Protective Hematopoietic Effect of Estrogens in a Mouse Model of Thrombosis: Respective Roles of Nuclear Versus Membrane Estrogen Receptor α.

abstract：:PTH secretion is tightly regulated by extracellular calcium ([Ca2+]e) and in turn regulates calcium homeostasis through its action on target tissues. We investigated the mechanism and physiological significance of intracellular calcium ([Ca2+]i) levels in relation to the secretion of PTH in single bovine parathyroid c...

journal_title：Endocrinology

authors： Miki H,Maercklein PB,Fitzpatrick LA

更新日期：1995-07-01 00:00:00

abstract：:To determine the basis for the marked daily variability in circulating luteinizing hormone (LH) in the female lamb shortly after birth and to determine whether circulating follicle-stimulating hormone (FSH) exhibits similar variability during this period of life, serum levels of both gonadotropins were monitored frequ...

journal_title：Endocrinology

authors： Foster DL,Jaffe RB,Niswender GD

更新日期：1975-01-01 00:00:00

abstract：:The aim of the study was to investigate the influence of severe hyperthyroidism on plasma high-density lipoprotein cholesterol (HDL-C). Recently, it was shown in mice that increasing doses of T(3) up-regulate hepatic expression of scavenger receptor class B, type I, resulting in increased clearance of plasma HDL-C. He...

journal_title：Endocrinology

authors： Tancevski I,Wehinger A,Demetz E,Eller P,Duwensee K,Huber J,Hochegger K,Schgoer W,Fievet C,Stellaard F,Rudling M,Patsch JR,Ritsch A

更新日期：2008-07-01 00:00:00

abstract：:Acute leptin increase as well as endogenous hyperleptinemia evoked by high-fat diets (HF) activate fatty acid metabolism in nonadipose tissues. This supports the notion that hyperleptinemia is pivotal to prevent/delay steatosis during periods of positive energy balance. We have previously shown that long-term HF spare...

journal_title：Endocrinology

authors： Guzmán-Ruiz R,Somoza B,Gil-Ortega M,Merino B,Cano V,Attané C,Castan-Laurell I,Valet P,Fernández-Alfonso MS,Ruiz-Gayo M

更新日期：2010-03-01 00:00:00

abstract：:In thyroid epithelial cells, TSH via cAMP induces a rounding up of the cells associated with actin stress fiber disruption, expression of differentiation genes and cell cycle progression. Here we have evaluated the role of small G proteins of the Rho family and their impact on the actin cytoskeleton in these different...

journal_title：Endocrinology

authors： Fortemaison N,Blancquaert S,Dumont JE,Maenhaut C,Aktories K,Roger PP,Dremier S

更新日期：2005-12-01 00:00:00

abstract：:The effects of K+ depletion and ouabain (0.1, 0.5, and 1 mM) on glucagon and insulin release from the in vitro perfused rat pancreas were studied in the absence or presence of arginine (10 mM). In the absence of arginine, K+ depletion resulted in an inhibition of glucagon release, both at a low (2.8 mM) and a higher (...

journal_title：Endocrinology

authors： Leclercq-Meyer V,Marchand J,Malaisse WJ

更新日期：1983-07-01 00:00:00

abstract：:We have characterized opioid binding sites in the Sertoli cells of adult and 18-day-old rat testes. Maximal specific etorphine binding was attained after 30 min at 4 C. The binding was reversible, with association and dissociation rate constants of 0.98 X 10(5) M-1 min-1 and 0.33 min-1, respectively. Scatchard analyse...

journal_title：Endocrinology

authors： Fabbri A,Tsai-Morris CH,Luna S,Fraioli F,Dufau ML

更新日期：1985-12-01 00:00:00

abstract：:Six pony mares were ovariectomized (OVX) on day 16 of diestrus during June and July, 1972, to study short term changes in plasma luteinizing hormone (LH) concentrations. Plasma LH was higher (P less than .05) 3 days after OVX (1.76 ng/ml) than the day after OVX (1.01 ng/ml), and a gradual increase occurred over the fi...

journal_title：Endocrinology

authors： Garcia MC,Ginther OJ

更新日期：1976-04-01 00:00:00

abstract：:The insulin-like growth factor-II (IGF-II)/Mannose 6-P receptor (Man 6-P) is a multifunctional receptor that binds two unrelated ligands, IGF-II and lysosomal enzymes that contain Man 6-P recognition markers. Although this receptor has been extensively characterized in mammalian cells, binding of radiolabeled IGF-II t...

journal_title：Endocrinology

authors： Yang YW,Robbins AR,Nissley SP,Rechler MM

更新日期：1991-02-01 00:00:00

abstract：:We investigated the effect of epidermal growth factor (EGF) on collagen and protein synthesis in clone MC3T30-E1, a cell line which retains osteoblast-like characteristics. EGF at concentrations of 2-50 ng/ml significantly the hydroxyproline content of the cell layer. These effects were completely abolished by the add...

journal_title：Endocrinology

authors： Hiramatsu M,Kumegawa M,Hatakeyama K,Yajima T,Minami N,Kodama H

更新日期：1982-12-01 00:00:00

abstract：:The neuroendocrine basis for short-day induced testicular regression was studied in Syrian hamsters of the LSH/Ss Lak strain. Adult animals were maintained either under long or short days (14:10D or 6L:18D, respectively) and given single, daily ip injections of N-methyl-D-aspartate (NMDA) (25 mg/kg BW); control animal...

journal_title：Endocrinology

authors： Urbanski HF

更新日期：1990-11-01 00:00:00

abstract：:Ghrelin was recently identified as an endogenous ligand of the GH secretagogue receptor. The novel peptide hormone is produced by gastric A-like cells, and circulating levels rise before feeding, suggestive of ghrelin as an endogenous hunger factor. ghrelin stimulates food intake and promotes adiposity after periphera...

journal_title：Endocrinology

authors： Tang-Christensen M,Vrang N,Ortmann S,Bidlingmaier M,Horvath TL,Tschöp M

更新日期：2004-10-01 00:00:00

abstract：:Stearoyl-CoA desaturase-1 (SCD-1) plays a pivotal role in an increase of triglyceride by an excess of dietary carbohydrate intake. Dietary carbohydrates increase SCD-1 gene expression in liver by sterol response element binding protein (SREBP)-1c-dependent and SREBP-1c -independent pathways. Previous report demonstrat...

journal_title：Endocrinology

authors： Hashimoto K,Ishida E,Miura A,Ozawa A,Shibusawa N,Satoh T,Okada S,Yamada M,Mori M

更新日期：2013-01-01 00:00:00

abstract：:In muscular dystrophy there is an imbalance between muscle protein synthesis and protein degradation, resulting in net muscle catabolism and progressive muscle weakness and wasting. Both insulin and insulin-like growth factor I (IGF-I) are known to have an anabolic effect on skeletal muscle, which is believed to be en...

journal_title：Endocrinology

authors： Zdanowicz MM,Moyse J,Wingertzahn MA,O'Connor M,Teichberg S,Slonim AE

更新日期：1995-11-01 00:00:00

abstract：:The direct effects of epinephrine and norepinephrine (NE) on lipid mobilization were studied in coho salmon liver slices incubated in vitro. Fatty acid (FA) release from liver slices was measured continuously by pH-stat titration. The pH-stat assay system was validated by simultaneous colorimetric measurement of FA an...

journal_title：Endocrinology

authors： Sheridan MA

更新日期：1987-06-01 00:00:00

abstract：:The molecular forms of GnRH in amphibia have not been characterized structurally. An antiserum to mammalian GnRH that shows appreciable cross-reactivity with chicken GnRH-I ([Gln8]GnRH), chicken GnRH-II ([His5,Trp7,Tyr8]GnRH), and salmon GnRH ([Trp7, Leu8]GnRH) was used in a RIA to detect GnRH-related peptides in an e...

journal_title：Endocrinology

authors： Conlon JM,Collin F,Chiang YC,Sower SA,Vaudry H

更新日期：1993-05-01 00:00:00

abstract：:Adipose tissue inflammation is associated with the development of insulin resistance. In obese adipose tissue, lipopolysaccharides (LPSs) and saturated fatty acids trigger inflammatory factors that mediate a paracrine loop between adipocytes and macrophages. However, the inflammatory signaling proteins underlying this...

journal_title：Endocrinology

authors： Ceppo F,Berthou F,Jager J,Dumas K,Cormont M,Tanti JF

更新日期：2014-03-01 00:00:00

abstract：:Previous studies have demonstrated that uterine progesterone (P) receptor is under dual hormonal control; estradiol (E2) induces the synthesis of cytosolic P receptor, and P induces the loss of its own receptor and antagonizes E2-induced P receptor replenishment. The objective of this study was to examine the contribu...

journal_title：Endocrinology

authors： Okulicz WC

更新日期：1986-06-01 00:00:00

abstract：:Twelve weeks of high-fat diet feeding causes ghrelin resistance in arcuate neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons. In the current study, we investigated whether diet-induced weight loss could restore NPY/AgRP neuronal responsiveness to ghrelin and whether ghrelin mediates rebound weight gain after ...

journal_title：Endocrinology

authors： Briggs DI,Lockie SH,Wu Q,Lemus MB,Stark R,Andrews ZB

更新日期：2013-02-01 00:00:00

abstract：:The nuclear orphan receptor human estrogen receptor-related receptor (ERR)-alpha is implicated in bone metabolism. We studied the effect of ERRalpha silencing in human mesenchymal stem cells (hMSCs) during osteoblastogenesis. We found that ERRalpha silencing led to an increase of bone sialoprotein and a decrease of os...

journal_title：Endocrinology

authors： Delhon I,Gutzwiller S,Morvan F,Rangwala S,Wyder L,Evans G,Studer A,Kneissel M,Fournier B

更新日期：2009-10-01 00:00:00

abstract：:GH treatment increases protein deposition and the efficiency of dietary protein used for growth. To identify the mechanisms that regulate tissue protein synthesis in response to exogenous GH treatment, fully fed, growing swine were treated with GH for 7 d. Fasted and fed pigs were infused with [1-(13)C]leucine to dete...

journal_title：Endocrinology

authors： Bush JA,Kimball SR,O'Connor PM,Suryawan A,Orellana RA,Nguyen HV,Jefferson LS,Davis TA

更新日期：2003-04-01 00:00:00

abstract：:The relationship between FSH-induced acquisition of LH/hCG receptors and the steroidogenic capacity of granulosa cells from estrogen-primed hypophysectomized rat ovaries has been examined. Granulosa cells harvested from the immature preantral follicles of animals not treated with FSH (controls) displayed negligible sp...

journal_title：Endocrinology

authors： Hillier SG,Zeleznik AJ,Ross GT

更新日期：1978-03-01 00:00:00

abstract：:Sertoli cells regulate differentiation and development of the testis and are essential for maintaining adult testis function. To model the effects of dysregulating Sertoli cell number during development or aging, we have used acute diphtheria toxin-mediated cell ablation to reduce Sertoli cell population size. Results...

journal_title：Endocrinology

authors： Rebourcet D,Darbey A,Monteiro A,Soffientini U,Tsai YT,Handel I,Pitetti JL,Nef S,Smith LB,O'Shaughnessy PJ

更新日期：2017-09-01 00:00:00

abstract：:PTH stimulates bone formation and increases hematopoietic stem cells through mechanisms as yet uncertain. The purpose of this study was to identify mechanisms by which PTH links actions on cells of hematopoietic origin with osteoblast-mediated bone formation. C57B6 mice (10 d) were nonlethally irradiated and then admi...

journal_title：Endocrinology

authors： Koh AJ,Novince CM,Li X,Wang T,Taichman RS,McCauley LK

更新日期：2011-12-01 00:00:00

abstract：:L-Triiodothyronine in vitro increased the uptake of the non-metabolizable amino acid, alpha-aminoisobutyrate, into isolated rat thymocytes. This effect was evident at extracellular free hormone concentrations of 10-7 to 5 times 10-8M and was due to a marked inhibition of amino acid efflux. In contrast, insulin and dib...

journal_title：Endocrinology

authors： Goldfine ID,Simons CG,Ingbar SH

更新日期：1975-03-01 00:00:00

abstract：:IGF-I mediates growth-promoting actions of GH. In the present study we investigated whether the somatostatin analog octreotide blunts the stimulatory effects of GH and/or IGF-I on bone growth in hypophysectomized rats infused for 6 d with vehicle, GH, or IGF-I. We found that octreotide significantly suppressed the GH-...

journal_title：Endocrinology

authors： Zapf J,Gosteli-Peter M,Weckbecker G,Hunziker EB,Reinecke M

更新日期：2002-08-01 00:00:00

abstract：:Steroid hormone synthesis is a vital function of the adrenal cortex, serves a critical role in gonadal function, and maintains pregnancy if normally executed in the placenta. The substrate for the synthesis of all steroid hormones is cholesterol, and its conversion to the first steroid, pregnenolone, by the cholestero...

journal_title：Endocrinology

authors： Yivgi-Ohana N,Sher N,Melamed-Book N,Eimerl S,Koler M,Manna PR,Stocco DM,Orly J

更新日期：2009-02-01 00:00:00

abstract：:Previous immunohistochemical and in situ hybridization studies of sheep, goats, and rodents indicated that kisspeptin (KP), neurokinin B (NKB), and dynorphin A (DYN) are extensively colocalized in the hypothalamic arcuate nucleus, thus providing a basis for the KP/NKB/DYN (KNDy) neuron concept; in both sexes, KNDy neu...

journal_title：Endocrinology

authors： Hrabovszky E,Sipos MT,Molnár CS,Ciofi P,Borsay BÁ,Gergely P,Herczeg L,Bloom SR,Ghatei MA,Dhillo WS,Liposits Z

更新日期：2012-10-01 00:00:00

abstract：:A protein [steroidogenesis-inducing protein (SIP)] has been isolated from human ovarian follicular fluid and shown previously to stimulate steroidogenesis in Leydig cells, adrenal cells, and early luteal cells. Since proteins and peptides known to regulate steroidogenesis, such as gonadotropins and growth factors, als...

journal_title：Endocrinology

authors： Khan SA,Teerds K,Dorrington J

更新日期：1992-02-01 00:00:00

abstract：:Loss of circulating 17β-estradiol (E2) that occurs during menopause can have detrimental effects on cognitive function. The efficacy of hormone replacement therapy declines as women become farther removed from the menopausal transition, yet the molecular mechanisms underlying this age-related switch in E2 efficacy are...

journal_title：Endocrinology

authors： Shults CL,Pinceti E,Rao YS,Pak TR

更新日期：2015-11-01 00:00:00