Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis.

abstract：:The nuclear translocation of PRL is demonstrated at the immunofluorescence and electron microscopic (EM) levels in interleukin-2 (IL2)-stimulated cloned T-cells and concanavalin A-stimulated splenocytes. This translocation occurs 2-10 h after IL2 stimulation, and is reversed by the addition of anti-PRL antiserum into ...

journal_title：Endocrinology

authors： Clevenger CV,Sillman AL,Prystowsky MB

更新日期：1990-12-01 00:00:00

abstract：:Dispersed cells from whole testes or from isolated interstitial tissue of mature rats, yielded two distinct populations of Leydig cells when subjected to centrifugation in a 0-40% metrizamide gradient. One population (I) was found in a fractions with a density of 1.085-1.117 g/cm3, and the other population (II) was fo...

journal_title：Endocrinology

authors： Payne AH,Downing JR,Wong KL

更新日期：1980-05-01 00:00:00

abstract：:We have studied potential mechanisms by which zinc deficiency (ZD) may result in growth impairment in young animals. Dietary-induced ZD in young rats resulted in diminished skeletal growth as measured by tibial epiphyseal width. Treatment with bovine GH (bGH) did not increase skeletal growth suggesting GH resistance r...

journal_title：Endocrinology

authors： Oner G,Bhaumick B,Bala RM

更新日期：1984-05-01 00:00:00

abstract：:Hypophysiotrophic neurons projecting to hypophyseal portal vessels in the median eminence of the hypothalamus maintain the operation of the master gland, the pituitary, by secreting releasing and release-inhibiting hormones into the bloodstream. LHRH, synthesized in neurons of the rat prosencephalon, is one of the key...

journal_title：Endocrinology

authors： Liposits Z,Reid JJ,Negro-Vilar A,Merchenthaler I

更新日期：1995-05-01 00:00:00

abstract：:Recent evidence indicates that endogenous GnRH is required for maintenance of its own pituitary receptors (GnRH-R). We have measured GnRH-R in pituitaries of hypogonadotrophic hypogonadal (hpg) mice, in whom hypothalamic GnRH is deficient or absent. The GnRH-R concentration in hpg male mouse pituitaries was 10.6 +/- 1...

journal_title：Endocrinology

authors： Young LS,Speight A,Charlton HM,Clayton RN

更新日期：1983-07-01 00:00:00

abstract：:In several mammalian species, luteinizing hormone-releasing hormone (LHRH) neurons have been shown to migrate from nasal regions to the brain during early development. Using immunocytochemistry, we have identified LHRH containing neurons in developing chick embryos. In embryonic day 4 (E4) and E5 animals, a small grou...

journal_title：Endocrinology

authors： Norgren RB Jr,Lehman MN

更新日期：1991-03-01 00:00:00

abstract：:There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubertal and adult ages. ...

journal_title：Endocrinology

authors： França LR,Suescun MO,Miranda JR,Giovambattista A,Perello M,Spinedi E,Calandra RS

更新日期：2006-03-01 00:00:00

abstract：:Corticotropin-releasing factor receptor type 2beta, expressed in the rodent cardiovascular system, is a member of the G protein-coupled receptor family. This receptor is coupled positively to adenylate cyclase and is bound preferentially by the urocortin (Ucn)-related peptides (Uncs): Ucn, Ucn II, and Ucn III. In the ...

journal_title：Endocrinology

authors： Kageyama K,Suda T

更新日期：2003-06-01 00:00:00

abstract：:We have investigated the effect of GH on microtubular physiology in Chinese hamster ovary (CHO) cells stably transfected with the complementary DNA for the rat GH receptor (CHO-GHR(1-638)). We show here that after 30 min of human GH (hGH) treatment of CHO-GHR(1-638) cells, there was a significant increase in the level...

journal_title：Endocrinology

authors： Goh EL,Pircher TJ,Lobie PE

更新日期：1998-10-01 00:00:00

abstract：:Hexose-6-phosphate dehydrogenase (EC 1.1.1.47) catalyzes the conversion of glucose 6-phosphate to 6-phosphogluconolactone within the lumen of the endoplasmic reticulum, thereby generating reduced nicotinamide adenine dinucleotide phosphate. Reduced nicotinamide adenine dinucleotide phosphate is a necessary cofactor fo...

journal_title：Endocrinology

authors： Rogoff D,Ryder JW,Black K,Yan Z,Burgess SC,McMillan DR,White PC

更新日期：2007-10-01 00:00:00

abstract：:The microenvironment of placental mesenchymal stem cells (PMSCs) is dynamic throughout gestation and determines changes in cell fate. In vivo, PMSCs initially develop in low-oxygen tension and low IGF-I concentrations, and both increase gradually with gestation. The impact of varying concentrations of IGF-I and changi...

journal_title：Endocrinology

authors： Youssef A,Iosef C,Han VK

更新日期：2014-04-01 00:00:00

abstract：:The 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta HSD-2) enzyme is thought to confer aldosterone specificity upon mineralocorticoid target tissues by protecting the mineralocorticoid receptor from binding by the more abundant glucocorticoids, corticosterone and cortisol. We have developed a Chinese hamster ovar...

journal_title：Endocrinology

authors： Morita H,Zhou M,Foecking MF,Gomez-Sanchez EP,Cozza EN,Gomez-Sanchez CE

更新日期：1996-06-01 00:00:00

abstract：:To elucidate the temporal profile of adaptive changes of the islets of Langerhans to the increased insulin demands of pregnancy, we have studied islet cell proliferation and insulin secretion during gestation in the rat. 5-Bromo-2'-deoxyuridine incorporation into dividing islet cells was significantly (P less than 0.0...

journal_title：Endocrinology

authors： Parsons JA,Brelje TC,Sorenson RL

更新日期：1992-03-01 00:00:00

abstract：:Central and peripheral humoral responses of the adrenocortical system were measured for 2 h after the application of several stimuli. Two min after the onset of the stresses of sham-adrenalectomy or laparotomy with intestinal traction there was a 4-6 fold increase in hypothalamic CRF content as compared to control con...

journal_title：Endocrinology

authors： Sato T,Sato M,Shinsako J,Dallman MF

更新日期：1975-08-01 00:00:00

abstract：:Recent evidence has suggested that a circadian rhythm exists for plasma beta-endorphin-like immunoreactivity. The purpose of the present study was to examine the long term effects of surgical trauma on plasma beta-endorphin dynamics. Blood samples for RIA were obtained from female baboons every 4 h for three 48-h peri...

journal_title：Endocrinology

authors： McIntosh TK

更新日期：1987-05-01 00:00:00

abstract：:Ghrelin is a growth hormone-releasing peptide recently discovered in the stomach of rat and human as an endogenous ligand for growth hormone-secretagogue receptor. In the present study, a full-length cDNA for mouse ghrelin has been cloned from the stomach using the oligo-capping and rapid amplification methods, and th...

journal_title：Endocrinology

authors： Tanaka M,Hayashida Y,Iguchi T,Nakao N,Nakai N,Nakashima K

更新日期：2001-08-01 00:00:00

abstract：:The homozygous ablation of the gene encoding the PTH/PTHrP receptor (PPR(-/-)) leads to early lethality and limited developmental defects, including an acceleration of chondrocyte differentiation. In contrast to the findings in homozygous PTHrP-ablated (PTHrP(-/-)) animals, these PPR(-/-) mice show an increase in cort...

journal_title：Endocrinology

authors： Soegiarto DW,Kiachopoulos S,Schipani E,Jüppner H,Erben RG,Lanske B

更新日期：2001-12-01 00:00:00

abstract：:The biosynthesis of estrogens is catalyzed by aromatase P450 (P450arom), the product of the CYP19 gene. The tissue-specific expression of the CYP19 gene is regulated by means of tissue-specific promoters through the use of alternative splicing mechanisms. Thus, transcripts containing various 5'-untranslated termini ar...

journal_title：Endocrinology

authors： Sun T,Zhao Y,Mangelsdorf DJ,Simpson ER

更新日期：1998-04-01 00:00:00

abstract：:QRFP, an RFamide peptide, was recently identified as an endogenous ligand of an orphan G protein-coupled receptor, GPR103. Recent investigation revealed that acute intracerebroventricular (ICV) administration of QRFP26/P518/26RFa, a constitutive part of QRFP43 (43-amino acid-residue form of QRFP), increases appetite i...

journal_title：Endocrinology

authors： Moriya R,Sano H,Umeda T,Ito M,Takahashi Y,Matsuda M,Ishihara A,Kanatani A,Iwaasa H

更新日期：2006-06-01 00:00:00

abstract：:Estrogens have been shown to have positive and negative effects on anxiety and depressive-like behaviors, perhaps explained by the existence of two distinct estrogen receptor (ER) systems, ERalpha and ERbeta. The ERbeta agonist, diarylpropionitrile (DPN) has been shown to have anxiolytic properties in rats. DPN exists...

journal_title：Endocrinology

authors： Weiser MJ,Wu TJ,Handa RJ

更新日期：2009-04-01 00:00:00

abstract：:The actions of IGF-I and IGF-II are thought to be largely due to their activation of the IGF-I receptor. However, IGF-II can also bind with high affinity to, and effectively activate, an isoform of the insulin receptor (IR-A) that lacks a sequence at the carboxyl-terminal end of the extracellular alpha subunit due to ...

journal_title：Endocrinology

authors： Denley A,Brierley GV,Carroll JM,Lindenberg A,Booker GW,Cosgrove LJ,Wallace JC,Forbes BE,Roberts CT Jr

更新日期：2006-02-01 00:00:00

abstract：:The effects of morphine on the release of dopamine from tuberoinfundibular neurons and the release of PRL from the anterior pituitary gland were studied in diestrous female rats. Morphine ions ejected iontophoretically in minute quantities into the arcuate nuclei (using one electrode per nucleus) were found to reduce ...

journal_title：Endocrinology

authors： Haskins JT,Gudelsky GA,Moss RL,Porter JC

更新日期：1981-03-01 00:00:00

abstract：:In order to compare, in vitro, the TSH suppressive effects of iodothyronines, rat pituitary quarters were first preincubated with T4, T3, rT3, or 3,3'-diiodothyronine (T2) in Gey and Gey buffer containing 1% bovine serum albumin for 2 h at 37 C and then incubated at 37 C for 1 h with the iodothyronine under study and ...

journal_title：Endocrinology

authors： Chopra IJ,Carlson HE,Solomon DH

更新日期：1978-08-01 00:00:00

abstract：:The levels of two steroid-binding proteins, progesterone-binding globulin (PBG) (1) and corticosteroid-binding globulin (CBG), present in the plasma of pregnant guinea pigs were determined just before and after parturition. Both PBG (3.37 +/- 2.1 microM) and CBG (10.1 +/- 1.7 microM) were present in high levels just b...

journal_title：Endocrinology

authors： Raymoure WJ,Kuhn RW

更新日期：1980-06-01 00:00:00

abstract：:Three distinct receptor types for natriuretic peptides (NP) have been identified in human tissue. "A" and "B" receptors initiate biological actions, whereas the "C" receptor has a clearance function. It has been proposed that the natural ligand for the B receptor is c-type natriuretic peptide (CNP), rather than atrial...

journal_title：Endocrinology

authors： Canaan-Kühl S,Jamison RL,Myers BD,Pratt RE

更新日期：1992-01-01 00:00:00

abstract：:We have used in situ hybridization histochemistry to investigate interactions between the thyroid and adrenal axes in the rat. Propylthiouracil (PTU)-induced hypothyroidism caused a significant reduction in CRH gene transcripts in the paraventricular nucleus of male rats, with a concomitant decrease in both POMC gene ...

journal_title：Endocrinology

authors： Shi ZX,Levy A,Lightman SL

更新日期：1994-03-01 00:00:00

abstract：:Decidual tissue of the rat produces a hormone with physiological and biochemical characteristics similar to those of PRL. Because PRL affects both follicular and luteal production of testosterone and estradiol, it was of interest to determine whether decidual luteotropin affects basal and/or LH-stimulated ovarian secr...

journal_title：Endocrinology

authors： Gibori G,Kalison B,Warshaw ML,Basuray R,Glaser LA

更新日期：1985-05-01 00:00:00

abstract：:Studying the mechanisms for the complex pathogenesis of polycystic ovary syndrome (PCOS) requires animal models with endocrine, reproductive, and metabolic features of the syndrome. Hyperandrogenism seems to be a central factor in PCOS, leading to anovulation and insulin resistance. In female rats, continuous administ...

journal_title：Endocrinology

authors： Maliqueo M,Sun M,Johansson J,Benrick A,Labrie F,Svensson H,Lönn M,Duleba AJ,Stener-Victorin E

更新日期：2013-01-01 00:00:00

abstract：:Angiotensin II binds to the angiotensin II receptors type 1 (AT1 receptors) in adrenocortical cells and triggers an intracellular signaling cascade leading to changes in the gene expression pattern. Here, we show that stimulation with angiotensin II induces the expression of biologically active early growth response (...

journal_title：Endocrinology

authors： Thiel G,Rössler OG

更新日期：2011-11-01 00:00:00

abstract：:Fibroblast growth factor 9 (FGF9) signal has a role in organogenesis of the mammalian testis by controlling migration of mesonephric cells to the XY gonad, but neither it nor the FGF receptors is expressed sex-specifically. Of the Sprouty genes encoding antagonists of receptor tyrosine kinases including FGFr, mSprouty...

journal_title：Endocrinology

authors： Chi L,Itäranta P,Zhang S,Vainio S

更新日期：2006-08-01 00:00:00