Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis.

abstract：:Male Siberian hamsters undergo physiological weight change in changing photoperiod. Weight loss was induced by food restriction in long days to mimic short-day weight loss, or by food restriction superimposed on short-day weight loss, to test the hypothesis that the hypothalamus differentiates between weight change in...

journal_title：Endocrinology

authors： Mercer JG,Moar KM,Logie TJ,Findlay PA,Adam CL,Morgan PJ

更新日期：2001-10-01 00:00:00

abstract：:To investigate GH's role in diabetic end organ damage, experimental diabetes was induced with streptozotocin (STZ) in bovine GH (bGH) or bGH antagonist transgenic mice and in their nontransgenic (NTG) litter mates. Body growth, blood glucose, serum insulin-like growth factor-I levels, liver GH receptor (GHR) binding, ...

journal_title：Endocrinology

authors： Chen NY,Chen WY,Bellush L,Yang CW,Striker LJ,Striker GE,Kopchick JJ

更新日期：1995-02-01 00:00:00

abstract：:Magnocellular hypothalamic neurons in the rat supraoptic nucleus (SON) normally produce either vasopressin (VP) or oxytocin (OT). Here we demonstrate that many magnocellular neurons in the SON of lactating rats synthesize both hormones at the same time. We show the colocalization of the messenger (m) RNA that encodes ...

journal_title：Endocrinology

authors： Mezey E,Kiss JZ

更新日期：1991-10-01 00:00:00

abstract：:Fibrosis (extracellular matrix accumulation) is the final end point in diabetic cardiomyopathy. The current study evaluated the therapeutic effects of the antifibrotic hormone relaxin (RLX) in streptozotocin-treated transgenic mRen-2 rats, which undergo pathological and functional features similar to human diabetes. T...

journal_title：Endocrinology

authors： Samuel CS,Hewitson TD,Zhang Y,Kelly DJ

更新日期：2008-07-01 00:00:00

abstract：:To examine diurnal differences in the proportions of receptors that were occupied and activated by basal and stress levels of corticosterone, we measured available type I (mineralocorticoid) and type II (glucocorticoid) adrenal steroid receptor levels in brain, pituitary, and immune tissues of unstressed and acutely s...

journal_title：Endocrinology

authors： Spencer RL,Miller AH,Moday H,Stein M,McEwen BS

更新日期：1993-11-01 00:00:00

abstract：:Term pregnancy human placenta contains hCG/LH receptor mRNA transcripts and immunoreactive receptor protein. Both the receptor transcripts and receptor proteins are present only in trophoblasts. These findings led us to investigate whether hCG can regulate its own synthesis in term pregnancy human placenta. Treatment ...

journal_title：Endocrinology

authors： Licht P,Cao H,Lei ZM,Rao CV,Merz WE

更新日期：1993-12-01 00:00:00

abstract：:The concentration-activity profiles for insulin and insulin-like growth factor I (IGF-I; in the presence of and insulin-like growth factor I (IGF-I; in the presence of hydrocortisone and PRL) have been compared in terms of the accumulation of beta-casein mRNA, total casein synthesis, and alpha-lactalbumin and basal ca...

journal_title：Endocrinology

authors： Prosser CG,Sankaran L,Hennighausen L,Topper YJ

更新日期：1987-04-01 00:00:00

abstract：:Enhanced epinephrine secretion from adrenal chromaffin cells (ACCs) is an important homeostatic response to severe systemic inflammation during sepsis. Evidence suggests that increased activation of ACCs by preganglionic sympathetic neurons and direct alterations in ACC function contribute to this response. However, t...

journal_title：Endocrinology

authors： Lukewich MK,Lomax AE

更新日期：2014-01-01 00:00:00

abstract：:To investigate further brain-pituitary-gonadal interrelationships we have generated mice in which the gene encoding the FSH receptor has been disrupted. Female FSH receptor knockout (FSHRKO) mice were infertile. The ovaries were significantly reduced in size, with follicular development arrested at the preantral stage...

journal_title：Endocrinology

authors： Abel MH,Wootton AN,Wilkins V,Huhtaniemi I,Knight PG,Charlton HM

更新日期：2000-05-01 00:00:00

abstract：:The actions of IGF-I and IGF-II are thought to be largely due to their activation of the IGF-I receptor. However, IGF-II can also bind with high affinity to, and effectively activate, an isoform of the insulin receptor (IR-A) that lacks a sequence at the carboxyl-terminal end of the extracellular alpha subunit due to ...

journal_title：Endocrinology

authors： Denley A,Brierley GV,Carroll JM,Lindenberg A,Booker GW,Cosgrove LJ,Wallace JC,Forbes BE,Roberts CT Jr

更新日期：2006-02-01 00:00:00

abstract：:To examine the molecular genetic basis for the age-related increase in PRL secretion and decrease in LH production in the rat, we measured steady state levels of PRL and LH beta mRNA in pituitary homogenates and cell lysates from monolayer adenohypophyseal cultures. These mRNA levels were compared with the correspondi...

journal_title：Endocrinology

authors： Stewart DA,Blackman MR,Kowatch MA,Danner DB,Roth GS

更新日期：1990-02-01 00:00:00

abstract：:Although kisspeptin is the primary stimulator of gonadotropin-releasing hormone secretion and therefore the hypothalamic-pituitary-gonadal axis, recent findings suggest kisspeptin can also regulate additional neuroendocrine processes including release of growth hormone (GH). Here we show that central delivery of kissp...

journal_title：Endocrinology

authors： Foradori CD,Whitlock BK,Daniel JA,Zimmerman AD,Jones MA,Read CC,Steele BP,Smith JT,Clarke IJ,Elsasser TH,Keisler DH,Sartin JL

更新日期：2017-10-01 00:00:00

abstract：:Intermittent PTH administration increases bone turnover, resulting in net anabolic effects on bone. These effects are primarily mediated by intracellular cAMP signaling. However, the molecular mechanisms that regulate PTH activity in bone remain incompletely understood. beta-Arrestin2, a G protein-coupled receptor reg...

journal_title：Endocrinology

authors： Ferrari SL,Pierroz DD,Glatt V,Goddard DS,Bianchi EN,Lin FT,Manen D,Bouxsein ML

更新日期：2005-04-01 00:00:00

abstract：:Human osteoblast-like cells (HOB) produce vascular endothelial growth factor (VEGF), the steady state level of which is stimulated by 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. As osteoblasts and endothelial cells are proximally located in skeletal tissue, we investigated the anabolic effects of 1,25-(OH)2D3 and VEGF on...

journal_title：Endocrinology

authors： Wang DS,Miura M,Demura H,Sato K

更新日期：1997-07-01 00:00:00

abstract：:Thyroid hormones are essential for normal development and metabolism. Their synthesis requires transport of iodide into thyroid follicles. The mechanisms involving the apical efflux of iodide into the follicular lumen are poorly elucidated. The discovery of mutations in the SLC26A4 gene in patients with Pendred syndro...

journal_title：Endocrinology

authors： Pesce L,Bizhanova A,Caraballo JC,Westphal W,Butti ML,Comellas A,Kopp P

更新日期：2012-01-01 00:00:00

abstract：:The roles of alpha- and beta-subunits of human TSH (hTSH) were studied by investigating the inhibitory effects of monoclonal antibodies on the biological activity of hTSH. Four monoclonal antibodies directed toward different epitopes on the beta-subunit (hTSH beta) inhibited completely the receptor binding of hTSH to ...

journal_title：Endocrinology

authors： Endo Y,Tetsumoto T,Nagasaki H,Kashiwai T,Tamaki H,Amino N,Miyai K

更新日期：1990-07-01 00:00:00

abstract：:A serum-free, hormone- and factor-supplemented, defined medium was developed which maintains functional activity of primary cultures of adult islet cells and continuous islet cell lines. Medium supplements examined included proteose peptone (PP), transferrin (TrFe), insulin-like growth factor-I (IGF-I), an insulinotro...

journal_title：Endocrinology

authors： Clark SA,Chick WL

更新日期：1990-04-01 00:00:00

abstract：:Endothelin (ET) and GnRH act through specific receptors to promote Ca2+ mobilization and influx pathways in pituitary gonadotrophs. In the present study cytoplasmic calcium ([Ca2+]i) and secretory responses to these two agonists are compared. In single gonadotrophs, low concentrations of both agonists cause oscillator...

journal_title：Endocrinology

authors： Stojilković SS,Iida T,Cesnjaj M,Catt KJ

更新日期：1992-12-01 00:00:00

abstract：:Somatostatin was infused via the portal vein at a rate of 50 ng/min in a group of eight conscious dogs beginning 30 min before and continuing for 6 h after the ingestion of an 800-g fat-protein meal. The fasting and postprandial levels of plasma somatostatin-like immunoreactivity (SLI), insulin, glucagon, and triglyce...

journal_title：Endocrinology

authors： Schusdziarra V,Harris V,Arimura A,Unger RH

更新日期：1979-06-01 00:00:00

abstract：:Male Sprague-Dawley rats were infused continuously for 13 days with vehicle or 75 pmol (31.2 ng)/day 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] by means of Alzet osmotic minipumps implanted s.c. Animals infused with 1,25-(OH)2D3 exhibited mild hypercalcemia (11.2 vs. 10.2 mg/dl in controls), a 136% increase in the serum ...

journal_title：Endocrinology

authors： Wronski TJ,Halloran BP,Bikle DD,Globus RK,Morey-Holton ER

更新日期：1986-12-01 00:00:00

abstract：:Osteoclast precursors reach sites of osteoclast formation and remodelling via the vasculature and are therefore destined to encounter endothelium before migrating to the bone surface. Here we investigated the hypothesis that endothelium may be involved in the regulation of osteoclast precursor recruitment to sites of ...

journal_title：Endocrinology

authors： McGowan NW,Walker EJ,Macpherson H,Ralston SH,Helfrich MH

更新日期：2001-04-01 00:00:00

abstract：:Graves' hyperthyroidism is an organ-specific autoimmune disease mediated by stimulatory autoantibodies against the TSH receptor (TSHR; thyroid-stimulating antibodies), causing thyroid hyperplasia and hyperthyroidism. Development of this ailment is well known to be under polygenic and environmental control. For example...

journal_title：Endocrinology

authors： Nagayama Y,McLachlan SM,Rapoport B,Oishi K

更新日期：2004-11-01 00:00:00

abstract：:Important enzymes for thyroid hormone metabolism, antioxidative defense, and intracellular redox control contain selenocysteine (Sec) in their active centers. Expression of these selenoproteins is tightly controlled, and a sex-specific phenotype is observed on disturbance of selenium (Se) transport in mice. Therefore,...

journal_title：Endocrinology

authors： Riese C,Michaelis M,Mentrup B,Götz F,Köhrle J,Schweizer U,Schomburg L

更新日期：2006-12-01 00:00:00

abstract：:The gene encoding the human TNF alpha receptor (TNFR) 2 contains polymorphisms in the 3' untranslated region (UTR). Previous studies have shown that some variant alleles in this region are associated with obesity and insulin resistance. However, the effect of these polymorphisms on the expression of TNFR2 has not been...

journal_title：Endocrinology

authors： Puga I,Lainez B,Fernández-Real JM,Buxadé M,Broch M,Vendrell J,Espel E

更新日期：2005-05-01 00:00:00

abstract：:In the ewe, photoperiod modulates LH and PRL secretion as well as median eminence (ME) dopaminergic activity. The studies reported here were designed to characterize the functional significance of this photoperiodic modulation of ME dopaminergic neuron activity in relation to the regulation of LH and PRL secretion. Th...

journal_title：Endocrinology

authors： Viguié C,Thibault J,Thiéry JC,Tillet Y,Malpaux B

更新日期：1997-01-01 00:00:00

abstract：:Impairments in the estradiol (E2)-induced surge of LH occur as aging female rodents lose reproductive cycles. These and other impairments can be substantially attenuated by ovariectomy of the young adult. In female rats, plasma PRL tends to increase with age, whereas in male rats, GH tends to decrease; PRL is regulate...

journal_title：Endocrinology

authors： Mobbs CV,Cheyney D,Sinha YN,Finch CE

更新日期：1985-02-01 00:00:00

abstract：:Agouti-related protein (AGRP) is a homologue of the agouti gene product and, when overexpressed, promotes obesity. Like neuropeptide Y (NPY) messenger RNA (mRNA), AGRP mRNA is produced in the hypothalamic arcuate nucleus and is elevated in leptin-deficient ob/ob and leptin-resistant db/db mice. These data suggest that...

journal_title：Endocrinology

authors： Mizuno TM,Mobbs CV

更新日期：1999-02-01 00:00:00

abstract：:In contrast to other systems in which angiotensin-II (AII) inhibits adenylyl cyclase, in fetal skin fibroblasts the peptide stimulates cAMP accumulation. The mechanism of this novel effect was studied by analysis of the actions of AII and other regulators on the adenylyl cyclase system in cultured cells. In the presen...

journal_title：Endocrinology

authors： Johnson MC,Aguilera G

更新日期：1992-11-01 00:00:00

abstract：:We previously described significant differences in maximal testosterone production by Leydig cells from the following strains of inbred mice: C57BL/10J, C57BL/6J, DBA/2J, and C3H/HeJ. To evaluate whether these differences in maximal testosterone production related to the activities of the steroidogenic enzymes of the ...

journal_title：Endocrinology

authors： Stalvey JR,Payne AH

更新日期：1984-10-01 00:00:00

abstract：:Calcium (Ca2+) ionophore A23187 increased the intracellular cAMP content and PRL release in normal rat anterior pituitary cells. Cotreatment with dopamine reduced both control and A23187-stimulated cAMP accumulation and PRL release. The dopamine antagonist spiperone restored the response of cAMP to ionophoric stimulat...

journal_title：Endocrinology

authors： Schettini G,Cronin MJ,MacLeod RM

更新日期：1983-05-01 00:00:00