Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy.

abstract：:In temperate zones, animals restrict breeding to specific seasons to maximize the survival of their offspring. Birds have evolved highly sophisticated mechanisms of seasonal regulation, and their testicular mass can change 100-fold within a few weeks. Recent studies on Japanese quail revealed that seasonal gonadal dev...

journal_title：Endocrinology

authors： Ikegami K,Atsumi Y,Yorinaga E,Ono H,Murayama I,Nakane Y,Ota W,Arai N,Tega A,Iigo M,Darras VM,Tsutsui K,Hayashi Y,Yoshida S,Yoshimura T

更新日期：2015-02-01 00:00:00

abstract：:The time sequence of the metabolism of [4-14C] pregnenolone to testosterone in homogenates of human and rat testis was studied with special emphasis on the chain of events in the early 15 min of incubation. The incubations were performed at 32 C in the presence of NAD and a NADPH-generating system. The various interme...

journal_title：Endocrinology

authors： Weusten JJ,Smals AG,Hofman JA,Kloppenborg PW,Benraad TJ

更新日期：1987-05-01 00:00:00

abstract：:The effects of estrogen on the synthesis of pituitary PRL mRNA and PRL and the release of PRL into plasma were investigated in male and female normal and hypogonadal (hpg) mice. Because the hpg mouse is totally deficient in hypothalamic GnRH, it provides an excellent model for investigating the effects of estrogen and...

journal_title：Endocrinology

authors： Stanley HF,Curtis A,Sheward WJ,Roberts JL,Fink G

更新日期：1986-12-01 00:00:00

abstract：:The present studies were designed to evaluate the binding characteristics of arginine vasopressin (AVP), using rat anterior pituitary dispersed cells, in correlation with the biological activity of the peptide. Synthetic AVP released ACTH from dispersed anterior pituitary cells in a concentration-dependent fashion, wi...

journal_title：Endocrinology

authors： Spinedi E,Negro-Vilar A

更新日期：1984-06-01 00:00:00

abstract：:Daily administration of an inhibitor of 5 alpha-reductase, 17 beta-testosterone carboxylic acid, significantly attenuated the stimulatory effect of testosterone propionate on penile erections displayed by castrated male rats which were restrained in a supine position. This treatment, however, failed to affect mating b...

journal_title：Endocrinology

authors： Bradshaw WG,Baum MJ,Awh CC

更新日期：1981-10-01 00:00:00

abstract：:GH is known to increase the formation of bone and hard tissues of the tooth (dentine, cementum, and enamel), as do bone morphogenetic proteins. GH receptors are expressed in these tissues and could mediate local growth responses. Here we report that both GH and insulin-like growth factor I (IGF-I) are able to increase...

journal_title：Endocrinology

authors： Li H,Bartold PM,Zhang CZ,Clarkson RW,Young WG,Waters MJ

更新日期：1998-09-01 00:00:00

abstract：:The importance of monoaminergic mechanisms for the regulation of GH-releasing factor (GRF)-stimulated GH secretion was studied in perifused rat anterior pituitaries. Dopamine (greater than 1 microL) reduced GRF-stimulated GH release, but 5-hydroxytryptamine (5-HT; 1 mL) had no effect. The substrates for L-aromatic ami...

journal_title：Endocrinology

authors： Lindström P,Ohlsson L

更新日期：1987-02-01 00:00:00

abstract：:Photoaffinity labeling with underivatized T3 was used to identify T3-binding proteins in the membrane of rat erythrocytes. UV irradiation of ghosts and peripheral protein-depleted membranes in the presence of [125I]T3 resulted in the covalent attachment of 125I to membrane proteins (analyzed by polyacrylamide gel elec...

journal_title：Endocrinology

authors： Samson M,Osty J,Blondeau JP

更新日期：1993-06-01 00:00:00

abstract：:Mouse kidney and urinary glycosphingolipids from developing C57BL/6J and adults of several other inbred strains were analyzed by high performance liquid chromatographic techniques. Glycosphingolipids from male and female C57BL/6J kidneys were similar until the fifth week of age. Galactosylceramide containing nonhydrox...

journal_title：Endocrinology

authors： McCluer RH,Deutsch CK,Gross SK

更新日期：1983-07-01 00:00:00

abstract：:Pancreatic beta-cells and HIT-T15 cells exhibit oscillations of cytosolic calcium ([Ca2+]i) that are dependent on glucose metabolism and appear to trigger pulsatile insulin secretion. Significantly, differences in the pattern of this [Ca2+]i oscillatory activity may have important implications for our understanding of...

journal_title：Endocrinology

authors： Leech CA,Holz GG 4th,Habener JF

更新日期：1994-07-01 00:00:00

abstract：:Neuropeptide Y (NPY) is a powerful orexigenic factor, and alphaMSH is a melanocortin (MC) peptide that induces satiety by activating the MC4 receptor subtype. Genetic models with disruption of MC4 receptor signaling are associated with obesity. In the present study, a 7-day intracerebroventricular infusion to male rat...

journal_title：Endocrinology

authors： Raposinho PD,Castillo E,d'Alleves V,Broqua P,Pralong FP,Aubert ML

更新日期：2000-12-01 00:00:00

abstract：:Peptide-YY (PYY) is a novel enteric peptide that is structurally related to pancreatic polypeptide and neuropeptide-Y. The objectives of the present experiments were to characterize the following aspects of PYY metabolism: the distribution of PYY in the canine gastrointestinal tract, the release of PYY in response to ...

journal_title：Endocrinology

authors： Greeley GH Jr,Jeng YJ,Gomez G,Hashimoto T,Hill FL,Kern K,Kurosky T,Chuo HF,Thompson JC

更新日期：1989-03-01 00:00:00

abstract：:The aim of this study was to determine whether bisphenol A (BPA) has adverse effects on cardiovascular functions in CD-1 mice and define sex-specific modes of BPA action in the heart. Dams and analyzed progeny were maintained on a defined diet containing BPA (0.03, 0.3, 3, 30, or 300 ppm) that resulted in BPA exposure...

journal_title：Endocrinology

authors： Belcher SM,Gear RB,Kendig EL

更新日期：2015-03-01 00:00:00

abstract：:Type 1 transforming growth factor-beta (TGF beta 1) was found to be a potent inducer of the secretion of a 49,000 mol wt protein by normal rat kidney (NRK) cells. This protein was related to type 1 plasminogen activator inhibitor (PAI-1) on the basis of molecular mass, activity in the presence of sodium dodecyl sulfat...

journal_title：Endocrinology

authors： Newman MJ,Lane EA,Iannotti AM,Nugent MA,Pepinsky RB,Keski-Oja J

更新日期：1990-06-01 00:00:00

abstract：:LH supplementation in assisted reproductive technology cycles improves the ongoing pregnancy rate in women with poor ovarian response (POR). However, our knowledge of the precise role of LH during the follicular phase of the menstrual cycle is incomplete. To explore the role of LH in the maturation of small antral fol...

journal_title：Endocrinology

authors： Hattori K,Orisaka M,Fukuda S,Tajima K,Yamazaki Y,Mizutani T,Yoshida Y

更新日期：2018-06-01 00:00:00

abstract：:Insulin-like growth factors (IGFs), when isolated from serum or tissue fluids, are usually found as part of a protein complex which also contains one of several IGF binding proteins (IGFBPs). Although some IGFBPs have been shown to alter interactions of IGFs with their receptors in vitro and can modify the responses o...

journal_title：Endocrinology

authors： Green BN,Jones SB,Streck RD,Wood TL,Rotwein P,Pintar JE

更新日期：1994-02-01 00:00:00

abstract：:Oxytocin receptor (OTR) expression in human myometrium increases over 150-fold from the beginning of pregnancy to the end. In the present studies, we examined potential mechanisms of OTR up-regulation, using myometrial cells in primary culture from women in late gestation. OTR ligand-binding sites and steady-state mRN...

journal_title：Endocrinology

authors： Jeng YJ,Soloff SL,Anderson GD,Soloff MS

更新日期：2003-01-01 00:00:00

abstract：:The mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily of transcription factors, is activated by aldosterone and mediates its natriferic action in tight epithelia. MR is also expressed in nonepithelial tissues. Importantly, it mediates the deleterious effects of inappropriately high aldoster...

journal_title：Endocrinology

authors： Aguilar-Sánchez C,Hernández-Díaz I,Lorenzo-Díaz F,Navarro JF,Hughes TE,Giraldez T,Alvarez de la Rosa D

更新日期：2012-07-01 00:00:00

abstract：:Cannabinoids (CBs) exert untoward effects on reproduction by reducing LH secretion and suppressing gonadal function. Recent evidence suggests these effects are due primarily to hypothalamic dysfunction; however, the mechanism is obscure. Using immortalized hypothalamic GnRH neurons, we find these cells produce and sec...

journal_title：Endocrinology

authors： Gammon CM,Freeman GM Jr,Xie W,Petersen SL,Wetsel WC

更新日期：2005-10-01 00:00:00

abstract：:Nicotine is a potent stimulus for the secretion of ACTH, and norepinephrinergic neurons originating in the brainstem are involved. Prior reports using in vivo microdialysis in alert rats have shown that nicotine, administered i.p. or into the fourth ventricle, stimulated the release of norepinephrine (NE) into the hyp...

journal_title：Endocrinology

authors： Fu Y,Matta SG,Valentine JD,Sharp BM

更新日期：1997-05-01 00:00:00

abstract：:Acute nephrectomy seriously impairs hypovolemic adrenal epinephrine (E) release in the anesthetized dog. That systemically delivered angiotensin II totally restores E release to acutely anephric dogs is equally clear, but the dose-response relationship of this angiotensin II effect is not known. Adrenal secretion rate...

journal_title：Endocrinology

authors： Badder EM,Duarte B,Seaton JF,Hamaji M,Harrison TS

更新日期：1985-11-01 00:00:00

abstract：:Pituitary homeobox 1 (Ptx1) is a homeodomain-containing transcription factor acting on transcription of all pituitary hormone genes. Its expression is first detected in the stomodeal ectoderm and is maintained in all derivatives of this structure, including Rathke's pouch. We now show that Ptx1 is expressed in all pit...

journal_title：Endocrinology

authors： Lanctôt C,Gauthier Y,Drouin J

更新日期：1999-03-01 00:00:00

abstract：:The enhancement of metabolic rate by thyroid hormone in target tissues is accompanied by increased glucose utilization, which in skeletal muscle and many other tissues is regulated at the level of membrane transport. To elucidate the role of thyroid hormone as a regulator of glucose transport in skeletal muscle, we ha...

journal_title：Endocrinology

authors： Weinstein SP,Watts J,Haber RS

更新日期：1991-07-01 00:00:00

abstract：:Although prolactinomas can be effectively treated with dopamine agonists, about 20% of patients develop dopamine resistance or tumor recurrence after surgery, indicating a need for better understanding of underlying disease mechanisms. Although estrogen-induced rat prolactinomas have been widely used to investigate th...

journal_title：Endocrinology

authors： Tong Y,Zheng Y,Zhou J,Oyesiku NM,Koeffler HP,Melmed S

更新日期：2012-08-01 00:00:00

abstract：:Hypothyroid animals secrete not only more TSH, but also qualitatively different TSH, with altered oligosaccharides. To explore the cellular mechanism of oligosaccharide modulation by thyroid status, 40 mice were treated without or with propylthiouracil (PTU), and pituitaries were removed after 1, 2, 3, 4, and 6 weeks....

journal_title：Endocrinology

authors： Helton TE,Magner JA

更新日期：1994-11-01 00:00:00

abstract：:Adult rats which have received monosodium-L-glutamate (MSG, 4 mg/g BW) on alternate days for the first 10 days of life manifest central nervous system lesions largely restricted to the retina and the arcuate nucleus of the hypothalamus in which nearly 90% of the perikarya are destroyed, leaving axons in passage intact...

journal_title：Endocrinology

authors： Greeley GH Jr,Nicholson GF,Nemeroff CB,Youngblood WW,Kizer JS

更新日期：1978-07-01 00:00:00

abstract：:Chronically elevated circulating glucocorticoid levels are although to enhance vulnerability to psychopathology. Here we hypothesized that such sustained glucocorticoid levels, disturbing corticosterone pulsatility, attenuate glucocorticoid receptor signaling and target gene responsiveness to an acute challenge in the...

journal_title：Endocrinology

authors： Sarabdjitsingh RA,Isenia S,Polman A,Mijalkovic J,Lachize S,Datson N,de Kloet ER,Meijer OC

更新日期：2010-03-01 00:00:00

abstract：:In preovulatory ovarian follicles, the oocyte is maintained in meiotic prophase arrest by natriuretic peptide precursor C (NPPC) and its receptor natriuretic peptide receptor 2 (NPR2). LH treatment results in the decrease of NPR2 guanylyl cyclase activity that promotes resumption of meiosis. We investigated the regula...

journal_title：Endocrinology

authors： Wang Y,Kong N,Li N,Hao X,Wei K,Xiang X,Xia G,Zhang M

更新日期：2013-09-01 00:00:00

abstract：:The present study was conducted to examine the effect of LH on phospholipid metabolism in corpora luteal tissue. Collagenase-dispersed cells obtained from bovine corpora lutea of early pregnancy were incubated with 32PO4 in the presence or absence of LH and examined for their ability to incorporate this label into pho...

journal_title：Endocrinology

authors： Davis JS,Farese RV,Marsh JM

更新日期：1981-08-01 00:00:00

abstract：:Anterior pituitary cells from adult male rats were cultured on a natural extracellular matrix (ECM). From the 5th day, spindle-shaped cells, fusing to form elongated fibers, were observed among the epithelial cells. These fibers later increased in size and number and were identified as striated muscle fibers, based on...

journal_title：Endocrinology

authors： Spira O,Atzmon R,Rahamim E,Bar-Shavit R,Gross J,Gordon A,Vlodavsky I

更新日期：1988-06-01 00:00:00