Modulation of glucocorticoid induction of tyrosine aminotransferase gene expression by variations in cell density.

abstract：:We constructed seven chimeric molecules in which sequential segments in the cDNA for thyroid peroxidase (TPO) were replaced with the homologous regions of myeloperoxidase (MPO) cDNA. The sizes of the translated cDNA segments A through G ranged from 23-175 amino acid residues in length. The TPO-MPO cDNA chimeras, inser...

journal_title：Endocrinology

authors： Nishikawa T,Nagayama Y,Seto P,Rapoport B

更新日期：1993-12-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) stimulates the formation of osteoclast-like tartrate-resistant acid phosphatase-positive multinucleated cells (TRAP + MNC) in vitro. This effect likely results from stimulation of adenylyl cyclase, which is mediated by two PGE2 receptors, designated EP2 and EP4. We used cells from mice in which...

journal_title：Endocrinology

authors： Li X,Okada Y,Pilbeam CC,Lorenzo JA,Kennedy CR,Breyer RM,Raisz LG

更新日期：2000-06-01 00:00:00

abstract：:The aim of this study was to investigate the direct effect of leptin on GH gene expression and secretion and the role of nitric oxide as a possible mediator in pig anterior pituitary cells. Pituitary cells from adult sows were treated for 4 or 24 h with rhleptin (from 0.1 nM to 1 microM) alone or in association with G...

journal_title：Endocrinology

authors： Baratta M,Saleri R,Mainardi GL,Valle D,Giustina A,Tamanini C

更新日期：2002-02-01 00:00:00

abstract：:The present study was conducted to elucidate the role of activin A in tubulogenesis of vascular endothelial cells. Activin A was produced in bovine aortic endothelial cells (BAEC). These cells also expressed the type I and type II activin receptors. When added to BAEC cultured in a collagen gel, activin A induced capi...

journal_title：Endocrinology

authors： Maeshima K,Maeshima A,Hayashi Y,Kishi S,Kojima I

更新日期：2004-08-01 00:00:00

abstract：:Hypothyroid patients and mice have been shown to have circulating TSH that is more highly sialylated than their euthyroid counterparts. To learn about the underlying cellular mechanisms responsible for this increased sialylation of TSH, we used in situ hybridization to examine the beta-galactoside alpha-2,6-sialyltran...

journal_title：Endocrinology

authors： Helton TE,Magner JA

更新日期：1994-06-01 00:00:00

abstract：:Characterization of glycoconjugates synthesized by polarized immature rabbit uterine epithelial (UE) cells in vitro, their vectorial patterns of secretion, and regulation by ovarian steroid hormones are reported. Large (mol wt, greater than 230 kDa) sialomucoglycoproteins and hyaluronate were primarily (86-96%) secret...

journal_title：Endocrinology

authors： Mani SK,Carson DD,Glasser SR

更新日期：1992-01-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF alpha) has been localized to the anterior pituitary, specifically to the lactotroph and somatotroph cell populations, by our previous studies. Since pituitary lactotrophs are known to undergo growth in response to estrogens, we have used an estradiol-induced pituitary hyperplasia/...

journal_title：Endocrinology

authors： Borgundvaag B,Kudlow JE,Mueller SG,George SR

更新日期：1992-06-01 00:00:00

abstract：:Animals maintained on retinol (vitamin A-alcohol)-deficient diets exhibit testicular atrophy and loss of the germinal epithelium. Retinoic acid (vitamin A-acid), when fed to retinol-deficient animals, does not prevent these lesions and had thus been thought not to play a role in the tests. Serum testosterone (T) level...

journal_title：Endocrinology

authors： Appling DR,Chytil F

更新日期：1981-06-01 00:00:00

abstract：:Adenylate cyclase of rat renal cortex was inhibited by angiotensin II (AII). Inhibition required Na+ (100-200 mM) and GTP (10(-8)-10(-4) M) and was opposed by the receptor antagonist [1-sarcosine, 8-isoleucine]AII. The EC50 value (+/- SE)for inhibition by AII was 3.7 +/- 1.2 nM, and the maximum inhibition (+/- SE) was...

journal_title：Endocrinology

authors： Woodcock EA,Johnston CI

更新日期：1982-11-01 00:00:00

abstract：:Previous studies have shown that mice missing gp130, the common receptor subunit for many cytokines, die at or before birth with multiple skeletal abnormalities. Furthermore, interactions between PTH and gp130 signaling have suggested that gp130 signaling might influence calcium homeostasis. We, therefore, examined th...

journal_title：Endocrinology

authors： Shin HI,Divieti P,Sims NA,Kobayashi T,Miao D,Karaplis AC,Baron R,Bringhurst R,Kronenberg HM

更新日期：2004-03-01 00:00:00

abstract：:The neuroendocrine hormones ACTH and corticotropin- releasing factor (CRF), which are involved in the stress response, have acute effects on arterial pressure. New evidence indicates that urocortin (UCN), the putative agonist for the CRF type 2 receptor, has selective cardiovascular actions. The responses to long-term...

journal_title：Endocrinology

authors： Weisinger RS,Blair-West JR,Burns P,Denton DA,Purcell B,Vale W,Rivier J,Weisinger HS,May CN

更新日期：2004-12-01 00:00:00

abstract：:The present studies aimed to identify mechanisms contributing to amylin/leptin synergy in reducing body weight and adiposity. We reasoned that if amylin/leptin harnessed complementary neuronal pathways, then in the leptin-sensitive state, amylin should augment leptin signaling/binding and that in the absence of endoge...

journal_title：Endocrinology

authors： Turek VF,Trevaskis JL,Levin BE,Dunn-Meynell AA,Irani B,Gu G,Wittmer C,Griffin PS,Vu C,Parkes DG,Roth JD

更新日期：2010-01-01 00:00:00

abstract：:Osteoclast precursors reach sites of osteoclast formation and remodelling via the vasculature and are therefore destined to encounter endothelium before migrating to the bone surface. Here we investigated the hypothesis that endothelium may be involved in the regulation of osteoclast precursor recruitment to sites of ...

journal_title：Endocrinology

authors： McGowan NW,Walker EJ,Macpherson H,Ralston SH,Helfrich MH

更新日期：2001-04-01 00:00:00

abstract：:L-700,653 is a potent nonpeptidyl GH secretagogue consisting of a benzolactam structure: (4'-[[3(R)-[[3-[(2(S),3-dihydroxypropyl) amino]3-methyl-1-oxobutyl]amino]2,3,4,5-tetrahydro-2-oxo-1H-1-benzaze pin- 1-yl]methyl][1,1'-biphenyl]2-carboxamide hydrochloride). When administered sc by a Medi-Jector device at 0, 0.003,...

journal_title：Endocrinology

authors： Chang CH,Rickes EL,Marsilio F,McGuire L,Cosgrove S,Taylor J,Chen H,Feighner S,Clark JN,De Vita R

更新日期：1995-03-01 00:00:00

abstract：:Smoltification is a transformation that occurs in some species of salmon, during which solitary fish in fresh water become schooling fish and migrate to the sea. This process is accompanied by large increases in plasma T4. T4 secretion rate and other parameters of T4 metabolism in juvenile coho salmon were estimated b...

journal_title：Endocrinology

authors： Specker JL,DiStefano JJ 3rd,Grau EG,Nishioka RS,Bern HA

更新日期：1984-07-01 00:00:00

abstract：:To better understand the role of peptide growth factors in sex steroid hormone-mediated growth of the female reproductive tract, the effect of estrogen on the expression of transforming growth factor-alpha (TGF alpha) in mouse uterus was investigated. Our results show that estrogen induces the expression of TGF alpha ...

journal_title：Endocrinology

authors： Nelson KG,Takahashi T,Lee DC,Luetteke NC,Bossert NL,Ross K,Eitzman BE,McLachlan JA

更新日期：1992-10-01 00:00:00

abstract：:Although GH plays a key role in postnatal growth, prenatal growth is thought to be GH independent. However, recent data has shown GH receptor/binding protein (GHR/BP) to be present in rat fetal tissues as early as fetal stage E12. The aim of the present study was to investigate tissue-specific production of the GHR/BP...

journal_title：Endocrinology

authors： Edmondson SR,Werther GA,Russell A,LeRoith D,Roberts CT Jr,Beck F

更新日期：1995-10-01 00:00:00

abstract：:The interaction of alloxan and cyclic AMP on glucose-induced insulin secretion was studied with the use of isolated rat islet perifusion. Simultaneous perifusion with cyclic AMP and alloxan did not protect the islets against the effect of alloxan. However, addition of dibutyryl cyclic AMP to the alloxan solution produ...

journal_title：Endocrinology

authors： Tomita T,Scarpelli DG

更新日期：1977-05-01 00:00:00

abstract：:Extracts of spinach contain somatostatin (SRIF)-related material (6-80 pg/g wet wt). The SRIF-related material, when purified on HPLC, was recovered as two major mol wt forms; one that eluted with a retention time similar to that of synthetic SRIF-28 and reacted in both N- and C-terminal-specific immunoassays, and a s...

journal_title：Endocrinology

authors： LeRoith D,Pickens W,Wilson GL,Miller B,Berelowitz M,Vinik AI,Collier E,Cleland CF

更新日期：1985-11-01 00:00:00

abstract：:Leptin has been shown to activate multiple signaling molecules in cultured cells, including Janus kinase-2, STAT (signal transducer and activator of transcription) proteins, and mitogen-activated protein kinase, and to stimulate the DNA-binding activity of STAT3 in mouse hypothalamus. In this study, the activation of ...

journal_title：Endocrinology

authors： McCowen KC,Chow JC,Smith RJ

更新日期：1998-11-01 00:00:00

abstract：:The present studies demonstrate that the murine adrenocortical tumor cell line Y-1 releases a digoxin-like immunoreactive material into both serum-supplemented nutrient medium and minimal Krebs-Ringer bicarbonate medium. Release of pregnenolone into minimal medium from these cells was consistently inhibited by additio...

journal_title：Endocrinology

authors： Doris PA,Kilgore MW,Durham D,Alberts D,Stocco DM

更新日期：1989-11-01 00:00:00

abstract：:Parathyroid hormone (PTH) secretion rate was measured in seven calves by using a technique which involved RIA of parathyroid venous blood collected during timed intervals and measured volumetrically. Infusion of solutions of NA2EDTA and MgCl2 into the jugular vein was used to alter plasma calcium and magnesium concent...

journal_title：Endocrinology

authors： Mayer GP,Hurst JG

更新日期：1978-06-01 00:00:00

abstract：:The present investigation was undertaken to examine the possible role of cAMP in PTH-stimulated prostaglandin (PG) production in organ cultures of neonatal mouse parietal bones. Cultures were treated with PTH, forskolin, isobutylmethylxanthine (IBMX), and 8-bromo-cAMP (8BrcAMP). We found that similar concentrations of...

journal_title：Endocrinology

authors： Klein-Nulend J,Bowers PN,Raisz LG

更新日期：1990-02-01 00:00:00

abstract：:Tamoxifen, a partial competitive antagonist to the estrogen receptor, is a potent inhibitor of the proliferation of experimental mammary carcinoma in the rat and is widely used clinically in the treatment of breast cancer. Blockade of estrogen receptors present on neoplastic cells represents the classic mechanism of a...

journal_title：Endocrinology

authors： Tannenbaum GS,Gurd W,Lapointe M,Pollak M

更新日期：1992-06-01 00:00:00

abstract：:Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (te...

journal_title：Endocrinology

authors： Castroneves LA,Jugo RH,Maynard MA,Lee JS,Wassner AJ,Dorfman D,Bronson RT,Ukomadu C,Agoston AT,Ding L,Luongo C,Guo C,Song H,Demchev V,Lee NY,Feldman HA,Vella KR,Peake RW,Hartigan C,Kellogg MD,Desai A,Salvatore D

更新日期：2014-10-01 00:00:00

abstract：:To determine whether altered noradrenergic activation of the hypothalamo-pituitary-adrenal (HPA) axis contributes to the attenuated neuroendocrine response to stress observed during lactation, the effect of intracerebroventricular injection of the alpha1-agonist methoxamine (100 microg) was compared between virgin and...

journal_title：Endocrinology

authors： Windle RJ,Brady MM,Kunanandam T,Da Costa AP,Wilson BC,Harbuz M,Lightman SL,Ingram CD

更新日期：1997-09-01 00:00:00

abstract：:To investigate the physiological role of GRF and somatostatin (SRIF) in GH secretion in adult male rats, we prepared in vitro models using the perifusion system of cultured rat anterior pituitary cells exposed to various combinations of human GRF-(1-44)NH2 (hGRF) and SRIF. We studied the following three models on GRF ...

journal_title：Endocrinology

authors： Sato M,Takahara J,Fujioka Y,Niimi M,Irino S

更新日期：1988-10-01 00:00:00

abstract：:Recent studies from our laboratory demonstrated clearly that only a portion of all Sertoli cells secrete transferrin (TF). These findings raised the possibility that differences in the functional type of Sertoli cells from one location to another may account in part for the stage-related variation in TF release along ...

journal_title：Endocrinology

authors： Garza MM,Schwarz LK,Bonner JM,Boockfor FR

更新日期：1991-04-01 00:00:00

abstract：:The levels of the GnRH receptor (GnRHR) and its messenger RNA depend on the pattern of administration of GnRH. In this study, internal deletion mutants in a luciferase reporter gene vector (GnRHR-pXP2) containing a 1226-bp promoter fragment of mouse GnRHR gene were used to examine the regulation of GnRHR gene transcri...

journal_title：Endocrinology

authors： Maya-Núñez G,Conn PM

更新日期：1999-08-01 00:00:00

abstract：:The lateral hypothalamic area (LHA) is essential for motivated ingestive and locomotor behaviors that impact body weight, yet it remains unclear how the neurochemically defined subpopulations of LHA neurons contribute to energy balance. In particular, the role of the large population of LHA neurotensin (Nts) neurons h...

journal_title：Endocrinology

authors： Brown J,Sagante A,Mayer T,Wright A,Bugescu R,Fuller PM,Leinninger G

更新日期：2018-09-01 00:00:00