The role of repressor proteins in the adrenergic induction of type II iodothyronine deiodinase in rat pinealocytes.

abstract：:Islet β-cell dysfunction that leads to impaired insulin secretion is a principal source of pathology of diabetes. In type 2 diabetes, this breakdown in β-cell health is associated with compromised islet-enriched transcription factor (TF) activity that disrupts gene expression programs essential for cell function and i...

journal_title：Endocrinology

authors： Davidson RK,Kanojia S,Spaeth JM

更新日期：2021-02-01 00:00:00

abstract：:The homozygous ablation of the gene encoding the PTH/PTHrP receptor (PPR(-/-)) leads to early lethality and limited developmental defects, including an acceleration of chondrocyte differentiation. In contrast to the findings in homozygous PTHrP-ablated (PTHrP(-/-)) animals, these PPR(-/-) mice show an increase in cort...

journal_title：Endocrinology

authors： Soegiarto DW,Kiachopoulos S,Schipani E,Jüppner H,Erben RG,Lanske B

更新日期：2001-12-01 00:00:00

abstract：:To date, the role of pancreatic hormones in pancreatic islet growth and differentiation is poorly understood. To address this issue, we examined mice with a disruption in the gene encoding prohormone convertase 2 (PC2). These mice are unable to process proglucagon, prosomatostatin, and other neuroendocrine precursors ...

journal_title：Endocrinology

authors： Vincent M,Guz Y,Rozenberg M,Webb G,Furuta M,Steiner D,Teitelman G

更新日期：2003-09-01 00:00:00

abstract：:We previously described significant differences in maximal testosterone production by Leydig cells from the following strains of inbred mice: C57BL/10J, C57BL/6J, DBA/2J, and C3H/HeJ. To evaluate whether these differences in maximal testosterone production related to the activities of the steroidogenic enzymes of the ...

journal_title：Endocrinology

authors： Stalvey JR,Payne AH

更新日期：1984-10-01 00:00:00

abstract：:The protein thiol-modifying agent arsenite, a potent activator of stress signaling, was used to examine the involvement of MAPKs in the regulation of cardiac substrate uptake. Arsenite strongly induced p38 MAPK phosphorylation in isolated rat cardiac myocytes but also moderately enhanced phosphorylation of p42/44 ERK ...

journal_title：Endocrinology

authors： Luiken JJ,Momken I,Habets DD,El Hasnaoui M,Coumans WA,Koonen DP,Glatz JF,Bonen A

更新日期：2006-11-01 00:00:00

abstract：:We have used immunohistochemistry to define the cellular distribution of GH receptors in the gastrointestinal tract (GIT) and its derivatives. Immunohistochemistry was performed in the adult rat GIT with a panel of characterized monoclonal antibodies to the GH receptor. The most intense and heterogeneous immunoreactiv...

journal_title：Endocrinology

authors： Lobie PE,Breipohl W,Waters MJ

更新日期：1990-01-01 00:00:00

abstract：:Effects of spironolactone, canrenone and canrenoate-K on adrenal cytochrome P450 (P450) and corticosteroid biosynthesis were examined by studying difference spectra, P450 reduction and corticoid hydroxylation in mitochondrial preparations isolated from zona fasciculata and zona glomerulosa of bovine adrenals and from ...

journal_title：Endocrinology

authors： Cheng SC,Suzuki K,Sadee W,Harding BW

更新日期：1976-10-01 00:00:00

abstract：:The somatic Sertoli cells of the testis are major targets for FSH and are important for the regulation of spermatogenesis. The binding of FSH to Sertoli cells activates the cAMP-dependent protein kinase A signaling pathway, resulting in phosphorylation of the cAMP response element-binding protein (CREB), which is requ...

journal_title：Endocrinology

authors： Walker WH,Fucci L,Habener JF

更新日期：1995-08-01 00:00:00

abstract：:Specialized metabolic sensors in the hypothalamus regulate blood glucose levels by influencing hepatic glucose output and hypoglycemic counterregulatory responses. Hypothalamic reactive oxygen species (ROS) may act as a metabolic signal-mediating responses to changes in glucose, other substrates and hormones. The role...

journal_title：Endocrinology

authors： Pauliina Markkula S,Lyons D,Yueh CY,Riches C,Hurst P,Fielding B,Heisler LK,Evans ML

更新日期：2016-12-01 00:00:00

abstract：:Blepharophimosis ptosis epicanthus inversus syndrome (BPES) is a human disorder caused by mutations in the forkhead transcription factor gene FOXL2 and is characterized by facial dysmorphology combined in some cases with ovarian failure. To better understand the role of FOXL2 in the etiology of ovarian failure in BPES...

journal_title：Endocrinology

authors： Loffler KA,Zarkower D,Koopman P

更新日期：2003-07-01 00:00:00

abstract：:The adipokine leptin regulates energy homeostasis through ubiquitously expressed leptin receptors. Leptin has a number of major signaling targets in the brain, including cells of the anterior pituitary (AP). We have previously reported that mice lacking leptin receptors in AP somatotropes display growth hormone (GH) d...

journal_title：Endocrinology

authors： Allensworth-James M,Banik J,Odle A,Hardy L,Lagasse A,Moreira ARS,Bird J,Thomas CL,Avaritt N,Kharas MG,Lengner CJ,Byrum SD,MacNicol MC,Childs GV,MacNicol AM

更新日期：2021-03-01 00:00:00

abstract：:Anandamide and 2-arachidonoylglycerol (2-AG), two endogenous ligands of the CB1 and CB2 cannabinoid receptor subtypes, inhibit the proliferation of PRL-responsive human breast cancer cells (HBCCs) through down-regulation of the long form of the PRL receptor (PRLr). Here we report that 1) anandamide and 2-AG inhibit th...

journal_title：Endocrinology

authors： Melck D,De Petrocellis L,Orlando P,Bisogno T,Laezza C,Bifulco M,Di Marzo V

更新日期：2000-01-01 00:00:00

abstract：:Male Siberian hamsters undergo physiological weight change in changing photoperiod. Weight loss was induced by food restriction in long days to mimic short-day weight loss, or by food restriction superimposed on short-day weight loss, to test the hypothesis that the hypothalamus differentiates between weight change in...

journal_title：Endocrinology

authors： Mercer JG,Moar KM,Logie TJ,Findlay PA,Adam CL,Morgan PJ

更新日期：2001-10-01 00:00:00

abstract：:The effect of delta 9-tetrahydrocannabinol (THC) on suckling-induced oxytocin release was investigated by recording intramammary pressure changes in suckled rats treated iv with THC (0.5 mg/kg BW) or vehicle. Latency to the first posttreatment milk ejection and posttreatment milk ejection intervals and pressure wave a...

journal_title：Endocrinology

authors： Tyrey L,Murphy LL

更新日期：1988-07-01 00:00:00

abstract：:The ileal proglucagon-derived peptides (PGDPs) play important roles in the regulation of gastric function and insulin secretion. We have previously demonstrated the existence of a proximal-distal enteroendocrine loop mediated by glucose-dependent insulinotropic peptide (GIP), through which intestinal PGDP secretion is...

journal_title：Endocrinology

authors： Roberge JN,Gronau KA,Brubaker PL

更新日期：1996-06-01 00:00:00

abstract：:The present study was designed to investigate the effect of PTH on calcium (Ca2+) transport through the luminal membrane of proximal and distal rabbit tubule segments. Proximal tubule and distal tubule segment suspensions were incubated with the hormone, and the luminal membranes were subsequently purified. Incubation...

journal_title：Endocrinology

authors： Lajeunesse D,Bouhtiauy I,Brunette MG

更新日期：1994-01-01 00:00:00

abstract：:The effect of active and passive immunization with luteinizing hormone-releasing hormone (LHRH) on serum LH and follicle-stimulating hormone (FSH) levels and the ultrastructure of the pituitary gonadotrophs was investigated in castrated male rats. Two weeks after castration, the animals were immunized with Glu1-LHRH c...

journal_title：Endocrinology

authors： Arimura A,Shino M,de la Cruz KG,Rennels EG,Schally AV

更新日期：1976-07-01 00:00:00

abstract：:Dipeptyl peptidase-4 (DPP-4) inhibitors modulate the progression of atherosclerosis. To gain insights into their mechanism of action, 9-wk-old male apolipoprotein E (apoE)-deficient mice were fed a DPP-4 inhibitor, anagliptin-containing diet. The effects of anagliptin were investigated in, a monocyte cell line, human ...

journal_title：Endocrinology

authors： Ervinna N,Mita T,Yasunari E,Azuma K,Tanaka R,Fujimura S,Sukmawati D,Nomiyama T,Kanazawa A,Kawamori R,Fujitani Y,Watada H

更新日期：2013-03-01 00:00:00

abstract：:Impaired trophoblast invasion is associated with pregnancy disorders such as early pregnancy loss and preeclampsia. There is evidence to suggest that the consumption of caffeine during pregnancy may increase the risk of pregnancy loss; however, little is known about the direct effect of caffeine on normal trophoblast ...

journal_title：Endocrinology

authors： Grant I,Cartwright JE,Lumicisi B,Wallace AE,Whitley GS

更新日期：2012-09-01 00:00:00

abstract：:PTH, via the PTH/PTH-related protein receptor type 1 that couples to both protein kinase A (PKA) and protein kinase C (PKC) pathways, and the canonical Wnt-beta-catenin signaling pathway play important roles in bone formation. In the present study we have examined the interaction between the PTH and Wnt signaling path...

journal_title：Endocrinology

authors： Tobimatsu T,Kaji H,Sowa H,Naito J,Canaff L,Hendy GN,Sugimoto T,Chihara K

更新日期：2006-05-01 00:00:00

abstract：:The levels of beta 1- and beta 3-adrenoreceptor mRNAs in several rat tissues were determined simultaneously with a sensitive nuclease protection assay. The beta 1-receptor gene was expressed to varying degrees in most tissues examined. By contrast, high levels of beta 3-receptor mRNA were only found in brown and white...

journal_title：Endocrinology

authors： Granneman JG,Lahners KN

更新日期：1992-01-01 00:00:00

abstract：:The effect of diabetes mellitus on the synthesis and secretion of thyroid hormone ws investigated in mice with streptozotocin-induced diabetes. Thyroid glands were labeled in vivo with 131I for 2 h. In control animals, TSH stimulated the synthesis of PB127I and 131I-labeled iodothyronines and simultaneously decreased ...

journal_title：Endocrinology

authors： Bagchi N,Brown TR,Shivers B,Lucas S,Mack RE

更新日期：1981-11-01 00:00:00

abstract：:The influences of mating on serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were evaluated in 4-day cyclic proestrous rats of the Wistar strain. Blood samples were collected via guillotine from mated and unmated controls at 1900-2000 h or 2100--2200 h. Serum LH levels were determined by tw...

journal_title：Endocrinology

authors： Moss RL,Dudley CA,Schwartz NB

更新日期：1977-02-01 00:00:00

abstract：:The effects of human pancreatic GH-releasing factor-40 (hpGRF-40; 0.01-100 nM) and (Bu)2cAMP (0.015-1.5 mM) on GH release from primary monolayer cultures of pituitary cells were evaluated in rats of three age groups: postnatal days 2 and 12, and young adult males (3-4 months). Both hpGRF-40 and (Bu)2cAMP elicited a do...

journal_title：Endocrinology

authors： Szabo M,Cuttler L

更新日期：1986-01-01 00:00:00

abstract：:Although nicotinic cholinergic agonists have functional effects on PC 12 cells, radioligand-binding sites have not been detected. We, therefore, studied PC 12 cells incubated in the presence of nerve growth factor (NGF) and determined that specific [3H]nicotine-binding sites were induced approximately 2.5-fold in the ...

journal_title：Endocrinology

authors： Madhok TC,Sharp BM

更新日期：1992-02-01 00:00:00

abstract：:Immunological and binding methods have been used to demonstrate that acute inflammation induced in the pregnant mouse by a single sc turpentine injection elicits plasma protein responses in the fetal as well as in the maternal compartment. The maternal response involves, along with the classical pattern of positive an...

journal_title：Endocrinology

authors： Vranckx R,Savu L,Maya M,Nunez EA

更新日期：1987-05-01 00:00:00

abstract：:The influence of the catecholamine hormones and some of their metabolites on the enzymatic degradation of met-enkephalin by rat brain homogenates has been evaluated. The enzyme activity was determined by the release of [125I]-tyrosine from radioiodinated met-enkephalin following Porapak Q column chromatography. Each o...

journal_title：Endocrinology

authors： Caffrey JL,Hodges DH

更新日期：1982-01-01 00:00:00

abstract：:Neurosteroids are steroids that are synthesized de novo in the brain and include some classical (adrenal and gonadal steroids) and some unique brain-specific steroids. Neurosteroids are thought to mediate their action through ion gated channel receptors such as gamma-aminobutyric acid(A) and N-methyl-D-aspartate rathe...

journal_title：Endocrinology

authors： Compagnone NA,Bulfone A,Rubenstein JL,Mellon SH

更新日期：1995-11-01 00:00:00

abstract：:The osteoclast is known to be derived from the hemopoietic stem cell, but its lineage and the mechanisms by which its differentiation is regulated are largely unknown. There is evidence that osteoclastic differentiation is induced through a contact-dependent interaction between bone marrow stromal cells and hemopoieti...

journal_title：Endocrinology

authors： Hattersley G,Kerby JA,Chambers TJ

更新日期：1991-01-01 00:00:00

abstract：:We have previously demonstrated that cultured rat thyroid cells do not exhibit constitutive expression of major histocompatibility (MHC) class II antigens. Using reovirus types 1 and 3, we infected 1B-6 cells (a cloned derivative of the Fisher rat cell line FRTL-5), and found a dose-dependent induction of thyroid cell...

journal_title：Endocrinology

authors： Neufeld DS,Platzer M,Davies TF

更新日期：1989-01-01 00:00:00