Role of protein kinase-C in the alpha 1-adrenoceptor-mediated responses of perfused rat liver.

abstract：:Sex differences in liver gene expression are determined by pituitary growth hormone secretion patterns, which regulate sex-dependent liver transcription factors and establish sex-specific chromatin states. Hypophysectomy (hypox) identifies two major classes of liver sex-biased genes, defined by their sex-dependent pos...

journal_title：Endocrinology

authors： Melia T,Waxman DJ

更新日期：2019-05-01 00:00:00

abstract：:Targeted disruption [knockout (KO)] of the mouse prolactin (PRL) gene created an animal model of primary isolated PRL deficiency in which there is no detectable PRL bioactivity. Pituitary glands of young adult female PRLKO mice were hyperplastic, and many cells had expanded cytoplasms with granular accumulations of an...

journal_title：Endocrinology

authors： Cruz-Soto ME,Scheiber MD,Gregerson KA,Boivin GP,Horseman ND

更新日期：2002-11-01 00:00:00

abstract：:In addition to androgens that are essential for maintenance of prostate growth and function, nonandrogenic hormones must also be considered to explain some regulatory events occurring in the prostate. The detection of LH/CG receptor (LH/CG-R) gene expression in some nongonadal tissues, has led us to consider LH as a p...

journal_title：Endocrinology

authors： Reiter E,McNamara M,Closset J,Hennen G

更新日期：1995-03-01 00:00:00

abstract：:Permanent effects of postnatal gonads on dopamine (DA)-mediated regulation of PRL secretion were examined in adult male rats of the Wistar-Imamichi strain. Rats were bilaterally orchidectomized at varying postnatal days, i.e. 8 h after birth [neonatal castration (NC)] or at 1, 2, 3, 4, or 6 weeks of age, and subjected...

journal_title：Endocrinology

authors： Watanobe H,Takebe K

更新日期：1987-06-01 00:00:00

abstract：:The two peptides pancreastatin and diazepam binding inhibitor (DBI) were recently demonstrated in pancreatic islets and were shown to inhibit insulin secretion in short term experiments. In the present study we investigated long term effects of pancreastatin and DBI on the DNA synthesis, polyamine content, and insulin...

journal_title：Endocrinology

authors： Sjöholm A,Funakoshi A,Efendić S,Ostenson CG,Hellerström C

更新日期：1991-06-01 00:00:00

abstract：:After reproductive senescence or gonadectomy, changes occur in neural gene expression, ultimately altering brain function. The endocrine mechanisms underlying these changes in gene expression beyond immediate hormone loss are poorly understood. To investigate this, we measured changes in gene expression the dorsal str...

journal_title：Endocrinology

authors： Meitzen J,Perry AN,Westenbroek C,Hedges VL,Becker JB,Mermelstein PG

更新日期：2013-05-01 00:00:00

abstract：:Endotoxin has been shown to stimulate GH secretion in human and sheep. However, changes in hypothalamic neurohormones involved in the GH regulation by endotoxin have never been studied in vivo. In sheep it is possible to collect hypophysial portal blood (HPB) and quantify GH-releasing hormone (GHRH) and somatostatin (...

journal_title：Endocrinology

authors： Briard N,Guillaume V,Frachebois C,Rico-Gomez M,Sauze N,Oliver C,Dutour A

更新日期：1998-06-01 00:00:00

abstract：:Organ weight was compared in adult mice with deletion of one (IRS-1-/+) or both (IRS-1-/-) copies of the insulin receptor substrate-1 (IRS-1) gene and IRS-1+/+ littermates. IRS-1-/+ mice showed modest reductions in weight of most organs in proportion to a decrease in body weight. IRS-1-/- mice showed major reductions ...

journal_title：Endocrinology

authors： Pete G,Fuller CR,Oldham JM,Smith DR,D'Ercole AJ,Kahn CR,Lund PK

更新日期：1999-12-01 00:00:00

abstract：:Transfer of corticosterone from serum to milk was studied in lactating rats after ether and pentobarbital anesthesia. Two minutes after the onset of anesthesia stress, total serum and milk corticosterone concentrations were not significantly different. By 30 min, corticosterone concentrations in serum increased to a p...

journal_title：Endocrinology

authors： Yeh KY

更新日期：1984-10-01 00:00:00

abstract：:Prolactin has been associated with many effects and has been implicated in the pathogenesis of pregnancy-related hypertensive disorders, although little is known about its vascular effects. The present study was designed to determine the primary effect of prolactin on regional vascular beds and the mechanisms involved...

journal_title：Endocrinology

authors： Molinari C,Grossini E,Mary DA,Uberti F,Ghigo E,Ribichini F,Surico N,Vacca G

更新日期：2007-08-01 00:00:00

abstract：:Food deprivation in laboratory rats induces profound changes in the neuroendocrine system. We have investigated the hypothalamic and pituitary responses of the hypothalamo-pituitary thyroid axis to 48-h food deprivation in Sprague-Dawley rats. Peripheral T3 and hypophysial portal TRH were measured by RIA, and TSH beta...

journal_title：Endocrinology

authors： Blake NG,Eckland DJ,Foster OJ,Lightman SL

更新日期：1991-11-01 00:00:00

abstract：:Although it is well known that chronic treatment with glucocorticoids inhibits somatic growth, the mechanism of action of this inhibitory effect is not completely understood. It is likely that glucocorticoids act at various levels, including pituitary, hypothalamus, and peripheral organs modulating GH synthesis, secre...

journal_title：Endocrinology

authors： Señarís RM,Lago F,Coya R,Pineda J,Diéguez C

更新日期：1996-12-01 00:00:00

abstract：:Defining the molecular genetics of diabetes gives new insight into the underlying etiology and so should help improve treatment. The genetic etiology is now known for most patients with beta-cell monogenic diabetes, allowing genetic classification. We review how this genetic knowledge alters treatment. Patients with a...

journal_title：Endocrinology

authors： Hattersley AT,Pearson ER

更新日期：2006-06-01 00:00:00

abstract：:The product of the ob/ob gene, leptin, is known to be able to exert a modulator, role on HPA axis function. The aim of the present study was to determine whether endogenous ACTH and glucocorticoids exert any regulatory effect on leptin secretion. For this purpose bilaterally adrenalectomized (ADX) or sham operated (Sh...

journal_title：Endocrinology

authors： Spinedi E,Gaillard RC

更新日期：1998-09-01 00:00:00

abstract：:To obtain large amounts of hTSH and to study the role of the N-linked oligosaccharides for its biological activity, hTSH was produced using recombinant baculovirus containing the human alpha-subunit and a hTSH beta-minigene, respectively, both under the control of the polyhedrin promoter. Expression in insect cells wa...

journal_title：Endocrinology

authors： Grossmann M,Wong R,Teh NG,Tropea JE,East-Palmer J,Weintraub BD,Szkudlinski MW

更新日期：1997-01-01 00:00:00

abstract：:Pulsatile administration of glucagon to perifused rat hepatocytes stimulates hepatocyte glucose production (HGP) more effectively than continuous administration. Having established that this effect was due to delayed relaxation of glucagon-stimulated HGP (t1/2 for decay = 3.54 +/- 0.60 min) we wished to examine the me...

journal_title：Endocrinology

authors： Weigle DS,Sweet IR,Goodner CJ

更新日期：1987-08-01 00:00:00

abstract：:[131I]Thyroglobulin [( 131I]Tg), prepared by either enzymatic iodination of human goiter Tg in vitro or isolation from the thyroids of rats previously injected with 131I, was digested with a solubilized enzyme mixture prepared from purified hog thyroid lysosomes. The digestion was performed at 37 C for 24 h under nitr...

journal_title：Endocrinology

authors： Tokuyama T,Yoshinari M,Rawitch AB,Taurog A

更新日期：1987-08-01 00:00:00

abstract：:On the basis of our previous observations indicating that a principle [possibly transforming growth factor-beta1 (TGFbeta1)] secreted by type 1 astrocytes may increase the release of LHRH in the GT1 cell line, it was deemed of interest to analyze whether TGFbeta1 might influence LHRH gene expression in addition to LHR...

journal_title：Endocrinology

authors： Galbiati M,Zanisi M,Messi E,Cavarretta I,Martini L,Melcangi RC

更新日期：1996-12-01 00:00:00

abstract：:In the present study we have used a high affinity photoaffinity label (PAL) agonist (pGlu-His-Trp-Ser-125I-iodoTyr-D-Lys(para-N3-Benzoyl)-Leu-Arg-P roNHEt) and a PAL antagonist (NAcD2Nal-D4ClPhe-D3Pal-Ser-125I-iodo-NMeTyr-D-L ys(para-N3-Benzoyl)Leu-Lys(Isp) - Pro-D-Ala-NH2) to covalently label the GnRH receptor. Rat p...

journal_title：Endocrinology

authors： Janovick JA,Haviv F,Fitzpatrick TD,Conn PM

更新日期：1993-08-01 00:00:00

abstract：:Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with improved cardiometabolic health and increased longevity. Increased lifespan during this dietary protein "dilution" has been explained by resource-mediated trade-...

journal_title：Endocrinology

authors： Larson KR,Russo KA,Fang Y,Mohajerani N,Goodson ML,Ryan KK

更新日期：2017-10-01 00:00:00

abstract：:Pregnancy-associated plasma protein-A (PAPP-A) is the major IGF binding protein-4 (IGFBP-4) protease in follicular fluid, consistent with its proposed role in folliculogenesis. Despite growing interest, almost nothing is known about how PAPP-A expression is regulated in any tissue. Here we show that FSH and oocytes re...

journal_title：Endocrinology

authors： Matsui M,Sonntag B,Hwang SS,Byerly T,Hourvitz A,Adashi EY,Shimasaki S,Erickson GF

更新日期：2004-08-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that plays a pivotal role in several immunoinflammatory and autoimmune diseases. In this study we examined the role of MIF in the development of immunoinflammatory diabetes induced in susceptible strains of mice by multiple low doses of strepto...

journal_title：Endocrinology

authors： Cvetkovic I,Al-Abed Y,Miljkovic D,Maksimovic-Ivanic D,Roth J,Bacher M,Lan HY,Nicoletti F,Stosic-Grujicic S

更新日期：2005-07-01 00:00:00

abstract：:Our previous work suggests that persistent protein malnutrition in immature domestic fowl (Gallus gallus domesticus) alters ACTH-adrenocortical cell interaction, possibly including ACTH receptors. To investigate this possibility, we measured some ACTH receptor parameters in isolated adrenocortical cells from normal an...

journal_title：Endocrinology

authors： Carsia RV,Weber H

更新日期：1988-02-01 00:00:00

abstract：:Three distinct receptor types for natriuretic peptides (NP) have been identified in human tissue. "A" and "B" receptors initiate biological actions, whereas the "C" receptor has a clearance function. It has been proposed that the natural ligand for the B receptor is c-type natriuretic peptide (CNP), rather than atrial...

journal_title：Endocrinology

authors： Canaan-Kühl S,Jamison RL,Myers BD,Pratt RE

更新日期：1992-01-01 00:00:00

abstract：:Endoglin is an integral membrane glycoprotein predominantly expressed on human endothelial cells and recently shown to bind transforming growth factor-beta 1 (TGF beta 1) with high affinity. We now report the cloning and sequencing of a full-length murine endoglin complementary DNA of 2902 base pairs which hybridizes ...

journal_title：Endocrinology

authors： St-Jacques S,Cymerman U,Pece N,Letarte M

更新日期：1994-06-01 00:00:00

abstract：:Immunoreactive neurophysin (Np) is demonstrated by the immunoperoxidase technique not only within neurones of the classical hypothalamo-neurohypophyseal system, but also in extrahypothalamic perikarya and fibers. Np-positive perikarya are found in the triangular nucleus of the septum. Np fibers join the stria terminal...

journal_title：Endocrinology

authors： Sofroniew MV,Weindl A

更新日期：1978-01-01 00:00:00

abstract：:Nitric oxide is a ubiquitous estrogen-regulated signaling molecule that has been implicated in the regulation of bone maturation and remodeling. To better understand the role that bone-cell-secreted nitric oxide plays in ovariectomy-induced modifications of bone turnover, we examined the expression of endothelial NO s...

journal_title：Endocrinology

authors： Grassi F,Fan X,Rahnert J,Weitzmann MN,Pacifici R,Nanes MS,Rubin J

更新日期：2006-09-01 00:00:00

abstract：:A binding protein for activin was purified from bovine pituitary by affinity chromatography on dextran sulfate-Sepharose CL-4B and activin-Affi-Gel 10. A 52,700-fold purification over the starting crude homogenate was achieved. The purified preparation showed two bands of 36 and 33 kilodalton in sodium dodecyl sulfate...

journal_title：Endocrinology

authors： Kogawa K,Nakamura T,Sugino K,Takio K,Titani K,Sugino H

更新日期：1991-03-01 00:00:00

abstract：:Glucocorticoid hormones act in the nucleus of the cell to alter expression of specific genes and change cell metabolism. In liver, these hormones have been reported to increase mitochondrial respiratory activity, which is regulated by both nuclear and mitochondrial gene products. We examined the effects of the synthet...

journal_title：Endocrinology

authors： Van Itallie CM

更新日期：1992-02-01 00:00:00

abstract：:Pure porcine cholecystokinin-33 [the triacontatriapeptide form of cholecystokinin (CCK-33)], gastric inhibitory polypeptide (GIP), and secretin were infused in rats in doses of 1, 10 and 1000 pmol/kg . min. The peptides were administered alone or in combination with glucose (40 mg/kg . min) or arginine (50 mg/kg . min...

journal_title：Endocrinology

authors： Szecówka J,Lins PE,Efendić S

更新日期：1982-04-01 00:00:00