Human stearoyl-CoA desaturase 1 (SCD-1) gene expression is negatively regulated by thyroid hormone without direct binding of thyroid hormone receptor to the gene promoter.

abstract：:Quantitative thyroid cell transplantation was used to evaluate the reestablishment of thyroid function in surgically thyroidectomized rats. Donor thyroid glands were enzymatically dispersed, and the cells were quantified, serially diluted, and inoculated into the sc fat pads of syngeneic recipient rats 1 day after sur...

journal_title：Endocrinology

authors： Domann FE,Mitchen JM,Clifton KH

更新日期：1990-12-01 00:00:00

abstract：:In osteoblasts, retinoic acid (RA) modulates the synthesis of various proteins, including collagen. However, little is known about the effects of RA on the regulation of interstitial collagenase synthesis and collagen degradation. After treatment of primary osteoblast-enriched (Ob) cells from fetal rat calvariae with ...

journal_title：Endocrinology

authors： Varghese S,Rydziel S,Jeffrey JJ,Canalis E

更新日期：1994-06-01 00:00:00

abstract：:In mammals, adrenal medulla chromaffin cells constitute a fundamental component of the sympathetic nervous system outflow, producing most of the circulating adrenaline. We recently found that the rhesus monkey adrenal gland expresses several genes in a 24-h rhythmic pattern, including TH (the rate-limiting enzyme in c...

journal_title：Endocrinology

authors： Lemos DR,Goodspeed L,Tonelli L,Antoch MP,Ojeda SR,Urbanski HF

更新日期：2007-12-01 00:00:00

abstract：:Acute effects of bisphenol (BPA), an environmental chemical, on estradiol (17α or β-E2)-dependent recognition memory and dendritic spines in the medial prefrontal cortex and hippocampus were investigated in adult female rats. Ovariectomized rats received BPA 30 min before or immediately after a sample trial (viewing o...

journal_title：Endocrinology

authors： Inagaki T,Frankfurt M,Luine V

更新日期：2012-07-01 00:00:00

abstract：:To address the role of the GH-binding protein (GHBP) in GH physiology, two forms of recombinant human GHBP (rhGHBP) were given alone or in combination with rhGH to hypophysectomized rats or GH-deficient dwarf rats. Hypophysectomized rats were given daily sc injections of excipient, hGH, rhGHBP, or rhGH plus rhGHBP (pr...

journal_title：Endocrinology

authors： Clark RG,Mortensen DL,Carlsson LM,Spencer SA,McKay P,Mulkerrin M,Moore J,Cunningham BC

更新日期：1996-10-01 00:00:00

abstract：:Graves' hyperthyroidism is an organ-specific autoimmune disease mediated by stimulatory autoantibodies against the TSH receptor (TSHR; thyroid-stimulating antibodies), causing thyroid hyperplasia and hyperthyroidism. Development of this ailment is well known to be under polygenic and environmental control. For example...

journal_title：Endocrinology

authors： Nagayama Y,McLachlan SM,Rapoport B,Oishi K

更新日期：2004-11-01 00:00:00

abstract：:At micromolar (pharmacological) concentrations, the action of tamoxifen on the proliferation of estrogen-dependent cells can be mediated not only by the estrogen receptor (ER), but also by other target molecules, such as protein kinase-C (PKC), which are easily inhibited by antiestrogens in cell-free experiments. By d...

journal_title：Endocrinology

authors： Astruc ME,Chabret C,Bali P,Gagne D,Pons M

更新日期：1995-03-01 00:00:00

abstract：:Estrogens are essential hormones for the regulation of fertility. Cellular responses to estrogens are mediated by estrogen receptor α (ESR1) and estrogen receptor β (ESR2). In mouse and rat models, disruption of Esr1 causes infertility in both males and females. However, the role of ESR2 in reproductive function remai...

journal_title：Endocrinology

authors： Rumi MAK,Singh P,Roby KF,Zhao X,Iqbal K,Ratri A,Lei T,Cui W,Borosha S,Dhakal P,Kubota K,Chakraborty D,Vivian JL,Wolfe MW,Soares MJ

更新日期：2017-07-01 00:00:00

abstract：:Traditionally, it has been thought that the bioavailable fraction of circulating serum hormones, i.e. that which is available for cellular uptake and is physiologically active, is limited to the free (nonprotein bound) hormone. However, recent evidence, based on acute organ uptake of labeled hormone, suggests that the...

journal_title：Endocrinology

authors： Glass AR,Vigersky RA,Rajatanavin R,Pardridge W,Smallridge RC,Wartofsky L,Burman KD

更新日期：1984-05-01 00:00:00

abstract：:Estrogen unresponsiveness among primate species can result from overexpression of a heterogeneous nuclear ribonucleoprotein (hnRNP) that competes with estrogen receptor (ER) for binding to the estrogen-response element (ERE). This hnRNP has been coined the "ERE-binding protein" (ERE-BP). The ERE-BP is a member of the ...

journal_title：Endocrinology

authors： Chen H,Stuart W,Hu B,Nguyen L,Huang G,Clemens TL,Adams JS

更新日期：2005-10-01 00:00:00

abstract：:Mammary gland is an organ that undergoes cycles of growth, differentiation, and function during pregnancy and lactation. Although it is known that the gland enhances its sensitivity to insulin during lactation, it remains to be investigated whether this increased sensitivity develops during pregnancy and which are the...

journal_title：Endocrinology

authors： Carrascosa JM,Ramos P,Molero JC,Herrera E

更新日期：1998-02-01 00:00:00

abstract：:A variety of human malignancies overexpresses isoform A of the insulin receptor (IR-A) and produces IGFs (IGF-I and/or IGF-II). IR-A binds IGF-II with high affinity (although 4-fold lower than that for insulin), whereas it binds IGF-I with low affinity (approximately 30-fold lower than that for insulin). However, in e...

journal_title：Endocrinology

authors： Sacco A,Morcavallo A,Pandini G,Vigneri R,Belfiore A

更新日期：2009-08-01 00:00:00

abstract：:We studied the involvement of the cAMP pathway in the regulation of beta TC1 cell growth with the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) and the activator of adenylate cyclase forskolin. We examined the effect of the increase in cAMP content on the serum-induced resumption of the cell cycle of ...

journal_title：Endocrinology

authors： Lavergne C,Breant B,Rosselin G

更新日期：1992-11-01 00:00:00

abstract：:A major issue of in the treatment of diabetes is the risk of hypoglycemia. Hypoglycemia is detected both centrally and peripherally in the porto-hepatic area. The portal locus for hypoglycemic detection was originally described using the "local irrigation of the liver" approach in a canine model. Further work using po...

journal_title：Endocrinology

authors： Ionut V,Castro AV,Woolcott OO,Stefanovski D,Iyer MS,Broussard JL,Mkrtchyan H,Burch M,Elazary R,Kirkman E,Bergman RN

更新日期：2014-04-01 00:00:00

abstract：:Functional disruption of either MC3R or MC4R results in obesity, implicating both in the control of energy homeostasis. The ligands for these receptors are derived from the prohormone proopiomelancortin (POMC), which is posttranslationally processed to produce a set of melanocortin peptides with a range of activities ...

journal_title：Endocrinology

authors： Tung YC,Piper SJ,Yeung D,O'Rahilly S,Coll AP

更新日期：2006-12-01 00:00:00

abstract：:The effect of TSH stimulation on cellular (c)-myc mRNA content in cultured thyroid cells was examined by Northern blot analysis. Polyadenylated mRNA was prepared from quiescent FRTL-5 rat thyroid cells and from cells stimulated by TSH for 8 h. A major 2.1 kilobase (kb) transcript was enhanced 5.5-fold by TSH. (Bu)2cAM...

journal_title：Endocrinology

authors： Dere WH,Hirayu H,Rapoport B

更新日期：1985-11-01 00:00:00

abstract：:The ABCB1-type multidrug resistance efflux transporter P-glycoprotein (P-gp) has been hypothesized to regulate hypothalamic-pituitary-adrenal axis activity by limiting the access of glucocorticoids to the brain. In vivo systemic administration studies using P-gp-deficient mice have shown increased glucocorticoid entry...

journal_title：Endocrinology

authors： Mason BL,Pariante CM,Thomas SA

更新日期：2008-10-01 00:00:00

abstract：:Dipeptidyl peptidase-IV (DPPIV) is a serine proteinase widely distributed in mammalian tissues, including lymphocytes, where it is identical to the T-cell activation antigen, cluster differentiation antigen-26. In the present study, DPPIV enzymatic activity was found in uterine secretions of unilaterally pregnant ewes...

journal_title：Endocrinology

authors： Liu WJ,Hansen PJ

更新日期：1995-02-01 00:00:00

abstract：:cAMP is involved in the regulation of secretory activity in lactotrope, thyrotrope, and gonadotrope cells. The present study examined whether pulsatile or intermittent changes in cAMP are more effective than a continuous stimulation in increasing pituitary hormone gene expression. Pituitaries from adult female rats we...

journal_title：Endocrinology

authors： Haisenleder DJ,Yasin M,Marshall JC

更新日期：1992-12-01 00:00:00

abstract：:A proteinaceous secretion from phagocytizing polymorphonuclear leukocytes, termed "leukocytic endogenous mediator" (LEM), has been shown to have marked effects on hepatic amino acid transport and RNA and protein synthesis. A single injection of LEM results in a marked accumulation of labeled nonmetabolizable model ami...

journal_title：Endocrinology

authors： Wannemacher RW Jr,Pekarek RS,Thompson WL,Curnow RT,Beall FA,Zenser TV,DeRubertis FR,Beisel WR

更新日期：1975-03-01 00:00:00

abstract：:Food deprivation in laboratory rats induces profound changes in the neuroendocrine system. We have investigated the hypothalamic and pituitary responses of the hypothalamo-pituitary thyroid axis to 48-h food deprivation in Sprague-Dawley rats. Peripheral T3 and hypophysial portal TRH were measured by RIA, and TSH beta...

journal_title：Endocrinology

authors： Blake NG,Eckland DJ,Foster OJ,Lightman SL

更新日期：1991-11-01 00:00:00

abstract：:The quantitative light microscope radioautographic approach was utilized to locate specific binding sites for blood-borne 125I-labeled ACTH1-24 in the rat brain. Specific binding occurred exclusively in the external zone of the median eminence, adjacent to the primary portal plexus, and to a lesser extent in the ventr...

journal_title：Endocrinology

authors： van Houten M,Khan MN,Khan RJ,Posner BI

更新日期：1981-06-01 00:00:00

abstract：:We analyzed the mechanism by which a Graves' disease-associated C/T polymorphism in the Kozak sequence of CD40 affects CD40 expression. CD40 expression levels on B cells in individuals with CT and TT genotypes were decreased by 13.3 and 39.4%, respectively, compared with the levels in CC genotypes (P = 0.012). Similar...

journal_title：Endocrinology

authors： Jacobson EM,Concepcion E,Oashi T,Tomer Y

更新日期：2005-06-01 00:00:00

abstract：:GH and insulin-like growth factor (IGF)-I are important components of the growth axis. We undertook to determine how plasma levels of these hormones altered with different seasonal and nutritional states in young male red deer to provide an insight into how the growth axis changes under these conditions. Growth rate a...

journal_title：Endocrinology

authors： Webster JR,Corson ID,Littlejohn RP,Stuart SK,Suttie JM

更新日期：1996-02-01 00:00:00

abstract：:The Src homology 2-containing tyrosine phosphatase, Shp-2, is a crucial enzyme that mediates intracellular signaling and is implicated in cell proliferation and differentiation. Here we investigated the involvement of the Shp-2 tyrosine phosphatase in determining the downstream signaling pathways initiated by the Ret ...

journal_title：Endocrinology

authors： D'Alessio A,Califano D,Incoronato M,Santelli G,Florio T,Schettini G,Carlomagno MS,Cerchia L,de Franciscis V

更新日期：2003-10-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), a prevalent growth factor secreted by bone cells, has important effects on bone remodeling. Hormones are known to regulate the synthesis of skeletal IGF-I, but there is limited information about the actions of growth factors on IGF-I synthesis. We tested the effects of basic fibro...

journal_title：Endocrinology

authors： Canalis E,Pash J,Gabbitas B,Rydziel S,Varghese S

更新日期：1993-07-01 00:00:00

abstract：:Thyroid hormones (THs) are charged and iodinated amino acid derivatives that need to pass the cell membrane facilitated by thyroid hormone transmembrane transporters (THTT) to exert their biological function. The importance of functional THTT is affirmed by the devastating effects of mutations in the human monocarboxy...

journal_title：Endocrinology

authors： Johannes J,Jayarama-Naidu R,Meyer F,Wirth EK,Schweizer U,Schomburg L,Köhrle J,Renko K

更新日期：2016-04-01 00:00:00

abstract：:Proinflammatory cytokines have been shown to influence the expression and function of the glucocorticoid receptor (GR). Specifically, several studies have found that cytokines induce a decrease in GR function, as evidenced by reduced sensitivity to glucocorticoid effects on functional end points. To investigate the po...

journal_title：Endocrinology

authors： Pariante CM,Pearce BD,Pisell TL,Sanchez CI,Po C,Su C,Miller AH

更新日期：1999-09-01 00:00:00

abstract：:The effects of LH on glucose metabolism within cumulus cell-enclosed bovine oocytes were determined. Cumulus cell-enclosed bovine oocytes were matured in vitro (IVM) in control medium alone or supplemented with LH, FSH, or TSH, then individually assayed for the metabolism of D-[5-3H]glucose, D-[1-14C]glucose, D-[6-14C...

journal_title：Endocrinology

authors： Zuelke KA,Brackett BG

更新日期：1992-12-01 00:00:00

abstract：:This study examined the effect of two thirds hepatectomy on rat liver insulin-like growth factor-II (IGF-II) receptors and IGF-II receptor messenger RNA (mRNA) levels. IGF-II receptor levels were determined in liver plasma membrane and Golgi/endosome fractions from sham-operated and hepatectomized rats by ligand bindi...

journal_title：Endocrinology

authors： Scott CD,Ballesteros M,Baxter RC

更新日期：1990-11-01 00:00:00