Disease progression in chronic relapsing experimental allergic encephalomyelitis is associated with reduced inflammation-driven production of corticosterone.

abstract：:Specific serum binding of 25-hydroxy-cholecalciferol (25-OHD3) was measured by saturation analysis in rats of various ages, and during vitamin D deprivation. The serum binding capacity for 25-OHD3 was observed to increase until age 6-8 weeks, then decline and remain stable thereafter at 3.7 x 10(-6) M. The 25-hydroxyv...

journal_title：Endocrinology

authors： Rojanasathit S,Haddad JG

更新日期：1977-03-01 00:00:00

abstract：:Type 3 deiodinase (D3), the physiologic inactivator of thyroid hormones, is induced during tissue injury and regeneration. This has led to the hypotheses that D3 impacts injury tolerance by reducing local T3 signaling and contributes to the fall in serum triiodothyronine (T3) observed in up to 75% of sick patients (te...

journal_title：Endocrinology

authors： Castroneves LA,Jugo RH,Maynard MA,Lee JS,Wassner AJ,Dorfman D,Bronson RT,Ukomadu C,Agoston AT,Ding L,Luongo C,Guo C,Song H,Demchev V,Lee NY,Feldman HA,Vella KR,Peake RW,Hartigan C,Kellogg MD,Desai A,Salvatore D

更新日期：2014-10-01 00:00:00

abstract：:11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) is thought to confer aldosterone specificity to mineralocorticoid target cells by protecting the mineralocorticoid receptor from occupancy by endogenous glucocorticoids. We have recently described a novel isoform of 11-OHSD in the renal aldosterone target cells (11 b...

journal_title：Endocrinology

authors： Náray-Fejes-Tóth A,Fejes-Tóth G

更新日期：1995-06-01 00:00:00

abstract：:Iodine deficiency (ID) induces TSH-independent microvascular activation in the thyroid via the reactive oxygen species/nitric oxide-hypoxia-inducible factor-1α/vascular endothelial growth factor (VEGF) pathway. We hypothesized the additional involvement of mammalian target of rapamycin (mTOR) as a positive regulator o...

journal_title：Endocrinology

authors： Craps J,Joris V,De Jongh B,Sonveaux P,Horman S,Lengelé B,Bertrand L,Many MC,Colin IM,Gérard AC

更新日期：2016-06-01 00:00:00

abstract：:PTH stimulates bone formation and increases hematopoietic stem cells through mechanisms as yet uncertain. The purpose of this study was to identify mechanisms by which PTH links actions on cells of hematopoietic origin with osteoblast-mediated bone formation. C57B6 mice (10 d) were nonlethally irradiated and then admi...

journal_title：Endocrinology

authors： Koh AJ,Novince CM,Li X,Wang T,Taichman RS,McCauley LK

更新日期：2011-12-01 00:00:00

abstract：:The rat uterine enzyme glycerylphosphorylcholine (GPC) diesterase found in the proestrous secretions was purified and characterized biochemically with respect to its subunit mol wt, native size, pI, and amino acid and carbohydrate composition. The 30-kDa protein was assessed to have a native mol wt of 105 kDa, as dete...

journal_title：Endocrinology

authors： Mitra J,Chowdhury M

更新日期：1991-09-01 00:00:00

abstract：:Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the lifespan of an individual. Although researchers from a myriad of disciplines are beginning to appreciate the importance of considering sex differences in the design ...

journal_title：Endocrinology

authors： Becker JB,Arnold AP,Berkley KJ,Blaustein JD,Eckel LA,Hampson E,Herman JP,Marts S,Sadee W,Steiner M,Taylor J,Young E

更新日期：2005-04-01 00:00:00

abstract：:Obesity is associated with chronic inflammation and liver steatoses. Numerous proinflammatory cytokines have been reported to regulate liver glucose and lipid metabolism, thus contributing to the pathogenesis of liver steatosis and/or metabolic dysfunction. Nuclear factor-κB-inducing kinase (NIK) is stimulated by many...

journal_title：Endocrinology

authors： Liu Y,Sheng L,Xiong Y,Shen H,Liu Y,Rui L

更新日期：2017-05-01 00:00:00

abstract：:Elevated activin A levels in inhibin-deficient mice promote the development of gonadal tumors and induce cachexia by reducing muscle, liver, stomach, and fat mass. Because activin A is an important regulator of tissue growth, inhibiting the actions of this TGFβ family ligand may halt or reverse pathology in diseased t...

journal_title：Endocrinology

authors： Makanji Y,Walton KL,Chan KL,Gregorevic P,Robertson DM,Harrison CA

更新日期：2011-10-01 00:00:00

abstract：:Polypeptide YY(3-36) (PYY(3-36)) is a gastrointestinal secreted molecule, agonist of neuropeptide Y (NPY) receptor subtypes Y2 and Y5, recently involved in the control of food intake. Notably, several factors with key roles in energy homeostasis conduct pleiotropic effects upon the reproductive axis. However, whether ...

journal_title：Endocrinology

authors： Fernandez-Fernandez R,Aguilar E,Tena-Sempere M,Pinilla L

更新日期：2005-03-01 00:00:00

abstract：:The quantities of estrone and estradiol were determined by radioimmunoassay in maternal and fetal plasma of the rhesus monkey from day 59 to 163 of gestation. A two way analysis of variance of data classified according to fetal sex and 3 pooled gestational ages for each hormone and for mother or fetus (4 analyses) rev...

journal_title：Endocrinology

authors： Resko JA,Pleom JG,Stadelman HL

更新日期：1975-08-01 00:00:00

abstract：:We previously reported a cooperative effect between insulin-like growth factor I (IGF-I) and 1,25-dihydroxy-vitamin D3 [1,25-(OH)2D3] in murine clonal osteoblastic cells, MCT3T3-E1. In the present study, the possible mechanism of interaction between these hormones was investigated. The effect of IGF-I on 1,25-(OH)2D3 ...

journal_title：Endocrinology

authors： Kurose H,Yamaoka K,Okada S,Nakajima S,Seino Y

更新日期：1990-04-01 00:00:00

abstract：:The estrogen receptor-alpha (ERalpha) pituitary-specific variant, TERP-1, is regulated dramatically by physiological status. We examined hormonal regulation of the TERP-1 promoter in transient transfection assays in GH3 somatolactotrope cells. We found that 17beta-estradiol (E2), genistein, androgen, pituitary adenyla...

journal_title：Endocrinology

authors： Bryant WM,Gibson MA,Shupnik MA

更新日期：2006-01-01 00:00:00

abstract：:We recently reported that fetal sheep corticotrophs (ACTH-producing cells) at 108 +/- 5 d (days) of gestation are relatively more responsive to CRH than to AVP, whereas those at 139 +/- 0 d (term = 145 d) and in the adult are more responsive to AVP. To further characterize these developmental changes, we used immunocy...

journal_title：Endocrinology

authors： Perez FM,Schwartz J,Rose JC

更新日期：1997-03-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a peptide found in a variety of hypothalamic loci which is frequently colocalized with catecholamines. It is also secreted into hypophyseal portal vessels. The injection of NPY into the third ventricle (3V) lowered plasma GH levels in conscious, freely moving male rats. To determine the physiol...

journal_title：Endocrinology

authors： Rettori V,Milenkovic L,Aguila MC,McCann SM

更新日期：1990-05-01 00:00:00

abstract：:Bovine granulosa cells seeded in the presence of serum on extracellular matrix-coated dishes proliferate actively when exposed to serum-free medium supplemented with insulin (2 microgram/ml), fibroblast growth factor (FGF, 100 ng/ml), and high density lipoprotein (HDL, 30 microgram protein/ml). The final density of th...

journal_title：Endocrinology

authors： Savion N,Lui GM,Laherty R,Gospodarowicz D

更新日期：1981-08-01 00:00:00

abstract：:Nuclear proteins extracted from purified nuclei with 0.4M KCl at pH 7.4 OR 8.5 are able to bind L-triiodothyronine (T3) giving rise to nuclear thyroid hormone binding protein-T3 (NTBP-T3) complexes. Binding is maximum in 3 h at 20 C. It is thermolabile even at 36 C, inhibited by p-hydroxymercuribenzoate and markedly e...

journal_title：Endocrinology

authors： Torresani J,DeGroot LJ

更新日期：1975-05-01 00:00:00

abstract：:GRK2 is a member of the G protein-coupled receptor kinase family that phosphorylates the activated form of beta-adrenergic and other G protein-coupled receptors and plays an important role in their desensitization and modulation. Alterations in thyroid hormone levels have been reported to lead to important changes in ...

journal_title：Endocrinology

authors： Penela P,Barradas M,Alvarez-Dolado M,Muñoz A,Mayor F Jr

更新日期：2001-03-01 00:00:00

abstract：:Frequent blood sampling via intraatrial cannula revealed daily rhythms of TSH and thyroid hormones in both male and female Wistar rats. Thermic ablation of the biological clock, i.e. the suprachiasmatic nucleus (SCN), eliminated the diurnal peak in circulating TSH and thyroid hormones. In addition, SCN lesions produce...

journal_title：Endocrinology

authors： Kalsbeek A,Fliers E,Franke AN,Wortel J,Buijs RM

更新日期：2000-10-01 00:00:00

abstract：:The effects of endothelin-1 (ET-1), a potent vasoconstrictor and mitogen to various cell types, on proliferation and differentiated functions of the murine Leydig tumor cell line MA-10 were investigated. Kinetic binding experiments at room temperature showed that [125I] ET-1 bound to MA-10 cells and reached equilibriu...

journal_title：Endocrinology

authors： Ergul A,Glassberg MK,Majercik MH,Puett D

更新日期：1993-02-01 00:00:00

abstract：:The effect of an activator of protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA), on the 5'-deiodinase (5'D) activity was studied in rat astroglial cells cultured in chemically defined medium. TPA promoted a large increase in the type II 5'D activity, which was maximal 5-10 h after addition of TPA and then d...

journal_title：Endocrinology

authors： Courtin F,Chantoux F,Gavaret JM,Toru-Delbauffe D,Jacquemin C,Pierre M

更新日期：1989-09-01 00:00:00

abstract：:The ability of the adult pancreas to generate new insulin (beta) cells has been controversial because of difficulties in unequivocally identifying the precursor population. We recently determined that beta cells were generated during development from precursors that expressed the homeodomain-containing transcription f...

journal_title：Endocrinology

authors： Fernandes A,King LC,Guz Y,Stein R,Wright CV,Teitelman G

更新日期：1997-04-01 00:00:00

abstract：:The regulation of GRF secretion was studied using a fetal rat hypothalamic cell culture system. The cells were subjected to short term release experiments on days 10-18 after plating, and GRF secretion was assessed by RIA. The identity of GRF immunoreactivity in the incubation medium was confirmed by reverse phase liq...

journal_title：Endocrinology

authors： Baes M,Vale WW

更新日期：1989-01-01 00:00:00

abstract：:Calcium (Ca2+) ionophore A23187 increased the intracellular cAMP content and PRL release in normal rat anterior pituitary cells. Cotreatment with dopamine reduced both control and A23187-stimulated cAMP accumulation and PRL release. The dopamine antagonist spiperone restored the response of cAMP to ionophoric stimulat...

journal_title：Endocrinology

authors： Schettini G,Cronin MJ,MacLeod RM

更新日期：1983-05-01 00:00:00

abstract：:We studied the effect of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) activation on serum concentrations and tissue expression of resistin, adiponectin, and adiponectin receptor-1 and -2 (AdipoR1 and AdipoR2) mRNA in normal mice and mice with insulin resistance induced by lipogenic, simple-carbohydrat...

journal_title：Endocrinology

authors： Haluzik MM,Lacinova Z,Dolinkova M,Haluzikova D,Housa D,Horinek A,Vernerova Z,Kumstyrova T,Haluzik M

更新日期：2006-09-01 00:00:00

abstract：:The primate brain was thought to contain only the GnRH known as mammalian GnRH (mGnRH). This study investigates whether a second form of GnRH exists within the primate brain. We found that brain extracts from adult stumptail and rhesus monkeys contained two forms of GnRH that were similar to mGnRH and chicken GnRH-II ...

journal_title：Endocrinology

authors： Lescheid DW,Terasawa E,Abler LA,Urbanski HF,Warby CM,Millar RP,Sherwood NM

更新日期：1997-12-01 00:00:00

abstract：:Seven adult female rhesus monkeys were laparotomized at days 22, 42, and 157 of pregnancy and blood was collected from the uterine vein and peripheral circulation. Plasma samples were analyzed for monkey chorionic gonadotropin (mCG), monkey chorionic somatomammotropin (mCS), and prolactin by radioimmunoassay. Levels o...

journal_title：Endocrinology

authors： Walsh SW,Wolf RC,Meyer RK,Aubert ML,Friesen HG

更新日期：1977-03-01 00:00:00

abstract：:Little is known about the mechanisms of action of polypeptide hormones on chromatin structure and nuclear function. We have employed micrococcal nuclease to examine the effect of TSH on the accessibility of DNA in thyroid nuclei. Brief digestion of nuclear suspensions with 0.05-0.2 U/ml micrococcal nuclease at 26-28 C...

journal_title：Endocrinology

authors： Abe Y,Cooper E,Spaulding SW

更新日期：1982-06-01 00:00:00

abstract：:In the present study we investigated whether fetal exposure to flutamide affected messenger and protein levels of claudin-11, a key Sertoli cell factor in the establishment of the hemotesticular barrier, at the time of two key events of postnatal testis development: 1) before puberty (postnatal d 14) during the establ...

journal_title：Endocrinology

authors： Florin A,Maire M,Bozec A,Hellani A,Chater S,Bars R,Chuzel F,Benahmed M

更新日期：2005-03-01 00:00:00

abstract：:The effect of a potent agonistic LHRH analog D-Trp-6-LHRH on the hyperprolactinemia induced by haloperidol was tested in intact and ovariectomized female rats. The administration of D-Trp-6-LHRH at two dose levels (5 and 50 micrograms/day) for 20 days blocked the increase in serum PRL induced by haloperidol in intact ...

journal_title：Endocrinology

authors： Debeljuk L,Torres-Alemán I,Schally AV

更新日期：1985-06-01 00:00:00