Abstract:
:Glucagon-like peptide 1 (GLP-1) is both a gut-derived hormone and a neurotransmitter synthesized in the brain. Early reports suggested that GLP-1 acts in the periphery to promote insulin secretion and affect glucose homeostasis, whereas central GLP-1 reduces food intake and body weight. However, current research indicates that in fact, GLP-1 in each location plays a role in these functions. This review summarizes the evidence for involvement of peripheral and brain GLP-1 in food intake regulation and glucose homeostasis and proposes a model for the coordinated actions of GLP-1 at multiple sites.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Williams DLdoi
10.1210/en.2009-0220subject
Has Abstractpub_date
2009-07-01 00:00:00pages
2997-3001issue
7eissn
0013-7227issn
1945-7170pii
en.2009-0220journal_volume
150pub_type
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