A subset of gonadotropin-releasing hormone neurons in the ovine medial basal hypothalamus is activated during increased pulsatile luteinizing hormone secretion.

abstract：:The Pax6 transcription factor is crucial for pancreatic α-cells. Indeed, Pax6-deficient mouse models are characterized by markedly altered α-cell differentiation. Our objective was to investigate the role of Pax6 in glucagon secretion process. We used a Pax6-deficient model in rat primary enriched-α cells with specifi...

journal_title：Endocrinology

authors： Gosmain Y,Cheyssac C,Masson MH,Guérardel A,Poisson C,Philippe J

更新日期：2012-09-01 00:00:00

abstract：:Isolated renal cortical slices were used to study the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and 24,25-dihydroxyvitamin D3 [24,25](OH2)D3] by the rat kidney. Production of 1,25-(OH)2D3 and 24,25-(OH)2D3 was linear with time (30-90 min) and tissue weight (40-250 mg). Production of...

journal_title：Endocrinology

authors： Armbrecht HJ,Zenser TV,Davis BB

更新日期：1981-07-01 00:00:00

abstract：:The aim of the study was to investigate the influence of severe hyperthyroidism on plasma high-density lipoprotein cholesterol (HDL-C). Recently, it was shown in mice that increasing doses of T(3) up-regulate hepatic expression of scavenger receptor class B, type I, resulting in increased clearance of plasma HDL-C. He...

journal_title：Endocrinology

authors： Tancevski I,Wehinger A,Demetz E,Eller P,Duwensee K,Huber J,Hochegger K,Schgoer W,Fievet C,Stellaard F,Rudling M,Patsch JR,Ritsch A

更新日期：2008-07-01 00:00:00

abstract：:The estrogen receptor-alpha (ERalpha) pituitary-specific variant, TERP-1, is regulated dramatically by physiological status. We examined hormonal regulation of the TERP-1 promoter in transient transfection assays in GH3 somatolactotrope cells. We found that 17beta-estradiol (E2), genistein, androgen, pituitary adenyla...

journal_title：Endocrinology

authors： Bryant WM,Gibson MA,Shupnik MA

更新日期：2006-01-01 00:00:00

abstract：:The guinea pig adrenal cortex is grossly composed of two regions: an outer, yellow zone and an inner, brown zone. These zones, which represent 33% and 66% of the total adrenocortical volume, respectively, can be separated by blunt dissection. It has been previously reported that specific pregnenolone and pregnenolone ...

journal_title：Endocrinology

authors： Strott CA,Goff AK,Lyons CD

更新日期：1981-12-01 00:00:00

abstract：:The dose-dependent displacement characteristics of a biologically active 20,000 molecular weight human pituitary growth hormone variant (20K) and of human growth hormone (hGH) were compared using hGH liver plasma membrane receptors both from 20-30 day pregnant rabbits and from normal female rats and also using mammary...

journal_title：Endocrinology

authors： Sigel MB,Thorpe NA,Kobrin MS,Lewis UJ,Vanderlaan WP

更新日期：1981-04-01 00:00:00

abstract：:The effects of endothelin-1 (ET) on several tissues are mediated by prostaglandins. In this study, we investigated the actions of ET on bone and determined whether they are mediated through prostaglandin-dependent pathways. Bone resorption, collagen, and non-collagen protein synthesis and inositol phosphate (IP) produ...

journal_title：Endocrinology

authors： Tatrai A,Foster S,Lakatos P,Shankar G,Stern PH

更新日期：1992-08-01 00:00:00

abstract：:There are now robust data supporting the Developmental Origins of Health and Disease (DOHaD) paradigm. This includes human and animal data focusing on nutrition or environmental chemicals during development. However, the term DOHaD has not been generally accepted as the official term to be used when one is concerned w...

journal_title：Endocrinology

authors： Heindel JJ,Balbus J,Birnbaum L,Brune-Drisse MN,Grandjean P,Gray K,Landrigan PJ,Sly PD,Suk W,Cory Slechta D,Thompson C,Hanson M

更新日期：2015-10-01 00:00:00

abstract：:Attempts to assess human placental GH variant (hGH-V) and chorionic somatomammotropin (hCS) RNA in choriocarcinoma cell lines have been hampered by low levels of expression and limited sensitivity of RNA blotting analysis. We examined human choriocarcinoma BeWo, JAR, and JEG-3 cell lines as well as samples of complete...

journal_title：Endocrinology

authors： Lytras A,Bock ME,Dodd JG,Cattini PA

更新日期：1994-06-01 00:00:00

abstract：:Recent evidence indicates that endogenous GnRH is required for maintenance of its own pituitary receptors (GnRH-R). We have measured GnRH-R in pituitaries of hypogonadotrophic hypogonadal (hpg) mice, in whom hypothalamic GnRH is deficient or absent. The GnRH-R concentration in hpg male mouse pituitaries was 10.6 +/- 1...

journal_title：Endocrinology

authors： Young LS,Speight A,Charlton HM,Clayton RN

更新日期：1983-07-01 00:00:00

abstract：:Recent evidence has linked mitochondrial dysfunction and DNA damage, increased oxidative stress in skeletal muscle, and insulin resistance (IR). The purpose of this study was to determine the role of the DNA repair enzyme, human 8-oxoguanine DNA glycosylase/apurinic/apyrimidinic lyase (hOGG1), on palmitate-induced mit...

journal_title：Endocrinology

authors： Yuzefovych LV,Schuler AM,Chen J,Alvarez DF,Eide L,Ledoux SP,Wilson GL,Rachek LI

更新日期：2013-08-01 00:00:00

abstract：:Although implantation of GH3 pituitary epithelial cells has been shown to reverse thymic aging in rats, the differentiation pattern of T-lymphocytes within the reconstituted thymus glands has not been investigated. Syngeneic GH3 cells were implanted into 22-month-old female (old) Wistar-Furth rats. Eight weeks later, ...

journal_title：Endocrinology

authors： Li YM,Brunke DL,Dantzer R,Kelley KW

更新日期：1992-05-01 00:00:00

abstract：:The effect of naloxone (N-allylnoroxymorphone), a narcotic antagonist, on the morphine blockade of ovulation was studied. Female rats were treated with morphine (50 mg/kg) at the critical period, resulting in ovulatory blockade. The administration of naloxone (0.5 mg/kg) effectively reversed the anti-ovulatory effect ...

journal_title：Endocrinology

authors： Packman PM,Rothchild JA

更新日期：1976-07-01 00:00:00

abstract：:Bovine placental lactogen (bPL) has been isolated from bovine trophoblast and characterized as a 32 K mol wt protein which exists in three different forms which differ in their isoelectric point values and their amino acid compositions. Two of the three forms have been shown to have both bovine GH (bGH)- and bovine PR...

journal_title：Endocrinology

authors： Duello TM,Byatt JC,Bremel RD

更新日期：1986-09-01 00:00:00

abstract：:The maternal skeleton resorbs during lactation to provide calcium to milk and the lost mineral content is restored after weaning. The changes are particularly marked in Ctcgrp null mice, which lose 50% of spine mineral content during lactation but restore it fully. The known calciotropic hormones are not required for ...

journal_title：Endocrinology

authors： Collins JN,Kirby BJ,Woodrow JP,Gagel RF,Rosen CJ,Sims NA,Kovacs CS

更新日期：2013-04-01 00:00:00

abstract：:The purpose of this study was to examine the relative roles of FSH and LH in stimulating testicular inhibin secretion in the male rhesus monkey. Recombinant human (rh) FSH and rhCG were used as the gonadotropic stimuli, and juvenile rhesus monkeys, in which the endocrine activity of the pituitary-testicular axis was b...

journal_title：Endocrinology

authors： Majumdar SS,Winters SJ,Plant TM

更新日期：1997-04-01 00:00:00

abstract：:Previous studies showed that epidermal growth factor (EGF) and TGFalpha mimic the action of LH on the resumption of oocyte maturation. We tested whether EGF-like agents, such as amphiregulin (AR), epiregulin (ER), and betacellulin (BTC), also mediate the LH stimulation of the ovulatory response in the rat. LH induced ...

journal_title：Endocrinology

authors： Ashkenazi H,Cao X,Motola S,Popliker M,Conti M,Tsafriri A

更新日期：2005-01-01 00:00:00

abstract：:Tamoxifen, a partial competitive antagonist to the estrogen receptor, is a potent inhibitor of the proliferation of experimental mammary carcinoma in the rat and is widely used clinically in the treatment of breast cancer. Blockade of estrogen receptors present on neoplastic cells represents the classic mechanism of a...

journal_title：Endocrinology

authors： Tannenbaum GS,Gurd W,Lapointe M,Pollak M

更新日期：1992-06-01 00:00:00

abstract：:Embryo implantation is a highly synchronized event between an activated blastocyst and a receptive endometrium. The success of this process relies on the dynamic interplay of estrogen (E(2)) and progesterone (P(4)), however, the details of this interaction are not entirely clear. Recent data implicate E(2) and P(4) in...

journal_title：Endocrinology

authors： Frolova A,Flessner L,Chi M,Kim ST,Foyouzi-Yousefi N,Moley KH

更新日期：2009-03-01 00:00:00

abstract：:It is still controversial whether the bone-derived hormone fibroblast growth factor-23 (FGF23) has additional physiological functions apart from its well-known suppressive actions on renal phosphate reabsorption and vitamin D hormone synthesis. Here we analyzed premature aging, mineral homeostasis, carbohydrate metabo...

journal_title：Endocrinology

authors： Streicher C,Zeitz U,Andrukhova O,Rupprecht A,Pohl E,Larsson TE,Windisch W,Lanske B,Erben RG

更新日期：2012-04-01 00:00:00

abstract：:Chronically elevated fatty acids contribute to insulin resistance through poorly defined mechanisms. Endoplasmic reticulum (ER) stress and the subsequent unfolded protein response (UPR) have been implicated in lipid-induced insulin resistance. However, the UPR is also a fundamental mechanism required for cell adaptati...

journal_title：Endocrinology

authors： Achard CS,Laybutt DR

更新日期：2012-05-01 00:00:00

abstract：:Mesenchymal stroma/stem cells (MSCs) exist in adult tissues, such as adipose tissue and bone marrow, and differentiate into cells of multiple lineages. In previous studies, we found that MSCs differentiate into steroidogenic cells by forced expression of steroidogenic factor 1 (SF-1)/adrenal 4 binding protein (Ad4BP),...

journal_title：Endocrinology

authors： Tanaka T,Aoyagi C,Mukai K,Nishimoto K,Kodama S,Yanase T

更新日期：2020-03-01 00:00:00

abstract：:Previous studies showed that noncalcemic 20(OH)D3, a product of CYP11A1 action on vitamin D3, has antifibrotic activity in human dermal fibroblasts and in a bleomycin mouse model of scleroderma. In this study, we tested the role of retinoic acid-related orphan receptor γ (RORγ), which is expressed in skin, in the acti...

journal_title：Endocrinology

authors： Janjetovic Z,Postlethwaite A,Kang HS,Kim TK,Tuckey RC,Crossman DK,Qayyum S,Jetten AM,Slominski AT

更新日期：2021-01-01 00:00:00

abstract：:Leptin, a circulating 16-kDa protein secreted by adipocytes, decreases body weight by reducing food intake and enhancing energy utilization. Leptin receptors that share homology to the glycoprotein gp130 have been recently cloned. In addition, differentially spliced leptin receptor messenger RNAs have been identified....

journal_title：Endocrinology

authors： Liu C,Liu XJ,Barry G,Ling N,Maki RA,De Souza EB

更新日期：1997-08-01 00:00:00

abstract：:Although mothers against dpp (MAD) and its related proteins (MADR) are believed to be important components of the cell signaling pathway for the transforming growth factor beta (TGFbeta) superfamily, the presence and regulation of these signaling molecules in ovarian cells by TGFbeta is not known. In the present studi...

journal_title：Endocrinology

authors： Li M,Li J,Hoodless PA,Tzukazaki T,Wrana JL,Attisano L,Tsang BK

更新日期：1997-09-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic neuropeptide synthesized in the hypothalamus. A Leu34Phe missense mutation in proCART has been found in an obese family in humans. Here we show that humans bearing the Leu34Phe mutation in proCART have severely diminished levels of bioactive CART,...

journal_title：Endocrinology

authors： Yanik T,Dominguez G,Kuhar MJ,Del Giudice EM,Loh YP

更新日期：2006-01-01 00:00:00

abstract：:Granulosa cells isolated from the ovaries of pregnant mare serum gonadotropin (PMSG)-treated immature rats were cultured with relaxin or FSH. Both hormones increased the secretion of plasminogen activator into the culture medium. Relaxin caused a dose-related rise in plasminogen activator but did not increase cAMP or ...

journal_title：Endocrinology

authors： Too CK,Weiss TJ,Bryant-Greenwood GD

更新日期：1982-10-01 00:00:00

abstract：:This study was conducted to determine the feasibility of using replication-defective adenovirus vectors to express receptors for LH. Two vectors were constructed, one that directs the expression of wild-type human LH receptor (LHr; AdRSVLHrwt) and another that directs the expression of the constitutively activated D57...

journal_title：Endocrinology

authors： Bebia Z,Somers JP,Liu G,Ihrig L,Shenker A,Zeleznik AJ

更新日期：2001-06-01 00:00:00

abstract：:Insulin and epidermal growth factor (EGF) share a number of metabolic actions, including stimulation of protein synthesis and growth in certain tissues, and activation of apparent receptor tyrosine kinase activities. We have shown that insulin and EGF promote the phosphorylation of a number of intracellular proteins i...

journal_title：Endocrinology

authors： Blackshear PJ,Nemenoff RA,Avruch J

更新日期：1984-01-01 00:00:00

abstract：:The adrenal cortex contains a kallikrein-like enzyme that may lead to bradykinin (BK) formation. This study was designed to determine whether BK acts on adrenocortical cells to stimulate steroid secretion. BK, Lys-BK, a specific BK 2 (B2) receptor agonist, and desArg9-BK, a specific BK 1 (B1) receptor agonist, all sti...

journal_title：Endocrinology

authors： Rosolowsky LJ,Campbell WB

更新日期：1992-04-01 00:00:00