D-Trp-6-luteinizing hormone-releasing hormone inhibits hyperprolactinemia in female rats.

abstract：:Our previous studies implicated the involvement of protein kinase-A in the inhibitory effects of isoproterenol and relaxin on oxytocin-stimulated phosphoinositide turnover in rat myometrium. To understand the possible mechanisms involved, the properties and regulation of phospholipase-C (PLC) in purified myometrial pl...

journal_title：Endocrinology

authors： Wen Y,Anwer K,Singh SP,Sanborn BM

更新日期：1992-09-01 00:00:00

abstract：:Obesity and insulin resistance-related proteinuria is associated with oxidative stress and impaired tissue bioavailable nitric oxide. Recent data suggest that nicotinamide adenine dinucleotide phosphate oxidase-mediated oxidative injury to the proximal tubule, like that seen in the glomerulus, contributes to proteinur...

journal_title：Endocrinology

authors： Habibi J,Hayden MR,Sowers JR,Pulakat L,Tilmon RD,Manrique C,Lastra G,Demarco VG,Whaley-Connell A

更新日期：2011-02-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal axis involves timed signaling between the hypothalamus, pituitary, and adrenal glands and back to the brain, causing an inherently oscillating system. Corticosteroids such as corticosterone (CORT) are secreted in a circadian rhythm, characterized by low and high levels at the start o...

journal_title：Endocrinology

authors： den Boon FS,de Vries T,Baelde M,Joëls M,Karst H

更新日期：2019-04-01 00:00:00

abstract：:Developmental effects of genistein (Gen) on the mammary gland were investigated using outbred female CD-1 mice treated neonatally on d 1-5 by sc injections at doses of 0.5, 5, or 50 mg/kg.d. Examination of mammary gland whole mounts (no. 4) before puberty (4 wk) revealed no morphological differences in development aft...

journal_title：Endocrinology

authors： Padilla-Banks E,Jefferson WN,Newbold RR

更新日期：2006-10-01 00:00:00

abstract：:We have examined the effects of acute administration of the cannabinoid receptor type 1 (CB(1)) antagonist AM251 on the rat hypothalamic-pituitary-adrenal (HPA) axis with respect to both gender and time of day. Blood samples were collected from conscious male and female rats every 5 min using an automated blood sampli...

journal_title：Endocrinology

authors： Atkinson HC,Leggett JD,Wood SA,Castrique ES,Kershaw YM,Lightman SL

更新日期：2010-08-01 00:00:00

abstract：:Female infertility is often associated with deregulation of hormonal networks, and hyperprolactinemia is one of the most common endocrine disorders of the hypothalamic-pituitary axis affecting the reproductive functions. We have shown previously that transgenic female mice overexpressing human chorionic gonadotropin β...

journal_title：Endocrinology

authors： Ratner LD,Gonzalez B,Ahtiainen P,Di Giorgio NP,Poutanen M,Calandra RS,Huhtaniemi IT,Rulli SB

更新日期：2012-12-01 00:00:00

abstract：:There is strong evidence that kisspeptin acts to regulate GnRH secretion, but whether there is also a component of action on the gonadotropes is not clear. Using quantitative RT-PCR, we found that G protein-coupled receptor-54 mRNA is expressed in ovine pituitary cell fractions enriched for gonadotropes as well as in ...

journal_title：Endocrinology

authors： Smith JT,Rao A,Pereira A,Caraty A,Millar RP,Clarke IJ

更新日期：2008-04-01 00:00:00

abstract：:Selenoproteins contain the essential trace element selenium whose deficiency leads to major disorders including cancer, male reproductive system failure, or autoimmune thyroid disease. Up to now, 25 selenoprotein-encoding genes were identified in mammals, but the spatiotemporal distribution, regulation, and function o...

journal_title：Endocrinology

authors： Tanguy Y,Falluel-Morel A,Arthaud S,Boukhzar L,Manecka DL,Chagraoui A,Prevost G,Elias S,Dorval-Coiffec I,Lesage J,Vieau D,Lihrmann I,Jégou B,Anouar Y

更新日期：2011-11-01 00:00:00

abstract：:Tobacco smoking favorably influences the course of Hashimoto thyroiditis, possibly through the antiinflammatory proprieties of nicotine. In this study we tested anatabine, another tobacco alkaloid, in a model of experimental autoimmune thyroiditis. Experimental autoimmune thyroiditis was induced by different doses of ...

journal_title：Endocrinology

authors： Caturegli P,De Remigis A,Ferlito M,Landek-Salgado MA,Iwama S,Tzou SC,Ladenson PW

更新日期：2012-09-01 00:00:00

abstract：:Studies were carried out to determine the origin of the immediate increase in plasma calcium following acute calcitonin deficiency in mature rats. Animals were pre-labelled with 45calcium 24 hours and 4 weeks before thyroparathyroidectomy (TPTX) and 1 hour, 24 hours, 2 and 4 weeks before nephrectomy and TPTX and bled ...

journal_title：Endocrinology

authors： Kalu DN,Hadji-Georgopoulos A,Foster GV

更新日期：1976-02-01 00:00:00

abstract：:The estrogen-induced and -dependent Syrian hamster renal tumor is the most intensively studied model in estrogen carcinogenesis. Yet, it remains confounding that the kidney of this species behaves as an estrogen target tissue. As both reproductive and urinary systems arise from the same germinal ridge, we propose that...

journal_title：Endocrinology

authors： Li JJ,Weroha SJ,Davis MF,Tawfik O,Hou X,Li SA

更新日期：2001-09-01 00:00:00

abstract：:Anterior pituitary cells from adult male rats were cultured on a natural extracellular matrix (ECM). From the 5th day, spindle-shaped cells, fusing to form elongated fibers, were observed among the epithelial cells. These fibers later increased in size and number and were identified as striated muscle fibers, based on...

journal_title：Endocrinology

authors： Spira O,Atzmon R,Rahamim E,Bar-Shavit R,Gross J,Gordon A,Vlodavsky I

更新日期：1988-06-01 00:00:00

abstract：:Endoglin is an integral membrane glycoprotein predominantly expressed on human endothelial cells and recently shown to bind transforming growth factor-beta 1 (TGF beta 1) with high affinity. We now report the cloning and sequencing of a full-length murine endoglin complementary DNA of 2902 base pairs which hybridizes ...

journal_title：Endocrinology

authors： St-Jacques S,Cymerman U,Pece N,Letarte M

更新日期：1994-06-01 00:00:00

abstract：:Although kisspeptin is the primary stimulator of gonadotropin-releasing hormone secretion and therefore the hypothalamic-pituitary-gonadal axis, recent findings suggest kisspeptin can also regulate additional neuroendocrine processes including release of growth hormone (GH). Here we show that central delivery of kissp...

journal_title：Endocrinology

authors： Foradori CD,Whitlock BK,Daniel JA,Zimmerman AD,Jones MA,Read CC,Steele BP,Smith JT,Clarke IJ,Elsasser TH,Keisler DH,Sartin JL

更新日期：2017-10-01 00:00:00

abstract：:In temperate zones, animals restrict breeding to specific seasons to maximize the survival of their offspring. Birds have evolved highly sophisticated mechanisms of seasonal regulation, and their testicular mass can change 100-fold within a few weeks. Recent studies on Japanese quail revealed that seasonal gonadal dev...

journal_title：Endocrinology

authors： Ikegami K,Atsumi Y,Yorinaga E,Ono H,Murayama I,Nakane Y,Ota W,Arai N,Tega A,Iigo M,Darras VM,Tsutsui K,Hayashi Y,Yoshida S,Yoshimura T

更新日期：2015-02-01 00:00:00

abstract：:The effects of hypophysectomy and GH on blood pressure and renin secretion were studied. Within 2 weeks after removal of the pituitary gland of rats, mean arterial blood pressure declined 30%, and heart rate fell 50%. No significant effect of hypophysectomy on blood volume or hematocrit was noted. Within 2 h after the...

journal_title：Endocrinology

authors： Honeyman TW,Goodman HM,Fray JC

更新日期：1983-05-01 00:00:00

abstract：:In rodents, soluble leptin receptor (SLR) may be generated by alternative splicing of ObR mRNA and/or as a cleavage product of ObR membrane-anchored receptors. In this study, we investigated the contribution of both processes on the generation of SLR in 3-, 8-, and 24-month-old Wistar rats fed ad libitum (AL) or under...

journal_title：Endocrinology

authors： Gallardo N,Arribas C,Villar M,Ros M,Carrascosa JM,Martínez C,Andrés A

更新日期：2005-11-01 00:00:00

abstract：:In the mouse, there is a large family of paralogous genes closely related to PRL. The objective of this report was to investigate the organization of the mouse PRL gene family locus. PRL family genes reside on chromosome 13 of the mouse genome. The PRL gene family members were localized to a series of overlapping bact...

journal_title：Endocrinology

authors： Wiemers DO,Shao LJ,Ain R,Dai G,Soares MJ

更新日期：2003-01-01 00:00:00

abstract：:The brain has traditionally been considered to be a target site of peripheral steroid hormones. By contrast, new findings over the past decade have shown that the brain itself also has the capability of forming steroids de novo, the so-called neurosteroids. De novo neurosteroidogenesis in the brain from cholesterol is...

journal_title：Endocrinology

authors： Tsutsui K

更新日期：2008-06-01 00:00:00

abstract：:Mouse kidney and urinary glycosphingolipids from developing C57BL/6J and adults of several other inbred strains were analyzed by high performance liquid chromatographic techniques. Glycosphingolipids from male and female C57BL/6J kidneys were similar until the fifth week of age. Galactosylceramide containing nonhydrox...

journal_title：Endocrinology

authors： McCluer RH,Deutsch CK,Gross SK

更新日期：1983-07-01 00:00:00

abstract：:Macrophages are known to release a lipophilic factor that stimulates testosterone production by Leydig cells. This macrophage-derived factor (MDF) is thought to be physiologically relevant, because removal of macrophages from the testis results in altered testosterone secretion and reduced fertility. The purpose of th...

journal_title：Endocrinology

authors： Nes WD,Lukyanenko YO,Jia ZH,Quideau S,Howald WN,Pratum TK,West RR,Hutson JC

更新日期：2000-03-01 00:00:00

abstract：:Stat proteins are SH2 domain-containing transcription factors that are activated by various cytokines and growth factors. In a previous work, we have identified Stat 5B as a substrate of the insulin receptor based on yeast two-hybrid and mammalian cell transfection studies. In the present study, we have approached the...

journal_title：Endocrinology

authors： Sawka-Verhelle D,Tartare-Deckert S,Decaux JF,Girard J,Van Obberghen E

更新日期：2000-06-01 00:00:00

abstract：:This study was initiated to investigate the significance of uterine cell death and proliferation during the estrous cycle and early pregnancy and their correlation with sex steroids in hamsters where blastocyst implantation occurs in only progesterone-primed uteri. The results obtained in hamsters were also compared w...

journal_title：Endocrinology

authors： Zhang Q,Paria BC

更新日期：2006-05-01 00:00:00

abstract：:To assess the consequences of prolonged exposure to elevated levels of LH/human chorionic gonadotropin (hCG) in the female, we developed a transgenic (TG) mouse model (hCGbeta+) that overexpresses the hCGbeta-subunit cDNA. Because of the promoter used, ubiquitin C, the transgene is expressed in multiple tissues, inclu...

journal_title：Endocrinology

authors： Rulli SB,Kuorelahti A,Karaer O,Pelliniemi LJ,Poutanen M,Huhtaniemi I

更新日期：2002-10-01 00:00:00

abstract：:Acidosis has been implicated in the pathogenesis of various metabolic bone diseases. Experimental acid ingestion is known to stimulate the release of bone mineral in humans and increase osteoclastic resorption surfaces in animals, but the mechanism has remained unclear. We have investigated the effect of medium pH on ...

journal_title：Endocrinology

authors： Arnett TR,Dempster DW

更新日期：1986-07-01 00:00:00

abstract：:It has previously been established that neuropeptide-Y (NPY) is a potent inhibitor of alpha MSH release from the pars intermedia of the amphibian Xenopus laevis. The location of binding sites for NPY in the pars intermedia of the pituitary has now been studied with light microscopic autoradiography, using a dispersed ...

journal_title：Endocrinology

authors： De Rijk EP,Cruijsen PM,Jenks BG,Roubos EW

更新日期：1991-02-01 00:00:00

abstract：:The incidence of obesity, with its impact on the development of comorbidities, including diabetes and cardiovascular disease, represents one of the greatest global health threats of the 21st century. This is particularly damning considering the vast progress that has been made in understanding the factors and molecula...

journal_title：Endocrinology

authors： Perez-Tilve D

更新日期：2017-05-01 00:00:00

abstract：:The nuclear translocation of PRL is demonstrated at the immunofluorescence and electron microscopic (EM) levels in interleukin-2 (IL2)-stimulated cloned T-cells and concanavalin A-stimulated splenocytes. This translocation occurs 2-10 h after IL2 stimulation, and is reversed by the addition of anti-PRL antiserum into ...

journal_title：Endocrinology

authors： Clevenger CV,Sillman AL,Prystowsky MB

更新日期：1990-12-01 00:00:00

abstract：:Specific receptors for tetradecapeptide somatostatin (S-14) in rat adrenal cortical membranes were quantitated by direct binding studies using [125I-Tyr11]S-14. Competitive inhibition of this radioligand by S-14 showed that these receptors constitute a single class of high affinity binding sites [dissociation constant...

journal_title：Endocrinology

authors： Srikant CB,Patel YC

更新日期：1985-05-01 00:00:00

abstract：:Thyroid hormones regulate bone homeostasis, and exogenously induced hyperthyroidism and hypothyroidism in mice was recently found to be associated with an altered expression of the Wnt inhibitor Dickkopf-1 (Dkk1), a determinant of bone mass. Here, we assessed the role of Dkk1 in thyroid hormone-induced changes in bone...

journal_title：Endocrinology

authors： Tsourdi E,Colditz J,Lademann F,Rijntjes E,Köhrle J,Niehrs C,Hofbauer LC,Rauner M

更新日期：2019-03-01 00:00:00