Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor.

abstract：:3 beta-Hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4-isomerase (3 beta HSD) is a NAD(+)-dependent membrane-bound enzyme that catalyzes the oxidation of delta 5-3 beta-hydroxysteroids to delta 4-3-keto structures during adrenal, gonadal, and placental steroidogenesis. Enzyme activity is located in both microsomes...

journal_title：Endocrinology

authors： Sauer LA,Chapman JC,Dauchy RT

更新日期：1994-02-01 00:00:00

abstract：:We used differential display PCR on two GnRH producing cell lines to identify genes involved in GnRH gene expression and neuronal migration. RNA from Gn10 cells (derived from a tumor in the olfactory area when GnRH neurons are migrating and make low levels of GnRH) and from GT1-7 cells (derived from a tumor in forebra...

journal_title：Endocrinology

authors： Fang Z,Xiong X,James A,Gordon DF,Wierman ME

更新日期：1998-08-01 00:00:00

abstract：:In this study, we investigated the transcriptional regulation of the adrenergic induction of type II iodothyronine deiodinase (Dio2) in rat pinealocytes. Treatment of pinealocytes with norepinephrine (NE) caused an increase in the mRNA level of Dio2 that peaked around 2 h and declined over the next 5 h. Both beta- and...

journal_title：Endocrinology

authors： Chik CL,Wloka MT,Price DM,Ho AK

更新日期：2007-07-01 00:00:00

abstract：:To date, the role of pancreatic hormones in pancreatic islet growth and differentiation is poorly understood. To address this issue, we examined mice with a disruption in the gene encoding prohormone convertase 2 (PC2). These mice are unable to process proglucagon, prosomatostatin, and other neuroendocrine precursors ...

journal_title：Endocrinology

authors： Vincent M,Guz Y,Rozenberg M,Webb G,Furuta M,Steiner D,Teitelman G

更新日期：2003-09-01 00:00:00

abstract：:3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished from endogenous T(4) ...

journal_title：Endocrinology

authors： Hackenmueller SA,Marchini M,Saba A,Zucchi R,Scanlan TS

更新日期：2012-11-01 00:00:00

abstract：:Two experiments tested whether serotonergic neurons participate in the acute feedback effects of estradiol on LH and PRL secretion. In the first study, ovariectomized female rats received oil vehicle or estradiol benzoate and were killed 3 h later. The turnover of serotonin [5-hydroxytryptamine (5-HT)] in microdissect...

journal_title：Endocrinology

authors： Johnson MD,Crowley WR

更新日期：1983-12-01 00:00:00

abstract：:The present study was undertaken to investigate the role of angiotensin II (Ang II) in ovulation and ovarian steroidogenesis and prostaglandin (PG) production via the Ang II receptors in rabbit ovaries. In in vitro perfused rabbit ovaries, PD123319, a selective nonpeptide antagonist for AT2 receptors, reduced the Ang ...

journal_title：Endocrinology

authors： Yoshimura Y,Karube M,Aoki H,Oda T,Koyama N,Nagai A,Akimoto Y,Hirano H,Nakamura Y

更新日期：1996-04-01 00:00:00

abstract：:The ability to respond to variations in nutritional status depends on regulatory systems that monitor nutrient intake and adaptively alter metabolism and feeding behavior during nutrient restriction. There is ample evidence that the restriction of water, sodium, or energy intake triggers adaptive responses that conser...

journal_title：Endocrinology

authors： Hill CM,Qualls-Creekmore E,Berthoud HR,Soto P,Yu S,McDougal DH,Münzberg H,Morrison CD

更新日期：2020-03-01 00:00:00

abstract：:C-type natriuretic peptide (CNP) is produced by the vascular smooth muscle cells (SMCs) of injured and atherosclerotic arteries, in which it may exert autocrine control over SMCs by binding to its principal receptors, NPR-B and NPR-C, but few studies have examined the factors that regulate CNP expression in human SMCs...

journal_title：Endocrinology

authors： Mendonça MC,Doi SQ,Glerum S,Sellitti DF

更新日期：2006-09-01 00:00:00

abstract：:Melanocortin receptor 4 (MCR4) and CB(1) cannabinoid receptors independently modulate food intake. Although an interaction between the cannabinoid and melanocortin systems has been found in recovery from hemorrhagic shock, the interaction between these systems in modulating food intake has not yet been examined. The p...

journal_title：Endocrinology

authors： Verty AN,McFarlane JR,McGregor IS,Mallet PE

更新日期：2004-07-01 00:00:00

abstract：:The pineal hormone melatonin regulates reproductive function in seasonally breeding mammals. Recent studies using 125I-labeled 2-iodomelatonin (I-MEL) reveal that the distribution of putative melatonin receptors is species-specific; only the hypophysial pars tuberalis (PT) is a consistent site of I-MEL binding in all ...

journal_title：Endocrinology

authors： Weaver DR,Reppert SM

更新日期：1990-11-01 00:00:00

abstract：:A detailed understanding of the mechanism of action of estrogen on bones is still lacking. The present study was designed to examine possible modulation by 17 beta-estradiol (E2) on the effects of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] and on vitamin D receptors (VDR) in the ROS 17/2.8 osteoblast-like cell line. Cell...

journal_title：Endocrinology

authors： Liel Y,Kraus S,Levy J,Shany S

更新日期：1992-05-01 00:00:00

abstract：:Tear fluid is known to contain many different hormones with relevance for ocular surface homeostasis. We studied the presence and functional role of insulin-like factor 3 (INSL3) and its cognate receptor RXFP2 (relaxin/insulin-like family peptide receptor 2) at the ocular surface and in tears. Expression of human INSL...

journal_title：Endocrinology

authors： Hampel U,Klonisch T,Sel S,Schulze U,Garreis F,Seitmann H,Zouboulis CC,Paulsen FP

更新日期：2013-06-01 00:00:00

abstract：:Flavonoids are functional constituents of many fruits and vegetables. Some flavonoids have antidiabetic properties because they improve altered glucose and oxidative metabolisms of diabetic states. Procyanidins are flavonoids with an oligomeric structure, and it has been shown that they can improve the pathological ox...

journal_title：Endocrinology

authors： Pinent M,Blay M,Bladé MC,Salvadó MJ,Arola L,Ardévol A

更新日期：2004-11-01 00:00:00

abstract：:Pharmacological studies have suggested that the somatostatin (SS) receptor is heterogeneous and may exhibit subtypes selective for SS-14 and SS-28. Whether this heterogeneity can be explained by separate molecular forms of the receptor protein is unclear. In the present study, we have developed a novel photosensitive ...

journal_title：Endocrinology

authors： Srikant CB,Murthy KK,Escher EE,Patel YC

更新日期：1992-05-01 00:00:00

abstract：:The distribution and density of selectively labeled mu-, delta-, and kappa-opioid binding sites were examined by in vitro radioautography in the hypothalamus of normal, estradiol valerate (EV)-injected, and estradiol (E2)-implanted female rats. Hypothalamic beta-endorphin concentration was also examined by RIA in thes...

journal_title：Endocrinology

authors： Desjardins GC,Beaudet A,Brawer JR

更新日期：1990-12-01 00:00:00

abstract：:As a metabolic sensor, the serine/threonine protein kinase AMP-activated protein kinase (AMPK) promotes the adaptation of cells to signals arising from nutrients, hormones, and growth factors. The ability of IGF-I to stimulate protein synthesis is suppressed by AMPK, therefore, these studies were undertaken to determi...

journal_title：Endocrinology

authors： Ning J,Xi G,Clemmons DR

更新日期：2011-08-01 00:00:00

abstract：:The mechanism by which the proto-oncogene, c-fos, is up-regulated in response to PGE2 in the mouse osteoblastic (MC3T3-E1) cell line was investigated using RT-PCR. c-fos messenger RNA up-regulation by dmPGE2 is rapid, starting 10 min post stimulation, and transient. The specific protein kinase A (PKA) inhibitor, H89, ...

journal_title：Endocrinology

authors： Fitzgerald J,Dietz TJ,Hughes-Fulford M

更新日期：2000-01-01 00:00:00

abstract：:A miniature thermoelectric probe was used to record continuously tissue blood flow in the anterior pituitary gland of anesthetized dogs. The output of the flow probe is linear in the range of tissue blood flow encountered in the pituitary. Probe placement required minimal tissue trauma, and zero blood flow was recorde...

journal_title：Endocrinology

authors： Kopaniky DR,Gann DS

更新日期：1975-09-01 00:00:00

abstract：:The importance of monoaminergic mechanisms for the regulation of GH-releasing factor (GRF)-stimulated GH secretion was studied in perifused rat anterior pituitaries. Dopamine (greater than 1 microL) reduced GRF-stimulated GH release, but 5-hydroxytryptamine (5-HT; 1 mL) had no effect. The substrates for L-aromatic ami...

journal_title：Endocrinology

authors： Lindström P,Ohlsson L

更新日期：1987-02-01 00:00:00

abstract：:Diets lacking soy and alpha-alpha derivatives that are considered to be estrogen-free by standard bioassays (uterotrophic assay and vaginal opening) have been revealed to contain considerable amounts of compounds able to transcriptionally activate the estrogen receptors (ERs) and stimulate luciferase expression in sev...

journal_title：Endocrinology

authors： Ciana P,Brena A,Sparaciari P,Bonetti E,Di Lorenzo D,Maggi A

更新日期：2005-12-01 00:00:00

abstract：:The maternal plasma concentrations of GH and PRL increase dramatically upon the initiation of lactation in the rat. In light of the fact that these two hormones have evolved from one common precursor, we sought to determine if the neuroendocrine mechanisms regulating their concomitant increase during lactation are com...

journal_title：Endocrinology

authors： Wehrenberg WB,Gaillard RC

更新日期：1989-01-01 00:00:00

abstract：:We recently reported that chronic 17β-estradiol (E2) treatment in mice decreases platelet responsiveness, prolongs the tail-bleeding time and protects against acute thromboembolism via the hematopoietic estrogen receptor alpha (ERα), and independently of ERβ. Here, we have explored the respective roles of membrane vs ...

journal_title：Endocrinology

authors： Valéra MC,Fontaine C,Lenfant F,Cabou C,Guillaume M,Smirnova N,Kim SH,Chambon P,Katzenellenbogen JA,Katzenellenbogen BS,Payrastre B,Arnal JF

更新日期：2015-11-01 00:00:00

abstract：:We have studied calmodulin (CaM)-like activity and calcium (Ca++)-regulated phosphodiesterase (PDE) activity in cells from the rat adrenal zona glomerulosa (ZG) and zona fasciculata (ZF). Boiled cell sonicates from the ZG and ZF activated CaM-deficient PDE in a dose-dependent fashion by 2.0- to 2.3-fold. The propertie...

journal_title：Endocrinology

authors： Koletsky RJ,Brown EM,Williams GH

更新日期：1983-08-01 00:00:00

abstract：:The importance of thyroid hormone (TH) in wound healing is not well understood. To gain insight, we evaluated the impact of TH deficiency on wound-healing genes in cultured keratinocytes. By RT-PCR, keratin 6a (K6a) and 16 (K16) gene expression in TH replete cells was 3.8- (P < 0.005) and 1.9-fold (P < 0.05) greater, ...

journal_title：Endocrinology

authors： Safer JD,Crawford TM,Holick MF

更新日期：2004-05-01 00:00:00

abstract：:The pregnancy hormone relaxin has recently been shown to be cardio-protective. Despite its well-established antifibrotic actions in the heart, the effects of relaxin on cardiomyocytes (CM) remain to be determined. We investigated effects of isoform 2 of the human relaxin (H2-relaxin) on CM hypertrophy and apoptosis. I...

journal_title：Endocrinology

authors： Moore XL,Tan SL,Lo CY,Fang L,Su YD,Gao XM,Woodcock EA,Summers RJ,Tregear GW,Bathgate RA,Du XJ

更新日期：2007-04-01 00:00:00

abstract：:The mechanism by which aluminum chloride stimulates de novo bone formation is unknown. To evaluate the role of bone remodeling and mature osteoblastic function in aluminum-induced neoosteogenesis, we compared the osteogenic effects of aluminum in normal beagles to those in animals with low turnover osteomalacia induce...

journal_title：Endocrinology

authors： Quarles LD,Drezner MK

更新日期：1992-07-01 00:00:00

abstract：:Patients with noninsulin-dependent diabetes mellitus exhibit increased proportions of plasma proinsulin and proinsulin conversion intermediates. We used hyperinsulinemic diabetic and nondiabetic Psammomys obesus to study the possible relationship between steady state pancreatic insulin stores and the proportion of pro...

journal_title：Endocrinology

authors： Gadot M,Leibowitz G,Shafrir E,Cerasi E,Gross DJ,Kaiser N

更新日期：1994-08-01 00:00:00

abstract：:The 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta HSD-2) enzyme is thought to confer aldosterone specificity upon mineralocorticoid target tissues by protecting the mineralocorticoid receptor from binding by the more abundant glucocorticoids, corticosterone and cortisol. We have developed a Chinese hamster ovar...

journal_title：Endocrinology

authors： Morita H,Zhou M,Foecking MF,Gomez-Sanchez EP,Cozza EN,Gomez-Sanchez CE

更新日期：1996-06-01 00:00:00

abstract：:Insulin radioreceptor assays were developed using splenic leukocytes and peripheral erythrocytes from individual mice. Splenic leukocytes were prepared using an NH4Cl buffer which did not alter insulin binding, but gave much higher yields than density gradient methods. Mouse erythrocytes were isolated from heparinized...

journal_title：Endocrinology

authors： Shimizu F,Kahn CR

更新日期：1982-02-01 00:00:00