Abstract:
:Removal of the 18-hydroxy group of the hemiacetal form of aldosterone transforms its activity from that of pure agonist to predominant antagonist. The 18-deoxy derivative possesses one third of the binding affinity of aldosterone for the cytoplasmic mineralocorticoid receptor of rat kidney and exhibits an approximate 2:1 antagonist to agonist ratio in both toad bladder and adrenalectomized rat bioassay systems. The promising properties of the 11 beta,18-oxidopregnane tested included very low androgen receptor affinity and approximately equal effectiveness in vitro and in vivo in displacing aldosterone from mineralocorticoid-binding sites in the rat.
journal_name
Endocrinologyjournal_title
Endocrinologyauthors
Ulick S,Marver D,Adam WR,Funder JWdoi
10.1210/endo-104-5-1352subject
Has Abstractpub_date
1979-05-01 00:00:00pages
1352-6issue
5eissn
0013-7227issn
1945-7170journal_volume
104pub_type
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