Characterization of thyroid hormone binding to apolipoprotein-E: localization of the binding site in the exon 3-coded domain.

abstract：:Dynamic bone histomorphometry, [3H]thymidine radioautography, and Northern analysis for bone matrix proteins and insulin-like growth factor-I (IGF-I) were performed in calvariae of ovariectomized (OVX) and estrogen-treated OVX rats. Treatment of OVX rats with diethylstilbestrol (DES) for 2 weeks reduced the periosteal...

journal_title：Endocrinology

authors： Turner RT,Backup P,Sherman PJ,Hill E,Evans GL,Spelsberg TC

更新日期：1992-08-01 00:00:00

abstract：:A new hydrolase activity has been identified by its capability of cleaving t-boc-Ala-Ala-Pro-Ala-AMC, the released 7-amino-4-methylcoumarin (AMC) being quantified fluorometrically. The activity in the 28,000 X g supernatant fraction of homogenates of weanling mouse uterus was about one fifth that of the adult mouse. T...

journal_title：Endocrinology

authors： Katz J,Finlay TH,Tom C,Levitz M

更新日期：1980-12-01 00:00:00

abstract：:To examine the role of androgen receptor (AR) in Sertoli cells (SC), we used a SC-specific AR knockout (S-AR-/y) mouse to further evaluate the chronological changes of seminiferous tubules and the molecular mechanisms of SC androgen/AR signals on spermatogenesis. Testes morphology began changing as early as postnatal ...

journal_title：Endocrinology

authors： Wang RS,Yeh S,Chen LM,Lin HY,Zhang C,Ni J,Wu CC,di Sant'Agnese PA,deMesy-Bentley KL,Tzeng CR,Chang C

更新日期：2006-12-01 00:00:00

abstract：:Fibroblasts represent one of the in vivo sites of extrahepatic insulin-like growth factor I (IGF-I) production. In this study, cultured fibroblasts prepared from the skin of neonatal rats were used as a model to assess the role of serum in regulating IGF-I messenger RNA (mRNA) levels. IGF-I mRNA, as demonstrated by No...

journal_title：Endocrinology

authors： Lowe WL Jr,Kummer M,Karpen CW,Wu XD

更新日期：1990-12-01 00:00:00

abstract：:Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although researchers from a myriad of disciplines are beginning to appreciate the importance of considering sex differences in the design ...

journal_title：Endocrinology

authors： Becker JB,Arnold AP,Berkley KJ,Blaustein JD,Eckel LA,Hampson E,Herman JP,Marts S,Sadee W,Steiner M,Taylor J,Young E

更新日期：2005-04-01 00:00:00

abstract：:The rat esophagus shares some cellular features with skin squamous epithelium and striated muscle that express high levels of corticotropin-releasing factor type 2 (CRF2) receptors or their cognate ligand urocortin (Ucn) 1, 2, and 3. We investigated the expression and cell signaling of CRF2 receptors and ligands in th...

journal_title：Endocrinology

authors： Wu SV,Yuan PQ,Wang L,Peng YL,Chen CY,Taché Y

更新日期：2007-04-01 00:00:00

abstract：:The GnRH decapeptide controls reproductive function through its release from neuroendocrine terminals in the median eminence, a site where there is a convergence of numerous nerve terminals and glial cells. Previous work showed dynamic changes in the GnRH-glial-capillary network in the median eminence under different ...

journal_title：Endocrinology

authors： Yin W,Wu D,Noel ML,Gore AC

更新日期：2009-12-01 00:00:00

abstract：:Patients with noninsulin-dependent diabetes mellitus exhibit increased proportions of plasma proinsulin and proinsulin conversion intermediates. We used hyperinsulinemic diabetic and nondiabetic Psammomys obesus to study the possible relationship between steady state pancreatic insulin stores and the proportion of pro...

journal_title：Endocrinology

authors： Gadot M,Leibowitz G,Shafrir E,Cerasi E,Gross DJ,Kaiser N

更新日期：1994-08-01 00:00:00

abstract：:The Rice H500 rat Leydig cell tumor is a well characterized model of humoral hypercalcemia of malignancy (HHM). Circulating concentrations of PTH-related protein (PTHRP) have not been reported in this or any other animal model of HHM. Taking advantage of the marked N-terminal amino acid homology between rodent and hum...

journal_title：Endocrinology

authors： Gaich G,Burtis WJ

更新日期：1990-09-01 00:00:00

abstract：:The mouse mammary gland and uterus expressed the gene for the secretory protein lactotransferrin under various physiological conditions. Lactotransferrin, however, was induced by estrogen in a time- and dose-dependent fashion in the uterus of the immature mouse, but was not affected by estrogen in the mammary gland. D...

journal_title：Endocrinology

authors： Teng CT,Pentecost BT,Chen YH,Newbold RR,Eddy EM,McLachlan JA

更新日期：1989-02-01 00:00:00

abstract：:In bone, early events in inflammation involve the production and release of primary proinflammatory cytokines, such as interleukin-1 beta. By activation of target cells, these cytokines are thought to induce a second wave of cytokines, including monocyte chemoattractant protein-1 (MCP-1). MCP-1 is a cytokine that stim...

journal_title：Endocrinology

authors： Rahimi P,Wang CY,Stashenko P,Lee SK,Lorenzo JA,Graves DT

更新日期：1995-06-01 00:00:00

abstract：:The effects of human pancreatic GH-releasing factor-40 (hpGRF-40; 0.01-100 nM) and (Bu)2cAMP (0.015-1.5 mM) on GH release from primary monolayer cultures of pituitary cells were evaluated in rats of three age groups: postnatal days 2 and 12, and young adult males (3-4 months). Both hpGRF-40 and (Bu)2cAMP elicited a do...

journal_title：Endocrinology

authors： Szabo M,Cuttler L

更新日期：1986-01-01 00:00:00

abstract：:We have developed a highly sensitive and specific RIA for propylthiouracil (PTU) which uses 125I-labeled PTU as the radioactive ligand. At a final antibody dilution of 1:10,000, the detection limit for PTU was 100 pg; cross-reactivity with circulating, urinary, and intrathyroid PTU metabolites was negligible. Using th...

journal_title：Endocrinology

authors： Halpern R,Cooper DS,Kieffer JD,Saxe V,Mover H,Maloof F,Ridgway EC

更新日期：1983-09-01 00:00:00

abstract：:Although the neurohypophyseal hormone oxytocin (OT) is best know for its role in reproduction, OT also stimulates natriuresis at physiological plasma levels. This effect is mediated via specific renal OT receptors (OTRs). In the present study, we have characterized rat renal OTR gene transcripts and assessed their reg...

journal_title：Endocrinology

authors： Breton C,Neculcea J,Zingg HH

更新日期：1996-07-01 00:00:00

abstract：:Activin A is a gonadal protein originally isolated from follicular fluid and is recognized as a local regulator of granulosa cell differentiation. Whether activin A promotes folliculogenesis, however, still remains unclarified. The present study was designed to elucidate the effect of activin A on follicular growth in...

journal_title：Endocrinology

authors： Yokota H,Yamada K,Liu X,Kobayashi J,Abe Y,Mizunuma H,Ibuki Y

更新日期：1997-11-01 00:00:00

abstract：:TGF-beta is a multifunctional factor involved in regulating a variety of cellular activities. In mammals, TGF-beta is known to regulate reproduction, including ovarian functions. The role of TGF-beta in lower vertebrates, such as fish, is poorly understood. To examine the role of TGF-beta in fish reproduction, cDNAs e...

journal_title：Endocrinology

authors： Kohli G,Hu S,Clelland E,Di Muccio T,Rothenstein J,Peng C

更新日期：2003-05-01 00:00:00

abstract：:PTHrP is produced in vessels and acts as a local modulator of tone. We recently reported that PTHrP(1-34) is able to induce vasorelaxation in rat uterine arteries, but in pregnancy, this response is blunted and becomes strictly endothelium dependent. The present study aimed to get insights into the mechanisms involved...

journal_title：Endocrinology

authors： Meziani F,Tesse A,Welsch S,Kremer H,Barthelmebs M,Andriantsitohaina R,Schneider F,Gairard A

更新日期：2008-02-01 00:00:00

abstract：:Exposure of FRTL-5 cells to iodide (I-) in excess of 3 microM suppresses the concentrative uptake of I-. The depression of I- uptake measured at the steady state is due to decrease in the rate of I- influx and not to an effect on I- efflux. Exposure to NaI is associated with decreased T4 secretion and also depressed N...

journal_title：Endocrinology

authors： Grollman EF,Smolar A,Ommaya A,Tombaccini D,Santisteban P

更新日期：1986-06-01 00:00:00

abstract：:The present study used perforated-patch electrophysiology and calcium imaging in GnRH transgenic mouse lines to determine the mechanisms underlying the potent excitatory effects of kisspeptin upon GnRH neurons in the acute brain slice preparation. Kisspeptin (100 nm) depolarized (6 +/- 1 mV) and/or evoked an 87 +/- 4%...

journal_title：Endocrinology

authors： Liu X,Lee K,Herbison AE

更新日期：2008-09-01 00:00:00

abstract：:It has previously been established that neuropeptide-Y (NPY) is a potent inhibitor of alpha MSH release from the pars intermedia of the amphibian Xenopus laevis. The location of binding sites for NPY in the pars intermedia of the pituitary has now been studied with light microscopic autoradiography, using a dispersed ...

journal_title：Endocrinology

authors： De Rijk EP,Cruijsen PM,Jenks BG,Roubos EW

更新日期：1991-02-01 00:00:00

abstract：:To study blood capillary growth in the hyperplastic thyroid gland, rats were fed 0.25% thiouracil in a low iodine diet for time intervals up to 100 days. Thyroids were fixed by vascular perfusion and embeded in Epon. Whole lobes were sectioned from pole to pole and slides were prepared of sections every 0.3 mm. Capill...

journal_title：Endocrinology

authors： Wollman SH,Herveg JP,Zeligs JD,Ericson LE

更新日期：1978-12-01 00:00:00

abstract：:Corticostatic peptides are a family of arginine-rich cysteine-rich peptides that inhibit ACTH-stimulated corticosterone (B) production in rat adrenal cell suspensions. In this communication we describe a new method for the facile isolation and purification of these basic peptides from rabbit adult lung. We then descri...

journal_title：Endocrinology

authors： Zhu Q,Solomon S

更新日期：1992-03-01 00:00:00

abstract：:Experiments were done to examine whether rat relaxin is dipsogenic and whether such dipsogenic effects of rat relaxin are related to time of injection during the light-dark cycle. Female rats were fitted with a chronic intra-cerebro-ventricular (i.c.v.) cannula. Rat relaxin (2.5, 5, 10, 25, 50, or 100 ng/2 microl in 0...

journal_title：Endocrinology

authors： Summerlee AJ,Hornsby DJ,Ramsey DG

更新日期：1998-05-01 00:00:00

abstract：:The effects of gamma-aminobutyric acid (GABA) on the spontaneous and TRH-induced TSH release were investigated in vitro on perifused rat pituitaries. The dynamic pattern of TSH release was measured in response to a 6-min pulse of TRH (10 nM) with or without GABA addition. GABA had no effect on spontaneous TSH release ...

journal_title：Endocrinology

authors： Tapia-Arancibia L,Roussel JP,Astier H

更新日期：1987-09-01 00:00:00

abstract：:In GH4C1 cells, membrane depolarization induces a rapid and sustained increase in the cytosolic free calcium concentration ([Ca2+]i). In the present study we have investigated the role of [Ca2+]i in the regulation of basal intracellular pH (pHi). Depolarizing GH4C1 cells in buffer containing 0.4 mM extracellular Ca2+ ...

journal_title：Endocrinology

authors： Törnquist K,Tashjian AH Jr

更新日期：1992-02-01 00:00:00

abstract：:The role of 11 beta,20-dihydroxy-3-oxopregna-4,17(20)-dien-21-al (F enol aldehyde) as an intermediate in the biological conversion of cortisol to a 17-deoxy-21-oic acid was studied in vitro with mouse liver as the source of enzyme. The substrate, [1,2-3H]F enol aldehyde, was synthesized and found to contain cis and tr...

journal_title：Endocrinology

authors： Singer CJ,Iohan F,Monder C

更新日期：1986-09-01 00:00:00

abstract：:The present study was undertaken to determine whether T3 could modify anterior pituitary Ca++ metabolism under basal conditions and in the presence of TRH. Paired hemipituitaries from hypothyroid rats were preincubated with T3 (10(-7) M) for 2 h, allowed to accumulate 45Ca++ for the third hour, and repeatedly washed i...

journal_title：Endocrinology

authors： Schrey MP,Larsen PR

更新日期：1981-05-01 00:00:00

abstract：:Changes in insulin, somatostatin, and glucagon secretion during the development of obesity in rats after ventromedial hypothalamic (VMH) lesions were evaluated by measuring fasting hormone levels and their secretion from the isolated perfused pancreas. Fasting peripheral insulin levels were not altered 1 week after th...

journal_title：Endocrinology

authors： Seino Y,Seino S,Takemura J,Tsuda K,Nishi S,Ishida H,Seno M,Usami M,Ikeda M,Imura H

更新日期：1984-02-01 00:00:00

abstract：:The rapid and temporary suppression of reproductive behavior is often assumed to be an important feature of the adaptive acute stress response. However, how this suppression operates at the mechanistic level is poorly understood. The enzyme aromatase converts testosterone to estradiol in the brain to activate reproduc...

journal_title：Endocrinology

authors： Dickens MJ,Cornil CA,Balthazart J

更新日期：2011-11-01 00:00:00

abstract：:Notch signaling is an evolutionarily conserved pathway, which regulates cell proliferation, differentiation, and apoptosis. It has been reported that the members of Notch signaling are expressed in mammalian ovaries, but the exact functions of this pathway in follicle development is still unclear. In this study, prima...

journal_title：Endocrinology

authors： Zhang CP,Yang JL,Zhang J,Li L,Huang L,Ji SY,Hu ZY,Gao F,Liu YX

更新日期：2011-06-01 00:00:00