Photoaffinity labeling identification of a specific binding protein for the anabolic steroids stanozolol and danazol: an oligomeric protein regulated by age, pituitary hormones, and ethinyl estradiol.

abstract：:Hypoxia-inducible factor-1 (HIF-1) is a decisive element for the transcriptional regulation of many genes expressed in hypoxic conditions. In vascular smooth muscle cells, the vasoactive hormone angiotensin II (Ang II) is a very potent inducer and activator of HIF-1. As opposed to hypoxia, which induces HIF-1alpha by ...

journal_title：Endocrinology

authors： Lauzier MC,Pagé EL,Michaud MD,Richard DE

更新日期：2007-08-01 00:00:00

abstract：:Reproductive function is dependent on the interaction between GnRH and its cognate receptor found on gonadotrope cells of the anterior pituitary gland. GnRH activation of the GnRH receptor (GnRHR) is a potent stimulus for increased expression of multiple genes including the gene encoding the GnRHR itself. Thus, homolo...

journal_title：Endocrinology

authors： Ellsworth BS,White BR,Burns AT,Cherrington BD,Otis AM,Clay CM

更新日期：2003-03-01 00:00:00

abstract：:We investigated the role of peritubular cell-Sertoli cell interactions in the control of Sertoli cell function by androgens. Decreased FSH-inducible aromatase activity and increased secretion of androgen-binding protein (ABP) were used as parameters of androgen action on Sertoli cells. It is demonstrated that cocultur...

journal_title：Endocrinology

authors： Verhoeven G,Cailleau J

更新日期：1988-10-01 00:00:00

abstract：:The nuclear receptor steroidogenic factor 1/adrenal 4 binding protein (SF-1/Ad4BP) is an essential regulator of endocrine development and function, and the expression of the corresponding gene (sf-1/ad4bp) is precisely regulated in a time- and tissue-dependent manner. We previously demonstrated that the basal promoter...

journal_title：Endocrinology

authors： Hoivik EA,Bjanesoy TE,Mai O,Okamoto S,Minokoshi Y,Shima Y,Morohashi K,Boehm U,Bakke M

更新日期：2011-05-01 00:00:00

abstract：:The development of white adipose tissue involves both the hypertrophy of existing adipocytes and the proliferation and differentiation of preadipocytes. Adipogenic differentiation is inhibited by TGFβ signaling through Smad2/3, and IGF binding protein-3 (IGFBP-3) is also known to activate Smad2/3 signaling in some cel...

journal_title：Endocrinology

authors： de Silva HC,Firth SM,Twigg SM,Baxter RC

更新日期：2012-10-01 00:00:00

abstract：:We have developed and characterized a primary cell culture system to study the regulation of 17 alpha-hydroxylase cytochrome P450 (P45017 alpha) gene expression in bovine thecal cells. Conditions have been established for the dispersal and growth of thecal cells isolated from bovine follicles, which maintain the expre...

journal_title：Endocrinology

authors： Demeter-Arlotto M,Rainey WE,Simpson ER

更新日期：1993-03-01 00:00:00

abstract：:The present studies were designed to evaluate the binding characteristics of arginine vasopressin (AVP), using rat anterior pituitary dispersed cells, in correlation with the biological activity of the peptide. Synthetic AVP released ACTH from dispersed anterior pituitary cells in a concentration-dependent fashion, wi...

journal_title：Endocrinology

authors： Spinedi E,Negro-Vilar A

更新日期：1984-06-01 00:00:00

abstract：:Reduced and S-carbamidomethylated human GH (RCAM-hGH) was digested with human plasmin, yielding a mixture of products. These were partially separated by chromatography on DEAE-cellulose, yielding three major fractions: Da and Db, which were equipotent with native hGH in the weight gain test; and Dc, which was about ha...

journal_title：Endocrinology

authors： Mills JB,Kostyo JL,Moseley MH,Reagan CR,Wilhelmi AE

更新日期：1978-05-01 00:00:00

abstract：:Neonatal exposure to high doses of estrogen results in permanent suppression of prostate growth and reduced sensitivity to androgens in adulthood. It is unclear whether alterations in prostate growth are due to a direct effect of estrogens on the gland or are the result of hypothalamic-pituitary-gonadal axis suppressi...

journal_title：Endocrinology

authors： Jarred RA,Cancilla B,Prins GS,Thayer KA,Cunha GR,Risbridger GP

更新日期：2000-09-01 00:00:00

abstract：:The insulin-like growth factor-II (IGF-II)/Mannose 6-P receptor (Man 6-P) is a multifunctional receptor that binds two unrelated ligands, IGF-II and lysosomal enzymes that contain Man 6-P recognition markers. Although this receptor has been extensively characterized in mammalian cells, binding of radiolabeled IGF-II t...

journal_title：Endocrinology

authors： Yang YW,Robbins AR,Nissley SP,Rechler MM

更新日期：1991-02-01 00:00:00

abstract：:Preincubation of rat pituitary cells in primary culture with rat GH-releasing factor (rGRF) resulted in substantial desensitization to subsequent GRF stimulation. rGRF-directed GH release and intracellular cAMP accumulation decreased in the desensitized cells. Whereas prior treatment of rat pituitary cells caused part...

journal_title：Endocrinology

authors： Ceda GP,Hoffman AR

更新日期：1985-04-01 00:00:00

abstract：:In order to elucidate potential sites of direct GH action on the kidney, we used in situ hybridization to localize GH receptor (GHR) gene expression during the course of development and in the adult rat. In order to illuminate potential interactions between GH and insulin-like growth factor-I (IGF-I) in regulating ren...

journal_title：Endocrinology

authors： Chin E,Zhou J,Bondy CA

更新日期：1992-12-01 00:00:00

abstract：:To study the role of the epithelial calcium channel transient receptor potential vanilloid type 6 (TRPV6) and the calcium-binding protein calbindin-D9k in intestinal calcium absorption, TRPV6 knockout (KO), calbindin-D9k KO, and TRPV6/calbindin-D(9k) double-KO (DKO) mice were generated. TRPV6 KO, calbindin-D9k KO, and...

journal_title：Endocrinology

authors： Benn BS,Ajibade D,Porta A,Dhawan P,Hediger M,Peng JB,Jiang Y,Oh GT,Jeung EB,Lieben L,Bouillon R,Carmeliet G,Christakos S

更新日期：2008-06-01 00:00:00

abstract：:The FOXO family of forkhead transcription factors stimulates the transcription of target genes involved in many fundamental cell processes, including cell survival, cell cycle progression, DNA repair, and insulin sensitivity. The activity of FOXO proteins is principally regulated by activation of protein kinase B (PKB...

journal_title：Endocrinology

authors： Tsai WC,Bhattacharyya N,Han LY,Hanover JA,Rechler MM

更新日期：2003-12-01 00:00:00

abstract：:Hyperandrogenism is the central feature of polycystic ovary syndrome (PCOS). Due to the intricate relationship between hyperandrogenism and insulin resistance in PCOS, 50%-70% of these patients also present with hyperinsulinemia. Metformin, an insulin sensitizer, has been used to reduce insulin resistance and improve ...

journal_title：Endocrinology

authors： Lee BH,Indran IR,Tan HM,Li Y,Zhang Z,Li J,Yong EL

更新日期：2016-01-01 00:00:00

abstract：:This study was undertaken to examine short photoperiod (SD; 8 h of light, 16 h of darkness)-induced alterations in reproductive endocrine and neuroendocrine parameters in the male white-footed mouse, Peromyscus leucopus. Exposure to SD for 8 weeks caused dramatic reductions in testis and seminal vesicle weights, decre...

journal_title：Endocrinology

authors： Glass JD,Ferreira S,Deaver DR

更新日期：1988-08-01 00:00:00

abstract：:The purpose of these experiments was to determine if the powerful effect of sodium chloride concentration on angiotensin II- and potassium-stimulated aldosterone secretion by isolated perfused adrenal glands is mediated by the sodium or chloride ion or by the obligatory change in osmolality. We used isolated Ringer's ...

journal_title：Endocrinology

authors： Schneider EG,Radke KJ,Ulderich DA,Taylor RE Jr

更新日期：1985-04-01 00:00:00

abstract：:It was shown previously that epidermal growth factor (EGF) plays a role in the testosterone-dependent fetal Wolffian duct differentiation. In this communication, the role of EGF was further investigated by determining whether EGF receptor plays a role in mediating the effect of EGF during Wolffian duct (male duct) dif...

journal_title：Endocrinology

authors： Gupta C,Jaumotte J

更新日期：1993-10-01 00:00:00

abstract：:Although the effectiveness of nuclear hormone-receptor complexes is known to depend on coregulator partner proteins, relatively little is known about the roles of coregulators in uterine development and early stages of pregnancy and implantation. Because conventional genetic deletion of the coregulator, repressor of e...

journal_title：Endocrinology

authors： Park S,Yoon S,Zhao Y,Park SE,Liao L,Xu J,Lydon JP,DeMayo FJ,O'Malley BW,Bagchi MK,Katzenellenbogen BS

更新日期：2012-08-01 00:00:00

abstract：:A 50-70% depletion in the anterior pituitary concentration of PRL occurred within 5 min of electrical stimulation of a single abdominal mammary nerve of urethane-anesthetized lactating rats previously nonsuckled for 6-8 h. The stimulus parameters were: 1-msec pulses, 10-20/sec at 5-30 V applied 5 sec on and 10 sec off...

journal_title：Endocrinology

authors： Mena F,Pacheco P,Grosvenor CE

更新日期：1980-02-01 00:00:00

abstract：:Mouse kidney and urinary glycosphingolipids from developing C57BL/6J and adults of several other inbred strains were analyzed by high performance liquid chromatographic techniques. Glycosphingolipids from male and female C57BL/6J kidneys were similar until the fifth week of age. Galactosylceramide containing nonhydrox...

journal_title：Endocrinology

authors： McCluer RH,Deutsch CK,Gross SK

更新日期：1983-07-01 00:00:00

abstract：:After reproductive senescence or gonadectomy, changes occur in neural gene expression, ultimately altering brain function. The endocrine mechanisms underlying these changes in gene expression beyond immediate hormone loss are poorly understood. To investigate this, we measured changes in gene expression the dorsal str...

journal_title：Endocrinology

authors： Meitzen J,Perry AN,Westenbroek C,Hedges VL,Becker JB,Mermelstein PG

更新日期：2013-05-01 00:00:00

abstract：:The role of GH during the ovine estrous cycle is unknown. In this study, pituitary GH mRNA and peripheral serum GH levels were measured in ewes representing the major phases of the estrous cycle. There was a significant rise (P less than 0.05) in both GH mRNA and serum GH concentrations during the follicular phase of ...

journal_title：Endocrinology

authors： Landefeld TD,Suttie JM

更新日期：1989-09-01 00:00:00

abstract：:Increased matrix extracellular phosphoglycoprotein (MEPE) expression occurs in several phosphate and bone-mineral metabolic disorders. To resolve whether MEPE plays a role, we created a murine model overexpressing MEPE protein (MEPE tgn) in bone. MEPE tgn mice displayed a growth and mineralization defect with altered ...

journal_title：Endocrinology

authors： David V,Martin A,Hedge AM,Rowe PS

更新日期：2009-09-01 00:00:00

abstract：:We examined the levels and stability of glucocorticoid receptor activity in cytosol preparations of rat lung and other tissues. [3H]Dexamethasome binding capacity at 2 C in lung cytosol decreases with a t1/2 of 40 min in the absence of steroid or a sulfhydryl compound. This rapid inactivation of unbound receptor is pr...

journal_title：Endocrinology

authors： Granberg JP,Ballard PL

更新日期：1977-04-01 00:00:00

abstract：:Various neuropeptides have recently been isolated from the thymus, suggesting an interaction between the neuroendocrine and immune systems. We report here that the human thymus synthesizes a further peptide hormone, namely atrial natriuretic peptide (ANP). This is documented by the following findings. ANP and its proh...

journal_title：Endocrinology

authors： Vollmar AM,Schulz R

更新日期：1990-05-01 00:00:00

abstract：:We have recently identified gonadotropes as target cells for ATP action via ATP receptors of the P2U subtype. The present studies have used gonadotrope-derived alpha T3-1 cells to examine the possible signaling mechanisms subserving ATP action in gonadotropes. Addition of ATP produced a biphasic intracellular Ca2+ (Ca...

journal_title：Endocrinology

authors： Chen ZP,Kratzmeier M,Poch A,Xu S,McArdle CA,Levy A,Mukhopadhyay AK,Lightman SL

更新日期：1996-01-01 00:00:00

abstract：:Humanin (HN) is a novel 24-amino acid mitochondrial-derived peptide that has demonstrated diverse cytoprotective effects, including an emerging role in diabetes. The purpose of this study was to examine the pharmacokinetics of humanin analogues, which show great potential as therapeutic agents (HNG and the non-IGFBP-3...

journal_title：Endocrinology

authors： Chin YP,Keni J,Wan J,Mehta H,Anene F,Jia Y,Lue YH,Swerdloff R,Cobb LJ,Wang C,Cohen P

更新日期：2013-10-01 00:00:00

abstract：:The adrenal gland is highly vascularized with tightly regulated blood flow that is closely correlated with steroidogenesis. Mechanisms involved in the regulation of adrenal blood flow and vascular tone are largely unknown. The present study characterizes the contractile responses of isolated small cortical arteries fr...

journal_title：Endocrinology

authors： Zhang DX,Gauthier KM,Campbell WB

更新日期：2004-04-01 00:00:00

abstract：:The purpose of this study was to determine whether normal morphological development occurs in pituitary corticotrophs deprived of products of the hypothalamic paraventricular nucleus (PVN), e.g. corticotropin releasing hormone and arginine vasopressin (AVP), after PVN lesions. In addition, we have attempted to ascerta...

journal_title：Endocrinology

authors： McDonald TJ,Hoffman GE,Nathanielsz PW

更新日期：1992-09-01 00:00:00