Abstract:
:The aim of the study was to investigate the influence of severe hyperthyroidism on plasma high-density lipoprotein cholesterol (HDL-C). Recently, it was shown in mice that increasing doses of T(3) up-regulate hepatic expression of scavenger receptor class B, type I, resulting in increased clearance of plasma HDL-C. Here, we show that severe hyperthyroidism in mice did not affect hepatic expression of scavenger receptor class B, type I, but reduced hepatic expression of ATP-binding cassette transporter 1, accompanied by a 40% reduction of HDL-C. The sterol content of bile, liver, and feces was markedly increased, accompanied by up-regulation of hepatic cholesterol 7alpha-hydroxylase, and ATP-binding cassette transporter 5, which is known to promote biliary sterol secretion upon dimerization with ATP-binding cassette transporter 8. Both control and hyperthyroid mice exerted identical plasma clearance of iv injected [(3)H]HDL-C, supporting the view that severe hyperthyroidism does not affect HDL-C clearance but, rather, its formation via hepatic ATP-binding cassette transporter 1.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Tancevski I,Wehinger A,Demetz E,Eller P,Duwensee K,Huber J,Hochegger K,Schgoer W,Fievet C,Stellaard F,Rudling M,Patsch JR,Ritsch Adoi
10.1210/en.2007-1387subject
Has Abstractpub_date
2008-07-01 00:00:00pages
3708-12issue
7eissn
0013-7227issn
1945-7170pii
en.2007-1387journal_volume
149pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::The pineal hormone melatonin regulates reproductive function in seasonally breeding mammals. Recent studies using 125I-labeled 2-iodomelatonin (I-MEL) reveal that the distribution of putative melatonin receptors is species-specific; only the hypophysial pars tuberalis (PT) is a consistent site of I-MEL binding in all ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-5-2607
更新日期:1990-11-01 00:00:00
abstract::Relaxin is a naturally occurring regulator of collagen turnover. In this study, we determined the role of endogenous relaxin in the pathogenesis of primary tubulointerstitial fibrosis after unilateral ureteric obstruction (UUO). Four- to 6-wk-old relaxin (RLX) gene-knockout (RLX(-/-)) and age-matched wild-type (RLX(+/...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-0814
更新日期:2007-02-01 00:00:00
abstract::In addition to 17beta-estradiol binding, estrogen receptor (ER) transcriptional activity could be controlled by intracellular kinase signaling pathways activated by growth factors. In this report we present evidence suggesting that glycogen synthase kinase 3 (GSK3), an effector kinase of the phosphatidylinositol 3-kin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-1224
更新日期:2006-06-01 00:00:00
abstract::Hashimoto thyroiditis can be partially reproduced in mice by immunization with thyroglobulin or, more recently, thyroperoxidase. This experimental autoimmune thyroiditis (EAT) model has been extensively characterized during early disease phases (up to d 35 after immunization). By extending the analysis of EAT to 100 d...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0639
更新日期:2009-01-01 00:00:00
abstract::Acylation-stimulating protein (ASP) is a potent lipogenic protein produced by adipocytes. In vitro studies have shown that ASP increases triglyceride synthesis and glucose transport in both murine and human adipocytes. Our initial study indicated that complement C3-deficient (-/-) mice (and, therefore, ASP deficient) ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.3.7364
更新日期:2000-03-01 00:00:00
abstract::Although LHRH can stimulate the release of both LH and FSH from the pituitary, there are a number of instances in which the secretion of LH and FSH are divergent. Previous studies from our laboratory have indicated that pulsatile LH and FSH secretion are independently regulated by gonadal factors. We have, therefore, ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-118-2-609
更新日期:1986-02-01 00:00:00
abstract::Rat reticulocytes contain a cytosol activator protein (RCAP) that augments hormone-sensitive adenylate cyclase activity in the rat reticulocyte and other systems. In a previous publication, using a highly purified preparation of RCAP, we reported that the stimulatory guanine nucleotide-binding protein (Ns) was require...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-117-1-264
更新日期:1985-07-01 00:00:00
abstract::When colonic crypt cells isolated from intact rats are incubated with [3H]corticosterone specific nuclear binding is displaced by neither aldosterone nor the antiglucocorticoid RU38486, suggesting that [3H]corticosterone is binding to a site distinct from classical mineralocorticoid and glucocorticoid receptors. TLC r...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.8.8754750
更新日期:1996-08-01 00:00:00
abstract::Magnocellular hypothalamic neurons in the rat supraoptic nucleus (SON) normally produce either vasopressin (VP) or oxytocin (OT). Here we demonstrate that many magnocellular neurons in the SON of lactating rats synthesize both hormones at the same time. We show the colocalization of the messenger (m) RNA that encodes ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-4-1814
更新日期:1991-10-01 00:00:00
abstract::We investigated the effects of intraventricular (ivt) injection of bombesin on the TRH-induced increase in temperature in the midbrain reticular formation (mrf) of the rat brain under pentobarbital anesthesia. Ivt injection of TRH in a dose of 3 nmol significantly antagonized the decrease in brain temperature induced ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-4-1864
更新日期:1986-10-01 00:00:00
abstract::Dipeptyl peptidase-4 (DPP-4) inhibitors modulate the progression of atherosclerosis. To gain insights into their mechanism of action, 9-wk-old male apolipoprotein E (apoE)-deficient mice were fed a DPP-4 inhibitor, anagliptin-containing diet. The effects of anagliptin were investigated in, a monocyte cell line, human ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1855
更新日期:2013-03-01 00:00:00
abstract::Steroid receptors, including estrogen receptor (ER) and progesterone receptors (PR), form associations with heat shock proteins (Hsps). Dissociation of Hsps activates PR, whereas retention of Hsp90 in vitro stimulates ER. Progesterone and estrogen, interacting with their receptors, regulate myometrial contractility th...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.12.8940400
更新日期:1996-12-01 00:00:00
abstract::We have investigated the production and actions of a growth regulatory protein, insulin-like growth factor binding protein (IGFBP)-3, in the androgen-responsive prostate carcinoma cell line LNCaP. Confluent monolayers of cells secreted approximately 0.7 ng/ml IGFBP-3 over 24 h. Dihydrotestosterone (DHT, 10 nM) and 1,2...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.7.7534
更新日期:2000-07-01 00:00:00
abstract::Serum retinol-binding protein 4 (RBP4) levels are increased in insulin-resistant humans and correlate with severity of insulin resistance in metabolic syndrome. Quantitative Western blotting (qWestern) has been the most accurate method for serum RBP4 measurements, but qWestern is technically complex and labor intensiv...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1750
更新日期:2012-03-01 00:00:00
abstract::Estrogen is implicated in many autoimmune diseases and is a robust immunomodulator. For example, it regulates interferon (IFN)-gamma, a cytokine believed to up-regulate inducible nitric oxide synthase (iNOS). A notable gap in the literature is a lack of information on the regulation of nitric oxide in immune tissues b...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-0829
更新日期:2006-02-01 00:00:00
abstract::Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in this region. In the present study, we addressed the hypothesis t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1739
更新日期:2012-11-01 00:00:00
abstract::In this study, we investigated the transcriptional regulation of the adrenergic induction of type II iodothyronine deiodinase (Dio2) in rat pinealocytes. Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA level of Dio2 that peaked around 2 h and declined over the next 5 h. Both beta- and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0166
更新日期:2007-07-01 00:00:00
abstract::The effects of K+ depletion and ouabain (0.1, 0.5, and 1 mM) on glucagon and insulin release from the in vitro perfused rat pancreas were studied in the absence or presence of arginine (10 mM). In the absence of arginine, K+ depletion resulted in an inhibition of glucagon release, both at a low (2.8 mM) and a higher (...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-113-1-178
更新日期:1983-07-01 00:00:00
abstract::31P nuclear magnetic resonance (NMR) was used to study the effects of 17 beta-estradiol on the content of phosphates and on the flux catalyzed by creatine kinase in immature rat uteri. Perifusion with oxygenated medium at 36 C maintained the uteri in a viable state for at least 10 h in vitro during 31P NMR measurement...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-122-4-1631
更新日期:1988-04-01 00:00:00
abstract::To probe the possible role of endogenous opiates in Sertoli cell proliferation during testicular development, the effect of interfering with beta-endorphin action either in vivo or in vitro was determined. The percent of Sertoli cells dividing was measured with quantitative autoradiography in [methyl 3H]-thymidine-exp...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-4-1876
更新日期:1986-10-01 00:00:00
abstract::In an effort to define biochemical events relevant to the adipogenic action of GH, the effect of GH on expression of the cytoskeletal element vinculin was studied in 3T3-F442A preadipose cells. Results from Western blotting indicated that in serum-free medium 2 nM met-hGH induced an approximately 100% increase in vinc...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-1-527
更新日期:1991-07-01 00:00:00
abstract::Explants from nonmenstrual endometria cultured in the absence of ovarian hormones undergo tissue breakdown. Addition of estradiol and progesterone (EP) prevents proteolysis. Explants include stromal and epithelial compartments which play different but complementary roles in endometrial physiology, including tissue rem...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1398
更新日期:2010-09-01 00:00:00
abstract::Peroxisome proliferator activated receptor (PPARγ) is a nuclear receptor transcription factor that regulates adipogenesis and energy homeostasis. Recent studies suggest PPARγ may mediate some of its metabolic effects through actions in the brain. We used a Cre-recombinase-dependent (using NestinCre) conditionally acti...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1524
更新日期:2016-11-01 00:00:00
abstract::To date, the role of pancreatic hormones in pancreatic islet growth and differentiation is poorly understood. To address this issue, we examined mice with a disruption in the gene encoding prohormone convertase 2 (PC2). These mice are unable to process proglucagon, prosomatostatin, and other neuroendocrine precursors ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0088
更新日期:2003-09-01 00:00:00
abstract::Transcription activator-like effector nucleases (TALENs) are a powerful approach for targeted genome editing and have been proved to be effective in several organisms. In this study, we reported that TALENs can induce somatic mutations in Nile tilapia, an important species for worldwide aquaculture, with reliably high...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2013-1451
更新日期:2013-12-01 00:00:00
abstract::The testis contains many peptides originally described as originating in the central nervous system. The physiological function of these factors in the testis is generally unknown. We previously reported that the rat testis contains both a peptide with GH-releasing hormone-like immunoactivity (tGHRH-LI) and a mRNA spe...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-5-2336
更新日期:1990-11-01 00:00:00
abstract::Developmental effects of genistein (Gen) on the mammary gland were investigated using outbred female CD-1 mice treated neonatally on d 1-5 by sc injections at doses of 0.5, 5, or 50 mg/kg.d. Examination of mammary gland whole mounts (no. 4) before puberty (4 wk) revealed no morphological differences in development aft...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2006-0389
更新日期:2006-10-01 00:00:00
abstract::During the preovulatory and estradiol-progesterone-induced GnRH-LH surge, a subpopulation of GnRH neurons transiently expresses the transcription factor c-fos, which is a useful marker of cell activation. To further characterize this subpopulation of GnRH neurons, multiple immunohistochemical procedures were applied t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.2.7299
更新日期:2000-02-01 00:00:00
abstract::It has been shown that acute administration of interleukin-1 (IL-1) to rats elicits a transitory increase in plasma ACTH and corticosterone (B) levels. To investigate the effects of chronic administration of IL-1 on plasma ACTH and B levels, in the present study rats were equipped with Alzet osmotic minipumps loaded w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.3.1311230
更新日期:1992-03-01 00:00:00
abstract::131I therapy is a widely accepted treatment for differentiated thyroid cancers which can accumulate iodide. We evaluated the efficiency of 131I therapy against tumors which are transfected with the Na+/I- symporter (NIS) gene. We transfected the rat NIS cDNA expression vector into malignantly transformed rat thyroid c...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.10.5571
更新日期:1997-10-01 00:00:00