Abstract:
:The quantities of estrone and estradiol were determined by radioimmunoassay in maternal and fetal plasma of the rhesus monkey from day 59 to 163 of gestation. A two way analysis of variance of data classified according to fetal sex and 3 pooled gestational ages for each hormone and for mother or fetus (4 analyses) revealed significant elevations in fetal estradiol and maternal estrone concentrations with age. All other comparisons were not significant by these analyses. The concentrations of estradiol were greater in maternal than in fetal plasma [769 +/- 64 (SE) pg/ml, N = 63 VS 57 +/- 6 (SE) pg/ml, N = 77, P less than 0.01] by a t test. Estrone, on the other hand, was similar in mother and fetus [265 +/- 30 (SE) pg/ml, N = 60 vs 318 +/- 37 (SE) pg/ml, N = 73, P greater than 0.05]. No sex differences in the concentrations of these hormones were observed except in the fetus after 150 days of gestation. At this time plasma from female fetuses contained significantly more estradiol than plasma from male fetuses [118 +/- 20 (SE) pg/ml, N = 7 vs 61 +/- 10 (SE) pg/ml, N = 19, P less than 0.01]. Except for estradiol in female fetuses, the concentrations of estrogen were significantly higher in the umbilical vein than in the umbilical artery, an indication that the placenta is a major source of fetal estrogen in this species. Estrone and estradiol were significantly correlated in both the fetal and maternal circulation, r = 0.58, P less than 0.001 and r = 0.39, P less than 0.01 respectively. The results provide quantitative data about the estrogen miliue in which the monkey fetus develops and suggest mechanisms for controlling fetal estrogen in this species.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Resko JA,Pleom JG,Stadelman HLdoi
10.1210/endo-97-2-425subject
Has Abstractpub_date
1975-08-01 00:00:00pages
425-30issue
2eissn
0013-7227issn
1945-7170journal_volume
97pub_type
杂志文章相关文献
ENDOCRINOLOGY文献大全abstract::Hypothalamic lesions or deficient melanocortin (MC) signaling via MC4 receptor (MC4r) mutations often lead to hyperphagia and severe treatment-resistant obesity. We tested the methionine aminopeptidase 2-inhibitor beloranib (ZGN-440) in 2 male rat models of obesity, one modeling hypothalamic obesity with a combined me...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2016-1665
更新日期:2017-01-01 00:00:00
abstract::We examined the gene expression of V-1, a novel soluble protein with the cdc10/SWI6 motif, in pseudopregnant rat ovaries. Northern blot analysis on days 1, 5, and 11 of pseudopregnancy revealed an approximately 2-fold increase in the V-1 messenger RNA (mRNA) expression level on day 5 to that on day 1, and no significa...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.4.8625920
更新日期:1996-04-01 00:00:00
abstract::Localized expression of cytochromes P450 17 alpha-hydroxylase (P450c17) and aromatase (P450arom) was investigated in embryonic cell layers of elongating porcine blastocysts by immunocytochemistry. Blastocysts were flushed from the uterus on day 12 of pregnancy, fixed in paraformaldehyde, embedded in paraffin, sectione...
journal_title:Endocrinology
pub_type: 更正并重新发布的文章,杂志文章
doi:10.1210/endo.135.6.7988410
更新日期:1994-12-01 00:00:00
abstract::The nuclear translocation of PRL is demonstrated at the immunofluorescence and electron microscopic (EM) levels in interleukin-2 (IL2)-stimulated cloned T-cells and concanavalin A-stimulated splenocytes. This translocation occurs 2-10 h after IL2 stimulation, and is reversed by the addition of anti-PRL antiserum into ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-6-3151
更新日期:1990-12-01 00:00:00
abstract::It is well established that sexually dimorphic neural regions are organized by steroid hormones during development. In many species, neonatal males are exposed to more testosterone than their female littermates, and ultimately it is the estradiol, produced by aromatization of testosterone, that affects sexual differen...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-0183
更新日期:2008-08-01 00:00:00
abstract::As ovariectomy induces obesity in rats, we have investigated the influence of ovariectomy and hormone replacement on the proliferation and differentiation capacities of rat cultured preadipocytes removed from different fat depots (femoral sc, parametrial, and perirenal). Ovariectomy induced increased proliferation and...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.138.7.5246
更新日期:1997-07-01 00:00:00
abstract::Notch signaling is an evolutionarily conserved pathway, which regulates cell proliferation, differentiation, and apoptosis. It has been reported that the members of Notch signaling are expressed in mammalian ovaries, but the exact functions of this pathway in follicle development is still unclear. In this study, prima...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2010-1182
更新日期:2011-06-01 00:00:00
abstract::Both peroxisome proliferator-activated receptor-alpha (PPARalpha) and pancreatic/duodenal homeobox-1 (PDX-1) have been reported to be associated with glucose-stimulated insulin secretion (GSIS), but the relationship between PPARalpha and PDX-1 is not yet fully understood. In the present study, we tested the hypothesis...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-1275
更新日期:2008-02-01 00:00:00
abstract::In the present study we have used a high affinity photoaffinity label (PAL) agonist (pGlu-His-Trp-Ser-125I-iodoTyr-D-Lys(para-N3-Benzoyl)-Leu-Arg-P roNHEt) and a PAL antagonist (NAcD2Nal-D4ClPhe-D3Pal-Ser-125I-iodo-NMeTyr-D-L ys(para-N3-Benzoyl)Leu-Lys(Isp) - Pro-D-Ala-NH2) to covalently label the GnRH receptor. Rat p...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.133.2.8393780
更新日期:1993-08-01 00:00:00
abstract::The hippocampus is essentially involved in learning and memory processes. Its functions are affected by various neuromodulators, including 17beta-estradiol, testosterone, and retinoid. Brain-synthesized steroid hormones act as autocrine and paracrine modulators. The regulatory mechanism underlying brain steroidogenesi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2008-1644
更新日期:2009-09-01 00:00:00
abstract::Prolactin (PRL) is tonically inhibited by dopamine (DA) released from neurons in the arcuate and periventricular nuclei. Kisspeptin plays a pivotal role in LH regulation. In rodents, kisspeptin neurons are found mostly in the anteroventral periventricular and arcuate nuclei, but the physiology of arcuate kisspeptin ne...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2009-1414
更新日期:2010-07-01 00:00:00
abstract::This study examined the effect of two thirds hepatectomy on rat liver insulin-like growth factor-II (IGF-II) receptors and IGF-II receptor messenger RNA (mRNA) levels. IGF-II receptor levels were determined in liver plasma membrane and Golgi/endosome fractions from sham-operated and hepatectomized rats by ligand bindi...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-127-5-2210
更新日期:1990-11-01 00:00:00
abstract::The effect of gonadotropins on phosphodiesterase activity of rat granulosa cells was studied in an in vitro model. Granulosa cells were prepared from hypophysectomized or intact, estrogen-primed immature female rats and treated with FSH, hCG, or (Bu)2cAMP in vitro. Phosphodiesterase activity was determined in cell hom...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-114-6-2361
更新日期:1984-06-01 00:00:00
abstract::The type 1 PTH/PTH-related peptide receptor (PTH1R) is a class B G protein-coupled receptor that demonstrates immunoreactivity in the nucleus as well as cytoplasm of target cells. Our previous studies on the PTH1R have shown that it associates with the importin family of transport regulatory proteins. To investigate t...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2007-0157
更新日期:2007-05-01 00:00:00
abstract::The xenoestrogen bisphenol A (BPA) has been shown to mimic estrogen both in vivo and in vitro. BPA stimulates PRL secretion and the expression of a PRL regulating factor from the posterior pituitary in the estrogen-sensitive Fischer 344 rat (F344), but not in Sprague-Dawley (SD) rats. The goal of the present studies w...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.139.6.6027
更新日期:1998-06-01 00:00:00
abstract::In bone, early events in inflammation involve the production and release of primary proinflammatory cytokines, such as interleukin-1 beta. By activation of target cells, these cytokines are thought to induce a second wave of cytokines, including monocyte chemoattractant protein-1 (MCP-1). MCP-1 is a cytokine that stim...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.6.7750500
更新日期:1995-06-01 00:00:00
abstract::Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. Gremlin, a BMP antagonist, is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. However, its effects in vivo are not known. To investigate the actions of gremlin on bone remodeling in...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2004-0766
更新日期:2005-02-01 00:00:00
abstract::In male rats maintained on a 12 h light-dark schedule (6 AM-6 PM), there is a nyctohemeral cycle of plasma prolactin which consists of a nadir at 11:30 AM and an apogee at approximately 11:30 PM. In rats exposed to constant darkness, this rhythm persists for 7 days. Seven days of constant light, however, reverses this...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-96-5-1230
更新日期:1975-05-01 00:00:00
abstract::Differences in the catalytic activity of the placental and gonadal isozymes of porcine aromatase cytochrome P450 (P450arom) were examined in cell lines exhibiting stable expression of recombinant enzyme. Cell lines were selected that expressed high, but similar, immunodetectable levels of each isozyme based on Western...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.140.11.7140
更新日期:1999-11-01 00:00:00
abstract::We examined whether mitogen-activated protein (MAP) kinase was activated by stimulation of the cAMP pathway and whether MAP kinase activation was involved in synthesis of PRL and GH in GH(3) cells. Treatment of the cells with a cAMP analog, 8-(4-chlorophenylthio)cAMP (CPT-cAMP), activated MAP kinase and increased PRL ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.142.7.8226
更新日期:2001-07-01 00:00:00
abstract::Stimulators of bone resorption, such as PTH, 1,25-dihydroxycholecalciferol [1,25-(OH)2D3], or prostaglandin E2 (PGE2), do not cause calcium release from cultured calvaria of the genetically determined osteopetrotic microphthalmic (mi/ mi) mouse, due to a defect in the function of osteoclasts. To investigate the capaci...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-112-3-945
更新日期:1983-03-01 00:00:00
abstract::Although renal hypertrophy occurs rapidly after uninephrectomy, restoring the majority of renal excretory function, it remains unknown whether similar compensatory mechanisms maintain 1,25-dihydroxyvitamin D production (and calcium homeostasis). To address this issue we compared plasma calcitriol levels and renal 25-h...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-124-5-2118
更新日期:1989-05-01 00:00:00
abstract::Glucose-dependent insulinotropic peptide (GIP) is a 42-amino acid peptide synthesized and secreted from endocrine cells in the small intestine. The role of GIP in coupling nutrient intake and insulin secretion, the incretin effect, is well known. We report that GIP receptor messenger RNA and protein are present in nor...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.141.3.7366
更新日期:2000-03-01 00:00:00
abstract::A thyroid transcription factor-1 (TTF-1)-binding element in the rat TSH receptor (TSHR) promoter, between -189 and -175 basepairs (bp), is important for both thyroid-specific expression and thyroid-specific TSH/cAMP autoregulation of the TSHR. The identification of an up-stream TTF-1-binding site and its relationship ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.136.1.7828540
更新日期:1995-01-01 00:00:00
abstract::The action of the cyclic peptide polymyxin B (a well known inhibitor of protein kinase C) on adrenal steroid synthesis was examined with Y-1 adrenal tumor cells. Polymyxin B produces a biphasic effect on the stimulation of steroid synthesis by 2 nM ACTH in these cells, with inhibition at low concentrations (less than ...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-121-1-290
更新日期:1987-07-01 00:00:00
abstract::We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs) together with hyperglycemia are synergistic in causing islet beta-cell damage because high glucose inhibits fat oxidation and consequently lipid detoxification. The effects of 1-2 d culture of both rat INS 832/13 cells and hu...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0410
更新日期:2003-09-01 00:00:00
abstract::A highly conserved region in the PTH promoter was identified using the basic local alignment search tool (BLAST) 2 Sequences comparison. Strong specific complexes were observed with a DNA probe that contained much of the computer-derived conserved sequence in the EMSA using bovine parathyroid gland (bPTG) nuclear extr...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2003-0119
更新日期:2003-07-01 00:00:00
abstract::Nitric oxide (NO) is a free radical produced by the action of NO synthases (NOS) and is known to be involved in the regulation of many reproductive events that occur in the oviducts. The oviducts are highly specialized organs that play crucial roles in reproduction by providing an optimal environment for the final mat...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/en.2005-1548
更新日期:2006-12-01 00:00:00
abstract::The 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta HSD-2) enzyme is thought to confer aldosterone specificity upon mineralocorticoid target tissues by protecting the mineralocorticoid receptor from binding by the more abundant glucocorticoids, corticosterone and cortisol. We have developed a Chinese hamster ovar...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo.137.6.8641180
更新日期:1996-06-01 00:00:00
abstract::The regulation of delta 5-3 beta-hydroxysteroid dehydrogenase-isomerase (3 beta-HSD) was studied in primary cultures of rat adrenocortical cells. In the absence of ACTH, this enzymic activity was found to decay with a half-life of 3.1 days, which was similar to the half-life of the enzyme activity induced by ACTH in v...
journal_title:Endocrinology
pub_type: 杂志文章
doi:10.1210/endo-111-2-427
更新日期:1982-08-01 00:00:00