Abstract:
:Although many studies have investigated the complex interrelationships between thyroid hormone levels and insulin-glucose secretion and action, there is at present a lack of information concerning the effects of various thyroid hormone levels on insulin receptors. In the present study, rat liver membranes were prepared from control, hyperthyroid [10 micrograms L-T4 (T4)/100 g BW for 14 days], and hypothyroid rats and the binding characteristics of [125I]iodoinsulin to these membranes were studied. In addition, serum T3, T4, glucose, and insulin levels were measured. The mean (+/- SD) serum T4 and T3 levels were higher (P less than 0.05) in the T4-injected rats than in the hypothyroid rats (T4, 9.1 +/- 0.6 vs. 1.7 +/- 0.4 microgram/dl; T3, 144 +/- 18 vs. 30 +/- 16 ng/dl). When compared to controls, glucose levels were higher in the hypothyroid rats (116 +/- 11 vs. 141 +/- 14 mg/dl; P less than 0.05) and were statistically unaltered in thyrotoxicosis. Plasma insulin levels were increased in hypothyroidism (6.5 +/- 0.8 vs. 10.8 +/- 2.9 microU/ml; P less than 0.05) and decreased in thyrotoxicosis (7.5 +/- 0.5 vs. 28.3 +/- 15 microU/ml; P less than 0.05). Despite these alterations, membrane binding and the derived Scatchard plots were not significantly different in the hyperthyroid or hypothyroid groups. In summary, the present studies indicate that plasma membrane insulin receptor number and affinity are unaltered regardless of the thyroid state of the rat.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
DeRuyter H,Burman KD,Wartofsky L,Taylor SIdoi
10.1210/endo-110-6-1922subject
Has Abstractpub_date
1982-06-01 00:00:00pages
1922-5issue
6eissn
0013-7227issn
1945-7170journal_volume
110pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Species-specific differences in genes encoding type II GnRH receptor indicate that a functional hepta-helical receptor is produced in monkeys but not in rodents, cows, chimpanzees, or humans. To further investigate the extent of evolutionary differences, we sequenced the type II GnRH receptor gene from wild-type Soay ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1625
更新日期:2004-05-01 00:00:00
abstract::The effects of insulin to stimulate metabolic and mitogenic responses were examined in Rat 1 fibroblast cells that overexpressed either normal (HIRc) or kinase-deficient human insulin receptors. When studied at the optimal growth stage for each cell line, insulin-stimulated responses measured in cells containing kinas...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.4.7534700
更新日期:1995-04-01 00:00:00
abstract::Cholera toxin (CT) injected ip on day 1 (day of ovulation) of the 4-day hamster estrous cycle, when circulatory progesterone is high and estrogen low, induced a massive uterine decidual reaction, a progesterone-dependent growth normally triggered by the implanting blastocyst. However, CT injected ip on day 3, when cir...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-6-2095
更新日期:1983-06-01 00:00:00
abstract::C-type natriuretic peptide (CNP), found in endothelial cells, chondrocytes, and neurons, binds its cognate transmembrane receptor, natriuretic peptide receptor-B (NPR-B/GC-B), and stimulates the synthesis of the intracellular signaling molecule, cGMP. The known physiologic consequences of this binding event are vasore...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2002-220702
更新日期:2003-01-01 00:00:00
abstract::In different types of mammalian cells, insulin has been shown to promote the release of an inositol phosphate glycan (InsP-glycan) through the hydrolysis of a glycosyl-phosphatidylinositol (glycosyl-PtdIns). This InsP-glycan, which has been demonstrated to be taken up by intact cells, may mediate some of the biologica...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.134.3.8119190
更新日期:1994-03-01 00:00:00
abstract::The 3'5'-cyclic GMP (cGMP) pathway is known to influence ovarian functions, including steroidogenesis, ovulation, and granulosa cell proliferation. We show here that cGMP-phosphodiesterase (PDE) activity increased in a gonadotropin-dependent manner more than 3-fold in the cumulus-oocyte complex (COC) after 24 h in vit...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0547
更新日期:2008-11-01 00:00:00
abstract::Free radical production and lipid peroxidation are potentially important mediators in testicular physiology and toxicology. The cytochrome P450 enzymes of the steroidogenic pathway are known to produce free radicals. The present study was conducted to elucidate in vivo the gonadotropin regulation of free radical-media...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.1.8536600
更新日期:1996-01-01 00:00:00
abstract::GH is secreted in a pulsatile manner, the pattern of which plays an important role in the regulation of growth and metabolism. Sex steroids are also known to participate in metabolic regulation. The present study was undertaken to elucidate the relationship between changes in GH pulsatility and metabolic transition du...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-1434
更新日期:2005-06-01 00:00:00
abstract::In order to study whether changes in adenohypophysial dopamine are only related to PRL release or also to the variation of LH or FSH, dopamine (DA) in the pars distalis was measured during the estrous cycle and after castration of both male and female rats. Catecholamines were assayed using a highly sensitive radioenz...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-106-6-1682
更新日期:1980-06-01 00:00:00
abstract::Both somatostatin (SRIF) and urotensin II, a dodecapeptide from the teleost caudal neurosecretory system, inhibit PRL release from the organ-cultured rostral pars distalis of the tilapia, Sarotherodon mossambicus, in a dose-related manner. The inhibitory action of SRIF on PRL release was completely prevented by the pr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-110-3-910
更新日期:1982-03-01 00:00:00
abstract::Ghrelin is a peptide hormone primarily produced in the previously unidentified X/A endocrine cells of the stomach. Extensive studies have focused on the effects of ghrelin on growth hormone release and appetite regulation. However, the mechanisms regulating ghrelin secretion are less understood. In the present study, ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1040
更新日期:2012-08-01 00:00:00
abstract::Glial cell line-derived neurotrophic factor (GDNF) is expressed in many neuronal and non-neuronal tissues during development as well as in adult animals. GDNF signaling is mediated through a two-component system consisting of the so called GDNF receptor-alfa (GFRalpha1) which binds to GDNF. Thereafter this complex bin...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.5.7548
更新日期:2000-05-01 00:00:00
abstract::Gastrin is natriuretic, but its renal molecular targets and signal transduction pathways are not fully known. In this study, we confirmed the existence of CCKBR (a gastrin receptor) in male human renal proximal tubule cells and discovered that gastrin induced S6 phosphorylation, a downstream component of the phosphati...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2012-1813
更新日期:2013-02-01 00:00:00
abstract::We have studied the long-term effects of nicotinamide (NIC) on the synthesis of NO by insulin producing cells. NIC delays the formation of nitrite by interleukin (IL)-1 beta-(IL-1, 25 U/ml)-stimulated RINm5F cells, and previous exposure of cells to IL-1 for 15 h prevents this effect. The delay is associated with a lac...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.11.8895350
更新日期:1996-11-01 00:00:00
abstract::Invasion of human trophoblasts is promoted through activation of wingless (Wnt) signaling, suggesting a role of the pathway in placental development and morphogenesis. However, details on the process such as involvement of canonical and/or noncanonical Wnt signaling cascades as well as their target genes are largely u...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-0557
更新日期:2010-01-01 00:00:00
abstract::In previous studies we found that plasma angiotensinogen levels were reduced by lesions of the hypothalamic paraventricular nuclei. To determine if the decrease was caused by decreased secretion of hormones that normally stimulate angiotensinogen secretion by the liver, we correlated the changes in plasma angiotensino...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-129-2-901
更新日期:1991-08-01 00:00:00
abstract::The adrenal cortex contains a kallikrein-like enzyme that may lead to bradykinin (BK) formation. This study was designed to determine whether BK acts on adrenocortical cells to stimulate steroid secretion. BK, Lys-BK, a specific BK 2 (B2) receptor agonist, and desArg9-BK, a specific BK 1 (B1) receptor agonist, all sti...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.130.4.1312440
更新日期:1992-04-01 00:00:00
abstract::Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor-β superfamily and plays a critical role in regulating ovarian follicle function. Currently, the role of BMP2 during cumulus expansion remains to be determined. The aim of this study was to investigate the effect of BMP2 on the regulation of ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2017-00436
更新日期:2017-10-01 00:00:00
abstract::Loss-of-function mutations in the X-linked immunoglobulin superfamily, member 1 (IGSF1) gene cause central hypothyroidism. IGSF1 is a transmembrane glycoprotein of unknown function expressed in thyrotropin (TSH)-producing thyrotrope cells of the anterior pituitary gland. The protein is cotranslationally cleaved, with ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1788
更新日期:2017-04-01 00:00:00
abstract::Chronically elevated fatty acids contribute to insulin resistance through poorly defined mechanisms. Endoplasmic reticulum (ER) stress and the subsequent unfolded protein response (UPR) have been implicated in lipid-induced insulin resistance. However, the UPR is also a fundamental mechanism required for cell adaptati...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-1881
更新日期:2012-05-01 00:00:00
abstract::GH promptly increases cytosolic free calcium ([Ca2+]i) in freshly isolated rat adipocytes. Adipocytes deprived of GH for 3 h or longer are incapable of increasing [Ca2+]i in response to GH, but instead respond in an insulin-like manner. Insulin blocks the GH-induced increase in [Ca2+]i in GH-replete cells and stimulat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.2.7310
更新日期:2000-02-01 00:00:00
abstract::Primary ovarian insufficiency (POI) resulting from ovarian autoimmunity is a poorly understood clinical condition lacking in effective treatments. Understanding the targets of the autoimmune response and induction of ovarian-specific tolerance would allow development of focused therapies to preserve fertility in an at...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-0022
更新日期:2011-06-01 00:00:00
abstract::We previously reported the existence of a descending multisynaptic, pituitary-independent, neural pathway between the hypothalamus and the testes in the male rat. Stimulation of this pathway by the intracerebroventricular (icv) injection of IL-1beta or corticotropin-releasing factor blunts the testosterone (T) respons...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-1441
更新日期:2004-04-01 00:00:00
abstract::Cholecystokinin (CCK)/gastrin receptors were characterized in calf pancreatic plasma membranes from newborns, 28- and 119-day-old milk-fed preruminants, and 119-day-old weaned ruminants. Scatchard analysis of [125I]Bolton-Hunter reagent-[Thr28,Nle31]CCK-(25-33) binding indicated two classes of binding sites: high affi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.3.8365360
更新日期:1993-09-01 00:00:00
abstract::Vasoactive intestinal polypeptide (VIP) was measured by RIA in the hypophysial portal blood of rats after total hypophysectomy. The mean (+/- SE) VIP concentrations were 1332 +/- 171 pg/ml (range, 300-3868 pg/ml) under urethane anesthesia and 1735 +/- 707 pg/ml under pentobarbital anesthesia. The concentrations of VIP...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-108-2-395
更新日期:1981-02-01 00:00:00
abstract::IGF1-a small, single-chain, secreted peptide in mammals-is essential for normal somatic growth and is involved in a variety of other physiological and pathophysiological processes. IGF1 expression appears to be controlled by several different signaling mechanisms in mammals, with GH playing a key role by activating an...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2018-00259
更新日期:2018-06-01 00:00:00
abstract::During lung development there is tension between positive and negative regulators of fibroblast-epithelial communication controlling type II cell differentiation. A clinical consequence of imbalance of this tension is the increased risk for respiratory distress syndrome in male infants. We hypothesized that chronic in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.8.7615
更新日期:2000-08-01 00:00:00
abstract::Clinically, approximately 30% of women who receive synthetic glucocorticoids (sGC) for risk of preterm labor carry to term. In vitro studies have shown that sGC acutely regulate the placental system A amino acid transporter, but there are no comparable data in vivo. Hence, the objective of our study was to examine the...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2011-0104
更新日期:2011-09-01 00:00:00
abstract::Stress-responsive neurons of the hypothalamic paraventricular nucleus (PVN) show functional plasticity and adapt to repeated restraint (RR) stress. To investigate whether neuronal adaptation to the homotypic stress also affects their response to a heterotypic stressor, we used in situ hybridization with intronic and e...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.8.6943
更新日期:1999-08-01 00:00:00
abstract::Acidosis has been implicated in the pathogenesis of various metabolic bone diseases. Experimental acid ingestion is known to stimulate the release of bone mineral in humans and increase osteoclastic resorption surfaces in animals, but the mechanism has remained unclear. We have investigated the effect of medium pH on ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-119-1-119
更新日期:1986-07-01 00:00:00