Short pulses of low dose thyrotropin-releasing hormone do not affect thyroid hormone secretion from perfused dog thyroid lobes.

abstract：UNLABELLED:The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonists, exendin-4 and liraglutide, suppress food intake and body weight. The mediating site(s) of action for the anorectic effects produced by peripheral administration of these GLP-1R agonists are not known. Experiments addressed whether food intak...

journal_title：Endocrinology

authors： Kanoski SE,Fortin SM,Arnold M,Grill HJ,Hayes MR

更新日期：2011-08-01 00:00:00

abstract：:For centuries our image of the skeleton has been one of an inert structure playing a supporting role for muscles and a protective role for inner organs like the brain. Cell biology and physiology modified this view in the 20st century by defining the constant interplay between bone-forming and bone resorbing cells tha...

journal_title：Endocrinology

authors： Ducy P

更新日期：2020-10-01 00:00:00

abstract：:Little is known about the mechanisms of action of polypeptide hormones on chromatin structure and nuclear function. We have employed micrococcal nuclease to examine the effect of TSH on the accessibility of DNA in thyroid nuclei. Brief digestion of nuclear suspensions with 0.05-0.2 U/ml micrococcal nuclease at 26-28 C...

journal_title：Endocrinology

authors： Abe Y,Cooper E,Spaulding SW

更新日期：1982-06-01 00:00:00

abstract：:Rat melanin-concentrating hormone (MCH) is a homolog of the peptide first isolated from salmon pituitary glands which produces melanosome aggregation within melanophores of teleost fish as well as interacting with the hypothalamic-pituitary axis. We have previously characterized the rat and human MCH counterparts as i...

journal_title：Endocrinology

authors： Parkes D,Vale W

更新日期：1992-10-01 00:00:00

abstract：:A member of the interferon-inducible p200 family of proteins, p204, has recently been reported to function in the development of many mesoderm-derived tissues, such as bone, muscle, and cartilage. However, no published study has yet investigated the role of p204 in adipogenesis. Our preliminary experiments showed that...

journal_title：Endocrinology

authors： Xiao J,Sun B,Cai GP

更新日期：2010-07-01 00:00:00

abstract：:There is considerable evidence that CRH can suppress food intake. As hypothalamic CRH, a main site of CRH expression, is also negatively regulated by glucocorticoids, it is unclear whether anorexia and weight loss in adrenal insufficiency are attributable to elevated CRH or to decreased glucocorticoid levels. To disti...

journal_title：Endocrinology

authors： Jacobson L

更新日期：1999-01-01 00:00:00

abstract：:Adrenocortical carcinoma (ACC) is an aggressive cancer with a 5-year survival rate <35%. Mortality remains high due to lack of targeted therapies. Using bioinformatic analyses, we identified maternal embryonic leucine zipper kinase (MELK) as 4.1-fold overexpressed in ACC compared with normal adrenal samples. High MELK...

journal_title：Endocrinology

authors： Kiseljak-Vassiliades K,Zhang Y,Kar A,Razzaghi R,Xu M,Gowan K,Raeburn CD,Albuja-Cruz M,Jones KL,Somerset H,Fishbein L,Leong S,Wierman ME

更新日期：2018-07-01 00:00:00

abstract：:Progesterone released by cumulus cells surrounding the egg induces a Ca2+ influx into human sperm cells via the cationic channel of sperm (CatSper) Ca2+ channel and controls multiple Ca2+-dependent responses essential for fertilization. We hypothesized that chemical UV filters may mimic the physiological action of pro...

journal_title：Endocrinology

authors： Rehfeld A,Dissing S,Skakkebæk NE

更新日期：2016-11-01 00:00:00

abstract：:We have previously established the value of 2-dimensional electrophoretic mRNA activity profiles for investigating the hepatic genomic response to several metabolic perturbations, such as thyroid hormone or GH treatment, diabetes, high carbohydrate diet, starvation, and uremia. We now report the effects of adrenalecto...

journal_title：Endocrinology

authors： Beyer HS,Carr FE,Mariash CN,Oppenheimer JH

更新日期：1985-06-01 00:00:00

abstract：:Studies were undertaken to investigate the effects of synthetic 1-24 adrenocorticotropin (ACTH), bovine alpha melanocyte-stimulating hormone (alpha-MSH), and ovine beta lipotropin (beta-LPH) on plasma calcium and phosphate in rabbits. Equimolar concentrations of these hormones were infused intravenously in intact and ...

journal_title：Endocrinology

authors： Gildersleeve DL,Pearson TA,Baghdiantz A,Foster GV

更新日期：1975-12-01 00:00:00

abstract：:The Ca2+ response of individual cells to TRH was investigated in excitable pituitary GH3 and in nonexcitable Hela cells transfected with the TRH receptor complementary DNA (HelaR cells). GH3 cells typically responded to 1 microM TRH with an immediate transient [Ca2+]i spike (mean peak [Ca2+]i = 1.5 microM) followed by...

journal_title：Endocrinology

authors： Nelson EJ,Hinkle PM

更新日期：1994-09-01 00:00:00

abstract：:We previously reported that human fibroblasts secrete a protease into their conditioned medium that cleaves insulin-like growth factor binding protein-5 (IGFBP-5) into non-IGF-I binding fragments. Because the protease activity in the fibroblast medium has characteristics of both serine and metalloproteases, the activi...

journal_title：Endocrinology

authors： Nam TJ,Busby WH Jr,Clemmons DR

更新日期：1996-12-01 00:00:00

abstract：:GH secretion is altered by exercise in humans. In an attempt to investigate the underlying mechanisms, we developed a rodent model. GH secretion was assayed in male and female rats that were sedentary (not exercised), acutely exercised, and chronically exercised. Sedentary males showed typical pulsatile GH secretion. ...

journal_title：Endocrinology

authors： Butkus JA,Brogan RS,Giustina A,Kastello G,Sothmann M,Wehrenberg WB

更新日期：1995-06-01 00:00:00

abstract：:The structural requirements for the inhibition of net bone collagen synthesis by parathyroid hormone (PTH) in vitro have been examined by study of the effects of selected fragments and analogs of bovine PTH (bPTH) upon the incorporation of [3H]proline into collagenase-digestible and -nondigestible proteins by neonatal...

journal_title：Endocrinology

authors： Bringhurst FR,Potts JT Jr

更新日期：1981-01-01 00:00:00

abstract：:The action of sex steroids on the growth and differentiation of target tissues requires the presence of specific intracellular receptors. We compared the distribution of cells containing estrogen receptor (ER) and/or progesterone receptor (PR) in rabbit uterus by immunohistochemistry using monoclonal antibodies direct...

journal_title：Endocrinology

authors： Zaino RJ,Clarke CL,Feil PD,Satyaswaroop PG

更新日期：1989-11-01 00:00:00

abstract：:Dopamine D2 receptor agonists are commonly used in the control of PRL-secreting adenomas, and the sensitivity of dopamine agonists during long term therapy is exquisite. However, the molecular mechanisms responsible for the maintenance of this cellular sensitivity to dopamine agonists remain poorly understood. In the ...

journal_title：Endocrinology

authors： Ng GY,Varghese G,Chung HT,Trogadis J,Seeman P,O'Dowd BF,George SR

更新日期：1997-10-01 00:00:00

abstract：:The incidence of obesity, with its impact on the development of comorbidities, including diabetes and cardiovascular disease, represents one of the greatest global health threats of the 21st century. This is particularly damning considering the vast progress that has been made in understanding the factors and molecula...

journal_title：Endocrinology

authors： Perez-Tilve D

更新日期：2017-05-01 00:00:00

abstract：:Poor growth before birth increases the risk of non-insulin-dependent diabetes mellitus (NIDDM) and impairs insulin secretion relative to sensitivity. We investigated the effects of intrauterine growth restriction in sheep on insulin secretion, beta-cell mass, and function from before birth to young adulthood and its m...

journal_title：Endocrinology

authors： Gatford KL,Mohammad SN,Harland ML,De Blasio MJ,Fowden AL,Robinson JS,Owens JA

更新日期：2008-10-01 00:00:00

abstract：:Mice deficient in the thyroid hormone (TH) transporter Mct8 (Mct8KO) have increased 5'-deiodination and impaired TH secretion and excretion. These and other unknown mechanisms result in the low-serum T(4), high T(3), and low rT(3) levels characteristic of Mct8 defects. We investigated to what extent each of the 5'-dei...

journal_title：Endocrinology

authors： Liao XH,Di Cosmo C,Dumitrescu AM,Hernandez A,Van Sande J,St Germain DL,Weiss RE,Galton VA,Refetoff S

更新日期：2011-03-01 00:00:00

abstract：:Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Dietary carbohydrates increase SCD-1 gene expression in liver by sterol response element binding protein (SREBP)-1c-dependent and SREBP-1c -independent pathways. Previous report demonstrat...

journal_title：Endocrinology

authors： Hashimoto K,Ishida E,Miura A,Ozawa A,Shibusawa N,Satoh T,Okada S,Yamada M,Mori M

更新日期：2013-01-01 00:00:00

abstract：:Long-term glucocorticoid treatment impairs the survival and bone formation of osteogenic cells, leading to bone mass loss. The Wnt inhibitor Dickkopf-1 (DKK1) acts as a potent bone-remodeling factor that mediates several types of skeletal disorders. Whereas excess glucocorticoid is known to disturb Wnt signaling in os...

journal_title：Endocrinology

authors： Wang FS,Ko JY,Yeh DW,Ke HC,Wu HL

更新日期：2008-04-01 00:00:00

abstract：:Previous immunohistochemical and in situ hybridization studies of sheep, goats, and rodents indicated that kisspeptin (KP), neurokinin B (NKB), and dynorphin A (DYN) are extensively colocalized in the hypothalamic arcuate nucleus, thus providing a basis for the KP/NKB/DYN (KNDy) neuron concept; in both sexes, KNDy neu...

journal_title：Endocrinology

authors： Hrabovszky E,Sipos MT,Molnár CS,Ciofi P,Borsay BÁ,Gergely P,Herczeg L,Bloom SR,Ghatei MA,Dhillo WS,Liposits Z

更新日期：2012-10-01 00:00:00

abstract：:Dipeptidyl peptidase-IV (DPPIV) is a serine proteinase widely distributed in mammalian tissues, including lymphocytes, where it is identical to the T-cell activation antigen, cluster differentiation antigen-26. In the present study, DPPIV enzymatic activity was found in uterine secretions of unilaterally pregnant ewes...

journal_title：Endocrinology

authors： Liu WJ,Hansen PJ

更新日期：1995-02-01 00:00:00

abstract：:Apolipoprotein-E (apoE) has been shown by noncovalent binding and photoaffinity labeling with [125I]T4 to possess a single L-T4 binding site with a K5 of about 3 x 10(7) M-1 and a relative affinity for analogs of L-T4 = D-T4 = rT3 = triiodothyroacetic acid > L-T3. T4 binding was not affected by the flavonoid EMD 21388...

journal_title：Endocrinology

authors： Benvenga S,Cahnmann HJ,Robbins J

更新日期：1993-09-01 00:00:00

abstract：:Monocarboxylate transporter 8 (MCT8) is a thyroid hormone transmembrane transporter expressed in many cell types, including neurons. Mutations that inactivate transport activity of MCT8 cause severe X-linked psychomotor retardation in male patients, a syndrome originally described as the Allan-Herndon-Dudley syndrome....

journal_title：Endocrinology

authors： Braun D,Schweizer U

更新日期：2015-12-01 00:00:00

abstract：:Ghrelin, a novel GH-releasing acylated peptide, was recently isolated from rat stomach. It stimulated the release of GH from the anterior pituitary through the GH secretagogue receptor (GHS-R). Ghrelin messenger RNA and the peptide are present in rat stomach, but its cellular source has yet to be determined. Using two...

journal_title：Endocrinology

authors： Date Y,Kojima M,Hosoda H,Sawaguchi A,Mondal MS,Suganuma T,Matsukura S,Kangawa K,Nakazato M

更新日期：2000-11-01 00:00:00

abstract：:Smoltification is a transformation that occurs in some species of salmon, during which solitary fish in fresh water become schooling fish and migrate to the sea. This process is accompanied by large increases in plasma T4. T4 secretion rate and other parameters of T4 metabolism in juvenile coho salmon were estimated b...

journal_title：Endocrinology

authors： Specker JL,DiStefano JJ 3rd,Grau EG,Nishioka RS,Bern HA

更新日期：1984-07-01 00:00:00

abstract：:Glucocorticoids induce tyrosine aminotransferase (TAT) in hepatoma cells. We have previously shown that both the concentration of the agonist dexamethasone (Dex) required for half-maximal induction (EC50) and the amount of agonist activity produced by the antagonist dexamethasone 21-mesylate (Dex-Mes), expressed as a ...

journal_title：Endocrinology

authors： Oshima H,Simons SS Jr

更新日期：1992-04-01 00:00:00

abstract：:In several mammalian species, luteinizing hormone-releasing hormone (LHRH) neurons have been shown to migrate from nasal regions to the brain during early development. Using immunocytochemistry, we have identified LHRH containing neurons in developing chick embryos. In embryonic day 4 (E4) and E5 animals, a small grou...

journal_title：Endocrinology

authors： Norgren RB Jr,Lehman MN

更新日期：1991-03-01 00:00:00

abstract：:Adrenal secretory rates of catecholamines in response to a repeated stimulus have not been described. We have used repeated small hemorrhages spaced 24 h apart in pentobarbital anesthetized dogs prepared with a chronic adrenal venous catheter to study this question. Our results confirm earlier reports that an initial ...

journal_title：Endocrinology

authors： Lilly MP,Engeland WC,Gann DS

更新日期：1982-12-01 00:00:00