Conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in renal slices from the rat.

abstract：:Hypothalamic lesions or deficient melanocortin (MC) signaling via MC4 receptor (MC4r) mutations often lead to hyperphagia and severe treatment-resistant obesity. We tested the methionine aminopeptidase 2-inhibitor beloranib (ZGN-440) in 2 male rat models of obesity, one modeling hypothalamic obesity with a combined me...

journal_title：Endocrinology

authors： Elfers CT,Roth CL

更新日期：2017-01-01 00:00:00

abstract：:Neonatal thymectomy at 3 days of age in mice results in ovarian dysgenesis, characterized by early follicular and oocyte loss, followed by a high incidence of ovarian tumorigenesis. Thymectomized animals with dysgenetic ovaries had extremely high levels of circulating PRL and gonadotropins before the appearance of the...

journal_title：Endocrinology

authors： Michael SD,Taguchi O,Nishizuka Y

更新日期：1981-06-01 00:00:00

abstract：:Sorbin is a 153-amino acid peptide that was initially discovered in the porcine duodenum. We have reported previously that this peptide regulates intestinal electrolyte transport and have described accumulation sites in the rat digestive tract. In the present study, we investigated the anatomical distribution and the ...

journal_title：Endocrinology

authors： El Fadil FA,Nicol P,Leduque P,Berger F,Descroix-Vagne M,Pansu D

更新日期：1997-11-01 00:00:00

abstract：:There is a growing body of evidence that subtle decreases in maternal thyroid hormone during gestation can impact fetal brain development. The present study examined the impact of graded levels of thyroid hormone insufficiency on brain development in rodents. Maternal thyroid hormone insufficiency was induced by expos...

journal_title：Endocrinology

authors： Goodman JH,Gilbert ME

更新日期：2007-06-01 00:00:00

abstract：:Estrogens have been shown to have positive and negative effects on anxiety and depressive-like behaviors, perhaps explained by the existence of two distinct estrogen receptor (ER) systems, ERalpha and ERbeta. The ERbeta agonist, diarylpropionitrile (DPN) has been shown to have anxiolytic properties in rats. DPN exists...

journal_title：Endocrinology

authors： Weiser MJ,Wu TJ,Handa RJ

更新日期：2009-04-01 00:00:00

abstract：:Relaxin was localized in cells of corpora lutea of pregnant rats at the ultrastructural level using a highly specific antirat relaxin serum and the unlabeled peroxidase-antiperoxidase technique. Electron-dense, membrane-bound granules (maximum diameter, 270 nm), which are present in luteal cells during the last third ...

journal_title：Endocrinology

authors： Anderson MB,Sherwood OD

更新日期：1984-04-01 00:00:00

abstract：:31P nuclear magnetic resonance (NMR) was used to study the effects of 17 beta-estradiol on the content of phosphates and on the flux catalyzed by creatine kinase in immature rat uteri. Perifusion with oxygenated medium at 36 C maintained the uteri in a viable state for at least 10 h in vitro during 31P NMR measurement...

journal_title：Endocrinology

authors： Degani H,Victor TA,Kaye AM

更新日期：1988-04-01 00:00:00

abstract：:Pancreatic membrane receptors for cholecystokinin (CCK) in obese and nonobese Zucker rats were compared with the use of a biologically active [125I]iodo-CCK-8 radioprobe. Membrane homogenates from obese rats bound half the amount of radioligand in 2 h as did membranes from lean rats (specifically bound, 7.0% vs. 14.0%...

journal_title：Endocrinology

authors： Praissman M,Izzo RS

更新日期：1986-08-01 00:00:00

abstract：:The signals that regulate cardiac myocyte maturation in the neonatal heart are not completely understood. In our study we examined the effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] on primary cultures of ventricular myocytes isolated from neonatal rat hearts. Our data show that 1,25-(OH)2D3 inhibited an increase ...

journal_title：Endocrinology

authors： O'Connell TD,Giacherio DA,Jarvis AK,Simpson RU

更新日期：1995-02-01 00:00:00

abstract：:Pancreatic islets express the superoxide-producing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system, but its role remains unknown. To address this, we studied the mechanisms of impaired insulin secretion induced by diphenyleneiodium (DPI), an NADPH oxidase inhibitor. We investigated the effects of DP...

journal_title：Endocrinology

authors： Imoto H,Sasaki N,Iwase M,Nakamura U,Oku M,Sonoki K,Uchizono Y,Iida M

更新日期：2008-11-01 00:00:00

abstract：:Recent studies have demonstrated that passive immunization of neonatal rats to GRF inhibited their somatic growth through the suppression of GH secretion. In this study, we investigated the changes in pituitary GRF receptor (GRFR) expression in GRF antibody (GRF-ab) treated rats. Neonatal rats were treated from day 1 ...

journal_title：Endocrinology

authors： Horikawa R,Hellmann P,Cella SG,Torsello A,Day RN,Muller EE,Thorner MO

更新日期：1996-06-01 00:00:00

abstract：:Isolated bone cells are often described according to the presence of PTH- and calcitonin (CT)-sensitive adenylate cyclase activities. Osteoblasts are thought to be cells with PTH-sensitive adenylate cyclase but without CT response, and osteoclasts are thought to be CT-sensitive cells. We have studied the adenylate cyc...

journal_title：Endocrinology

authors： Gutierrez GE,Mundy GR,Katz MS

更新日期：1984-12-01 00:00:00

abstract：:The differential regulation of neurotensin (NT), calcitonin (CT), and CT gene-related peptide (CGRP) production was studied in the clonal, rat C cell-derived, 44-2C cell line. Two experimental paradigms were used: cells were incubated with maximally effective concentrations of calcium (4.0 mM); alternatively, cells we...

journal_title：Endocrinology

authors： Zeytin FN,Rusk S,Leff SE

更新日期：1987-07-01 00:00:00

abstract：:We investigated the effects of acute (24-h) peroxisome proliferator-activated receptor (PPAR)alpha activation by WY14,643 (pirinixic acid) treatment on glucose-stimulated insulin secretion (GSIS) during pregnancy, in the rat, in relation to insulin sensitivity. GSIS after iv glucose challenge (500 mg/kg) was increased...

journal_title：Endocrinology

authors： Sugden MC,Greenwood GK,Smith ND,Holness MJ

更新日期：2003-01-01 00:00:00

abstract：:Plasma chromogranin-A (CgA) concentrations correlate with severe cardiovascular diseases, whereas CgA-derived vasostatin-I and catestatin elicit cardiosuppression via an antiadrenergic/nitric oxide-cGMP mediated mechanism. Whether these phenomena are related is unknown. We here investigated whether and to what extent ...

journal_title：Endocrinology

authors： Pasqua T,Corti A,Gentile S,Pochini L,Bianco M,Metz-Boutigue MH,Cerra MC,Tota B,Angelone T

更新日期：2013-09-01 00:00:00

abstract：:The inhibitory effect of T3 on TSH release was studied on a population of thyrotroph-enriched cells prepared from bovine pituitary glands by centrifugal elutriation. The cells (2.0 X 10(5)/ml) were cultured for 2 days and then exposed to TRH, phorbol-12 myristate-13 acetate (PMA), or calcium ionophore (A23187) with or...

journal_title：Endocrinology

authors： Yanagisawa M,Mirell CJ,Hershman JM

更新日期：1988-05-01 00:00:00

abstract：:To study the physiological regulation of the iodothyronine 5'-deiodinases (I-5'D), we have examined the effects of some thiol blockers and of thyroid status on I-5'D activities both in vitro and in vivo. At low (less than 5 mM) concentrations of dithiothreitol, propylthiouracil (PTU) inhibited I-5'D in the brain, pitu...

journal_title：Endocrinology

authors： Goswami A,Rosenberg IN

更新日期：1990-05-01 00:00:00

abstract：:p-Tyramine, an endogenous amine with sympathomimetic action, is found in the mammalian hypothalamus. When injected ip, p-tyramine reduced serum PRL without altering LH and TSH serum titers in adult orchidectomized rats and rats subjected to ether or immobilization stress. The hyperprolactinemia achieved by this last p...

journal_title：Endocrinology

authors： Becú-Villalobos D,Lacau de Mengido IM,Libertun C

更新日期：1985-05-01 00:00:00

abstract：:Pancreatic glucokinase (GK) is considered an important element of the glucose-sensing unit in pancreatic beta-cells. It is possible that the brain uses similar glucose-sensing units, and we employed GK immunohistochemistry and confocal microscopy to examine the anatomical distribution of GK-like immunoreactivities in ...

journal_title：Endocrinology

authors： Maekawa F,Toyoda Y,Torii N,Miwa I,Thompson RC,Foster DL,Tsukahara S,Tsukamura H,Maeda K

更新日期：2000-01-01 00:00:00

abstract：:We recently found that the Japanese red-bellied newt, Cynops pyrrhogaster, actively produces 7alpha-hydroxypregnenolone, a previously undescribed amphibian neurosteroid. 7alpha-Hydroxypregnenolone stimulates locomotor activity of male newts. Locomotor activity of male newts increases during the breeding period as in o...

journal_title：Endocrinology

authors： Haraguchi S,Koyama T,Hasunuma I,Vaudry H,Tsutsui K

更新日期：2010-05-01 00:00:00

abstract：:Adrenals express a high level of neutral cholesteryl ester hydrolase (CEH) activity, and male rats have greater activity than females; however, the identity of the enzyme(s) responsible for this activity and the basis for the sex differences are unknown. Using mice in which hormone-sensitive lipase (HSL) was inactivat...

journal_title：Endocrinology

authors： Kraemer FB,Shen WJ,Natu V,Patel S,Osuga J,Ishibashi S,Azhar S

更新日期：2002-03-01 00:00:00

abstract：:A novel NADPH-dependent cytosolic 3,5,3'-triiodo-L-thyronine (T3)-binding protein (CTBP) was purified by sequential fractionation of rat liver cytosol on Q-Sepharose, phenyl-Sepharose, red-Sepharose, and polyacrylamide gel electrophoresis under nondenaturing conditions. The CTBP had a sedimentation coefficient of 5.1S...

journal_title：Endocrinology

authors： Kobayashi M,Hashizume K,Suzuki S,Ichikawa K,Takeda T

更新日期：1991-10-01 00:00:00

abstract：:Progesterone has the capacity to suppress hypothalamic dopaminergic neuronal activity on proestrous afternoon and prolong or amplify the preovulatory prolactin surge in rats. In the present study, we examined enzyme activity and phosphorylation state of tyrosine hydroxylase (TH) in the stalk-median eminence of cycling...

journal_title：Endocrinology

authors： Liu B,Arbogast LA

更新日期：2008-04-01 00:00:00

abstract：:The ghrelin receptor (GhrR) is known for its strong orexigenic effects in pharmacological doses and has long been considered as a promising target for the treatment of obesity. Several antagonists have been developed to decrease the orexigenic signaling, but none of these have been approved for the treatment of obesit...

journal_title：Endocrinology

authors： Hedegaard MA,Holst B

更新日期：2020-04-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF), an agent with important mitogenic effects for bone cells, exists in three isoforms, PDGF-AA, -BB, and -AB. PDGF-AB and -BB are the prevalent circulating isoforms, whereas normal unstimulated cells of the osteoblast lineage synthesize primarily PDGF-AA. We examined the effects of ...

journal_title：Endocrinology

authors： Rydziel S,Shaikh S,Canalis E

更新日期：1994-06-01 00:00:00

abstract：:Kisspeptins are new actors in the neuroendocrine regulation of reproduction. In vertebrates, the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 and kiss2, and two kiss receptors (GPR54), kiss1r and kiss2r. To provide detailed information on the organization of the kiss systems in ...

journal_title：Endocrinology

authors： Servili A,Le Page Y,Leprince J,Caraty A,Escobar S,Parhar IS,Seong JY,Vaudry H,Kah O

更新日期：2011-04-01 00:00:00

abstract：:Ovarian follicular development is initiated by FSH secreted from the pituitary gland. The FSH-induced follicular development involves granulosa cell proliferation and differentiation. We demonstrated that a growth factor of epidermal growth factor (EGF) family epiregulin was rapidly induced in the primary culture of r...

journal_title：Endocrinology

authors： Sekiguchi T,Mizutani T,Yamada K,Yazawa T,Kawata H,Yoshino M,Kajitani T,Kameda T,Minegishi T,Miyamoto K

更新日期：2002-12-01 00:00:00

abstract：:Specific binding sites for PRL were identified on isolated intestinal epithelial cells from both male and female rabbits. These receptors exhibited a very high affinity for PRL (Kd = 5 x 10(-11) M) and were immunologically very similar to the well characterized mammary PRL receptor. About 3500 PRL receptors/cell were ...

journal_title：Endocrinology

authors： Dusanter-Fourt I,Belair L,Gespach C,Djiane J

更新日期：1992-05-01 00:00:00

abstract：:The mechanisms by which oxytocin (OT) stimulates extracellular signal-regulated kinase 1/2 (ERK1/2) are only partially understood. OT receptor (OTR) signals predominantly through Galpha(q), but ERK1/2 phosphorylation (ERK1/2-P) in PHM1 myometrial cells was not eliminated by inhibition of downstream effectors such as p...

journal_title：Endocrinology

authors： Zhong M,Yang M,Sanborn BM

更新日期：2003-07-01 00:00:00

abstract：:In rodents, soluble leptin receptor (SLR) may be generated by alternative splicing of ObR mRNA and/or as a cleavage product of ObR membrane-anchored receptors. In this study, we investigated the contribution of both processes on the generation of SLR in 3-, 8-, and 24-month-old Wistar rats fed ad libitum (AL) or under...

journal_title：Endocrinology

authors： Gallardo N,Arribas C,Villar M,Ros M,Carrascosa JM,Martínez C,Andrés A

更新日期：2005-11-01 00:00:00