Abstract:
:The quantitative light microscope radioautographic approach was utilized to locate specific binding sites for blood-borne 125I-labeled ACTH1-24 in the rat brain. Specific binding occurred exclusively in the external zone of the median eminence, adjacent to the primary portal plexus, and to a lesser extent in the ventral arcuate nucleus. This localization may indicate that the hypophysiotropic median eminence is a new target site for circulating adrenocorticotropin. Alternatively, ACTH binding sites in the median eminence-arcuate region may provide the hypothalamus with a hormone-selective capacity to concentrate pituitary ACTH for possible retrograde transport and redistribution within the central nervous system.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
van Houten M,Khan MN,Khan RJ,Posner BIdoi
10.1210/endo-108-6-2385subject
Has Abstractpub_date
1981-06-01 00:00:00pages
2385-7issue
6eissn
0013-7227issn
1945-7170journal_volume
108pub_type
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