Renal growth hormone receptor gene expression: relationship to renal insulin-like growth factor system.

abstract：:Dihydrotestosterone (DHT) concentration was measured in prostatic tissue obtained from castrate or intact beagles treated with androgens and/or estradiol-17 beta. Also DHT concentration was measured in prostatic tissue of beagles ranging from 0.7-9.2 yr; some with and others without spontaneously occurring benign pros...

journal_title：Endocrinology

authors： Ewing LL,Berry SJ,Higginbottom EG

更新日期：1983-12-01 00:00:00

abstract：:We have shown that nonlactogenic rat (r) GH is far more potent than rPRL in inducing rat mammary development. To determine the relative roles of GH and PRL in mammary development and their mechanisms of action, we have compared the abilities of a group of native and mutant GHs, PRLs, and placental lactogens (PLs) to i...

journal_title：Endocrinology

authors： Feldman M,Ruan W,Cunningham BC,Wells JA,Kleinberg DL

更新日期：1993-10-01 00:00:00

abstract：:To determine if CRH and glucocorticoids are respectively required for hypophagia and catabolism in malnutrition, we have subjected wild-type (WT) and CRH knockout (KO) mice to dietary protein deprivation. Compared with WT mice, CRH KO mice exhibited greater decreases in food intake and negligible change in plasma cort...

journal_title：Endocrinology

authors： Jacobson L

更新日期：1999-08-01 00:00:00

abstract：:Steroid hormone synthesis is a vital function of the adrenal cortex, serves a critical role in gonadal function, and maintains pregnancy if normally executed in the placenta. The substrate for the synthesis of all steroid hormones is cholesterol, and its conversion to the first steroid, pregnenolone, by the cholestero...

journal_title：Endocrinology

authors： Yivgi-Ohana N,Sher N,Melamed-Book N,Eimerl S,Koler M,Manna PR,Stocco DM,Orly J

更新日期：2009-02-01 00:00:00

abstract：:The molecular links between membrane excitability and neurohormone synthesis were investigated using a simple model system: the bag cell neurons of Aplysia. We tested the hypothesis that the electrical afterdischarge, which leads to depletion of egg-laying hormone (ELH) by triggering secretion, rapidly stimulates ELH ...

journal_title：Endocrinology

authors： Lee W,Wayne NL

更新日期：1998-12-01 00:00:00

abstract：:The concentrations of ACTH and cortisol both rise in the plasma of fetal lambs during late pregnancy, reflecting maturation of the fetal hypothalamic-pituitary-adrenal axis and providing the stimulus for parturition. The failure of rising cortisol to suppress plasma ACTH may be due to altered sensitivity of glucocorti...

journal_title：Endocrinology

authors： Yang K,Jones SA,Challis JR

更新日期：1990-01-01 00:00:00

abstract：:The effects of LH on glucose metabolism within cumulus cell-enclosed bovine oocytes were determined. Cumulus cell-enclosed bovine oocytes were matured in vitro (IVM) in control medium alone or supplemented with LH, FSH, or TSH, then individually assayed for the metabolism of D-[5-3H]glucose, D-[1-14C]glucose, D-[6-14C...

journal_title：Endocrinology

authors： Zuelke KA,Brackett BG

更新日期：1992-12-01 00:00:00

abstract：:This study provides the first demonstration that human hepatocarcinoma-derived cell line HepG2 contains GnRH receptors and responds to various molecular forms of GnRH in terms of inhibition of proliferation in a time- and dose-related manner. In addition, GnRH peptides also significantly inhibited the uptake of [3H]th...

journal_title：Endocrinology

authors： Pati D,Habibi HR

更新日期：1995-01-01 00:00:00

abstract：:Several studies have revealed a variety of interactions between PTH and ACTH. The existence of a significant area of homology in the bioactive regions of the two molecules has been proposed as a possible reason for such interactions. To clarify the relationship, corticosteroidogenic and cAMP accumulative effects of bo...

journal_title：Endocrinology

authors： Rafferty B,Zanelli JM,Rosenblatt M,Schulster D

更新日期：1983-09-01 00:00:00

abstract：:Cultured astroglial cells were found to contain a type II 5'-deiodinase (5'D) activity which was increased by 10(-3) M (Bu)2cAMP but not by 2 X 10(-3) M n-butyrate. 8-Bromo-cAMP (8-Br-cAMP) (10(-3) M) also increased this enzyme activity. Cycloheximide (2 micrograms/ml) inhibited the 8-Br-cAMP effect on 5'D activity. F...

journal_title：Endocrinology

authors： Courtin F,Chantoux F,Pierre M,Francon J

更新日期：1988-09-01 00:00:00

abstract：:This study uses a high purity cell culture system to extend previous observations of factors controlling the end of the Sertoli cell proliferative phase. Thyroid hormone, retinoic acid, and testosterone were assessed for their ability to halt the proliferative phase and regulate the expression of markers associated wi...

journal_title：Endocrinology

authors： Buzzard JJ,Wreford NG,Morrison JR

更新日期：2003-09-01 00:00:00

abstract：:Recently, heterogeneity of POMC mRNA content between intermediate lobe melanotropes of the rat pituitary gland was demonstrated by in situ hybridization of tissue sections. In the present study the heterogeneity of POMC mRNA content in dispersed rat pituitary cells has been investigated. Acutely dispersed cells from a...

journal_title：Endocrinology

authors： Hatfield JM,Daikh DI,Adelman JP,Douglass J,Bond CT,Allen RG

更新日期：1989-03-01 00:00:00

abstract：:Pulsatile release of GnRH-1 is critical to stimulate gonadotropes of the anterior pituitary. This secretory pattern seems to be inherent to GnRH-1 neurons, however, the mechanisms underlying such episodical release remain unknown. In monkey nasal explants, the GnRH-1 population exhibits synchronized calcium events wit...

journal_title：Endocrinology

authors： Constantin S,Caraty A,Wray S,Duittoz AH

更新日期：2009-07-01 00:00:00

abstract：:To investigate the cellular mechanisms underlying the unique GH secretory apparatus of the androgen-resistant testicular feminized (Tfm) rat we employed a reverse hemolytic plaque assay to assess GH secretion by individual cells from normal male, normal female, and Tfm rats. Acutely dispersed pituitary cells were incu...

journal_title：Endocrinology

authors： Martha PM Jr,Krieg RJ Jr,Batson JM,Rogol AD,Evans WS

更新日期：1989-03-01 00:00:00

abstract：:Although acute leptin administration in the hypothalamus decreases food intake and increases peripheral energy metabolism, the peripheral actions of central chronic leptin administration are less understood. In this study, we investigated what effects chronic (7 d) intracerebroventricular (ICV) administration of lepti...

journal_title：Endocrinology

authors： Keung W,Palaniyappan A,Lopaschuk GD

更新日期：2011-11-01 00:00:00

abstract：:Mesenchymal stem cells can differentiate into mature chondrocytes, osteoblasts, and adipocytes. Excessive and dysfunctional visceral adipocytes increase upon menopause and importantly contribute to altered metabolism in postmenopausal women. We previously showed both plasma membrane and nuclear estrogen receptors alph...

journal_title：Endocrinology

authors： Ahluwalia A,Hoa N,Ge L,Blumberg B,Levin ER

更新日期：2020-11-01 00:00:00

abstract：:Three distinct receptor types for natriuretic peptides (NP) have been identified in human tissue. "A" and "B" receptors initiate biological actions, whereas the "C" receptor has a clearance function. It has been proposed that the natural ligand for the B receptor is c-type natriuretic peptide (CNP), rather than atrial...

journal_title：Endocrinology

authors： Canaan-Kühl S,Jamison RL,Myers BD,Pratt RE

更新日期：1992-01-01 00:00:00

abstract：:Hepatic synthesis of alpha 2u-globulin and its mRNA in the male rat is dependent on androgen, glucocorticoid, T4, insulin, and GH. Some of these hormones may act directly on the liver, while others may influence alpha 2u-globulin synthesis through indirect physiological changes. In the present study the specific role ...

journal_title：Endocrinology

authors： Murty CV,Rao KV,Roy AK

更新日期：1987-11-01 00:00:00

abstract：:As part of an ongoing investigation of the role of metabolic activation of estrogens in the genesis of cancers such as estrogen-induced renal tumors in hamsters, we have 1) determined steroid-17 beta-oxidoreductase activity of microsomes and cytosol prepared from hamster kidney and liver; 2) compared the rates of 2-, ...

journal_title：Endocrinology

authors： Zhu BT,Bui QD,Weisz J,Liehr JG

更新日期：1994-11-01 00:00:00

abstract：:Rabbit hearts perfused by the Langendorff technique were studied. The addition of ovine prolactin (NIH-P-S-10) to the perfusate in a concentration of 50 ng/ml produced rapid increases in both the amplitude and rate of contraction in 33 adult male hearts studied in winter. Prepubertal male animals showed no response, a...

journal_title：Endocrinology

authors： Nassar BA,Horrobin DF,Tynan M,Manku MS,Davies PA

更新日期：1975-10-01 00:00:00

abstract：:We recently reported that fetal sheep corticotrophs (ACTH-producing cells) at 108 +/- 5 d (days) of gestation are relatively more responsive to CRH than to AVP, whereas those at 139 +/- 0 d (term = 145 d) and in the adult are more responsive to AVP. To further characterize these developmental changes, we used immunocy...

journal_title：Endocrinology

authors： Perez FM,Schwartz J,Rose JC

更新日期：1997-03-01 00:00:00

abstract：:Endotoxin has been shown to stimulate GH secretion in human and sheep. However, changes in hypothalamic neurohormones involved in the GH regulation by endotoxin have never been studied in vivo. In sheep it is possible to collect hypophysial portal blood (HPB) and quantify GH-releasing hormone (GHRH) and somatostatin (...

journal_title：Endocrinology

authors： Briard N,Guillaume V,Frachebois C,Rico-Gomez M,Sauze N,Oliver C,Dutour A

更新日期：1998-06-01 00:00:00

abstract：:Neurotensin (NT) and Neuromedin N (NN) are two biologically active peptides present in one copy each in the C-terminal region of a 169-residue precursor. Four basic Lys-Arg doublets occur within the precursor and represent putative processing sites. We investigated the effects of dexamethasone on the biosynthesis and ...

journal_title：Endocrinology

authors： de Nadai F,Rovere C,Bidard JN,Laur J,Martinez J,Cuber JC,Kitabgi P

更新日期：1993-04-01 00:00:00

abstract：:In order to study whether changes in adenohypophysial dopamine are only related to PRL release or also to the variation of LH or FSH, dopamine (DA) in the pars distalis was measured during the estrous cycle and after castration of both male and female rats. Catecholamines were assayed using a highly sensitive radioenz...

journal_title：Endocrinology

authors： Chiocchio SR,Chafuen S,Tramezzani JH

更新日期：1980-06-01 00:00:00

abstract：:Stress-responsive neurons of the hypothalamic paraventricular nucleus (PVN) show functional plasticity and adapt to repeated restraint (RR) stress. To investigate whether neuronal adaptation to the homotypic stress also affects their response to a heterotypic stressor, we used in situ hybridization with intronic and e...

journal_title：Endocrinology

authors： Ma XM,Lightman SL,Aguilera G

更新日期：1999-08-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide (PACAP) is expressed at a high level in the fetal pituitary and decreases profoundly between embryonic day 19 and postnatal day 1 (PN1), with a further decrease from PN1 to PN4. In this series of experiments, we investigated the hypothesis that dopamine 2 receptor (Dr...

journal_title：Endocrinology

authors： Winters SJ,Ghooray DT,Yang RQ,Holmes JB,O'Brien AR,Morgan J,Moore JP Jr

更新日期：2014-07-01 00:00:00

abstract：:The ABCB1-type multidrug resistance efflux transporter P-glycoprotein (P-gp) has been hypothesized to regulate hypothalamic-pituitary-adrenal axis activity by limiting the access of glucocorticoids to the brain. In vivo systemic administration studies using P-gp-deficient mice have shown increased glucocorticoid entry...

journal_title：Endocrinology

authors： Mason BL,Pariante CM,Thomas SA

更新日期：2008-10-01 00:00:00

abstract：:Isolated renal cortical slices were used to study the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and 24,25-dihydroxyvitamin D3 [24,25](OH2)D3] by the rat kidney. Production of 1,25-(OH)2D3 and 24,25-(OH)2D3 was linear with time (30-90 min) and tissue weight (40-250 mg). Production of...

journal_title：Endocrinology

authors： Armbrecht HJ,Zenser TV,Davis BB

更新日期：1981-07-01 00:00:00

abstract：:The initial steps involved in mediating the transduction of PTH signal via its G protein-coupled receptors are well understood and occur through the activation of cAMP and phospholipase C pathways. However, the cellular and molecular mechanisms for subsequent receptor desensitization are less well understood. Recently...

journal_title：Endocrinology

authors： Miles RR,Sluka JP,Santerre RF,Hale LV,Bloem L,Boguslawski G,Thirunavukkarasu K,Hock JM,Onyia JE

更新日期：2000-01-01 00:00:00

abstract：:To assess a possible regulatory influence of opioids upon anterior pituitary function in the chimpanzee, we evaluated the effects of the specific opiate receptor antagonist naloxone and the agonistic enkephalin analog [D-Ala2, MePhe4,Met(o)-ol]enkephalin (FK 33-824; Sandoz) on serum levels of PRL, cortisol, FSH, and L...

journal_title：Endocrinology

authors： Gosselin RE,Blankstein J,Dent DW,Hobson WC,Fuller GB,Reyes FI,Winter JS,Faiman C

更新日期：1983-06-01 00:00:00