Expression of insulin-like growth factor-I (IGF-I) in the rat fallopian tube: possible autocrine and paracrine action of fallopian tube-derived IGF-I on the fallopian tube and on the preimplantation embryo.

abstract：:The effects of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF alpha) on basal and TRH-induced TSH release, and the effects of IL-1 beta on the uptake of [125I]T3 and [125I]T4 and on nuclear binding of [125I]T3 were examined. Furthermore, the release of other anterior pituitary hormones in the pres...

journal_title：Endocrinology

authors： Wassen FW,Moerings EP,Van Toor H,De Vrey EA,Hennemann G,Everts ME

更新日期：1996-05-01 00:00:00

abstract：:In this study, we demonstrate that disruption of neuroendocrine signaling is a major factor driving disease progression in myelin oligodendrocyte glycoprotein-induced chronic relapsing experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Although the initial episode of chronic relapsing ex...

journal_title：Endocrinology

authors： Stefferl A,Storch MK,Linington C,Stadelmann C,Lassmann H,Pohl T,Holsboer F,Tilders FJ,Reul JM

更新日期：2001-08-01 00:00:00

abstract：:Pulsatile release of GnRH-1 is critical to stimulate gonadotropes of the anterior pituitary. This secretory pattern seems to be inherent to GnRH-1 neurons, however, the mechanisms underlying such episodical release remain unknown. In monkey nasal explants, the GnRH-1 population exhibits synchronized calcium events wit...

journal_title：Endocrinology

authors： Constantin S,Caraty A,Wray S,Duittoz AH

更新日期：2009-07-01 00:00:00

abstract：:Antisera were raised against synthetic replicates of the carboxyl-terminal (C-terminal) fragment of the precursor to human GH-releasing factor (GRF) (pre-proGRF) whose structure was predicted from the complementary DNA cloned from a pancreatic tumor. These antisera were used along with antisera to human GRF itself to ...

journal_title：Endocrinology

authors： Bloch B,Baird A,Ling N,Guillemin R

更新日期：1986-01-01 00:00:00

abstract：:We examined the gene expression of V-1, a novel soluble protein with the cdc10/SWI6 motif, in pseudopregnant rat ovaries. Northern blot analysis on days 1, 5, and 11 of pseudopregnancy revealed an approximately 2-fold increase in the V-1 messenger RNA (mRNA) expression level on day 5 to that on day 1, and no significa...

journal_title：Endocrinology

authors： Song SY,Asakai R,Kenmotsu N,Taoka M,Isobe T,Yamakuni T

更新日期：1996-04-01 00:00:00

abstract：:In vivo and in vitro evidence indicates that FSH is a primary regulator of testicular inhibin production. However, recent reports suggest that LH may also promote inhibin secretion in vivo. To investigate whether LH regulates inhibin subunit messenger RNA (mRNA) expression as well, we examined the effects of hypophyse...

journal_title：Endocrinology

authors： Krummen LA,Morelos BS,Bhasin S

更新日期：1990-09-01 00:00:00

abstract：:The effect of the administration of sheep anti-LHRH gamma-globulin (anti-LHRHG) on the maintenance of pregnancy was investigated in rats. Nidation was confirmed by laparotomy on day 7 or 8 of pregnancy. In one experiment, rats were then injected iv with 1 ml anti-LHRHG or normal sheep gamma-globulin (NSG) daily from d...

journal_title：Endocrinology

authors： Nishi N,Arimura A,de la Cruz KG,Schally AV

更新日期：1976-04-01 00:00:00

abstract：:The castration-induced regression and testosterone stimulated regrowth of the vasculature in the rat ventral prostate lobe were studied using stereological techniques. Seven days after castration, the endothelial cell proliferation rate (bromodeoxyuridine labeling index); the total weights of blood vessel walls, blood...

journal_title：Endocrinology

authors： Franck-Lissbrant I,Häggström S,Damber JE,Bergh A

更新日期：1998-02-01 00:00:00

abstract：:The predisposition of the testis and ovary to primarily synthesize testosterone (T) and estradiol (E2), respectively, is due to gonadal-specific cell types that differentially express the various hydroxysteroid (17beta) dehydrogenase (HSD17B) isoforms. In testes, Leydig cells rely on LH stimulation to maintain express...

journal_title：Endocrinology

authors： Couse JF,Yates MM,Rodriguez KF,Johnson JA,Poirier D,Korach KS

更新日期：2006-08-01 00:00:00

abstract：:Some TSH receptors (TSHR) on the cell surface cleave into A and B subunits. Cleavage at upstream Site 1 is followed by the proteolytic excision of an intervening C peptide region terminating at a downstream Site 2. Although present evidence suggests that Site 1 lies between amino acid residues 303 and 317, the mechani...

journal_title：Endocrinology

authors： Tanaka K,Chazenbalk GD,McLachlan SM,Rapoport B

更新日期：2000-10-01 00:00:00

abstract：:The ability of FSH to stimulate the activity of ornithine decarboxylase (ODC) in the ovary of the immature rat and cycling hamster has been examined using specific antisera to gonadotropins. The stimulatory effect of FSH on ODC activity in the ovary of the immature rat was abolished when LH antiserum was administered ...

journal_title：Endocrinology

authors： Sheela Rani CS,Moudgal NR

更新日期：1979-05-01 00:00:00

abstract：:The synthesis and accumulation of prostatein, a major secretory protein of the rat ventral prostate, was examined in organ culture conditions. For the quantitation of this protein in the medium, a sensitive enzyme immunoassay was developed. The rat ventral prostate could be maintained in organ culture in defined mediu...

journal_title：Endocrinology

authors： Martikainen P,Härkönen P,Vanhala T,Mäkelä S,Viljanen M,Suominen J

更新日期：1987-08-01 00:00:00

abstract：:Analogs of the seco-steroid hormone, 1,25-dihydroxyvitamin D3 [1,25-(OH)-2D3] can preferentially stimulate genomic or nongenomic signaling pathways in osteoblasts. In this study, we used 1,25-(OH)2D3 analogs and voltage-sensitive Ca2+ channel (VSCC) ligands, including dihydropyridines (Bay K 8644 and nitrendipine), in...

journal_title：Endocrinology

authors： Khoury R,Ridall AL,Norman AW,Farach-Carson MC

更新日期：1994-12-01 00:00:00

abstract：:Cannabinoids (CBs) exert untoward effects on reproduction by reducing LH secretion and suppressing gonadal function. Recent evidence suggests these effects are due primarily to hypothalamic dysfunction; however, the mechanism is obscure. Using immortalized hypothalamic GnRH neurons, we find these cells produce and sec...

journal_title：Endocrinology

authors： Gammon CM,Freeman GM Jr,Xie W,Petersen SL,Wetsel WC

更新日期：2005-10-01 00:00:00

abstract：:To study the role of the epithelial calcium channel transient receptor potential vanilloid type 6 (TRPV6) and the calcium-binding protein calbindin-D9k in intestinal calcium absorption, TRPV6 knockout (KO), calbindin-D9k KO, and TRPV6/calbindin-D(9k) double-KO (DKO) mice were generated. TRPV6 KO, calbindin-D9k KO, and...

journal_title：Endocrinology

authors： Benn BS,Ajibade D,Porta A,Dhawan P,Hediger M,Peng JB,Jiang Y,Oh GT,Jeung EB,Lieben L,Bouillon R,Carmeliet G,Christakos S

更新日期：2008-06-01 00:00:00

abstract：:The potential role of basic fibroblast growth factor (bFGF) as a mediator of cell-cell interactions in the growth and development of the testis was examined. Nuclease protection analysis was used to evaluate bFGF gene expression in the testis and other male reproductive tract tissues. bFGF expression was evident in se...

journal_title：Endocrinology

authors： Mullaney BP,Skinner MK

更新日期：1992-12-01 00:00:00

abstract：:α7-Nicotinic acetylcholine receptor (α7nAChR) agonists confer protection against a wide variety of cytotoxic insults and suppress oxidative stress and apoptosis in various cell systems, including hepatocytes. We recently demonstrated that nicotine, when combined with a high-fat diet (HFD), triggers oxidative stress, a...

journal_title：Endocrinology

authors： Hasan MK,Friedman TC,Sims C,Lee DL,Espinoza-Derout J,Ume A,Chalfant V,Lee ML,Sinha-Hikim I,Lutfy K,Liu Y,Mahata SK,Sinha-Hikim AP

更新日期：2018-02-01 00:00:00

abstract：:Activators of protein kinase C, such as phorbol myristate acetate (PMA) and the synthetic diacylglycerol dioctanoylglycerol (diC8), either stimulate or inhibit PTH release depending on the extracellular Ca2+ concentration. By increasing PTH release at high extracellular Ca2+, these agents, in effect, block high Ca2(+)...

journal_title：Endocrinology

authors： Shoback DM,Chen TH

更新日期：1990-07-01 00:00:00

abstract：:As a model of the changes in peripheral iodothyronine metabolism that occur during ontogeny, we have studied the metabolism of 125I-labeled T4 and several of its partially deiodinated derivatives by the liver of the chick embryo. Homogenates of livers obtained from chicks varying in embryonic age from 8 days to the ti...

journal_title：Endocrinology

authors： Borges M,LaBourene J,Ingbar SH

更新日期：1980-12-01 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I), the principal IGF in adult rat serum, occurs complexed to specific binding proteins. After fractionation of serum on Sephadex G-200 at neutral pH, 62% of the immunoreactive IGF-I is recovered in the 150K region, 38% in the 40K region, and none is present as free 7.5K IGF-I. Adult ...

journal_title：Endocrinology

authors： Yang YW,Wang JF,Orlowski CC,Nissley SP,Rechler MM

更新日期：1989-09-01 00:00:00

abstract：:To investigate the participation of cyclic nucleotides in LHRH-mediated gonadotropin release, cells from the anterior pituitaries of 15-day-old female rats were fractionated on an albumin gradient by sedimentation at unit gravity. gonadotrophs and somatotrophs were detected in the fractions by histology and RIA of hor...

journal_title：Endocrinology

authors： Snyder G,Naor Z,Fawcett CP,McCann SM

更新日期：1980-11-01 00:00:00

abstract：:The temporal aspects of gonadotropin release were studied in infantile (14-day-old) female rats. Blood samples were collected using vena cava cannulae at 10-, 15-, 20-, or 30-min intervals and assayed for either LH alone or for both LH and FSH. Within individual animals, blood LH levels exhibited a degree of variabili...

journal_title：Endocrinology

authors： Frawley LS,Henricks DM

更新日期：1979-11-01 00:00:00

abstract：:Altered leptin action has been implicated in the pathophysiology of heart failure in obesity, a hallmark of which is extracellular matrix remodeling. Here, we characterize the direct influence of leptin on matrix metalloproteinase (MMP) activity in primary adult rat cardiac fibroblasts and focus on elucidating the mol...

journal_title：Endocrinology

authors： Schram K,Ganguly R,No EK,Fang X,Thong FS,Sweeney G

更新日期：2011-05-01 00:00:00

abstract：:Anandamide and 2-arachidonoylglycerol (2-AG), two endogenous ligands of the CB1 and CB2 cannabinoid receptor subtypes, inhibit the proliferation of PRL-responsive human breast cancer cells (HBCCs) through down-regulation of the long form of the PRL receptor (PRLr). Here we report that 1) anandamide and 2-AG inhibit th...

journal_title：Endocrinology

authors： Melck D,De Petrocellis L,Orlando P,Bisogno T,Laezza C,Bifulco M,Di Marzo V

更新日期：2000-01-01 00:00:00

abstract：:By acting in the brain, insulin suppresses food intake, whereas neuropeptide Y (NPY) has the opposite effect. Since fasting increases NPY gene expression in the hypothalamic arcuate nucleus (ARC) and also lowers circulating insulin levels, we hypothesized that the anorexiant effect of insulin could result from insulin...

journal_title：Endocrinology

authors： Schwartz MW,Marks JL,Sipols AJ,Baskin DG,Woods SC,Kahn SE,Porte D Jr

更新日期：1991-05-01 00:00:00

abstract：:IGF binding protein-2 (IGFBP-2) has been implicated in the development and spread of a number of tumor types, and its abrogation in experimental models of cancer is associated with decreased tumor growth. This suggests that targeted inhibition of IGFBP-2 expression in some cancers may have therapeutic benefit. In this...

journal_title：Endocrinology

authors： Martin JL,Baxter RC

更新日期：2007-05-01 00:00:00

abstract：:We previously identified a highly conserved specificity protein 1 (Sp1) DNA element in mammalian PTH promoters that acted as an enhancer of gene transcription and bound Sp1 and Sp3 proteins present in parathyroid gland nuclear extracts. More recently, a nuclear factor (NF)-Y element (NF-Y(prox)) was also described by ...

journal_title：Endocrinology

authors： Alimov AP,Park-Sarge OK,Sarge KD,Malluche HH,Koszewski NJ

更新日期：2005-08-01 00:00:00

abstract：:Glucocorticoids and their synthetic derivatives are known to alter cardiac function in vivo; however, the nature of these effects and whether glucocorticoids act directly on cardiomyocytes are poorly understood. To explore the role of glucocorticoid signaling in the heart, we used rat embryonic H9C2 cardiomyocytes and...

journal_title：Endocrinology

authors： Ren R,Oakley RH,Cruz-Topete D,Cidlowski JA

更新日期：2012-11-01 00:00:00

abstract：:A biologically active form of the epidermal growth factor (EGF) precursor has been detected in human fluids and secretions. The secreted protein identified in human urine and milk has an apparent molecular mass of 160-170 kilodaltons and exhibits an affinity for the glycosaminoglycan heparin. More importantly, the sec...

journal_title：Endocrinology

authors： Mroczkowski B,Reich M

更新日期：1993-01-01 00:00:00

abstract：:The expression of the lutropin receptor (LHR) in granulosa cells is a complex phenomenon under the hormonal control of FSH and estradiol. Using primary cultures of granulosa cells from immature female rats pretreated with diethylstilbestrol (a compound with estrogen-like activity), the role of FSH in LHR induction was...

journal_title：Endocrinology

authors： Chen S,Shi H,Liu X,Segaloff DL

更新日期：1999-05-01 00:00:00