz EJ,Dimaculangan DD,Lazar MA

更新日期：1994-08-01 00:00:00

abstract：:The ability of FSH to stimulate the activity of ornithine decarboxylase (ODC) in the ovary of the immature rat and cycling hamster has been examined using specific antisera to gonadotropins. The stimulatory effect of FSH on ODC activity in the ovary of the immature rat was abolished when LH antiserum was administered ...

journal_title：Endocrinology

authors： Sheela Rani CS,Moudgal NR

更新日期：1979-05-01 00:00:00

abstract：:We have recently demonstrated that fibroblast growth factor (FGF)-2 promotes neuroblastoma cell differentiation and overrides their mitogenic response to IGF-I. However, the mechanisms involved are unknown. SK-N-MC cells were cultured with FGF-2 (50 ng/ml) and/or IGF-I (100 ng/ml) up to 48 h. Fluorescence-activated ce...

journal_title：Endocrinology

authors： Higgins S,Wong SH,Richner M,Rowe CL,Newgreen DF,Werther GA,Russo VC

更新日期：2009-09-01 00:00:00

abstract：:Thyroid hormones increase bone turnover in vivo and stimulate bone resorption in vitro. Clinical states associated with excess circulating thyroid hormone levels are known to produce osteoporosis. To determine the effect of T3 on bone resorption, we used an isolated rat osteoclast bone resorption assay in the absence ...

journal_title：Endocrinology

authors： Britto JM,Fenton AJ,Holloway WR,Nicholson GC

更新日期：1994-01-01 00:00:00

abstract：:The testis contains many peptides originally described as originating in the central nervous system. The physiological function of these factors in the testis is generally unknown. We previously reported that the rat testis contains both a peptide with GH-releasing hormone-like immunoactivity (tGHRH-LI) and a mRNA spe...

journal_title：Endocrinology

authors： Pescovitz OH,Berry SA,Laudon M,Ben-Jonathan N,Martin-Myers A,Hsu SM,Lambros TJ,Felix AM

更新日期：1990-11-01 00:00:00

abstract：:Complementary DNA-encoding proteins with high homology to steroidogenic acute regulatory proteins (StAR) of mammals were cloned from rainbow trout head kidney and a mixture of several brook trout tissues. A cDNA encoding an MLN64 homolog was also cloned from brook trout. The C-terminal domains of rainbow trout StAR an...

journal_title：Endocrinology

authors： Kusakabe M,Todo T,McQuillan HJ,Goetz FW,Young G

更新日期：2002-06-01 00:00:00

abstract：:L-Triiodothyronine in vitro increased the uptake of the non-metabolizable amino acid, alpha-aminoisobutyrate, into isolated rat thymocytes. This effect was evident at extracellular free hormone concentrations of 10-7 to 5 times 10-8M and was due to a marked inhibition of amino acid efflux. In contrast, insulin and dib...

journal_title：Endocrinology

authors： Goldfine ID,Simons CG,Ingbar SH

更新日期：1975-03-01 00:00:00

abstract：:Thyroid hormones are of considerable importance for vertebrate reproductive function and during development. To further assess the role of these compounds in this capacity, we examined the expression pattern of the type 2 iodothyronine deiodinase (D2), which converts T(4) to the more active hormone T(3), in the rat ut...

journal_title：Endocrinology

authors： Galton VA,Martinez E,Hernandez A,St Germain EA,Bates JM,St Germain DL

更新日期：2001-05-01 00:00:00

abstract：:Regulatory elements present in the cytoplasmic carboxyl-terminal tails of G protein-coupled receptors contribute to agonist-dependent receptor desensitization, internalization, and association with accessory proteins such as beta-arrestin. The mammalian type I GnRH receptors are unique among the rhodopsin-like G prote...

journal_title：Endocrinology

authors： Pawson AJ,Faccenda E,Maudsley S,Lu ZL,Naor Z,Millar RP

更新日期：2008-03-01 00:00:00

abstract：:Two experiments tested whether serotonergic neurons participate in the acute feedback effects of estradiol on LH and PRL secretion. In the first study, ovariectomized female rats received oil vehicle or estradiol benzoate and were killed 3 h later. The turnover of serotonin [5-hydroxytryptamine (5-HT)] in microdissect...

journal_title：Endocrinology

authors： Johnson MD,Crowley WR

更新日期：1983-12-01 00:00:00