Ambient light modifies gonadotropin-releasing hormone pulse generator frequency in the rhesus monkey.

abstract：:A RIA for mouse placental lactogen-I (mPL-I) was developed using recombinant mPL-I as the standard, radioligand, and antigen for antiserum production. Displacement curves for dilutions of serum and placental extracts from pregnant mice were parallel to the recombinant mPL-I standard curve. Serum from male and nonpregn...

journal_title：Endocrinology

authors： Ogren L,Southard JN,Colosi P,Linzer DI,Talamantes F

更新日期：1989-11-01 00:00:00

abstract：:Circulating levels of the pancreatic beta-cell peptide hormone amylin and the gut peptide PYY[3-36] increase after nutrient ingestion. Both have been implicated as short-term signals of meal termination with anorexigenic and weight-reducing effects. However, their combined effects are unknown. We report that the combi...

journal_title：Endocrinology

authors： Roth JD,Coffey T,Jodka CM,Maier H,Athanacio JR,Mack CM,Weyer C,Parkes DG

更新日期：2007-12-01 00:00:00

abstract：:There is now general agreement that neurokinin B (NKB) acts via neurokinin-3-receptor (NK3R) to stimulate secretion of GnRH and LH in several species, including rats, mice, sheep, and humans. However, the roles of two other tachykinins, substance P (SP) and neurokinin A, which act primarily via NK1R and NK2R, respecti...

journal_title：Endocrinology

authors： Fergani C,Mazzella L,Coolen LM,McCosh RB,Hardy SL,Newcomb N,Grachev P,Lehman MN,Goodman RL

更新日期：2016-12-01 00:00:00

abstract：:The inhibitor of apoptosis proteins (IAPs) constitutes a family of highly conserved apoptosis suppressor proteins that were originally identified in baculoviruses. Although IAP homologs have recently been demonstrated to suppress apoptosis in mammalian cells, their expression and role in human ovarian epithelial cance...

journal_title：Endocrinology

authors： Li J,Feng Q,Kim JM,Schneiderman D,Liston P,Li M,Vanderhyden B,Faught W,Fung MF,Senterman M,Korneluk RG,Tsang BK

更新日期：2001-01-01 00:00:00

abstract：:Subcutaneous implantation of a silastic tubing containing crystalline estradiol in castrated female rats results in a circadian rhythm of LH release. Under such conditions, blockade of serotonin (5-HT) biosynthesis by p-chlorophenylalanine (PCPA) completely inhibits the afternoon elevation of plasma LH. Gonadotropin p...

journal_title：Endocrinology

authors： Héry M,Laplante E,Kordon C

更新日期：1976-08-01 00:00:00

abstract：:In addition to mineralocorticoid and glucocorticoid receptors, the kidney contains a third high affinity binding site for endogenous glucocorticoids, the type III receptor. These binding sites have been localized to the collecting duct, but their biological function has not yet been identified. We have used immunodiss...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Rusvai E,Fejes-Tóth G

更新日期：1994-04-01 00:00:00

abstract：:Hyperandrogenism, disturbance of the hypothalamus-pituitary-ovary axis followed by elevated serum luteinizing hormone (LH) levels, and insulin resistance are involved in the complicated pathophysiology of polycystic ovary syndrome (PCOS). Kisspeptin is coexpressed with neurokinin B (NKB) in the arcuate nucleus (ARC), ...

journal_title：Endocrinology

authors： Osuka S,Iwase A,Nakahara T,Kondo M,Saito A,Bayasula,Nakamura T,Takikawa S,Goto M,Kotani T,Kikkawa F

更新日期：2017-02-01 00:00:00

abstract：:After incubation with 0.5 mM isobutylmethylxanthine, 1 microM dexamethasone, and 1 microM insulin for 72 h, 3T3-L1 cells acquire the phenotypic characteristics of mature adipocytes, including a hormone-sensitive particulate cAMP phosphodiesterase activity. In addition, adipocytes contain soluble cAMP and calmodulin-se...

journal_title：Endocrinology

authors： Elks ML,Manganiello VC,Vaughan M

更新日期：1984-10-01 00:00:00

abstract：:Maintenance of male golden hamsters on short photoperiod leads to testicular regression due to pineal gland-mediated inhibition of the hypothalamo-hypophyseal reproductive system. This study clarifies the dynamics of the action of GnRH at the pituitary level after short photoperiod-induced gonadal regression. In Exp 1...

journal_title：Endocrinology

authors： Pieper DR

更新日期：1984-11-01 00:00:00

abstract：:A diurnal change of tuberoinfundibular dopaminergic (TIDA) neuronal activity exists in female rats, which is prerequisite for the estrogen-induced afternoon PRL surge. Because progesterone (P4) administered in the morning can advance and amplify the PRL surge, it is of interest to learn whether its action involves the...

journal_title：Endocrinology

authors： Yen SH,Pan JT

更新日期：1998-04-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central GLP-1 reduces food intake and body weight. However, current research indic...

journal_title：Endocrinology

authors： Williams DL

更新日期：2009-07-01 00:00:00

abstract：:Fibroblast growth factor (FGF) 21, a unique, largely liver-derived endocrine member of the FGF superfamily, is often thought of as a fasting factor owing to its induction in rodents during starvation. However, FGF21 is not increased by fasting for periods of <7 days in humans; instead, it rises sharply after acute alc...

journal_title：Endocrinology

authors： Gillum MP

更新日期：2018-05-01 00:00:00

abstract：:Thyroid hormone (T(3)) regulates growth, development, and differentiation. These activities are mediated by the nuclear thyroid hormone receptors (TRs), which belong to the steroid/TR superfamily of ligand-dependent transcription factors. The effect of T(3) treatment on target gene regulation was investigated in a TRa...

journal_title：Endocrinology

authors： Shih CH,Chen SL,Yen CC,Huang YH,Chen CD,Lee YS,Lin KH

更新日期：2004-06-01 00:00:00

abstract：:Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3...

journal_title：Endocrinology

authors： Chin YP,Keni J,Wan J,Mehta H,Anene F,Jia Y,Lue YH,Swerdloff R,Cobb LJ,Wang C,Cohen P

更新日期：2013-10-01 00:00:00

abstract：:Sodium butyrate (NaB), a dietary micronutrient, is a potent growth inhibitor that initiates cell differentiation in many cell types, including prostate cancer cells. The molecular mechanisms by which these effects occur remain largely unknown. In this study, we investigated the effects of NaB on the expression of IGF ...

journal_title：Endocrinology

authors： Tsubaki J,Hwa V,Twigg SM,Rosenfeld RG

更新日期：2002-05-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) inhibits the embryonic migration of GnRH neurons and regulates hypothalamic GnRH release. A subset of GnRH neurons expresses GABA along their migratory route in the nasal compartment before entering the brain, suggesting that GABA produced by GnRH neurons may help regulate the migratory ...

journal_title：Endocrinology

authors： Heger S,Seney M,Bless E,Schwarting GA,Bilger M,Mungenast A,Ojeda SR,Tobet SA

更新日期：2003-06-01 00:00:00

abstract：:Proper development of the seminiferous tubules (or testis cords in embryos) is critical for male fertility. Sertoli cells, somatic components of the seminiferous tubules, serve as nurse cells to the male germline, and thus their numbers decide the quantity of sperm output in adulthood. We previously identified activin...

journal_title：Endocrinology

authors： Archambeault DR,Tomaszewski J,Childs AJ,Anderson RA,Yao HH

更新日期：2011-11-01 00:00:00

abstract：:The effect of methysergide (MES, 2.5 mg/100 g body wt), a serotonin antagonist, on prolactin release has been studied in lactating and ovariectomized rats. MES caused significant increases in prolactin release in both animals. Studies in ovariectomized, hypophysectomized rats indicate that this effect is not due to a ...

journal_title：Endocrinology

authors： Gallo RV,Rabii J,Moberg GP

更新日期：1975-11-01 00:00:00

abstract：:IGF-II has been reported to decrease neonatal islet cell apoptosis and in vitro adult islet cell necrosis and apoptosis, but the usefulness of IGF-II in a transplantation setting is unknown. We evaluated the effect of in vitro IGF-II incubations on microencapsulated rat islet survival both in vitro and in minimal mass...

journal_title：Endocrinology

authors： Robitaille R,Dusseault J,Henley N,Rosenberg L,Hallé JP

更新日期：2003-07-01 00:00:00

abstract：:More than 150 hypothalamic fractions were reassayed for luteinizing hormone-releasing hormone (LHRH) and follicle stimulating hormone-releasing hormone (FSHRH) activities in search for LHRH and FSHRH which differ from the decapeptide (pyro)Glu-His-Trp-Ser-Try-Gly-Leu-Arg-Pro-Gly-NH2 (I). Among the porcine fractions te...

journal_title：Endocrinology

authors： Schally AV,Arimura A,Redding TW,Debeljuk L,Carter W,Dupont A,Vilchez-Martinez JA

更新日期：1976-02-01 00:00:00

abstract：:Analysis of GH gene structure in the mouse permits evolutionary comparisons with GH gene structure in the rat and provides information about the mechanism responsible for heritable deficiencies of anterior pituitary hormones. The little mutation in mice is analogous to autosomal recessive, isolated, partial deficiency...

journal_title：Endocrinology

authors： Parks JS,Herd JE,Wurzel JM,Martial JA

更新日期：1982-05-01 00:00:00

abstract：:Ovarian hormones, including 17β-estradiol, are implicated in numerous physiological processes, including sleep. Beginning at puberty, girls report more sleep complaints than boys, which is maintained throughout the reproductive life stage. Sleep problems are exacerbated during the menopausal transition, evidenced by g...

journal_title：Endocrinology

authors： Brown AMC,Gervais NJ

更新日期：2020-09-01 00:00:00

abstract：:Some TSH receptors (TSHR) on the cell surface cleave into A and B subunits. Cleavage at upstream Site 1 is followed by the proteolytic excision of an intervening C peptide region terminating at a downstream Site 2. Although present evidence suggests that Site 1 lies between amino acid residues 303 and 317, the mechani...

journal_title：Endocrinology

authors： Tanaka K,Chazenbalk GD,McLachlan SM,Rapoport B

更新日期：2000-10-01 00:00:00

abstract：:The serum pharmacokinetics of recombinant human inhibin A (rh-inhibin A) and rh-activin A were examined in immature female Sprague Dawley-derived rats after iv and sc injection of the drugs. After iv administration of rh-inhibin A (120 micrograms/kg), the serum concentrations were described by a biexponential equation...

journal_title：Endocrinology

authors： Woodruff TK,Krummen LA,Chen S,DeGuzman G,Lyon R,Baly DL,Allison DE,Garg S,Wong WL,Hebert N

更新日期：1993-02-01 00:00:00

abstract：:The injection of chlorpropamide into Brattleboro homozygous rats (di/di) has previously been shown to result in enhanced activation of renal medullary adenylate cyclase activity and increased renal medullary content of cAMP in response to 1-desamino-8-D-arginine vasopressin (dDAVP). In contrast, in vivo chlorpropamide...

journal_title：Endocrinology

authors： Moses AM,Fenner R,Schroeder ET,Coulson R

更新日期：1982-12-01 00:00:00

abstract：:The ability of different LH-like hormones, such as hCG, PMSG/equine (e) CG, ovine (o) LH, eLH, and rat (r) LH, to bind to and stimulate steroidogenesis in two types of rat gonadal cells was studied under the same experimental conditions. In both Leydig and granulosa cells, the maximal steroidogenic responses elicited ...

journal_title：Endocrinology

authors： Rani CS,Moudgal NR

更新日期：1985-02-01 00:00:00

abstract：:GH is known to increase the formation of bone and hard tissues of the tooth (dentine, cementum, and enamel), as do bone morphogenetic proteins. GH receptors are expressed in these tissues and could mediate local growth responses. Here we report that both GH and insulin-like growth factor I (IGF-I) are able to increase...

journal_title：Endocrinology

authors： Li H,Bartold PM,Zhang CZ,Clarkson RW,Young WG,Waters MJ

更新日期：1998-09-01 00:00:00

abstract：:RNA blot hybridization analysis with cloned rat CRF precursor (prepro-CRF) cDNA as a probe showed that prepro-CRF mRNA existed in rat hypothalamic and extrahypothalamic brain tissue, whereas it was undetectable in the pituitary and adrenal. To study the effect of glucocorticoid on the level of prepro-CRF mRNA in the h...

journal_title：Endocrinology

authors： Jingami H,Matsukura S,Numa S,Imura H

更新日期：1985-10-01 00:00:00

abstract：:The nuclear receptor steroidogenic factor 1/adrenal 4 binding protein (SF-1/Ad4BP) is an essential regulator of endocrine development and function, and the expression of the corresponding gene (sf-1/ad4bp) is precisely regulated in a time- and tissue-dependent manner. We previously demonstrated that the basal promoter...

journal_title：Endocrinology

authors： Hoivik EA,Bjanesoy TE,Mai O,Okamoto S,Minokoshi Y,Shima Y,Morohashi K,Boehm U,Bakke M

更新日期：2011-05-01 00:00:00

abstract：:The heart has epicardial adipose tissue that produces adipokines and mesenchymal stem cells. Systemic adipose tissue is involved in the pathophysiology of obesity-related heart diseases. However, the method for analyzing the direct interaction between adipose tissue and cardiomyocytes has not been established. Here we...

journal_title：Endocrinology

authors： Anan M,Uchihashi K,Aoki S,Matsunobu A,Ootani A,Node K,Toda S

更新日期：2011-04-01 00:00:00