A new hormone-response hydrolase activity in the mouse uterus.

abstract：:The actions of IGFs are regulated at various levels. One mechanism involves binding to IGF-binding protein-3 (IGFBP-3) for transport, thus governing bioavailability. IGFBP3 transcription is modulated by many hormones and agents that stimulate or inhibit growth. We have previously shown in pediatric and adult cohorts a...

journal_title：Endocrinology

authors： Paquette J,Bessette B,Ledru E,Deal C

更新日期：2007-12-01 00:00:00

abstract：:Proinflammatory cytokines have been shown to influence the expression and function of the glucocorticoid receptor (GR). Specifically, several studies have found that cytokines induce a decrease in GR function, as evidenced by reduced sensitivity to glucocorticoid effects on functional end points. To investigate the po...

journal_title：Endocrinology

authors： Pariante CM,Pearce BD,Pisell TL,Sanchez CI,Po C,Su C,Miller AH

更新日期：1999-09-01 00:00:00

abstract：:Maternal nutrient restriction at specific stages of gestation has differential effects on fetal development such that the offspring are programmed to be at increased risk of adult disease. We investigated the effect of gestational age and maternal nutrition on the maternal plasma concentration of leptin and cortisol t...

journal_title：Endocrinology

authors： Bispham J,Gopalakrishnan GS,Dandrea J,Wilson V,Budge H,Keisler DH,Broughton Pipkin F,Stephenson T,Symonds ME

更新日期：2003-08-01 00:00:00

abstract：:Lefty/Ebaf polypeptides, novel members of the TGF-beta superfamily, are involved in endometrial differentiation and embryo implantation. Recently, we showed that, during undisturbed estrous cycle, lefty is present in mouse uterine horn primarily in a precursor form. Here, we show that decidual differentiation of endom...

journal_title：Endocrinology

authors： Tang M,Mikhailik A,Pauli I,Giudice LC,Fazelabas AT,Tulac S,Carson DD,Kaufman DG,Barbier C,Creemers JW,Tabibzadeh S

更新日期：2005-12-01 00:00:00

abstract：:Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity, which can amplify...

journal_title：Endocrinology

authors： Doig CL,Fletcher RS,Morgan SA,McCabe EL,Larner DP,Tomlinson JW,Stewart PM,Philp A,Lavery GG

更新日期：2017-06-01 00:00:00

abstract：:Some TSH receptors (TSHR) on the cell surface cleave into A and B subunits. Cleavage at upstream Site 1 is followed by the proteolytic excision of an intervening C peptide region terminating at a downstream Site 2. Although present evidence suggests that Site 1 lies between amino acid residues 303 and 317, the mechani...

journal_title：Endocrinology

authors： Tanaka K,Chazenbalk GD,McLachlan SM,Rapoport B

更新日期：2000-10-01 00:00:00

abstract：:SH2B1 is an SH2 domain-containing adaptor protein that plays a key role in the regulation of energy and glucose metabolism in both rodents and humans. Genetic deletion of SH2B1 in mice results in obesity and type 2 diabetes. Single-nucleotide polymorphisms in the SH2B1 loci and chromosomal deletions of the SH2B1 loci ...

journal_title：Endocrinology

authors： Morris DL,Cho KW,Rui L

更新日期：2010-08-01 00:00:00

abstract：:Prokineticin-1 (PK1) is a recently described protein with a wide range of functions, including tissue-specific angiogenesis, modulation of inflammatory responses, and regulation of hemopoiesis. The aim of this study was to investigate the localization and expression of PK1 and PK receptor-1 (PKR1), their signaling pat...

journal_title：Endocrinology

authors： Denison FC,Battersby S,King AE,Szuber M,Jabbour HN

更新日期：2008-07-01 00:00:00

abstract：:We previously reported that TNF-alpha-induced apoptosis of lactotropes is estrogen dependent and predominant at proestrus. Here we observed that TNF-alpha (50 ng/ml) failed to induce apoptosis of anterior pituitary cells from ovariectomized rats cultured in the presence of progesterone (10(-6) m). However, progesteron...

journal_title：Endocrinology

authors： Candolfi M,Jaita G,Zaldivar V,Zárate S,Ferrari L,Pisera D,Castro MG,Seilicovich A

更新日期：2005-02-01 00:00:00

abstract：:Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes. Elevated cytokines impair beta-cell function and survival. A recent clinical trial shows that blocking IL-1beta signaling by IL-1 receptor antagonist (IL-1Ra) improves beta-cell secretory function in patients with type 2 diabetes. In the ...

journal_title：Endocrinology

authors： Sauter NS,Schulthess FT,Galasso R,Castellani LW,Maedler K

更新日期：2008-05-01 00:00:00

abstract：:Prolonged stimulation of cells by beta-adrenergic receptor agonists may lead to diminished responsiveness of the cells to subsequent activation by catecholamines. This phenomenon has been termed desensitization; the mechanism(s) for desensitization may involve an apparent loss in the number of beta-adrenergic receptor...

journal_title：Endocrinology

authors： Tsujimoto G,Manger WM,Hoffman BB

更新日期：1984-04-01 00:00:00

abstract：:The present study was undertaken to investigate the role of angiotensin II (Ang II) in ovulation and ovarian steroidogenesis and prostaglandin (PG) production via the Ang II receptors in rabbit ovaries. In in vitro perfused rabbit ovaries, PD123319, a selective nonpeptide antagonist for AT2 receptors, reduced the Ang ...

journal_title：Endocrinology

authors： Yoshimura Y,Karube M,Aoki H,Oda T,Koyama N,Nagai A,Akimoto Y,Hirano H,Nakamura Y

更新日期：1996-04-01 00:00:00

abstract：:On the basis of our previous observations indicating that a principle [possibly transforming growth factor-beta1 (TGFbeta1)] secreted by type 1 astrocytes may increase the release of LHRH in the GT1 cell line, it was deemed of interest to analyze whether TGFbeta1 might influence LHRH gene expression in addition to LHR...

journal_title：Endocrinology

authors： Galbiati M,Zanisi M,Messi E,Cavarretta I,Martini L,Melcangi RC

更新日期：1996-12-01 00:00:00

abstract：:To examine the physiological effects of norepinephrine (NE) in the paraventricular nucleus of the hypothalamus (PVH) on CRF gene expression and CRF release, NE was microinjected bilaterally into the PVH of conscious rats, and kinetic studies were performed on the levels of POMC messenger RNA (mRNA) in the anterior pit...

journal_title：Endocrinology

authors： Itoi K,Suda T,Tozawa F,Dobashi I,Ohmori N,Sakai Y,Abe K,Demura H

更新日期：1994-11-01 00:00:00

abstract：:In the rat ovary, follicle cells produce and respond to activin, but as yet, the functional significance of the autocrine/paracrine effects of ovarian activin remains equivocal. To assess the effects of activin on folliculogenesis, normal cycling female rats were injected once every 8 h over a 40-h period with recombi...

journal_title：Endocrinology

authors： Erickson GF,Kokka S,Rivier C

更新日期：1995-11-01 00:00:00

abstract：:We demonstrated previously that glucocorticoids differentially affect the levels of the two pituitary gonadotropins, LH and FSH, both in vivo and in vitro. In vivo, the effect of glucocorticoids is GnRH independent, indicating a direct action on the gonadotrope, and it leads to selective up-regulation of the pituitary...

journal_title：Endocrinology

authors： Kilen SM,Szabo M,Strasser GA,McAndrews JM,Ringstrom SJ,Schwartz NB

更新日期：1996-09-01 00:00:00

abstract：:To better understand the role of peptide growth factors in sex steroid hormone-mediated growth of the female reproductive tract, the effect of estrogen on the expression of transforming growth factor-alpha (TGF alpha) in mouse uterus was investigated. Our results show that estrogen induces the expression of TGF alpha ...

journal_title：Endocrinology

authors： Nelson KG,Takahashi T,Lee DC,Luetteke NC,Bossert NL,Ross K,Eitzman BE,McLachlan JA

更新日期：1992-10-01 00:00:00

abstract：:Neurons that produce kisspeptin play a critical role in reproduction. However, understanding the molecular physiology of kisspeptin neurons has been limited by the lack of an in vivo marker for those cells. Here, we report the development of a Kiss1-CreGFP knockin mouse, wherein the endogenous Kiss1 promoter directs t...

journal_title：Endocrinology

authors： Gottsch ML,Popa SM,Lawhorn JK,Qiu J,Tonsfeldt KJ,Bosch MA,Kelly MJ,Rønnekleiv OK,Sanz E,McKnight GS,Clifton DK,Palmiter RD,Steiner RA

更新日期：2011-11-01 00:00:00

abstract：:Infection-induced inflammation, frequently associated with increased production of proinflammatory cytokines, is considered a significant contributor to preterm birth. A G protein-coupled cannabinoid receptor 2 (CB2), encoded by Cnr2, is expressed in various immune cells and was shown to modulate immune responses. We ...

journal_title：Endocrinology

authors： Sun X,Cappelletti M,Li Y,Karp CL,Divanovic S,Dey SK

更新日期：2014-10-01 00:00:00

abstract：:Testicular LH receptor occupancy and steroidogenic responses were measured in adult male rats after intracardiac injections of [125I]iodo-hCG (0.5--5 x 10(6) cpm) mixed with known amounts of nonradioactive hCG to yield doses ranging from 10 ng to 300 micrograms. Uptake of the hormone by the testis was measured in the ...

journal_title：Endocrinology

authors： Huhtaniemi IT,Clayton RN,Catt KJ

更新日期：1982-09-01 00:00:00

abstract：:We have previously demonstrated that CGP 42112 (AT(2) agonist > or =1 nM) markedly reduces catecholamine biosynthesis through AT(2), which is the major angiotensin II (AngII) receptor subtype in cultured porcine chromaffin cells. Also, we have shown that CGP 42112 (> or =1 nM) induces a reduction in cGMP production in...

journal_title：Endocrinology

authors： Takekoshi K,Ishii K,Kawakami Y,Isobe K,Nakai T

更新日期：2001-07-01 00:00:00

abstract：:GH deficiency is known to be clinically associated with a high incidence of nonalcoholic fatty liver disease, and this can be reversed by GH administration. Here we investigated the mechanistic basis for this phenomenon using engineered male mice lacking different signaling elements of the GH receptor, hepatic stat5a/...

journal_title：Endocrinology

authors： Barclay JL,Nelson CN,Ishikawa M,Murray LA,Kerr LM,McPhee TR,Powell EE,Waters MJ

更新日期：2011-01-01 00:00:00

abstract：:Both somatostatin (SRIF) and urotensin II, a dodecapeptide from the teleost caudal neurosecretory system, inhibit PRL release from the organ-cultured rostral pars distalis of the tilapia, Sarotherodon mossambicus, in a dose-related manner. The inhibitory action of SRIF on PRL release was completely prevented by the pr...

journal_title：Endocrinology

authors： Grau EG,Nishioka RS,Bern HA

更新日期：1982-03-01 00:00:00

abstract：:Mutations in the GnRH receptor gene (GNRHR) can result in hypogonadotropic hypogonadism in humans. Unlike most mammals, mice lack a second form of GnRH (GnRH2) and a type 2 GnRH receptor. To determine whether the GnRH receptor is critical at all stages of reproduction and whether this receptor has additional physiolog...

journal_title：Endocrinology

authors： Wu S,Wilson MD,Busby ER,Isaac ER,Sherwood NM

更新日期：2010-03-01 00:00:00

abstract：:Daily nocturnal (N) and diurnal (D) surges of PRL are characteristic of a pseudopregnancy (psp) induced by cervical stimulation (CS). These semicircadian surges persist for 13-14 days, after which time they cease, and psp ends. The purpose of this study was to describe the involvement of the ovarian steroids in the ma...

journal_title：Endocrinology

authors： Gorospe WC,Freeman ME

更新日期：1981-04-01 00:00:00

abstract：:The study of epigenetics allows for the understanding of gene × environmental interactions and provides a mechanism by which brief internal or external environmental changes can shape lasting differences in gene function and behavior. Epigenetic processes appear to impact a wide variety of physiological processes with...

journal_title：Endocrinology

authors： Auger AP,Auger CJ

更新日期：2011-02-01 00:00:00

abstract：:Extracts of spinach contain somatostatin (SRIF)-related material (6-80 pg/g wet wt). The SRIF-related material, when purified on HPLC, was recovered as two major mol wt forms; one that eluted with a retention time similar to that of synthetic SRIF-28 and reacted in both N- and C-terminal-specific immunoassays, and a s...

journal_title：Endocrinology

authors： LeRoith D,Pickens W,Wilson GL,Miller B,Berelowitz M,Vinik AI,Collier E,Cleland CF

更新日期：1985-11-01 00:00:00

abstract：:The present studies demonstrate that the murine adrenocortical tumor cell line Y-1 releases a digoxin-like immunoreactive material into both serum-supplemented nutrient medium and minimal Krebs-Ringer bicarbonate medium. Release of pregnenolone into minimal medium from these cells was consistently inhibited by additio...

journal_title：Endocrinology

authors： Doris PA,Kilgore MW,Durham D,Alberts D,Stocco DM

更新日期：1989-11-01 00:00:00

abstract：:The temporal aspects of gonadotropin release were studied in infantile (14-day-old) female rats. Blood samples were collected using vena cava cannulae at 10-, 15-, 20-, or 30-min intervals and assayed for either LH alone or for both LH and FSH. Within individual animals, blood LH levels exhibited a degree of variabili...

journal_title：Endocrinology

authors： Frawley LS,Henricks DM

更新日期：1979-11-01 00:00:00

abstract：:p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achieved by this last p...

journal_title：Endocrinology

authors： Becú-Villalobos D,Lacau de Mengido IM,Libertun C

更新日期：1985-05-01 00:00:00