Growth hormone-releasing factor (GRF) regulates expression of its own receptor.

abstract：:Proglucagon, synthesized in the pancreatic islets and the intestinal L-cells, contains in its precursor structure glucagon, glicentin, and two glucagon-like peptides (GLP-I and GLP-II) separated by an intervening peptide (IP-II). We have cloned a stable rat islet cell line expressing the glucagon gene at high levels, ...

journal_title：Endocrinology

authors： Philippe J,Mojsov S,Drucker DJ,Habener JF

更新日期：1986-12-01 00:00:00

abstract：:Caveolae and their principal component caveolin have been implicated in playing a major role in G protein-mediated transmembrane signaling. We examined whether caveolin interacts with adenylyl cyclase, an effector of G protein signaling, using a 20-mer peptide derived from the N-terminus scaffolding domain of caveolin...

journal_title：Endocrinology

authors： Toya Y,Schwencke C,Couet J,Lisanti MP,Ishikawa Y

更新日期：1998-04-01 00:00:00

abstract：:Endothelin (ET) and GnRH act through specific receptors to promote Ca2+ mobilization and influx pathways in pituitary gonadotrophs. In the present study cytoplasmic calcium ([Ca2+]i) and secretory responses to these two agonists are compared. In single gonadotrophs, low concentrations of both agonists cause oscillator...

journal_title：Endocrinology

authors： Stojilković SS,Iida T,Cesnjaj M,Catt KJ

更新日期：1992-12-01 00:00:00

abstract：:Specific triiodothyronine receptor activity has been detected in rat lung nuclei isolated by Triton X-100, which was sensitive to pH and exhibited temperature-dependent association kinetics. This activity represented a single order of high affinity binding sites, with an apparent dissociation constant for 3,3',5-triio...

journal_title：Endocrinology

authors： Morishige WK,Guernsey DL

更新日期：1978-05-01 00:00:00

abstract：:The effects of dopamine on PRL secretion and lysosomal enzyme activity in anterior pituitary tissue from rats selected during various stages of the estrous cycle were examined under in vitro conditions. During the estrous cycle, there was a marked variation in the capacity of dopamine to stimulate the activity of the ...

journal_title：Endocrinology

authors： Nansel DD,Gudelsky GA,Reymond MJ,Porter JC

更新日期：1981-03-01 00:00:00

abstract：:The present study was conducted to examine the effect of LH on phospholipid metabolism in corpora luteal tissue. Collagenase-dispersed cells obtained from bovine corpora lutea of early pregnancy were incubated with 32PO4 in the presence or absence of LH and examined for their ability to incorporate this label into pho...

journal_title：Endocrinology

authors： Davis JS,Farese RV,Marsh JM

更新日期：1981-08-01 00:00:00

abstract：:In various forms of shock, TRH is equivalent to naloxone in reversing the hypotension and improving the survival rate. The present findings indicate that in spontaneously hypertensive rats (SHR), TRH has another naloxone-like effect in antagonizing the antihypertensive response to clonidine and alpha-methyldopa. When ...

journal_title：Endocrinology

authors： Kunos G,Newman F,Farsang C,Ungar W

更新日期：1984-12-01 00:00:00

abstract：:Glucocorticoids are potent inhibitors of prostaglandin (PG) release in vitro, but they fail to influence basal PG production in vivo. To test one possible explanation for this apparent discrepancy in the present study we investigated the effect of dexamethasone (DEX) on basal and antidiuretic hormone-stimulated renal ...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Fejes-Tóth G

更新日期：1986-12-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) is thought to confer aldosterone specificity to mineralocorticoid target cells by protecting the mineralocorticoid receptor from occupancy by endogenous glucocorticoids. We have recently described a novel isoform of 11-OHSD in the renal aldosterone target cells (11 b...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Fejes-Tóth G

更新日期：1995-06-01 00:00:00

abstract：:Hypothyroid patients and mice have been shown to have circulating TSH that is more highly sialylated than their euthyroid counterparts. To learn about the underlying cellular mechanisms responsible for this increased sialylation of TSH, we used in situ hybridization to examine the beta-galactoside alpha-2,6-sialyltran...

journal_title：Endocrinology

authors： Helton TE,Magner JA

更新日期：1994-06-01 00:00:00

abstract：:We have investigated, in young and aged rats, tuberoinfundibular dopaminergic (TIDA) and nigrostriatal neurons of the brain, and the role of the testes and anterior pituitary (AP) on 1) the in situ activity of tyrosine hydroxylase (TH), 2) translation of TH mRNA, as reflected by the mass of TH, and 3) transcription of...

journal_title：Endocrinology

authors： Aguila-Mansilla N,Kedzierski W,Porter JC

更新日期：1991-08-01 00:00:00

abstract：:Isoforms of the recently cloned vesicular glutamate transporters (VGLUT1-3) selectively accumulate glutamic acid into synaptic vesicles in excitatory axon terminals and are viewed as reliable markers for glutamatergic neurons. Our present studies provided dual-label in situ hybridization evidence that virtually all (9...

journal_title：Endocrinology

authors： Hrabovszky E,Turi GF,Kalló I,Liposits Z

更新日期：2004-09-01 00:00:00

abstract：:Nutritional programming, taking place in utero or early after birth, is closely linked with metabolic and appetite disorders in adulthood. Following the hypothesis that nutritional programming impacts hypothalamic neuronal organization, we report on discrepancies of multiple molecular and cellular early events that ta...

journal_title：Endocrinology

authors： Coupé B,Amarger V,Grit I,Benani A,Parnet P

更新日期：2010-02-01 00:00:00

abstract：:Experimental evidence indicates that the neonatal gonadal steroid environment is an important determinant of the sexual dimorphism of GH secretion and body growth. However, the influence of the sex steroids in GH control during adult life and their mechanism/site of action are largely unknown. In the present study we ...

journal_title：Endocrinology

authors： Painson JC,Thorner MO,Krieg RJ,Tannenbaum GS

更新日期：1992-01-01 00:00:00

abstract：:Diabetic cardiomyopathy is characterized by myocyte loss and myocardial fibrosis, leading to decreased elasticity and impaired contractile function. The study examines the downstream signaling whereby oxidative stress, induced by hyperglycemia, leads to myocardial fibrosis and impaired contractile function in the left...

journal_title：Endocrinology

authors： Aragno M,Mastrocola R,Alloatti G,Vercellinatto I,Bardini P,Geuna S,Catalano MG,Danni O,Boccuzzi G

更新日期：2008-01-01 00:00:00

abstract：:Flavonoids are functional constituents of many fruits and vegetables. Some flavonoids have antidiabetic properties because they improve altered glucose and oxidative metabolisms of diabetic states. Procyanidins are flavonoids with an oligomeric structure, and it has been shown that they can improve the pathological ox...

journal_title：Endocrinology

authors： Pinent M,Blay M,Bladé MC,Salvadó MJ,Arola L,Ardévol A

更新日期：2004-11-01 00:00:00

abstract：:We have shown previously that neonatal testicular gonocytes express platelet-derived growth factor receptors (PDGFR) alpha and beta. We report the expression of a novel PDGFRbeta (V1-PDGFRbeta) transcript in gonocytes of 3-d-old rat testes. V1-PDGFRbeta nucleotide sequence spans from intron 6 to exon 23 of the PDGFRbe...

journal_title：Endocrinology

authors： Wang Y,Culty M

更新日期：2007-05-01 00:00:00

abstract：:RIAs specific for the alpha-subunit of glycoprotein hormones were used to monitor the subunit conformation in ovine FSH and TSH and in recombinants of ovine LH alpha with (ovine and porcine) LH beta and hCG beta. Differences in log-logit slopes of the RIA dilution curves were interpreted to indicate changes, presumabl...

journal_title：Endocrinology

authors： Strickland TW,Puett D

更新日期：1982-07-01 00:00:00

abstract：:Maintenance of cell polarity is essential for Sertoli cell and blood-testis barrier (BTB) function and spermatogenesis; however, the signaling mechanisms that regulate the integrity of the cytoskeleton and polarity of Sertoli cells are not fully understood. Here, we demonstrate that rapamycin-insensitive component of ...

journal_title：Endocrinology

authors： Dong H,Chen Z,Wang C,Xiong Z,Zhao W,Jia C,Lin J,Lin Y,Yuan W,Zhao AZ,Bai X

更新日期：2015-11-01 00:00:00

abstract：:As we previously showed, we have synthesized a new family of 17β-estradiol-platinum(II) hybrids. Earlier studies revealed the VP-128 hybrid to show high efficiency compared with cisplatin toward hormone-dependent breast cancer cells. In the present research, we have studied the antitumor activity of VP-128 in vitro an...

journal_title：Endocrinology

authors： Brasseur K,Leblanc V,Fabi F,Parent S,Descôteaux C,Bérubé G,Asselin E

更新日期：2013-07-01 00:00:00

abstract：:Leptin signaling in the hypothalamic arcuate nucleus (ARC) is hypothesized to play an important role in energy homeostasis. To investigate whether leptin signaling limited to this brain area is sufficient to reduce food intake and body weight, we used adenoviral gene therapy to express the signaling isoform of the lep...

journal_title：Endocrinology

authors： Morton GJ,Niswender KD,Rhodes CJ,Myers MG Jr,Blevins JE,Baskin DG,Schwartz MW

更新日期：2003-05-01 00:00:00

abstract：:Impaired wound healing of skin is one of the most serious complications of diabetes. However, the pathogenesis of this process is not known, and it is unclear whether impaired insulin signaling could directly affect skin physiology. To elucidate the role of insulin in skin, we studied skin insulin receptor (IR) null m...

journal_title：Endocrinology

authors： Wertheimer E,Spravchikov N,Trebicz M,Gartsbein M,Accili D,Avinoah I,Nofeh-Moses S,Sizyakov G,Tennenbaum T

更新日期：2001-03-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), a prevalent growth factor secreted by bone cells, has important effects on bone remodeling. Hormones are known to regulate the synthesis of skeletal IGF-I, but there is limited information about the actions of growth factors on IGF-I synthesis. We tested the effects of basic fibro...

journal_title：Endocrinology

authors： Canalis E,Pash J,Gabbitas B,Rydziel S,Varghese S

更新日期：1993-07-01 00:00:00

abstract：:Somatostatin (SRIH) inhibits cell proliferation by interacting with five distinct SRIH receptor subtypes (SSTRs) activating several pathways in many tissues. We previously demonstrated that SRIH, by activating Src homology-2-containing protein, inhibits cell proliferation of the human medullary thyroid carcinoma cell ...

journal_title：Endocrinology

authors： Tagliati F,Zatelli MC,Bottoni A,Piccin D,Luchin A,Culler MD,Degli Uberti EC

更新日期：2006-07-01 00:00:00

abstract：:In mammals, the brain-specific protein munc18-1 regulates synaptic vesicle exocytosis at the synaptic junction, in a step before vesicle fusion. We hypothesize that the rate of biosynthesis of munc18-1 messenger RNA (mRNA) and the amount of munc18-1 present in neurons and neuroendocrine cells are related to the physio...

journal_title：Endocrinology

authors： Kolk SM,Berghs CA,Vaudry H,Verhage M,Roubos EW

更新日期：2001-05-01 00:00:00

abstract：:We examined the effects of ACTH and the Ca++ ionophore, A23187, on steroidogenesis and phospholipid metabolism during incubation of dispersed rat adrenal cells. Increasing doses of ACTH elicited nearly parallel increases in corticosterone production and adrenal inositide (mono- and di-) concentrations. As reported pre...

journal_title：Endocrinology

authors： Farese RV,Sabir MA,Larson RE

更新日期：1981-04-01 00:00:00

abstract：:Apolipoprotein-E (apoE) has been shown by noncovalent binding and photoaffinity labeling with [125I]T4 to possess a single L-T4 binding site with a K5 of about 3 x 10(7) M-1 and a relative affinity for analogs of L-T4 = D-T4 = rT3 = triiodothyroacetic acid > L-T3. T4 binding was not affected by the flavonoid EMD 21388...

journal_title：Endocrinology

authors： Benvenga S,Cahnmann HJ,Robbins J

更新日期：1993-09-01 00:00:00

abstract：:Neurons that produce kisspeptin play a critical role in reproduction. However, understanding the molecular physiology of kisspeptin neurons has been limited by the lack of an in vivo marker for those cells. Here, we report the development of a Kiss1-CreGFP knockin mouse, wherein the endogenous Kiss1 promoter directs t...

journal_title：Endocrinology

authors： Gottsch ML,Popa SM,Lawhorn JK,Qiu J,Tonsfeldt KJ,Bosch MA,Kelly MJ,Rønnekleiv OK,Sanz E,McKnight GS,Clifton DK,Palmiter RD,Steiner RA

更新日期：2011-11-01 00:00:00

abstract：:Fat intake has long been associated with the development of obesity. The studies described herein show that fat adversely affects adipocyte adrenergic receptor (AR) expression and function. As beta 3AR agonists have been shown to acutely reduce adipose tissue mass and improve thermogenesis in genetically obese rodents...

journal_title：Endocrinology

authors： Collins S,Daniel KW,Petro AE,Surwit RS

更新日期：1997-01-01 00:00:00

abstract：:Thyromimetics represent a class of experimental drugs that can stimulate tissue-selective thyroid hormone action. As such, thyromimetics should have effects on the hypothalamic-pituitary-thyroid (HPT) axis, but details of this action and the subsequent effects on systemic thyroid hormone levels have not been reported ...

journal_title：Endocrinology

authors： Ferrara SJ,Bourdette D,Scanlan TS

更新日期：2018-07-01 00:00:00