Abstract:
:The levels of two steroid-binding proteins, progesterone-binding globulin (PBG) (1) and corticosteroid-binding globulin (CBG), present in the plasma of pregnant guinea pigs were determined just before and after parturition. Both PBG (3.37 +/- 2.1 microM) and CBG (10.1 +/- 1.7 microM) were present in high levels just before parturition and were found to decrease with a half-life of 2 days after delivery. PBG and CBG were also found in the milk whey of lactating guinea pigs but at much lower levels (26.5 +/- 12 and 375 +/- 18 nM, respectively, on day 1 post partum). The whey content of each protein declined with a half-life of 3 days. The whey steroid-binding proteins were indistinguishable from their plasma counterparts on the basis of ion exchange and gel filtration chromatographies, sucrose gradient centrifugation, susceptibility to heat denaturation, and hormone binding specificity.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Raymoure WJ,Kuhn RWdoi
10.1210/endo-106-6-1747subject
Has Abstractpub_date
1980-06-01 00:00:00pages
1747-54issue
6eissn
0013-7227issn
1945-7170journal_volume
106pub_type
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